Navegação por assunto "photodynamic therapy"

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  • IPEN-DOC 26707

    TEDESCO, ANTONIO C.; RIBEIRO, MARTHA S. ; PAULA, LEONARDO B. de. Novas tecnologias em fotossensibilizadores para a terapia fotodinâmica. In: NUNEZ, SILVIA C. (Ed.); RIBEIRO, MARTHA S. (Ed.); GARCEZ, AGUINALDO S. (Ed.). PDT - Terapia Fotodinâmica Antimicrobiana na Odontologia. 2 ed.. Rio de Janeiro: Elsevier, 2019. p. 43-53, cap. 5.

    Palavras-Chave: photodynamic therapy; antimicrobial agents; commercialization; photosensitivity; nanotechnology; polymers; compatibility

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  • IPEN-DOC 24496

    SELLERA, FABIO P.; POGLIANI, FABIO C.; SABINO, CAETANO P. . Other practices in PDT. In: SELLERA, FABIO P. (Ed.); NASCIMENTO, CRISTIANE L. (Ed.); RIBEIRO, MARTHA S. (Ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 197-207, DOI: 10.1007/978-3-319-45007-0_13

    Observação: Livro na íntegra disponível. Consulte a biblioteca do IPEN.

    Abstract: In addition to clinical PDT applications regarding antimicrobial and antineoplastic activity, photodynamic reactions have also been used in several other practices such as for fish tank decontamination, water treatment, antiangiogenic therapy for age-related macular degeneration, decontamination of surfaces, and even inactivation of pathogens for blood transfusion. Nowadays, not all potentials of photodynamic reactions are commercially available yet, but they definitely deserve to be highlighted in this chapter as alternative applications of photodynamic reactions in veterinary medicine.

    Palavras-Chave: veterinary medicine; photodynamic therapy; sterilization; water treatment; decontamination

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  • IPEN-DOC 11809

    NUNEZ, S.C.; GARCEZ, A.S.; RIBEIRO, M.S.. PDT antimicrobiana em odontologia: mecanismos e Aplicacoes. In: TERAPIA FOTODINAMICA: INTEGRACAO DOS ASPECTOS MOLECULARES, TECNOLOGICOS E APLICACOES NA AREA DE SAUDE, 2o., 03-06 de junho, 2007, Sao Pedro, SP. Palestra... 2007.

    Palavras-Chave: photodynamic therapy; antimicrobial agents; dentistry

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  • IPEN-DOC 29710

    CABRAL, FERNANDA V. ; YOSHIMURA, TANIA M. ; SILVA, DANIELA de F.T. da ; CORTEZ, MAURO; RIBEIRO, MARTHA S. . Photodynamic therapy mediated by a red LED and methylene blue inactivates resistant leishmania amazonensis. Journal of the Optical Society of America A, v. 40, n. 5, p. 996-1005, 2023. DOI: 10.1364/JOSAA.482314

    Abstract: Cutaneous leishmaniasis is a neglected parasitic disease that leads to destructive lesions. The emergence of drug resistance has been a global concern over the past years. Photodynamic therapy (PDT) mediated by a red LED and methylene blue (MB) involves the overproduction of oxidative stress, which oxidizes several cellular biomolecules and prevents the selection of resistant strains. Herein, we investigated the potential of PDT mediated by MB against wild-type and miltefosine-resistant strains of Leishmania amazonensis. As a result, both strains were susceptible to PDT, thus encouraging us to seek the best conditions to overcome the drug resistance problem in cutaneous leishmaniasis.

    Palavras-Chave: protozoa; parasitic diseases; skin diseases; photodynamic therapy; methylene blue; light emitting diodes

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  • IPEN-DOC 28843

    SOUZA, SUEDEN O.; RAPOSO, BRUNO L.; SARMENTO-NETO, JOSE F.; REBOUCAS, JULIO S.; MACEDO, DANIELLE P.C.; FIGUEIREDO, REGINA C.B.Q.; SANTOS, BEATE S.; FREITAS, ANDERSON Z. ; CABRAL FILHO, PAULO E.; RIBEIRO, MARTHA S. ; FONTES, ADRIANA. Photoinactivation of yeast and biofilm communities of Candida albicans mediated by ZnTnHex-2-PyP4+ porphyrin. Journal of Fungi, v. 8, n. 6, p. 1-14, 2022. DOI: 10.3390/jof8060556

