Navegação por assunto "photodynamic therapy"

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  • IPEN-DOC 26721

    MORAES, MARCIA C.D. de; MORAES, PAULO N.L. de; ZEZELL, DENISE M. . aPDT em cirurgia de sinus lift e instalação imediata de implantes na presença de fístula oroantral. In: BRUGNERA JUNIOR, ALDO (Coord.); ZANIN, FATIMA (Coord.); NAMOUR, SAMIR (Coord.); SHIBLI, JAMIL A. (Coord.). Laser em odontologia: de clínico para clínico. São Paulo, SP: VW Cultural, 2019. p. 256-262, cap. 27.

    Palavras-Chave: dentistry; photodynamic therapy; microorganisms; anti-infective agents; sinuses

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  • IPEN-DOC 11770

    YAMADA JUNIOR, A.M. ; HAYEK, R.R.A.; GIOSO, M.A.; FERREIRA, J.; BATISTA SOBRINHO, C.A.; RIBEIRO, M.S. . Bacterial reduction by photodynamic therapy in peri-implantitis: an in vivo study. Brazilian Dental Journal, v. 15, Special issue, p. 84-84, 2004.

    Abstract: Progressive peri-implantar bone losses, which are accompanied by inflammatory process in the soft tissues is referred to as peri-implantitis. The aim of this study was to compare the effects of lethal photosensitization with the conventional technique on bacterial reduction in ligature induced peri-implantitis in dogs. Seventeen third premolars of eight Labrador dogs were extracted and, immediately after, the implants were submerged. After osseointegration, peri-implantitis was induced. After 4 months, ligature were removed and the same period was waited for natural induction of bacterial plaque. The dogs were randomly divided into two groups. In the conventional group, they were treated with the conventional techniques of mucoperiosteal flaps for scaling the implant surface and irrigation with chlorexidine. In the laser group, only mucoperiosteal scaling was carried out before photodynamic therapy. On the peri-implantar pocket an azulene paste was introduced and a GaAlAs low-power laser (l= 660 nm, P= 30 mW, E= 5,4 J and Dt= 3 min.) was applied. Microbiological samples were obtained before and immediately after treatment. The results of this study showed that Prevotella sp., Fusobacterium e S. Beta-haemolyticus were significantly reduced for the conventional and laser groups (100%,99.8%; 100%,100%; 85.7%,97.6%, respectively).

    Palavras-Chave: dentistry; teeth; implants; bone tissues; bacteria; photodynamic therapy; lasers; photosensitivity

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  • IPEN-DOC 22900

    LIMA, CASSIO A. ; GOULART, VIVIANE ; ZEZELL, DENISE . Chemometric methods applied to FTIR spectra to discriminate treated and non-treated cutaneous malignant lesions from healthy skin. In: LATIN AMERICA OPTICS AND PHOTONICS CONFERENCE, August 22-26, 2016, Medellín, Colombia. Proceedings... Washington, DC, USA: OSA, 2016.

    Abstract: Chemometric methods were used to differentiate FTIR spectra of treated and nontreated malignant lesions from healthy skin. We conclude that the method can be used to evaluate the biological changes promoted by photodynamic treatment.

    Palavras-Chave: skin; formation damage; melanomas; chemotherapy; photodynamic therapy

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  • IPEN-DOC 24254

    SELLERA, FABIO P.; NASCIMENTO, CRISTIANE L.; RIBEIRO, MARTHA S. . Clinical applications of antimicrobial PDT. In: SELLERA, FABIO P. (Ed.); NASCIMENTO, CRISTIANE L. (Ed.); RIBEIRO, MARTHA S. (Ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 169-196, DOI: 10.1007/978-3-319-45007-0_12

    Observação: Livro na íntegra disponível. Consulte a biblioteca do IPEN.

    Abstract: Antimicrobial photodynamic therapy (PDT) is a noninvasive, painless, and safe procedure that can be used on a wide range of diseases in clinical practice. Dermatology for dogs and cats is emerging as one of the main areas of interest for the application of this therapeutic approach; however, despite being a promising technique to treat various dermatological diseases, researchers and clinicians have made little use of this powerful tool. The farm animals’ medicine has evolved over the past few years, and the growing demand of consumers looking for absence of residues in animal products becomes essential in the search for alternatives to conventional treatments. Although the bulk of researches on PDT in veterinary medicine are to treat domestic animals, there is a great appeal for its clinical application in exotic, zoo, and wildlife medicine. In this chapter, we describe potential applications of PDT in veterinary clinical practice.

