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Itens para a visualização no momento 1-20 de 28
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FERREIRA, EDUARDO G.A.
; MARUMO, JULIO T.
; FRANCO, MARGARETH K.K.D.
; YOKAICHIYA, FABIANO; VICENTE, ROBERTO
. 10000 years cement: Can hydrated cement last as much as long-lived radionuclides?.
Cement and Concrete Composites,
v. 103,
p. 339-352,
2019.
DOI:
10.1016/j.cemconcomp.2019.05.016
Abstract:
This review is focused on the long-term performance of cementitious materials in a repository for radioactive
waste. During the last few years, the disposal of disused sealed radioactive sources (DSRS) in a borehole type
repository has been studied by many countries. The borehole concept is particularly useful to dispose of spent
nuclear fuel and DSRS. In boreholes for DSRS, cementitious materials are intended to be used as structural
material, immobilization matrix and as backfill. The understanding of the performance of these materials is
essential to ensure the safety of the facilities during their required lifetime, from centuries to many thousands of
years, depending on the initial activity and half-life of the waste. This review approaches the behavior of the
cement from the hydration and hardening to the long-term processes that can affect its durability. Three main
causes of failure of repository-engineered barriers are recognized: a) the formation of a preferential pathway for
the migration of the contained radionuclides to the biosphere; b) loss of resistance and cohesion of the structural
cementitious material; and c) the increase in the corrosion processes of the metallic components of the structures
that affect the overall containment of the facility.
Palavras-Chave: cement industry; portland cement; radioactive wastes; geologic formations; underground disposal; performance; chemical composition; mineralogy; radiations; magnetic fields; hydration
. 10000 years cement: Can hydrated cement last as much as long-lived radionuclides?. Cement and Concrete Composites, v. 103, p. 339-352, 2019. DOI: 10.1016/j.cemconcomp.2019.05.016. Disponível em: http://repositorio.ipen.br/handle/123456789/30368. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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URBANI, G.L.; FRANCO, M.K.K.D.
; YOKAICHIYA, F.
; VICENTE, R.
. Aplicação da química de radiação à questões tecnológicas do cimento relacionadas ao desenvolvimento de repositórios de rejeitos radioativos do modelo borehole.
In: BALDOVI, ALDREW A. (Ed.); CONCEIÇÃO, ANA C.S. (Ed.); ANTENOR, ANANDA de O.G. (Ed.); CHYOSHI, BRUNA (Ed.); COSTA, DANILO O. da (Ed.); ANDRADE, HEDLLA M. (Ed.); FARIA, JULIA K. (Ed.); KOHATSU, MARCIO Y. (Ed.); MENDES, MARIANA E. (Ed.); COELHO, LUCIA, H.G. (Coord.); TAMBOSI, LEANDRO R. (Coord.) SIMPÓSIO DE CIÊNCIA E TECNOLOGIA AMBIENTAL, 1st,
2-3 de outubro, 2019,
Santo André, SP.
Anais...
Santo André, SP: Universidade Federal do ABC,
2019.
p. 226-231.
Abstract:
Resíduos radioativos são usualmente descartados em repositórios do tipo borehole ou de superfície. Por questões de segurança, devem ser depositados em tambores e cobertos por cimento na sua destinação final. A radiação gama proveniente dos resíduos radioativos interage com a água livre da pasta de cimento e causa o fenômeno da radiólise. Essa interação que decompõe a água da pasta de cimento é estudada pela academia científica e ainda não é um consenso se a mesma afeta a resistência do concreto ou não. Para um melhor entendimento dessa questão, nesse estudo um modelo teórico simples é sugerido para quantificar a porcentagem da água que sofre radiólise e se essa perda é suficiente para afetar a resistência da barreira de cimento. O resultado indica que a quantidade de água perdida neste processo não é suficiente para diminuir a resistência do concreto. O modelo proposto foi aplicado para verificar os resultados experimentais, utilizando as condições iniciais expostas na literatura existente, com o propósito comparação e discussão sobre o fenômeno da radiólise.
Palavras-Chave: radioactive waste storage; storage facilities; portland cement; portland cement; boreholes; radiolysis
. Aplicação da química de radiação à questões tecnológicas do cimento relacionadas ao desenvolvimento de repositórios de rejeitos radioativos do modelo borehole. In: BALDOVI, ALDREW A. (ed.); CONCEIÇÃO, ANA C.S. (ed.); ANTENOR, ANANDA de O.G. (ed.); CHYOSHI, BRUNA (ed.); COSTA, DANILO O. da (ed.); ANDRADE, HEDLLA M. (ed.); FARIA, JULIA K. (ed.); KOHATSU, MARCIO Y. (ed.); MENDES, MARIANA E. (ed.); COELHO, LUCIA, H.G. (coord.); TAMBOSI, LEANDRO R. (coord.) SIMPÓSIO DE CIÊNCIA E TECNOLOGIA AMBIENTAL, 1st, 2-3 de outubro, 2019, Santo André, SP. Anais... Santo André, SP: Universidade Federal do ABC, 2019. p. 226-231. Disponível em: http://repositorio.ipen.br/handle/123456789/30984. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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COUTO, VERONICA M.; OLIVEIRA-NASCIMENTO, LAURA de; CABEÇA, LUIZ F.; GERALDES, DANILO C.; COSTA, JULIANA S.R.; RISKE, KARIN A.; FRANZ-MONTAN, MICHELLE; YOKAYCHIYA, FABIANO
; FRANCO, MARGARETH K.K.D.
; PAULA, ENEIDA de. Capsaicin-cyclodextrin complex enhances mepivacaine targeting and improves local anesthesia in inflamed tissues.
International Journal of Molecular Sciences,
v. 21,
n. 16,
p. 1-18,
2020.