    Abstract: Candida albicans is the main cause of superficial candidiasis. While the antifungals available are defied by biofilm formation and resistance emergence, antimicrobial photodynamic inactivation (aPDI) arises as an alternative antifungal therapy. The tetracationic metalloporphyrin Zn(II) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin (ZnTnHex-2-PyP4+) has high photoefficiency and improved cellular interactions. We investigated the ZnTnHex-2-PyP4+ as a photosensitizer (PS) to photoinactivate yeasts and biofilms of C. albicans strains (ATCC 10231 and ATCC 90028) using a blue light-emitting diode. The photoinactivation of yeasts was evaluated by quantifying the colony forming units. The aPDI of ATCC 90028 biofilms was assessed by the MTT assay, propidium iodide (PI) labeling, and scanning electron microscopy. Mammalian cytotoxicity was investigated in Vero cells using MTT assay. The aPDI (4.3 J/cm2) promoted eradication of yeasts at 0.8 and 1.5 µM of PS for ATCC 10231 and ATCC 90028, respectively. At 0.8 µM and same light dose, aPDI-treated biofilms showed intense PI labeling, about 89% decrease in the cell viability, and structural alterations with reduced hyphae. No considerable toxicity was observed in mammalian cells. Our results introduce the ZnTnHex-2-PyP4+ as a promising PS to photoinactivate both yeasts and biofilms of C. albicans, stimulating studies with other Candida species and resistant isolates.

    Palavras-Chave: fungi; yeasts; candida; photodynamic therapy; antimicrobial agents; porphyrins

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  • IPEN-DOC 24452

    SABINO, CAETANO P. ; HAMBLIN, MICHAEL R.. Photophysical and photochemical mechanisms. In: SELLERA, FABIO P. (Ed.); NASCIMENTO, CRISTIANE L. (Ed.); RIBEIRO, MARTHA S. (Ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 11-23, DOI: 10.1007/978-3-319-45007-0_2

    Observação: Livro na íntegra disponível. Consulte a biblioteca do IPEN.

    Abstract: Photodynamic therapy (PDT) harnesses the power of light in an elegant method to produce cytotoxic agents in a spatially and temporally controlled manner and specifically damage target cells and tissues. For photodynamic reactions to occur, the PS molecule must absorb at least one photon to be promoted to a sufficiently long-lived excited state and then induce photodynamic reactions in an oxygenated environment. Such properties guarantee that PDT has an exceptionally broad action spectrum against tumors or pathogens, and resistance occurrence is restricted to only a few exceptions that can be avoided using simple strategies. To fully understand the intricacies of the mechanisms by which PDT acts, it is clear that one must take advantage of all the basic sciences (e.g., physics, chemistry, and biology). In fact, such conceptual complexity still maintains constant scientific investigations to deeply understand the molecular basis of PDT. Curiously, it might also be one of the reasons to explain why this hundred-year-old technique is still not generally applied in clinics or taught in standard courses of pharmacology. In this chapter, we will attempt to use a multidisciplinary approach, with simple technical language and a minimum of mathematics and equations, to allow any student with minimal training in basic sciences to understand all the fundamental mechanisms of PDT.

    Palavras-Chave: photochemical reactions; photodynamic therapy; electromagnetic radiation; radiation sources

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  • IPEN-DOC 24453

    HAMBLIN, MICHAEL R.; SABINO, CAETANO P. . Photosensitizers. In: SELLERA, FABIO P. (Ed.); NASCIMENTO, CRISTIANE L. (Ed.); RIBEIRO, MARTHA S. (Ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 25-43, DOI: 10.1007/978-3-319-45007-0_3

    Observação: Livro na íntegra disponível. Consulte a biblioteca do IPEN.

    Abstract: Photodynamic therapy (PDT) was discovered over 100 years ago when it was observed that certain dyes could kill microorganisms when exposed to light in the presence of oxygen. Since those early days, PDT has mainly been developed as a cancer therapy with regulatory approvals and clinical trials steadily accumulating for different types of cancer and different photosensitizer structures. A very important milestone for PDT was the introduction of 5-aminolevulinic acid (ALA), which functions as a prodrug to induce endogenous porphyrin biosynthesis that acts as an endogenous photosensitizer produced by our cells. PDT with ALA and its derivatives have become mainstays of the clinical dermatologist’s practice covering everything from skin cancer, premalignant lesions, acne, and skin rejuvenation. Another milestone in PDT development was the realization that PDT may also be used as an effective antimicrobial modality and a potential treatment for localized infections. To some extent, this means that PDT has gone full circle and returned to its roots from when it was first discovered in 1900. In this chapter we discuss, in a contextualized fashion, what are the expected characteristics of an ideal photosensitizer and which are the main molecular frameworks used for development of synthetic, natural, and nanostructured photosensitizers.