    Palavras-Chave: antimicrobial agents; methylene blue; skin diseases; veterinary medicine; photodynamic therapy

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  • IPEN-DOC 10875

    HAYEK, R.R.A.; YAMADA JUNIOR, A.M. ; GARCEZ, A.S.; NUNEZ, S.C. ; SUZUKI, L.C.; RIBEIRO, M.S. . Comparation between photodynamic therapy and a bactericidal solution in the treatment of dental alveolitis microbiological evaluation. Brazilian Dental Journal, v. 15, Special issue, p. 110-110, 2004.

    Abstract: Photodynamic therapy is a new therapeutic modality to treat microbial infections. The aim of this pilot study was to compare this new therapeutic approach with clorhexidine in mini pigs induced alveolitis. Alveolitis is an inflammatory disease that involves the superficial bone layer in the dental alveolus. Eight dental elements were extracted from mini pigs and immediately after the alveolus were contaminated with Streptoccocus aureus. After seven days the area presented edema and hyperemia. In the clorhexidine group the alveolus were debrided and irrigated with a 0.12% solution of clorhexidine. In Laser group the alveolus were debrided and photodynamic therapy was performed consisting in the application of a azulene paste inside the alveolus with a preirradiation time of 5 minutes followed by irradiation with a low power diode laser, ?= 685 nm, P= 50 mW, E= 9 J, for 3 minutes. Microbiological samples were harvested before and after treatment for both groups with sterile paper points. The results showed bacterial reduction in both groups, although photodynamic therapy was significantly more effective to reduce the population of S. aureus. This finding indicates that photodynamic therapy can be an alternative method to the treatment of alveolitis.

    Palavras-Chave: dentistry; photodynamic therapy; germicides; inflammation

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  • IPEN-DOC 12991

    NUNEZ, S.C. ; GOMES, L.; GARCEZ, A.S.; LAGE-MARQUES, J.L.. Comparative study between photodynamic therapy and chemical solution on bacterial reduction in root canals. Brazilian Dental Journal, v. 15, Special issue, p. 85-85, 2004.

    Abstract: One of the major medical problems facing mankind in the next century will be the resistance of many pathogenic microbes to existing antibiotics. Oral bacteria can easily reach other body sites and also spread to other individuals. Therefore, antibiotic-resistant oral bacteria have the opportunity for rapid dissemination through the community and to transfer their resistance genes to other bacterial species. Photodynamic therapy involves the use of light-activated drugs which may offer an alternative approach to the use of traditional antimicrobial agents. The purpose of this study was to evaluate bacterial reduction in infected root canal. Thirty teeth with their root canals prepared were contaminated with Enterococcus faecalis. Control group was untreated. Chemical group was treated with sodium hypochlorite for 30 minutes and in the laser group, a photosensitizer paste was placed and maintained in the root canals for 5 minutes and irradiated with a diode laser, output power 10 mW and l= 685nm for 3 minutes. The bacterial reduction was significantly higher for laser group when compared to chemical and control groups. These results indicate photodynamic therapy as an effective method to kill E. faecalis.

    Palavras-Chave: photodynamic therapy; oral cavity; teeth; antimicrobial agents; microbial drug resistance

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  • IPEN-DOC 26706

    SABINO, CAETANO P.; RIBEIRO, MARTHA S. . Dosimetria na terapia fotodinâmica antimicrobiana. In: NUNEZ, SILVIA C. (Ed.); RIBEIRO, MARTHA S. (Ed.); GARCEZ, AGUINALDO S. (Ed.). PDT - Terapia Fotodinâmica Antimicrobiana na Odontologia. 2 ed.. Rio de Janeiro: Elsevier, 2019. p. 23-32, cap. 3.

