INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES
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Navegação por Agências de fomento "Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)"

Navegação por Agências de fomento "Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)"

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  • IPEN-DOC 28503

    BASSO, LUANA S.; MARANI, LUCIANO; GATTI, LUCIANA V. ; MILLER, JOHN B.; GLOOR, MANUEL; MELACK, JOHN; CASSOL, HENRIQUE L.G.; TEJADA, GRACIELA; DOMINGUES, LUCAS G. ; ARAI, EGIDIO; SANCHEZ, ALBER H.; CORREA, SERGIO M.; ANDERSON, LIANA; ARAGAO, LUIZ E.O.C.; CORREIA, CAIO S.C. ; CRISPIM, STEPHANE P.; NEVES, RAIANE A.L.. Amazon methane budget derived from multi-year airborne observations highlights regional variations in emissions. Communications Earth & Environment, v. 2, n. 1, p. 1-13, 2021. DOI: 10.1038/s43247-021-00314-4

    Abstract: Atmospheric methane concentrations were nearly constant between 1999 and 2006, but have been rising since by an average of ~8 ppb per year. Increases in wetland emissions, the largest natural global methane source, may be partly responsible for this rise. The scarcity of in situ atmospheric methane observations in tropical regions may be one source of large disparities between top-down and bottom-up estimates. Here we present 590 lower-troposphere vertical profiles of methane concentration from four sites across Amazonia between 2010 and 2018. We find that Amazonia emits 46.2 ± 10.3 Tg of methane per year (~8% of global emissions) with no temporal trend. Based on carbon monoxide, 17% of the sources are from biomass burning with the remainder (83%) attributable mainly to wetlands. Northwest-central Amazon emissions are nearly aseasonal, consistent with weak precipitation seasonality, while southern emissions are strongly seasonal linked to soil water seasonality. We also find a distinct east-west contrast with large fluxes in the northeast, the cause of which is currently unclear.

    Palavras-Chave: methane; emission; ecological concentration; climates; amazon river

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  • IPEN-DOC 27964

    GATTI, LUCIANA V. ; BASSO, LUANA S.; MILLER, JOHN B.; GLOOR, MANUEL; DOMINGUES, LUCAS G. ; CASSOL, HENRIQUE L.G.; TEJADA, GRACIELA; ARAGAO, LUIZ E.O.C.; NOBRE, CARLOS; PETERS, WOUTER; MARANI, LUCIANO; ARAI, EGIDIO; SANCHES, ALBER H.; CORREA, SERGIO M.; ANDERSON, LIANA; VON RANDOW, CELSO; CORREIA, CAIO S.C. ; CRISPIM, STEPHANE P.; NEVES, RAIANE A.L.. Amazonia as a carbon source linked to deforestation and climate change. Nature, v. 595, n. 7867, p. 388-393, 2021. DOI: 10.1038/s41586-021-03629-6

    Abstract: Amazonia hosts the Earth’s largest tropical forests and has been shown to be an important carbon sink over recent decades. This carbon sink seems to be in decline, however, as a result of factors such as deforestation and climate change. Here we investigate Amazonia’s carbon budget and the main drivers responsible for its change into a carbon source. We performed 590 aircraft vertical profiling measurements of lower-tropospheric concentrations of carbon dioxide and carbon monoxide at four sites in Amazonia from 2010 to 2018. We find that total carbon emissions are greater in eastern Amazonia than in the western part, mostly as a result of spatial differences in carbon-monoxide-derived fire emissions. Southeastern Amazonia, in particular, acts as a net carbon source (total carbon flux minus fire emissions) to the atmosphere. Over the past 40 years, eastern Amazonia has been subjected to more deforestation, warming and moisture stress than the western part, especially during the dry season, with the southeast experiencing the strongest trends. We explore the effect of climate change and deforestation trends on carbon emissions at our study sites, and find that the intensification of the dry season and an increase in deforestation seem to promote ecosystem stress, increase in fire occurrence, and higher carbon emissions in the eastern Amazon. This is in line with recent studies that indicate an increase in tree mortality and a reduction in photosynthesis as a result of climatic changes across Amazonia.