    Palavras-Chave: photosensitivity; photodynamic therapy; nanostructures; porphyrins

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  • IPEN-DOC 28539

    NUNEZ, SILVIA C.; RIBEIRO, MARTHA S. . Princípios básicos da terapia fotodinâmica. In: LAGO, ANDREA D.N. (Ed.). Laser na odontologia: conceitos e aplicações clínicas. São Luís, MA: EDUFMA, 2021. p. 143-155, cap. 9.

    Palavras-Chave: photodynamic therapy; photosensitivity; light emitting diodes; therapeutic uses; dentistry

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  • IPEN-DOC 28593

    SOUZA, MARESSA D.F. de ; ITRI, ROSANGELA; RIBEIRO, MARTHA S. . Reconstitution of Leishmania plasma membrane to understand the photodynamic effect. In: CONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th, October 4-8, 2021, São Paulo, SP. Abstract... São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq), 2021. p. 255-255.

    Abstract: Leishmaniasis is an important neglected disease. Photodynamic therapy (PDT) has been used to fight cutaneous leishmaniasis showing good results. However, PDT mechanisms in Leishmania parasites are not yet completely clarified. In this work, our objective was to develop a protocol to produce giant plasma membrane vesicles (GPMVs) from Leishmania amazonensis promastigotes to understand the mechanisms of action of methylene blue (MB)- mediated PDT on the cell membrane of parasites. For membrane extraction, several techniques were tested. The osmotic shock was the technique that presented the best yield and effectiveness. Phosphate and protein measurements were performed to confirm membrane extraction. For the growth of GPMVs, the best technique was electroforming using different frequencies and voltages in 4 cycles. Reconstituted GPMVs were observed by phasecontrast light microscopy. Subsequently, PDT was applied to GPMVs dispersed in an aqueous solution containing 50 μM MB and we verified the changes in permeability before and after exposure to light. The same process was applied to giant unilamellar vesicles (GUVs) with lipid compositions similar to the parasite membrane. The electroforming technique with the protocol developed in this work made it possible to obtain GPMVs from a promastigote membrane isolate of L. amazonensis. The membrane isolation technique was effective to extract the parasite's membrane while preserving lipids and proteins. In GUVs we observe an increase in the area during PDT in different compositions and loss of contrast. The GPMVs showed a loss of contrast as well as the GUVs but did not show an increase in area. This factor could be explained by the high degree of complexity of the membrane, which contains membrane proteins in addition to containing lipids.

    Palavras-Chave: therapy; photodynamic therapy; protozoa; parasitic diseases; cell membranes

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  • IPEN-DOC 29840

    CABRAL, FERNANDA V. ; SOUZA, TIAGO H. dos S.; SALLERA, FABIO P.; FONTES, ADRIANA; RIBEIRO, MARTHA S. . Strengthening collaborations at the Biology‑Physics interface: trends in antimicrobial photodynamic therapy. Biophysical Reviews, v. 15, n. 4, p. 685-697, 2023. DOI: 10.1007/s12551-023-01066-5

    Abstract: The unbridled use of antimicrobial drugs over the last decades contributed to the global dissemination of drug-resistant pathogens and increasing rates of life-threatening infections for which limited therapeutic options are available. Currently, the search for safe, fast, and efective therapeutic strategies to combat infectious diseases is a worldwide demand. Antimicrobial photodynamic therapy (APDT) rises as a promising therapeutic approach against a wide range of pathogenic microorganisms. APDT combines light, a photosensitizing drug (PS), and oxygen to kill microorganisms by oxidative stress. Since the APDT feld involves branches of biology and physics, the strengthening of interdisciplinary collaborations under the aegis of biophysics is welcome. Given this scenario, Brazil is one of the global leaders in the production of APDT science. In this review, we provide detailed reports of APDT studies published by the Laboratory of Optical Therapy (IPEN-CNEN), Group of Biomedical Nanotechnology (UFPE), and collaborators over the last 10 years. We present an integrated perspective of APDT from basic research to clinical practice and highlight its promising use, encouraging its adoption as an efective and safe technology to tackle important pathogens. We cover the use of methylene blue (MB) or Zn(II) porphyrins as PSs to kill bacteria, fungi, parasites, and pathogenic algae in laboratory assays. We describe the impact of MB-APDT in Dentistry and Veterinary Medicine to treat diferent infectious diseases. We also point out future directions combining APDT and nanotechnology. We hope this review motivates further APDT studies providing intuitive, vivid, and insightful information for the readers.