    Palavras-Chave: therapy; dosimetry; antimicrobial agents; photosensitivity; photodynamic therapy

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  • IPEN-DOC 19178

    BARCESSAT, ANA R.; HUANG, ISAAC; ROSIN, FLAVIA P.; PINTO JUNIOR, DECIO dos S.; ZEZELL, DENISE M. . Effect of topical 5-ALA mediated photodynamic therapy on proliferation index of keratinocytes in 4-NQo-induced potentially malignant oral lesions. Journal of Photochemistry and Photobiology B: Biology, v. 126, p. 33-41, 2013.

    Palavras-Chave: oral cavity; neoplasms; photodynamic therapy; photosensitivity; antigens; cell proliferation; immunoassay; histological techniques

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  • IPEN-DOC 11786

    GARCEZ, AGUINALDO S.; NUNEZ, SILVIA C.; LAGE MARQUES, JOSE L.; JORGE, ANTONIO O.C.; RIBEIRO, MARTHA S. . Efficiency of NaOCl and laser-assisted photosensitization on the reduction of enterococcus faecalis in vitro. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 102, p. e93-e98, 2006.

    Palavras-Chave: teeth; oral cavity; infrared spectra; laser radiation; microorganisms; bacteria; sodium; photodynamic therapy; photosensitivity

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  • IPEN-DOC 24497

    SELLERA, FABIO P.; NASCIMENTO, CRISTIANE L.; POGLIANI, FABIO C.; SABINO, CAETANO P. ; RIBEIRO, MARTHA S. . Future perspectives. In: SELLERA, FABIO P. (Ed.); NASCIMENTO, CRISTIANE L. (Ed.); RIBEIRO, MARTHA S. (Ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 209-222, DOI: 10.1007/978-3-319-45007-0_14

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    Abstract: Nowadays, it is clear that the activity of different photosensitizers (PSs) has a strong potential for moving photodynamic therapy (PDT) to clinical practice. Present technologies as dedicated light sources, new PSs, and nanotechnology are emerging strategies to promote PDT as a reliable, cost-effective, and safe approach to veterinary medicine. This chapter addresses an overview of emerging clinical applications and recent technologies to encourage veterinarians toward PDT.

    Palavras-Chave: veterinary medicine; photodynamic therapy; photosensitivity; diseases; therapeutic uses

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  • IPEN-DOC 24448

    SELLERA, FABIO P.; SABINO, CAETANO P. ; HAMBLIN, MICHAEL R.. History of PDT. In: SELLERA, FABIO P. (Ed.); NASCIMENTO, CRISTIANE L. (Ed.); RIBEIRO, MARTHA S. (Ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 1-10, DOI: 10.1007/978-3-319-45007-0_1

    Observação: Livro na íntegra disponível. Consulte a biblioteca do IPEN.

    Abstract: This chapter presents the brightest historical milestones behind the development of photodynamic therapy (PDT). We initially present how photodynamic reactions were first observed by scientists from three different countries in the beginning of the twentieth century. Oskar Raab, from Germany, observed by accident that protozoan cells stained with fluorescent dyes were killed upon illumination, while Prime, in France, reported that human subjects who ingested also fluorescent dyes for an experimental treatment of neurological diseases developed severe erythema after short exposure to sunlight. Niels Finsen, from Denmark, was awarded with the third Nobel Prize of Medicine in the history for the development of light-based treatments for skin infections. Following, we describe how PDT slowly evolved until the 1960–1970s when new generations of less toxic photosensitizers were developed for diagnosis and treatment of solid tumors. Only then PDT really became a hot scientific area that began to attract many researchers to the field. We also describe the first huge medical and economic impact that PDT as the first effective treatment for age-related macular degeneration, the leading cause of adult blindness in the world. Finally, we go through the main discoveries in veterinary medicine over the past years for the treatment of localized tumors and infections in diverse animal species.

    Palavras-Chave: photodynamic therapy; historical aspects; ultraviolet radiation; therapeutic uses

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  • IPEN-DOC 24464

    NASCIMENTO, CRISTIANE L.; SELLERA, FABIO P.; RIBEIRO, MARTHA S. . How to enter PDT in clinical practice?. In: SELLERA, FABIO P. (Ed.); NASCIMENTO, CRISTIANE L. (Ed.); RIBEIRO, MARTHA S. (Ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 111-123, DOI: 10.1007/978-3-319-45007-0_8

    Observação: Livro na íntegra disponível. Consulte a biblioteca do IPEN.