DOI:
10.3390/ijms21165741
Abstract:
Acidic environments, such as in inflamed tissues, favor the charged form of local anesthetics (LA). Hence, these drugs show less cell permeation and diminished potency. Since the analgesic capsaicin (CAP) triggers opening of the TRPV1 receptor pore, its combination with LAs could result in better uptake and improved anesthesia. We tested the above hypothesis and report here for the first time the analgesia effect of a two-drug combination (LA and CAP) on an inflamed tissue. First, CAP solubility increased up to 20 times with hydroxypropyl-beta-cyclodextrin (HP-β-CD), as shown by the phase solubility study. The resulting complex (HP-β-CD-CAP) showed 1:1 stoichiometry and high association constant, according to phase-solubility diagrams and isothermal titration calorimetry data. The inclusion complex formation was also confirmed and characterized by differential scanning calorimetry (DSC), X-ray diffraction, and 1H-NMR. The freeze-dried complex showed physicochemical stability for at least 12 months. To test in vivo performance, we used a pain model based on mouse paw edema. Results showed that 2% mepivacaine injection failed to anesthetize mice inflamed paw, but its combination with complexed CAP resulted in pain control up to 45 min. These promising results encourages deeper research of CAP as an adjuvant for anesthesia in inflamed tissues and cyclodextrin as a solubilizing agent for targeting molecules in drug delivery.
Palavras-Chave: anesthesia; inflammation; anesthetics; dextrin; scanning electron microscopy; differential thermal analysis; calorimetry
. Capsaicin-cyclodextrin complex enhances mepivacaine targeting and improves local anesthesia in inflamed tissues. International Journal of Molecular Sciences, v. 21, n. 16, p. 1-18, 2020. DOI: 10.3390/ijms21165741. Disponível em: http://200.136.52.105/handle/123456789/31612. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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VIGATO, ARYANE A.; MACHADO, IAN P.; FRANCO, MARGARETH K.K.D.
; YOKAICHIYA, FABIANO; SAIRRE, MIRELA I. de; ARAUJO, DANIELE R. de. Chemical and structural characterization of hybrid delivery systems studied by FTIR, NMR, and SAS techniques.
In: KESHARWANI, P. (Ed.); JAIN, N.K. (Ed.).
Hybrid Nanomaterials for Drug Delivery.
Cambridge, MA, United States: Woodhead Publishing,
2022.
p. 27-51,
cap. 2.
(Woodhead Publishing Series in Biomaterials).
DOI:
10.1016/B978-0-323-85754-3.00005-8
Abstract:
In recent years, the research for new classes of materials for biomedical applications has directed the synthesis and design of hybrid systems composed of two or more components (metals, clays, ceramics, bioglass, polymers, lipids, enzymes) conferring to them multifunctional properties, in general synergistic, different to those obtained for their parent components. One of the main advantages attributed to hybrid systems is their ability to modulate the drug release rate into the biological medium, which improve their therapeutic efficacy. However, this enhanced biomedical performance is a result of chemical interactions among material components that assume different levels of structural organization. This chapter provides a discussion about applications of three physicochemical techniques used for characterizing those materials, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, and small-angle scattering. Therefore a brief introduction on fundamental techniques followed by a discussion on relationships between composition and main chemical and structural finding are covered.
Palavras-Chave: nanomaterials; medical supplies; drug delivery; hybrid systems
. Chemical and structural characterization of hybrid delivery systems studied by FTIR, NMR, and SAS techniques. In: KESHARWANI, P. (ed.); JAIN, N.K. (ed.). Hybrid Nanomaterials for Drug Delivery. Cambridge, MA, United States: Woodhead Publishing, 2022. cap. 2. p. 27-51. (Woodhead Publishing Series in Biomaterials). DOI: 10.1016/B978-0-323-85754-3.00005-8. Disponível em: http://repositorio.ipen.br/handle/123456789/33235. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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BEZAMAT, JULIANA M.; YOKAICHIYA, FABIANO
; FRANCO, MARGARETH K.K.D.
; CASTRO, SIMONE R.; PAULA, ENEIDA de; CABEÇA, LUIS F.. Complexation of the local anesthetic pramoxine with hydroxypropyl-beta-cyclodextrin can improve its bioavailability.
Journal of Drug Delivery Science and Technology,
v. 55,
p. 1-8,
2020.
DOI:
10.1016/j.jddst.2019.101475
Abstract:
Local anesthetics are widely used in clinical procedures, to eliminate pain during/after invasive procedures. A
wide range of drug delivery systems has been developed to improve the effect of local anesthetics and/or to
reduce their toxicity. Pramoxine (PMX) is a topical anesthetic agent with an unusual (morpholine ring) structure
and low solubility (ca. 3 mM at pH 7.4). In this work, a novel formulation was devised for PMX in hydroxypropyl-
β-cyclodextrin (HP-β-CD). Host-guest inclusion complex was prepared by the co-solubilization method,
with complexation kinetics of 10 h, and 1:1 PMX/HP-β-CD stoichiometry. Complexation promoted 14-fold increase
in the solubility of PMX. X-ray diffraction measurements revealed loss of the crystalline PMX pattern in
the presence of HP-β-CD, an indication of inclusion complexation. Using 1H NMR (DOSY) experiments the association
constant of PMX to HP-β-CD (Ka = 923.1 mol/L) was determined, while nuclear Overhauser (ROESY)
analysis confirmed the formation of PMX/HP-β-CD inclusion complex, by detection of spatial proximities between
hydrogens from PMX aromatic ring and cyclodextrin's cavity. In two in vitro toxicity models (mouse 3T3
fibroblasts in culture and red blood cells hemolysis) pramoxine toxicity was significantly reduced upon complexation
into HP-β-CD. These results point out PMX/HP-β-CD as a promising pharmaceutical formulation to
improve the bioavailability of pramoxine, allowing its application beyond topical anesthesia.
Palavras-Chave: anesthesia; oligosaccharides; complexes; anesthetics; clathrates; nuclear magnetic resonance; stoichiometry; antimitotic drugs; hemolysis; chemical composition
. Complexation of the local anesthetic pramoxine with hydroxypropyl-beta-cyclodextrin can improve its bioavailability. Journal of Drug Delivery Science and Technology, v. 55, p. 1-8, 2020. DOI: 10.1016/j.jddst.2019.101475. Disponível em: http://repositorio.ipen.br/handle/123456789/31079. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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MILAGRE, MARIANA X.
; FRANCO, MARGARETH
; GENEZINI, FREDERICO
; WIMPORY, ROBERT C.; YOKAICHIYA, FABIANO; COSTA, ISOLDA
. A correlation between microstructure and residual stress in the 6061 Al–Mg–Si alloy with different thermomechanical process.