    Palavras-Chave: antimicrobial agents; methylene blue; inactivation; photodynamic therapy; photosensitivity; porphyrins; zinc

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  • IPEN-DOC 24645

    HAMBLIN, MICHAEL R.; SABINO, CAETANO P. . Systemic effects. In: SELLERA, FABIO P. (Ed.); NASCIMENTO, CRISTIANE L. (Ed.); RIBEIRO, MARTHA S. (Ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 73-91, DOI: 10.1007/978-3-319-45007-0_6

    Observação: Livro na íntegra disponível. Consulte a biblioteca do IPEN.

    Abstract: Photodynamic therapy (PDT) is a clinically approved practice for treatment of cancer and infectious diseases. PDT involves systemic or topical administration of a photosensitizer (PS), followed by irradiation of the target area with light of a wavelength matching the absorption band of the PS. In the presence of oxygen, photochemical reactions trigger the production of reactive oxygen species and, consequently, cell death by oxidative stress. Besides causing direct cytotoxicity to tumor cells, PDT induces destruction of the tumor vasculature releasing pro-inflammatory cytokines. Current literature supports that PDT is able to affect both the innate and adaptive responses of the immune system. In addition, PDT-induced adaptive immunity may attack distant untreated tumor cells and lead to development of antitumor memory immunity, which can potentially avoid the cancer relapse. Conversely, pro-inflammatory activity of PDT can also collaborate to resolve local infections since more neutrophils are recruited to the infected region.

    Palavras-Chave: veterinary medicine; animals; photodynamic therapy; tumor cells; neoplasms; immunity

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  • IPEN-DOC 26709

    NUNEZ, SILVIA C.; BAPTISTA, ALESSANDRA; RIBEIRO, MARTHA S. . Terapia fotodinâmica antimicrobiana: aplicação clínica, conceitos e perspectivas em odontologia. In: NUNEZ, SILVIA C. (Ed.); RIBEIRO, MARTHA S. (Ed.); GARCEZ, AGUINALDO S. (Ed.). PDT - Terapia Fotodinâmica Antimicrobiana na Odontologia. 2 ed.. Rio de Janeiro: Elsevier, 2019. p. 149-158, cap. 14.

    Palavras-Chave: photodynamic therapy; antimicrobial agents; dentistry; photosensitivity; radiation sources

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  • IPEN-DOC 29636

    SABINO, CAETANO P.; RIBEIRO, MARTHA S. ; WAINWRIGHT, MARK; ANJOS, CAROLINA dos; SELLERA, FABIO P.; DROPA, MILENA; NUNES, NATHALIA B.; BRANCINI, GUILHERME T.P.; BRAGA, GILBERTO U.L.; ARANA-CHAVEZ, VICTOR E.; FREITAS, RAUL O.; LINCOPAN, NILTON; BAPTISTA, MAURICIO S.. The biochemical mechanisms of antimicrobial photodynamic therapy. Photochemistry and Photobiology, v. 99, n. 2, p. 742-750, 2023. DOI: 10.1111/php.13685

    Abstract: The unbridled dissemination of multidrug-resistant pathogens is a major threat to global health and urgently demands novel therapeutic alternatives. Antimicrobial photodynamic therapy (aPDT) has been developed as a promising approach to treat localized infections regardless of drug resistance profile or taxonomy. Even though this technique has been known for more than a century, discussions and speculations regarding the biochemical mechanisms of microbial inactivation have never reached a consensus on what is the primary cause of cell death. Since photochemically generated oxidants promote ubiquitous reactions with various biomolecules, researchers simply assumed that all cellular structures are equally damaged. In this study, biochemical, molecular, biological and advanced microscopy techniques were employed to investigate whether protein, membrane or DNA damage correlates better with dose-dependent microbial inactivation kinetics. We showed that although mild membrane permeabilization and late DNA damage occur, no correlation with inactivation kinetics was found. On the other hand, protein degradation was analyzed by three different methods and showed a dose-dependent trend that matches microbial inactivation kinetics. Our results provide a deeper mechanistic understanding of aPDT that can guide the scientific community toward the development of optimized photosensitizing drugs and also rationally propose synergistic combinations with antimicrobial chemotherapy.