    Abstract: The photodynamic therapy stands out, not only for the few adverse effects to the veterinary patient but also for presenting environmental safety, not inducing microbial resistance and reducing generation of residual drugs on products intended for human consumption. After understanding the full potential of this new therapeutic modality through the previous chapters, the purpose of this chapter is to cover the main aspects to be considered by veterinarians to move PDT to clinical practice. It will be presented how the light source and photosensitizers should be chosen as well as the application modes for both antimicrobial and cancer PDT. Biosafety will also be addressed.

    Palavras-Chave: veterinary medicine; photodynamic therapy; antimicrobial agents; light sources

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  • IPEN-DOC 27454

    NAMBA, A.F.; DEL-VALLE, M. ; DAGHASTANLI, N.A.; ANA, P.A.. In vitro study of the microstructural effects of photodynamic therapy in medical supplies when used for disinfection. In: BRAZILIAN CONGRESS IN BIOMEDICAL ENGINEERING, 27th, October 26-30, 2020, Vitória, ES. Proceedings... Rio de Janeiro, RJ: Sociedade Brasileira de Engenharia Biomédica, 2020. p. 1705-1710.

    Abstract: Cleaning and disinfecting surfaces and materials in health services are primary elements in infection control measures. For thermosensitive materials, the chemical agents used have disadvantages such as the odor of the products, which can cause allergic reactions to patients and the nursing staff. Photodynamic therapy (PDT) has been shown to be an effective technique in the treatment of infections caused by different microorganisms; however, nothing is known about the effects of this technique on the microstructure of hospital supplies. This in vitro study aimed to evaluate the effects of 0.2% peracetic acid, 1% sodium hypochlorite and PDT with 0.01% methylene blue on the composition and color changes of hospital masks and extensions. For this purpose, 100 mask samples and 100 extension samples were randomly distributed in 20 experimental groups (n = 10, 10 groups for each material), in which the applied substance was varied (sodium hypochlorite, peracetic acid and PDT) and the number of applications (without application, 1, 2 or 3 applications). The compositional analysis was performed by Fourier transform infrared spectroscopy, while the color changes were evaluated using image analysis by CIElab method evaluating the parameters L*, a*, b* and ∆E. The statistical analysis was performed at 5% significance level. It was observed that all agents altered the composition of the materials in a similar way. Although all agents promoted changes in different parameters evaluated, peracetic acid and methylene blue alone altered the final color perceived only in extensions. It was concluded that 0.2% peracetic acid, 1% sodium hypochlorite and PDT alter the chemical composition of both masks and extensions, and that such changes have a positive relationship with the number of treatments performed. These compositional changes may be related to the color changes promoted in both materials by all agents tested.

    Palavras-Chave: photodynamic therapy; sterilization; medical supplies; lasers

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  • IPEN-DOC 28582

    RIBEIRO, MARTHA S. . Light-based non-thermal therapy: from basis to clinical applications. In: CONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th, October 4-8, 2021, São Paulo, SP. Abstract... São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq), 2021. p. 39-39.

    Abstract: Light-based non-thermal therapies are evolving as promising non-invasive and cost-effective medical technologies. These therapeutic platforms mainly encompass photobiomodulation (PBM) and photodynamic therapy (PDT), which use visible or near infrared (NIR) light to induce biological responses without any significant heating effects. For PBM, it is most commonly used red or NIR light to optimize light penetration into biological tissues. The photon absorption by natural chromophores at these spectral regions cause photophysical and photochemical reactions inside cells that trigger several biological effects such as to accelerate wound healing, reduce inflammation and relief pain, depending on light parameters and target tissue. On the other hand, PDT makes use of photoactivated drugs, also called as photosensitizers, which absorb light to induce chemical reactions that kill microbial or cancer cells by oxidative stress. Our group have been investigating the mechanisms and several applications of PBM and antimicrobial PDT (APDT) for almost 20 years. In this lecture I will share our experience in the area to discuss how PBM and APDT could be used to revolutionize health care in the photonics era. An integrated perspective from the basic mechanisms, preclinical and clinical trials for both therapies will be presented, including PBM on cancer management and APDT against drug-resistant pathogens. The lecture will also highlight future perspectives.