SN Applied Sciences,
v. 2,
n. 12,
2020.
DOI:
10.1007/s42452-020-03945-y
Abstract:
Depending on the nature of the loading during service, the level and nature of residual stress can contribute to the lower
service-life of a component. In this study the internal level of the residual stress of a 6061 Al–Mg–Si alloy with different
thermomechanical processes was evaluated by residual stress neutron diffraction (RSND). Commercial tempers such
as T6 (peak aged) and O (annealed) were compared with the 6061 alloy after different steps of a thermomechanical
processing used for the manufacturing of nuclear fuel plates, R3 and R9H60. The results showed that the lowest level
of residual stress was found for the peak age, T6 condition. This was associated with the highest microhardness value
(highest density of "β″ phase) and lowest grain size. The O temper was the only condition which showed compressive
residual stress and the most coarsened precipitates. The nuclear thermomechanical processes, R3 and R9H60, resulted
in increased level residual stress related to the T6 and showed a tensile nature in relation to its parent material (6061-O).
Moreover, the RSND technique allows observing that the texture is also higher for the samples processed by the nuclear
thermomechanical process due the hot rolling stage.
Palavras-Chave: microstructure; residual stresses; aluminium alloys; neutron diffraction; thermomechanical treatments; magnesium alloys; silicon alloys; friction welding
. A correlation between microstructure and residual stress in the 6061 Al–Mg–Si alloy with different thermomechanical process. SN Applied Sciences, v. 2, n. 12, 2020. DOI: 10.1007/s42452-020-03945-y. Disponível em: http://200.136.52.105/handle/123456789/31782. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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MILAGRE, MARIANA X.
; PEREIRA, MARCO S.
; GOMES, ANTONIO A.
; SCAPIN, MARCOS
; FRANCO, MARGARETH
; YOKAICHIYA, FABIANO; GENEZINI, FREDERICO
; COSTA, ISOLDA
. Corrosion characterization of the 6061 Al–Mg–Si alloy in synthetic acid rain using neutron tomography.
Applied Radiation and Isotopes,
v. 184,
p. 1-8,
2022.
DOI:
10.1016/j.apradiso.2022.110197
Abstract:
Neutron tomography has gained increasing importance as an imaging technique for materials characterization.
In general, neutron beams are able to show microstructure features of hydrogenous materials, even enfolded with
thick metal layers. In the present paper, neutron tomography and observation of cross section images were
successfully applied to investigate the corrosion features of the 6061 Al–Mg–Si alloy. The results showed good
agreement between neutron 3D tomography and the cross section images obtained in the high attenuation areas
of the samples, whereas significant differences in depth of corrosion penetration were obtained between the
results from Neutron Tomography and 3D optical profilometry.
Palavras-Chave: aluminium alloys; corrosion resistance; three-dimensional calculations; stresses; neutrons; tomography
. Corrosion characterization of the 6061 Al–Mg–Si alloy in synthetic acid rain using neutron tomography. Applied Radiation and Isotopes, v. 184, p. 1-8, 2022. DOI: 10.1016/j.apradiso.2022.110197. Disponível em: http://repositorio.ipen.br/handle/123456789/33155. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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SOUZA, ALEXANDRE P.S.
; OLIVEIRA, LUIZ P. de
; YOKAICHIYA, FABIANO; GENEZINI, FREDERICO A.
; FRANCO, MARGARETH K.K.D.
. A diffractometer project for Brazilian Multipurpose Reactor (RMB): McStas simulations and instrument optimization.
In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE,
October 21-25, 2019,
Santos, SP.
Proceedings...
Rio de Janeiro: Associação Brasileira de Energia Nuclear,
2019.
p. 1190-1199.
Abstract:
High-resolution di ractometer is one of the rst instruments of the set of 15 priority neutron scattering
instruments to be installed at the Brazilian Multipurpose Reactor (RMB). A basic project of this instrument
consists of the existence of three guides through which neutrons pass from source to sample to
guarantee maximum neutron
ux at the sample position. In this study we investigate guide geometry
performance considering xed di ractometer geometry and spatial arrangement. Comparisons between
di erent guide shapes and supermirrors are performed using software based on the Monte Carlo method,
McStas. Our conclusion shows that a better solution is splitting the initial
ux into two di erent guides
to obtain the maximum
ux at the sample position.
Palavras-Chave: computer codes; computerized simulation; configuration; diffractometers; monte carlo method; neutron flux; neutron guides; neutron sources; optimization; rmb reactor
. A diffractometer project for Brazilian Multipurpose Reactor (RMB): McStas simulations and instrument optimization. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE, October 21-25, 2019, Santos, SP. Proceedings... Rio de Janeiro: Associação Brasileira de Energia Nuclear, 2019. p. 1190-1199. Disponível em: http://repositorio.ipen.br/handle/123456789/30558. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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SOUZA, A.P.S.
; OLIVEIRA, L.P. de
; YOKAICHIYA, F.; GENEZINI, F.A.
; FRANCO, M.K.K.D.
. A diffractometer project for Brazilian Multipurpose Reactor (RMB): McStas simulations and instrument optimization.
Brazilian Journal of Radiation Sciences,
v. 9,
n. 1A,
p. 1-17,
2021.
DOI:
10.15392/bjrs.v9i1A.1499
Abstract:
The high-resolution diffractometer is one of the first instruments of the set of 15 priority neutron scattering instruments to be installed at the Brazilian Multipurpose Reactor (RMB). A basic project of this instrument consists of the existence of three guides through which neutrons pass from source to sample to guarantee maximum neutron flux at the sample position. In this study, we investigate guide geometry performance considering fixed diffractometer geometry and spatial arrangement. Comparisons between different guide shapes and supermirrors are performed using software based on the Monte Carlo method, McStas. Our conclusion shows that a better solution is splitting the initial flux into two different guides to obtain the maximum flux at the sample position.
Palavras-Chave: computer codes; computerized simulation; configuration; diffractometers; monte carlo method; neutron flux; neutron guides; neutron sources; optimization; rmb reactor
. A diffractometer project for Brazilian Multipurpose Reactor (RMB): McStas simulations and instrument optimization. Brazilian Journal of Radiation Sciences, v. 9, n. 1A, p. 1-17, 2021. DOI: 10.15392/bjrs.v9i1A.1499. Disponível em: http://repositorio.ipen.br/handle/123456789/32129. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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FERREIRA, EDUARDO
; VICENTE, ROBERTO
; TURRILLAS, XABIER; YOKAICHIYA, FABIANO; FRANCO, MARGARETH
; MARTINEZ, LUIS G.