    Palavras-Chave: antimicrobial agents; photodynamic therapy; biochemical reaction kinetics; microbial drug resistance

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  • IPEN-DOC 28857

    COLLINA, GABRIELA A. da; CABRAL, FERNANDA V. ; MONTEIRO, CAROLINA M.; MACHADO, GABRIELA B.; GONCALVES, JOSE M.L.A.; FREIRE, FERNANDA; PRATES, RENATO A.; RIBEIRO, MARTHA S. ; PAVANI, CHRISTIANE. The importance of combining methods to assess Candida albicans biofilms following photodynamic inactivation. Photodiagnosis and Photodynamic Therapy, v. 38, p. 1-6, 2022. DOI: 10.1016/j.pdpdt.2022.102769

    Abstract: Background: Methylene blue (MB)-mediated photodynamic inactivation (PDI) has shown good results in killing Candida spp. Although MB solutions are commonly used, new formulations have been designed to improve PDI. However, chemical substances in the formulation may interfere with the PDI outcome. In this sense, different methodologies should be used to evaluate PDI in vitro. Herein, we report different methodologies to evaluate the effects of PDI with an oral formulation (OF) containing 0.005% MB on Candida albicans biofilm. Methods: Biofilms were treated using the MB-OF, with 5 min pre-irradiation time and exposure to a 640 nm LED device (4.7 J/cm2). PDI was evaluated by the XTT reduction test, counting the colony forming units (CFU), a filamentation assay, crystal violet (CV) staining, and scanning electronic microscopy (SEM). Results: PDI was able to reduce around 1.5 log10 CFU/mL, even though no significant differences were noted in metabolic activity in comparison to the control immediately after PDI. A significant decrease in yeast to hyphae transition was observed after PDI, while the biofilm exhibited flattened cells and a reduced number of yeasts in SEM. The CV assay showed increased biomass. Conclusion: MB-OF-mediated PDI was effective in C. albicans biofilms, as it significantly reduced the CFU/mL and the virulence of surviving cells. The CV data were inconclusive, since the OF components interacted with the CV, making the data useless. Taken together, our data suggest that the association of different methods allows complementary responses to assess how PDI mediated by a formulation impacts biofilms.

    Palavras-Chave: antimicrobial agents; methylene blue; chemotherapy; photodynamic therapy

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  • IPEN-DOC 28858

    JESUS, VIVIANE P. dos S.; VIEIRA, PAULA F.A.; CINTRA, RICARDO C.; SANTANNA, LUCIANA B.; ZEZELL, DENISE M. ; CASTILHO, MAIARA L.; RANIERO LEANDRO. Triple-negative breast cancer treatment in xenograft models by bifunctional nanoprobes combined to photodynamic therapy. Photodiagnosis and Photodynamic Therapy, v. 38, p. 1-9, 2022. DOI: 10.1016/j.pdpdt.2022.102796

    Abstract: Triple-negative breast cancer (TNBC) overexpresses the Epidermal Growth Factor Receptor (EGFR), a characteristic of different types of tumors, linked to worse disease prognosis and risk of recurrence. Conventional treatments are also aggressive and can be morbid.. Therefore, t improvement and development of new methods are notorious. Photodynamic Therapy (PDT) is an effective method for treating different types of cancer by using light radiation to activate a photosensitizing agent (drug) in molecular oxygen presence, promoting cell death., Improving drug uptake in target cells could contribute to PDT efficiency. Accordingly, we developed a bifunctional nanoprobe (BN), used in PDT as a a treatment method in vivo against breast cancer. The BN uses gold nanoparticles with active targeting through the Epidermal Growth Factor (EGF) protein and Chlorine e6 (Ce6) carriers. We evaluated the therapeutic efficacy of in vivo xenograft in 4 groups: Saline, BN, Ce6+PDT, and BN+PDT. As a result, we observed that the BN+PDT group exhibited an excellent effect with greater selectivity to tumor tissue and tissue damage when compared to the Saline, BN, and Ce6+PDT groups. The results indicate a potential impact on breast cancer treatment in vivo.. In conclusion, our data propose that the BN developed heightened PDT efficacy through cellular DNA repair effects and tumor microenvironment.

    Palavras-Chave: neoplasms; mammary glands; nanoparticles; photodynamic therapy; photosensitivity

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Operando, inicialmente como uma base de dados referencial o Repositório foi disponibilizado na atual plataforma, em junho de 2015. No Repositório está disponível o acesso ao conteúdo digital de artigos de periódicos, eventos, nacionais e internacionais, livros, capítulos, dissertações, teses e relatórios técnicos.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.