    Palavras-Chave: climatic change; burns; carbon sources; emission; deforestation; troposphere; temperature measurement; environmental impacts; amazon river

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  • IPEN-DOC 29949

    LOPES, ISABELA S.; SILVA, FLAVIA R. de O. ; COURROL, LILIA C.. Aminolevulinic acid coated—silver, copper, and silver–copper nanoparticles: synthesis, characterization, and application in seed nanopriming. Journal of Plant Growth Regulation, v. 42, n. 9, p. 5842–5854, 2023. DOI: 10.1007/s00344-023-10969-2

    Abstract: Seed priming is a potential tool for improving productivity under diferent environmental conditions. Aminolevulinic acid (ALA) priming can enhance plant tolerance to abiotic stresses, such as salinity, drought, and extreme temperatures. Nanopriming, priming with nanoparticles, can increase seed germination, growth, and plant development. The goal of this work was to compare the germination, growth, and development of sunfower seeds primed at 25 °C for 24 h with fve treatments: water, ALA, silver, copper, and copper-silver nanoparticles (ALANPs) using a two-way analysis of variance. ALANPs were prepared by the photoreduction process (ALA as stabilizing/capping agent) and characterized by UV–Vis, transmission electron microscopy, FTIR, and Zeta potential. The germination percentage, shoot length, root length, seedling vigor index (Vi), and allometric coefcient were obtained on the 3rd, 6th, and 10th days after the priming process. The fuorescence spectra of chlorophyll extract of the whole seedling or directly in the cotyledons were measured. According to the results, seed priming with ALANPs enhanced sunfower seed germination capacity, seed growth, and increased chlorophyll production compared to water and ALA-primed seeds.

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  • IPEN-DOC 25090

    FALCAO, R.B. ; DAMMANN, EDGAR D.C.C. ; ROCHA, C.J. ; DURAZZO, M. ; ICHIKAWA, R.U. ; MARTINEZ, L.G. ; BOTTA, W.J.; LEAL NETO, R.M. . An alternative route to produce easily activated nanocrystalline TiFe powder. International Journal of Hydrogen Energy, v. 43, n. 33, p. 16107-16116, 2018. DOI: 10.1016/j.ijhydene.2018.07.027

    Abstract: In this paper, an alternative process route to produce active nanocrystalline TiFe compound was investigated. First, TiH2 and Fe powders were dry co-milled in a planetary ball mill for 5e40 h. TiH2 was selected as precursor powder, instead of Ti powder, due its fragility, which has proved to be beneficial to decrease powders adherence on milling tools. In terms of loose powder mass, milling yields ranged from 90 to 95 wt.%. Next, milled powders were post-heated at 873 K under dynamic high-vacuum for TiFe synthesis reaction. First hydrogen absorption was verified in situ during the cooling process of samples (until the room temperature), being the amount of hydrogen absorbed and desorbed by this samples measured by automated Sievert's apparatus, under constant hydrogen flow rate of 9 cm3. min-1 (dynamic measurements). Besides to allowing the first absorption in situ, the investigated process route also allowed the production of the non-stoichiometric TiFe compound (rich in Ti) in samples milled for shorter times (5 and 10 h), both characteristics associated with maintaining the mechanical compound activity. Each sample absorbed hydrogen at 2 MPa during the cooling process, requiring no additional thermal activation cycles, since the samples milled for shorter times (mainly for 10 h) could absorb hydrogen for the first time more easily. However, the samples milled for longer times (25 and 40 h) shown better results in terms of reversible and storage capacities (0.73 and 0.94 wt.%, respectively).