; CARVALHO, ALEXANDRE; MARUMO, JULIO T.
. Effects of gamma radiation on cementitious materials in repository environment.
In: ANNUAL WASTE MANAGEMENT CONFERENCE,
March 6-10, 2016,
Phoenix, Arizona, USA.
Proceedings...
Tempe, Arizona, USA: Waste Management Symposia,
2016.
p. 1-10.
Abstract:
Cementitious materials are widely used in the management of radioactive waste and have to perform as required for the period of service life of the installation. In order to assess the long term durability of cement paste in a deep borehole for radioactive wastes, specimens were casted in laboratory and exposed to a gamma radiation field. The effects of the radiation in the specimens were evaluated by X-Ray Diffraction, as changes observed in the mineralogy and microstructure of the material after irradiation doses varying between 0 (without radiation) and 10 MGy. It was observed that the specimens exposed to higher doses of gamma radiation (up to 3MGy) presented differences between surface and core, when compared with the samples with no radiation or exposed to low doses. These results are important to model the behavior of cementitious materials under the conditions expected in a borehole repository and to provide data for the safety assessment of the installation.
Palavras-Chave: boreholes; cements; comparative evaluations; gamma radiation; microstructure; nuclear materials management; radiation doses; radioactive wastes; risk assessment; service life; wear resistance; x-ray diffraction
. Effects of gamma radiation on cementitious materials in repository environment. In: ANNUAL WASTE MANAGEMENT CONFERENCE, March 6-10, 2016, Phoenix, Arizona, USA. Proceedings... Tempe, Arizona, USA: Waste Management Symposia, 2016. p. 1-10. Disponível em: http://repositorio.ipen.br/handle/123456789/31301. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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MITSUTAKE, HERY; SOUZA, ALESSANDRO D. de; YOKAICHIYA, FABIANO; FRANCO, MARGARETH K.K.D.
; CLEMENS, DANIEL; KENT, BEN; BREITKREITZ, MARCIA C.; RIBEIRO, LIGIA N. de M.; PAULA, ENEIDA de; BORDALLO, HELOISA N.. Evaluation of structural changes of benzocaine-loaded, optimized nanostructured lipid carriers using SANS and Raman imaging approaches.
In: CONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th,
October 4-8, 2021,
São Paulo, SP.
Abstract...
São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq),
2021.
p. 183-183.
Abstract:
Local anesthetics are substances that reversibly block the nerve-impulse conduction, alleviating pain without loss of
consciousness. Benzocaine, a poorly soluble local anesthetic, is an ester of para-aminobenzoic acid. Several
strategies of formulations can be used to improve bioavailability and decrease adverse effects of benzocaine. In this
study nanostructured lipid carriers (NLC) were employed. These lipid-based drug delivery carriers have a lipid core
composed of a blend of solid and liquid lipids, and a shelf of non-ionic surfactant. The main aim of this work was to
optimize benzocaine-loaded NLC and to investigate structural changes in these nanoparticles, under different
temperatures. The ratio of excipients (cetyl palmitate, Capmul® PG-8 NF and Pluronic®F68) and benzocaine in the
NLC was optimized using a 2 3 factorial design with respect to the following parameters: particle size, polydispersity
index (PDI) and zeta potentials. The interactions between the factors were found relevant to determine particle size
and PDI. Using desirability function, the best formulation conditions were found. Structural changes in optimized NLC
were observed with Small-Angle Neutron Scattering (SANS) and Raman imaging, in samples at 27, 37 and 40º C.
SANS pointed the formation of lamellar structures inside the NLC, which interlamellar distances increase at higher
temperature. Raman imaging showed that the incorporation of P68 and benzocaine in-between the lipids increased
at higher temperatures, explaining the changes in Q values (SANS). This work shows how different scattering
techniques can provide complementary information and be used together to characterize and understand the
physical, chemical, and structural changes on the organization of pharmaceutical carriers in drug delivery system.
Palavras-Chave: drugs; pharmacology; anesthetics; drug delivery; design; raman spectra
. Evaluation of structural changes of benzocaine-loaded, optimized nanostructured lipid carriers using SANS and Raman imaging approaches. In: CONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th, October 4-8, 2021, São Paulo, SP. Abstract... São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq), 2021. p. 183-183. Disponível em: http://repositorio.ipen.br/handle/123456789/32868. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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MITSUTAKE, HERY; SOUZA, ALESSANDRO D. de; YOKAICHIYA, FABIANO; FRANCO, MARGARETH K.K.D.
; CLEMENS, DANIEL; KENT, BEN; BREITKREITZ, MARCIA C.; RIBEIRO, LIGIA N. de M.; PAULA, ENEIDA de; BORDALLO, HELOISA N.. Evaluation of structural changes of benzocaine-loaded, optimized nanostructured lipid carriers using SANS and Raman imaging approaches.
Biophysical Reviews,
v. 13,
n. 6,
p. 1335-1335,
2021.
DOI:
10.1007/s12551-021-00845-2
Abstract:
INTRODUCTION
Local anesthetics are substances that reversibly block the nerve-impulse
conduction, alleviating pain without loss of consciousness. Benzocaine, a
poorly soluble local anesthetic, is an ester of para-aminobenzoic acid.
Several strategies of formulations can be used to improve bioavailability
and decrease adverse effects of benzocaine. In this study nanostructured
lipid carriers (NLC) were employed. These lipid-based drug delivery
carriers have a lipid core composed of a blend of solid and liquid lipids,
and a shelf of non-ionic surfactant.
OBJECTIVES
The main aim of this work was to optimize benzocaine-loaded NLC and
to investigate structural changes in these nanoparticles, under different
temperatures.
MATERIALS AND METHODS
The ratio of excipients (cetyl palmitate, Capmul® PG-8 NF and
Pluronic®F68) and benzocaine in the NLC was optimized using a 2 3
factorial design with respect to the following parameters: particle size,
polydispersity index (PDI) and zeta potentials.