    Palavras-Chave: antimicrobial agents; photodynamic therapy; therapy; modulation

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  • IPEN-DOC 29623

    NOVAES, G.A.; BLANK, M.H.; YOSHIMURA, T.M. ; RIBEIRO, M.S. ; PEREIRA, R.J.G.. Methylene blue-mediated antimicrobial photodynamic therapy on chicken semen. Photodiagnosis and Photodynamic Therapy, v. 41, p. 1-12, 2023. DOI: 10.1016/j.pdpdt.2023.103290

    Abstract: Background: Artificial insemination is widely employed in poultry, but high degrees of bacterial contamination are often observed in semen because of its passage through the cloaca. Consequently, most semen extenders for birds have antibiotics that could aggravate bacterial resistance. Methods: We evaluated the potential of antimicrobial photodynamic therapy (PDT) as an alternative to the use of antibiotics, and assessed whether changes in concentration and incubation time with methylene blue (MB), radiant exposure, and irradiance of light affect spermatozoa activity and bacteria in chicken semen. Results: Incubation with MB (< 25 µM) did not alter sperm motility, regardless of the pre-irradiation time (PIT, 1 or 5 min). Following 1 min of PIT with MB at 10 µM, samples were irradiated for 30, 60, 120, and 180 s at irradiances of 44, 29, and 17 mW/ cm² (660 nm LedBox). MB and light alone did not interfere with the analyzed parameters. However, when both factors were associated, increases in light dose led to greater reductions in sperm parameters, regardless of the irradiance used. Besides, PDT conditions that were less harmful to spermatozoa were not able to significantly reduce bacterial colonies in chicken semen. Conclusions: A failure in MB selectivity could explain unsuccessful bacterial reduction following PDT. Further research involving other photosensitizers or conjugating molecules to MB to target microbial cells is needed for PDT application in poultry breeders.

    Palavras-Chave: fowl; antibiotics; reproduction; microorganisms; chickens; photodynamic therapy

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  • IPEN-DOC 26708

    MIYAKAWA, WALTER; RIBEIRO, MARTHA S. . Métodos de microscopia para a análise do efeito antimicrobiano da terapia fotodinâmica. In: NUNEZ, SILVIA C. (Ed.); RIBEIRO, MARTHA S. (Ed.); GARCEZ, AGUINALDO S. (Ed.). PDT - Terapia Fotodinâmica Antimicrobiana na Odontologia. 2 ed.. Rio de Janeiro: Elsevier, 2019. p. 139-148, cap. 13.

    Palavras-Chave: microscopy; photodynamic therapy; microorganisms; optical microscopy; equipment

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  • IPEN-DOC 24457

    SABINO, CAETANO P. ; HAMBLIN, MICHAEL R.. Molecular damage. In: SELLERA, FABIO P. (Ed.); NASCIMENTO, CRISTIANE L. (Ed.); RIBEIRO, MARTHA S. (Ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 45-56, DOI: 10.1007/978-3-319-45007-0_4

    Observação: Livro na íntegra disponível. Consulte a biblioteca do IPEN.

    Abstract: Photodynamic therapy (PDT) rapidly produces large amounts of reactive oxygen species (ROS) to induce death of photosensitized cells. As previously described in Chap. 2, excited photosensitizer (PS) molecules can either donate electrons (type 1) or energy (type 2) to ground-state oxygen to produce superoxide radicals (O2•−) or singlet oxygen (1O2). Each type of ROS has characteristic chemical reactivity and reacts with different types of chemical bonds present in biomolecules and, consequently, will lead to different types of cell damage. Once again, what determines the mechanism of cell death directly depends on both: the PS localization site within the cell and total extent of oxidative stress produced during therapy (i.e., light dosimetry and efficiency of ROS generation). To elucidate the mechanisms of photooxidative damage and the consequent biological effects, this chapter will cover the most relevant chemical reactions related to oxidative damage caused by 1O2 and free radicals.

    Palavras-Chave: veterinary medicine; photodynamic therapy; oxygen; molecular structure; photosensitivity

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  • IPEN-DOC 24463

    RIBEIRO, MARTHA S. ; SABINO, CAETANO P. . Multimodality dosimetry. In: SELLERA, FABIO P. (Ed.); NASCIMENTO, CRISTIANE L. (Ed.); RIBEIRO, MARTHA S. (Ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 93-109, DOI: 10.1007/978-3-319-45007-0_7

    Observação: Livro na íntegra disponível. Consulte a biblioteca do IPEN.