    Palavras-Chave: nanostructures; powders; titanium hydrides; iron compounds; hydrides; milling; hydrogen storage

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  • IPEN-DOC 19227

    CHURA-CHAMBI, R.M.; CORDEIRO, Y.; MALAVASI, N.V.; LEMKE, L.S.; RODRIGUES, D.; MORGANTI, L. . An analysis of the factors that affect the dissociation of inclusion bodies and the refolding of endostatin under high pressure. Process Biochemistry, v. 48, n. 2, p. 250-259, 2013.

    Palavras-Chave: escherichia coli; proteins; hydrostatics; bacteria; inclusions; agglomeration; collagen; endothelium

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  • IPEN-DOC 19051

    MUCCILLO, R. ; MUCCILLO, E.N.S. . An experimental setup for shrinkage evaluation during electric field-assisted flash sintering: Application to yttria-stabilized zirconia. Journal of the European Ceramic Society, v. 33, n. 3, p. 515-520, 2013.

    Palavras-Chave: sintering; dilatometry; electric fields; impedance; scanning electron microscopy; yttrium oxides; zirconium oxides; grain growth; spectroscopy

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  • IPEN-DOC 26862

    GARCIA, PAULO R.A.F.; PRYMAK, OLEG; GRASMIK, VIKTORIA; PAPPERT, KEVIN; WLYSSES, WAGNER; OTUBO, LARISSA ; EPPLE, MATTHIAS; OLIVEIRA, CRISTIANO L.P.. An in situ SAXS investigation of the formation of silver nanoparticles and bimetallic silver–gold nanoparticles in controlled wet-chemical reduction synthesis. Nanoscale Advances, v. 2, n. 1, p. 225-238, 2020. DOI: 10.1039/c9na00569b

    Abstract: We present a study on the formation of silver (Ag) and bimetallic silver–gold (AgAu) nanoparticlesmonitored by in situ SAXS as well as by ex situ TEM, XRD and UV-vis analysis in a flow reactor at controlled reaction temperature. The formation mechanism of the nanoparticles is derived from the structural parameters obtained from the experimental data. The evolution of the average particle size of pure and alloyed nanoparticles shows that the particle growth occurs initially by a coalescence mechanism. The later growth of pure silver nanoparticles is well described by Ostwald ripening and for the alloyed nanoparticles by a process with a significantly slower growth rate. Additionally, the SAXS data of pure silver nanoparticles revealed two major populations of nanoparticles, the first one with a continuous crystal growth to a saturation plateau, and the second one probably with a continuous emergence of small new crystals. The particle sizes obtained by SAXS agree well with the results from transmission electron microscopy and X-ray diffraction. The present study demonstrates the capability of an in situ investigation of synthesis processes using a laboratory based SAXS instrument. Online monitoring of the synthesis permitted a detailed investigation of the structural evolution of the system.

    Palavras-Chave: nanoparticles; small angle scattering; x-ray diffraction; silver; bimetals; gold; monte carlo method; nanostructures; alloys

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  • IPEN-DOC 25206

    FREITAS, LUCAS F. de ; VARCA, GUSTAVO H.C. ; BATISTA, JORGE G. dos S. ; LUGAO, ADEMAR B. . An overview of the synthesis of gold nanoparticles using radiation technologies. Nanomaterials, v. 8, n. 11, 2018. DOI: 10.3390/nano8110939

    Abstract: At a nano-level, optical properties of gold are unique and gave birth to an emerging platform of nanogold-based systems for diverse applications, because gold nanoparticle properties are tunable as a function of size and shape. Within the available techniques for the synthesis of gold nanoparticles, the radiolytic synthesis allows proper control of the nucleation process without the need for reducing agents, in a single step, combined or not with simultaneous sterilization. This review details and summarizes the use of radiation technologies for the synthesis and preparation of gold nanoparticles concerning fundamental aspects, mechanism, current pathways for synthesis and radiation sources, as well as briefly outlines final applications and some toxicity aspects related to nanogold-based systems.