DISCUSSION AND RESULTS
The interactions between the factors were found relevant to determine
particle size and PDI. Using desirability function, the best formulation
conditions were found. Structural changes in optimized NLC were observed
with Small-Angle Neutron Scattering (SANS) and Raman imaging,
in samples at 27, 37 and 40º C. SANS pointed the formation of
lamellar structures inside the NLC, which interlamellar distances increase
at higher temperature. Raman imaging showed that the incorporation of
P68 and benzocaine in-between the lipids increased at higher temperatures,
explaining the changes in Q values (SANS).
CONCLUSION
This work shows how different scattering techniques can provide complementary
information and be used together to characterize and understand
the physical, chemical, and structural changes on the organization
of pharmaceutical carriers in drug delivery system.
. Evaluation of structural changes of benzocaine-loaded, optimized nanostructured lipid carriers using SANS and Raman imaging approaches. Biophysical Reviews, v. 13, n. 6, p. 1335-1335, 2021. DOI: 10.1007/s12551-021-00845-2. Disponível em: http://repositorio.ipen.br/handle/123456789/32884. Acesso em: $DATA.Como referenciar este item
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
-
SEPULVEDA, ANDERSON F.; VOLLRATH-KUMPGDEE, MONT; FRANCO, MARGARETH K.K.D.
; YOKAICHIYA, FABIANO; ARAUJO, DANIELE R. de. Hyaluronic acid incorporation modulates rheological and drug release properties in Poloxamer-based hydrogels.
In: ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY (SBBq), 51st; CONGRESS OF BRAZILIAN BIOPHYSICAL SOCIETY (SBBf)/LATIN AMERICAN FEDERATION OF BIOPHYSICAL SOCIETIES (Lafebs), 46th,
September 5-8, 2022,
Águas de Lindóia, SP.
Abstract...
São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq,
2022.
p. 254-254.
Abstract:
INTRODUCTION: Synthetic polymer Poloxamer (PL) 407 (15% and 30% w/w) and binary formulation PL 407 15% +
PL 338 15% (BF), with natural polymer hyaluronic acid 0.5% w/w, were designed as bupivacaine or ropivacaine
thermosensitive release systems. OBJECTIVES: The aim of this work is to characterize structure and stability of drug
delivery systems. MATERIALS AND METHODS: These systems were characterized by calorimetry, rheology, SANS,
and release profile. DISCUSSION AND RESULTS: Calorimetry results demonstrated all formulations are stable at
storage and physiological temperatures. PL 407 30% and BF systems are structurally more organized and with higher
consistency (G’/G’’ ~ 50) at 37 °C and with lower gelation temperature (Tg ~ 14 °C) than PL 407 15% ones (G’/G’’ ~
0.30 and Tg ~ 45 °C, respectively), however BFs have increased viscosity and slightly higher stiffness (G’/G’’ ~ 60)
when compared to PL 407 30% formulations, due to more hydrophilicity of PL 338 chains than PL 407. Adding HA, it
is observed enhanced viscosity but diminished consistency (G’/G’’ ~ 0.40). When a drug is incorporated, it is seen that
it promotes increased interaction between chains. Although material alteration when incorporating HA or drug is
observed, SANS results showed that the type of supramolecular structure is dependent on the concentration of
Poloxamer. Systems with low concentration of Poloxamer have lamellar type, while formulations with 30% of
Poloxamer have both cubic and hexagonal structures. In addition, PL 407 30% formulations undergo greater
compression when bupivacaine is added (~ 29.7 nm at 25 °C and 37 °C). As drug release profiles showed, BFs release
drugs in a more controlled way than other formulations. Moreover, HA hinders the release of both drugs.
CONCLUSION: Thus, it is clear that the incorporation of more hydrophilic polymers is able to modulate the drug release
rate according to the hydrogels rheological parameters.
. Hyaluronic acid incorporation modulates rheological and drug release properties in Poloxamer-based hydrogels. In: ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY (SBBq), 51st; CONGRESS OF BRAZILIAN BIOPHYSICAL SOCIETY (SBBf)/LATIN AMERICAN FEDERATION OF BIOPHYSICAL SOCIETIES (Lafebs), 46th, September 5-8, 2022, Águas de Lindóia, SP. Abstract... São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq, 2022. p. 254-254. Disponível em: http://repositorio.ipen.br/handle/123456789/33909. Acesso em: $DATA.Como referenciar este item
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
-
TREMARIN, BEATRIZ; YOKAICHIYA, FABIANO; KELLERMANN, GUINTHER; FRANCO, MARGARETH K.K.D.
; STORSBERG, JOACHIM. Improvement of the methodological strategies to product functionalizes antibodies using Small Angle Neutron Scattering (SANS).
Biophysical Reviews,
v. 13,
n. 6,
p. 1301-1301,
2021.
DOI:
10.1007/s12551-021-00845-2
Abstract:
INTRODUCTION
Antibodies are used by jawed vertebrates for defense against invading
pathogens. Usage of those versatile tools in a plethora of settings in clinics
and biomedical sciences hinges on functionalization strategies that retain
native antibody reactivity. To this date, antibody functionalization is performed
by trial and error.
OBJECTIVES
We aim to reduce costs by providing general principles to allow the full
spectrum of antibody functionalization by correlating functionalized antibody
reactivity to cognate antigen by small angle neutron scattering,
SANS, measurements and mathematical modeling of antibody and
antibody-antigen super-complexes, obtained by titration experiments.
MATERIALS AND METHODS
For this research we have used for as antibody pure goat anti rabbit
immunoglobulin, and for the antigen, pure Horseradish Peroxidase
Preliminary results show that the systems (antibody and
antibody-antigen complexes) do not change in the range of a temperature
related to storage temperature (25º C), body temperature (37º C) and 40º
C.
DISCUSSION AND RESULTS
These results will give us the pair distribution function of these systems
and the results will be viewed in light of published precedence to highlight
areas where future effort is needed to refine such versatile tools and
improve their production. However, between the antibody and the complexes
structure, different conformations were observed. The antibody
has a globular structure with a radius of gyration around 33 Å, and the
complexes display an elongated cylindrical shape with radius of gyration
around 63 Å.