    Abstract: PDT requires a multimodality approach for dosimetry because it works based on three essential components: light, photosensitizer, and molecular oxygen. Since these components are found in variable amounts inside target cells, PDT dosimetry is rather intricate. This chapter intends to address, with little mathematical complexity, the physical and chemical quantities that are most relevant for light and photosensitizer dosimetry as well as to present basic aspects of oxygen supply to achieve successful PDT interventions.

    Palavras-Chave: veterinary medicine; photodynamic therapy; dosimetry; light sources; lasers

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  • IPEN-DOC 27998

    FREITAS, LUCAS F. de . Nanomaterials for enhanced photodynamic therapy. In: INADA, NATALIA M. (Ed.). Photodynamic therapy: from basic science to clinical research. London, UK: IntechOpen, 2021. p. 1-16, cap. 12. DOI: 10.5772/intechopen.94255

    Abstract: Photodynamic therapy is a non-invasive option for eliminating superficial tumors and to control infections. However, despite some protocols are already approved for the clinic, PDT applications could be much broader if some of its main hindrances were overcome. For instance, the most efficient photosensitizers are hydrophobic, so if one injects them intravenously they tend to aggregate and to be internalized by phagocytes in the blood, impairing the delivery to the target site. In addition, visible light has a limited penetration in tissues, therefore the main applications of PDT are limited to superficial tumors unless an invasive procedure is used for the light to reach deeper sites. Another setback is the hypoxia that commonly happens in tumors, hindering the full potential of PDT as it depends on a constant oxygen supply. In this chapter the reader will find some strategies based on Nanotechnology to overcome these and other obstacles for PDT to reach its full clinical potential, i.e. hypoxia-reverting protocols, X-ray-driven PDT, Cherenkov radiation-driven PDT, and active tumor-targeting.

    Palavras-Chave: photodynamic therapy; nanotechnology; photons; x radiation; photosensitivity

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  • IPEN-DOC 28145

    OLIVEIRA, LUCAS N. de ; NASCIMENTO, ERIBERTO O. do; CALDAS, LINDA V.E. . A new natural detector for irradiations with blue LED light source in photodynamic therapy measurements via UV–Vis spectroscopy. Photochemical and Photobiological Sciences, v. 20, n. 11, p. 1381-1395, 2021. DOI: 10.1007/s43630-021-00088-w

    Abstract: Photodynamic therapy has been recently studied, bringing innovations regarding the reduction of exposure time to light by the patient. This work aimed to investigate the feasibility of using Coutarea hexandra (Jacq.) K. Schum (CHS) as a detector in photodynamic therapy measurements. For this, an irradiator containing a blue LED bulb lamp was utilized. The CHS samples were irradiated with ten doses from 0.60 up to 6.0 kJ/cm2, and six concentrations were prepared (1, 2, 3, 4, 5, and 6 mg/ml) for the CHS detector samples. After irradiation, the detector samples were evaluated using UV–Vis spectrophotometry. The results showed the behavior of the CHS detector with doses and concentrations, its sensitivity, and its linearity was also evaluated both by Wavelength Method (WM) and the Kernel Principal Component Regression (KPCR) Statistical Method. The values obtained indicate that this method can be applied to the CHS sample detector. In conclusion, the CHS is a promising detector in the field of photodynamic therapy.

    Palavras-Chave: photodynamic therapy; light emitting diodes; ultraviolet radiation; light bulbs; radiation detectors

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O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI, clique aqui.


2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI, clique aqui.

O Repositório Digital do IPEN é um equipamento institucional de acesso aberto, criado com o objetivo de reunir, preservar, disponibilizar e conferir maior visibilidade à Produção Científica publicada pelo Instituto, desde sua criação em 1956.

Operando, inicialmente como uma base de dados referencial o Repositório foi disponibilizado na atual plataforma, em junho de 2015. No Repositório está disponível o acesso ao conteúdo digital de artigos de periódicos, eventos, nacionais e internacionais, livros, capítulos, dissertações, teses e relatórios técnicos.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.