CONCLUSION
This study shows how the scattering techniques (SANS) can provide
useful information about the conformation of the antibody and
antibody-antigen formation and help to shed light in the understanding
the physical, chemical, and structural changes on the organization of these
important antibody functionalization for the immunological system.
. Improvement of the methodological strategies to product functionalizes antibodies using Small Angle Neutron Scattering (SANS). Biophysical Reviews, v. 13, n. 6, p. 1301-1301, 2021. DOI: 10.1007/s12551-021-00845-2. Disponível em: http://repositorio.ipen.br/handle/123456789/32882. Acesso em: $DATA.Como referenciar este item
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
-
TREMARIN, BEATRIZ; YOKAICHIYA, FABIANO; KELLERMANN, GUINTHER; FRANCO, MARGARETH K.K.D.
; STORSBERG, JOACHIM. Improvement of the methodological strategies to product functionalizes antibodies using Small Angle Neutron Scattering (SANS).
In: CONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th,
October 4-8, 2021,
São Paulo, SP.
Abstract...
São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq),
2021.
p. 138-138.
Abstract:
Antibodies are used by jawed vertebrates for defense against invading pathogens. Usage of those versatile tools in
a plethora of settings in clinics and biomedical sciences hinges on functionalization strategies that retain native
antibody reactivity. To this date, antibody functionalization is performed by trial and error. We aim to reduce costs by
providing general principles to allow the full spectrum of antibody functionalization by correlating functionalized
antibody reactivity to cognate antigen by small angle neutron scattering, SANS, measurements and mathematical
modeling of antibody and antibody-antigen super-complexes, obtained by titration experiments. For this research we
have used for as antibody pure goat anti rabbit immunoglobulin, and for the antigen, pure Horseradish Peroxidase
Preliminary results show that the systems (antibody and antibody-antigen complexes) do not change in the range of
a temperature related to storage temperature (25º C), body temperature (37º C) and 40º C. These results will give
us the pair distribution function of these systems and the results will be viewed in light of published precedence to
highlight areas where future effort is needed to refine such versatile tools and improve their production. However,
between the antibody and the complexes structure, different conformations were observed. The antibody has a
globular structure with a radius of gyration around 33 Å, and the complexes display an elongated cylindrical shape
with radius of gyration around 63 Å. This study shows how the scattering techniques (SANS) can provide useful
information about the conformation of the antibody and antibody-antigen formation and help to shed light in the
understanding the physical, chemical, and structural changes on the organization of these important antibody
functionalization for the immunological system.
Palavras-Chave: neutrons; small angle scattering; antigen-antibody reactions; biophysics
. Improvement of the methodological strategies to product functionalizes antibodies using Small Angle Neutron Scattering (SANS). In: CONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th, October 4-8, 2021, São Paulo, SP. Abstract... São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq), 2021. p. 138-138. Disponível em: http://repositorio.ipen.br/handle/123456789/32866. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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MARIANO, KELLI C.F.; NASCIMENTO, MONICA H.M. do; QUEROBINO, SAMYR M.; CAMPOS, ESTEFANIA V.R.; OLIVEIRA, JHONES L. de; YOKAICHIYA, FABIANO; FRANCO, MARGARETH K.K.D.
; ALBERTO-SILVA, CARLOS; PAULA, ENEIDA de; LOMBELLO, CHRISTIANE B.; LIMA, RENATA de; FRACETO, LEONARDO F.; ARAUJO, DANIELE R. de. Influence of chitosan-tripolyphosphate nanoparticles on thermosensitive polymeric hydrogels: structural organization, drug release mechanisms and cytotoxicity.
International Journal of Polymeric Materials and Polymeric Biomaterials,
v. 69,
n. 9,
p. 592-603,
2020.
DOI:
10.1080/00914037.2019.1596909
Abstract:
Chitosan-tripolyphosphate (CS-TPP) nanoparticles containing naproxen (NPX) were dispersed in
poloxamer (PL) as unique (PL407) or binary (PL407-PL403) systems. Nanoparticles presented diameter
of 250nm and zeta potential of 35mV with drug loading and encapsulation efficiency of
98.4 ± 0.3% and 36.9 ± 0.12%, respectively. NPX-CS-TPP shifted the sol-gel transition and micellization
temperatures. PL407-PL403 systems presented G0 >G00 compared to PL407. SAXS patterns
revealed transitions from lamellar to hexagonal phase organizations with low drug release rates, in
the presence of CS-TPP nanoparticles. NPX-CS-TPP-PL407 induced lower cytotoxicity compared to
PL407-PL403 in fibroblasts and osteoblasts, making them promising systems for intra-articular
delivery.
Palavras-Chave: polysaccharides; chitin; nanoparticles; antipyretics; drugs; viability; animal cells; sensitivity; temperature dependence; hydrogels
. Influence of chitosan-tripolyphosphate nanoparticles on thermosensitive polymeric hydrogels: structural organization, drug release mechanisms and cytotoxicity. International Journal of Polymeric Materials and Polymeric Biomaterials, v. 69, n. 9, p. 592-603, 2020. DOI: 10.1080/00914037.2019.1596909. Disponível em: http://repositorio.ipen.br/handle/123456789/31100. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
-
VIGATO, ARYANE A.; MACHADO, IAN P.; VALLE, MATHEUS del; ANA, PATRICIA A. da; SEPULVEDA, ANDERSON F.; YOKAICHIYA, FABIANO; FRANCO, MARGARETH K.K.D.
; LOIOLA, MESSIAS C.; TOFOLI, GIOVANA R.; CEREDA, CINTIA M.S.; SAIRRE, MIRELA I. de; ARAUJO, DANIELE R. de. Monoketonic curcuminoid-lidocaine co-deliver using thermosensitive organogels: from drug synthesis to epidermis structural studies.
Pharmaceutics,
v. 14,
n. 2,
p. 1-20,
2022.
DOI:
10.3390/pharmaceutics14020293
Abstract:
Organogels (ORGs) are remarkable matrices due to their versatile chemical composition and straightforward preparation. This study proposes the development of ORGs as dual drug-carrier systems, considering the application of synthetic monoketonic curcuminoid (m-CUR) and lidocaine (LDC) to treat topical inflammatory lesions. The monoketone curcuminoid (m-CUR) was synthesized by using an innovative method via a NbCl5–acid catalysis. ORGs were prepared by associating an aqueous phase composed of Pluronic F127 and LDC hydrochloride with an organic phase comprising isopropyl myristate (IPM), soy lecithin (LEC), and the synthesized m-CUR. Physicochemical characterization was performed to evaluate the influence of the organic phase on the ORGs supramolecular organization, permeation profiles, cytotoxicity, and epidermis structural characteristics. The physico-chemical properties of the ORGs were shown to be strongly dependent on the oil phase constitution. Results revealed that the incorporation of LEC and m-CUR shifted the sol-gel transition temperature, and that the addition of LDC enhanced the rheological G′/G″ ratio to higher values compared to original ORGs. Consequently, highly structured gels lead to gradual and controlled LDC permeation profiles from the ORG formulations. Porcine ear skin epidermis was treated with ORGs and evaluated by infrared spectroscopy (FTIR), where the stratum corneum lipids were shown to transition from a hexagonal to a liquid crystal phase. Quantitative optical coherence tomography (OCT) analysis revealed that LEC and m-CUR additives modify skin structuring. Data from this study pointed ORGs as promising formulations for skin-delivery.
Palavras-Chave: curcumin; gels; ketones; anesthetics; skin; inflammation
. Monoketonic curcuminoid-lidocaine co-deliver using thermosensitive organogels: from drug synthesis to epidermis structural studies. Pharmaceutics, v. 14, n. 2, p. 1-20, 2022. DOI: 10.3390/pharmaceutics14020293. Disponível em: http://repositorio.ipen.br/handle/123456789/33022. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
-
OLIVEIRA, L.P. de
; SOUZA, A.P.S.
; YOKAICHIYA, F.; GENEZINI, F.A.
; FRANCO, M.K.K.D.
. Monte Carlo simulations of the S-shaped neutron guide.
Journal of Instrumentation,
v. 15,
n. 1,
p. 1-14,
2020.
DOI:
10.1088/1748-0221/15/01/P01012
Abstract:
Neutron transport along guides is governed by the Liouville theorem and the technology
involved has advanced in recent decades. Computer simulations have proven to be useful tools in
the design and conception of neutron guide systems in facilities. In this study, we use a Monte
Carlo method to perform simulations for an S-shaped neutron guide with different dimensions for a
Small-Angle Neutron Scattering (SANS) instrument, through the MCSTAS software. Awavelength
cutoff is observed and shown to be dependent on the geometrical parameters of the guide. Results
for the neutron flux at sample position are presented and greater sensitivity of cutoffs concerning
the curvatures of the guides than to their lengths is noticed. Our results are in agreement with those
obtained from the Acceptance Diagram method and we analyse the beam divergence behaviour
along the S-shaped guide.
Palavras-Chave: monte carlo method; neutron guides; neutron sources; simulation; computerized simulation; computer calculations; shape; neutron transport; small angle scattering; computer codes
. Monte Carlo simulations of the S-shaped neutron guide. Journal of Instrumentation, v. 15, n. 1, p. 1-14, 2020. DOI: 10.1088/1748-0221/15/01/P01012. Disponível em: http://repositorio.ipen.br/handle/123456789/31371. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
-
SOUZA, A.P.S.
; OLIVEIRA, L.P. de
; YOKAICHIYA, F.; GENEZINI, F.A.
; FRANCO, M.K.K.D.
. Neutron Guide Building instruments of the Brazilian Multipurpose Reactor (RMB) project.
Journal of Instrumentation,
v. 15,
n. 4,
p. 1-24,
2020.
DOI:
10.1088/1748-0221/15/04/P04011
Abstract:
A growing community of scientists has been using neutrons in the most diverse areas
of science. In order to meet the researchers demand in the areas of physics, chemistry, materials
sciences, engineering, cultural heritage, biology and earth sciences, the Brazilian Multipurpose
Reactor (RMB) will provide 3 thermal guides and 3 cold guides, with the installation of several
instruments for materials characterization. In this study, we present a standard design requirement
of two primordial instruments, namely Sabiá and Araponga. They are, respectively, cold and
thermal neutron instruments and correspond to a Small-Angle Neutron Scattering (SANS) and
High-Resolution Powder Neutron Diffractometer (HRPND) to be installed in the Neutron Guide
Building (N02) of RMB. To provide adequate flux for both instruments, we propose here an initial
investigation of the use of simple and split guides to transport neutron beams to two different
instruments on the same guide. For this purpose, we use Monte Carlo simulations utilizing McStas
software to check the efficiency of thermal neutron transport for different basic configuration and
sources. By considering these results, it is possible to conclude that the split guide configuration
is, in most cases, more efficient than cases that use transmitted neutron beams independently of
source. We also verify that the employment of different coating indexes for concave and convex
surfaces on curved guides is crucial, at least on simulated cases, to optimise neutron flux (intensity
and divergence) and diminish facility installation cost.
Palavras-Chave: neutron guides; neutron sources; neutron transport; rmb reactor; buildings; cold neutrons; thermal neutrons; reactor instrumentation; simulators; small angle scattering; neutron diffraction; scattering; monte carlo method
. Neutron Guide Building instruments of the Brazilian Multipurpose Reactor (RMB) project. Journal of Instrumentation, v. 15, n. 4, p. 1-24, 2020. DOI: 10.1088/1748-0221/15/04/P04011. Disponível em: http://repositorio.ipen.br/handle/123456789/31372. Acesso em: $DATA.Como referenciar este itemEsta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
-
SEPULVEDA, ANDERSON F.; FRANCO, MARGARETH
; YOKAICHIYA, FABIANO; ARAUJO, DANIELE de. POLYana: a new software for rheological study of polymeric colloidal materials.
Biophysical Reviews,
v. 13,
n. 6,
p. 1464-1465,
2021.
DOI:
10.1007/s12551-021-00845-2
Abstract:
INTRODUCTION
POLYAna is a new executable software developed by SISLIBIO group for
rheological analysis of hydrogel and organogel systems and other colloidal
materials (nanoparticles and micelles). The software development aims to
facilitate the analysis of rheology data associated to both temperature- and
frequency-dependent analysis, viscosity and curve flow profiles.
OBJECTIVES
The software development aims to facilitate the analysis of rheology data
associated to both temperature- and frequency-dependent analysis, viscosity
and curve flow profiles.
MATERIALS AND METHODS
From raw data, several models are applied like power-law model for
frequency response and curve flow, Boltzmann law to calculate gelation
temperature and viscosity response under temperature,Maxwell model to
study interchain relationships in addition to other models such as
Bingham model, Cross model, and Herschel-Bulkley are also available.
POLYana outputs calculates rheological parameters like consistency, adhesion,
hysteresis, flow index, G’/G” ratio.
DISCUSSION AND RESULTS
To validate results obtained from POLYana, same data were analyzed by
applying other programs and same mathematical models. In this sense, rheological analysis of Poloxamer 407 in water solution (15 %) were
performed: from temperature-dependent G’ and G” analysis were obtained
gelation temperature of 45.46 ± 0.02 °C, η_0 = 0.08 ± 0.03 mPa*s,
η_max = (32.44 ± 0.17) mPa*s and dη/dT = (1.27 ± 0.02) mPa*s/°C by
fitting Boltzmann law (R2 = 0.998), which are similar to results obtained
by others softwares and found in literature. From temperature-dependent
G’ and G” analysis, it gets adhesion value of (1647.15 ± 18.01) mPa*sn
calculated from power-law model (R2 = 0.869), also similar to PRISM
results.
CONCLUSION
Also, other Poloxamer concentrations and hydrogels types have been
evaluated, showing close numbers to that previously reported. In order
to stablish structural relationships, one of POLYana tools is also to analyze
small-angle neutron scattering (SANS) and develop Monte Carlo
simulation for SANS and rheological analysis, simultaneously.
. POLYana: a new software for rheological study of polymeric colloidal materials. Biophysical Reviews, v. 13, n. 6, p. 1464-1465, 2021. DOI: 10.1007/s12551-021-00845-2. Disponível em: http://repositorio.ipen.br/handle/123456789/32890. Acesso em: $DATA.Como referenciar este item
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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A pesquisa no RD utiliza os recursos de busca da maioria das bases de dados. No entanto algumas dicas podem auxiliar para obter um resultado mais pertinente.
✔ É possível efetuar a busca de um autor ou um termo em todo o RD, por meio do Buscar no Repositório , isto é, o termo solicitado será localizado em qualquer campo do RD. No entanto esse tipo de pesquisa não é recomendada a não ser que se deseje um resultado amplo e generalizado.
✔ A pesquisa apresentará melhor resultado selecionando um dos filtros disponíveis em Navegar
✔ Os filtros disponíveis em Navegar tais como: Coleções, Ano de publicação, Títulos, Assuntos, Autores, Revista, Tipo de publicação são autoexplicativos. O filtro, Autores IPEN apresenta uma relação com os autores vinculados ao IPEN; o ID Autor IPEN diz respeito ao número único de identificação de cada autor constante no RD e sob o qual estão agrupados todos os seus trabalhos independente das variáveis do seu nome; Tipo de acesso diz respeito à acessibilidade do documento, isto é , sujeito as leis de direitos autorais, ID RT apresenta a relação dos relatórios técnicos, restritos para consulta das comunidades indicadas.
A opção Busca avançada utiliza os conectores da lógica boleana, é o melhor recurso para combinar chaves de busca e obter documentos relevantes à sua pesquisa, utilize os filtros apresentados na caixa de seleção para refinar o resultado de busca. Pode-se adicionar vários filtros a uma mesma busca.
Exemplo:
Buscar os artigos apresentados em um evento internacional de 2015, sobre loss of coolant, do autor Maprelian.
Autor: Maprelian
Título: loss of coolant
Tipo de publicação: Texto completo de evento
Ano de publicação: 2015
✔ Para indexação dos documentos é utilizado o Thesaurus do INIS, especializado na área nuclear e utilizado em todos os países membros da International Atomic Energy Agency – IAEA , por esse motivo, utilize os termos de busca de assunto em inglês; isto não exclui a busca livre por palavras, apenas o resultado pode não ser tão relevante ou pertinente.
✔ 95% do RD apresenta o texto completo do documento com livre acesso, para aqueles que apresentam o 
significa que e o documento está sujeito as leis de direitos autorais, solicita-se nesses casos contatar a Biblioteca do IPEN,
bibl@ipen.br
.
✔ Ao efetuar a busca por um autor o RD apresentará uma relação de todos os trabalhos depositados no RD. No lado direito da tela são apresentados os coautores com o número de trabalhos produzidos em conjunto bem como os assuntos abordados e os respectivos anos de publicação agrupados.
✔ O RD disponibiliza um quadro estatístico de produtividade, onde é possível visualizar o número dos trabalhos agrupados por tipo de coleção, a medida que estão sendo depositados no RD.
✔ Na página inicial nas referências são sinalizados todos os autores IPEN, ao clicar nesse símbolo será aberta uma nova página correspondente à aquele autor – trata-se da página do pesquisador.
✔ Na página do pesquisador, é possível verificar, as variações do nome, a relação de todos os trabalhos com texto completo bem como um quadro resumo numérico; há links para o Currículo Lattes e o Google Acadêmico ( quando esse for informado).
ATENÇÃO!
ESTE TEXTO "AJUDA" ESTÁ SUJEITO A ATUALIZAÇÕES CONSTANTES, A MEDIDA QUE NOVAS FUNCIONALIDADES E RECURSOS DE BUSCA FOREM SENDO DESENVOLVIDOS PELAS EQUIPES DA BIBLIOTECA E DA INFORMÁTICA.
O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.
A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.
1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI, clique aqui.
2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI, clique aqui.
O Repositório Digital do IPEN é um equipamento institucional de acesso aberto, criado com o objetivo de reunir, preservar, disponibilizar e conferir maior visibilidade à Produção Científica publicada pelo Instituto, desde sua criação em 1956.
Operando, inicialmente como uma base de dados referencial o Repositório foi disponibilizado na atual plataforma, em junho de 2015. No Repositório está disponível o acesso ao conteúdo digital de artigos de periódicos, eventos, nacionais e internacionais, livros, capítulos, dissertações, teses e relatórios técnicos.
A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.
O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.