    Palavras-Chave: gold; nanoparticles; gamma radiation; electron beams; x-ray sources; radiolysis; nanotechnology; medicine; diagnostic uses; ionizing radiations

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  • IPEN-DOC 29845

    GASPARIAN, P.B.R. ; MALTHEZ, A.L.M.C.; MARIANO, L.; CAMPOS, L.L. ; POLITANO, R. . An overview study on the TL and OSL dosimetry patent processes over time. Brazilian Journal of Radiation Sciences, v. 11, n. 1, p. 1-15, 2023. DOI: 10.15392/2319-0612.2023.2107

    Abstract: Since its discovery, ionizing radiation has been used in many different applications. Materials and methods have been developed to measure and quantify radiation doses. Thermoluminescence (TL) and Optically Stimulated Luminescence (OSL) are two techniques used for radiation dosimetry. Both TL and OSL are primarily applied in several areas, such as dating of ancient materials, equipment quality control and individual monitoring. One of the parameters to measure the knowledge and development of a technology is the number of patents related to the field. In this work, we established a methodology for patent search on the World Intellectual Property Organization (WIPO) database aiming to review the development of TL and OSL dosimetry over time. We concluded that along with the OSL technique development, the TL technique should continue to be explored in radiation dosimetry.

    Palavras-Chave: dosimetry; patents; thermoluminescence; property management; photoluminescence

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  • IPEN-DOC 27582

    LIMA, CAROLINE S.A. de ; BALOGH, TATIANA S. ; VARCA, JUSTINE P.R.O. ; VARCA, GUSTAVO H.C. ; LUGAO, ADEMAR B. ; CAMACHO-CRUZ, LUIS A.; BUCIO, EMILIO; KADLUBOWSKI, SLAWOMIR S.. An updated review of macro, micro, and nanostructured hydrogels for biomedical and pharmaceutical applications. Pharmaceutics, v. 12, n. 10, p. 1-28, 2020. DOI: 10.3390/pharmaceutics12100970

    Abstract: Hydrogels are materials with wide applications in several fields, including the biomedical and pharmaceutical industries. Their properties such as the capacity of absorbing great amounts of aqueous solutions without losing shape and mechanical properties, as well as loading drugs of different nature, including hydrophobic ones and biomolecules, give an idea of their versatility and promising demand. As they have been explored in a great number of studies for years, many routes of synthesis have been developed, especially for chemical/permanent hydrogels. In the same way, stimuli-responsive hydrogels, also known as intelligent materials, have been explored too, enhancing the regulation of properties such as targeting and drug release. By controlling the particle size, hydrogel on the micro- and nanoscale have been studied likewise and have increased, even more, the possibilities for applications of the so-called XXI century materials. In this paper, we aimed to produce an overview of the recent studies concerning methods of synthesis, biomedical, and pharmaceutical applications of macro-, micro, and nanogels.

    Palavras-Chave: hydrogels; drugs; synthesis; cross-linking; skin; animal tissues; gamma radiation

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  • IPEN-DOC 10452

    FANCIO, ELIZABETH . Analise das transformacoes de fase da hidroxiapatita em temperaturas altas por difracao de raios X com aplicacao do metodo de Rietveld. 2005. Tese (Doutoramento) - Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP, Sao Paulo. p. Orientador: Nelson Batista de Lima.

    Palavras-Chave: biological materials; compatibility; ceramics; calcium phosphates; apatites; heat treatments; phase studies; x-ray diffraction; mechanical properties; sintering; biological regeneration; bone tissues

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  • IPEN-DOC 06651

    BUENO, LUCIANA . Analise de radionuclideos naturais e chumbo em produtos alimenticios e dietas. 1999. Dissertacao (Mestrado) - Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP, Sao Paulo. 87 p. Orientador: Ieda Irma Lamas Cunha.

    Palavras-Chave: lead 210; polonium 210; lead; food; diet; ingestion; alpha spectroscopy; bismuth 210; geiger-mueller counters; absorption spectroscopy

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  • IPEN-DOC 13799

    CARUSO, MARCEL W. . Analise do efeito combinado da irradiacao e do tratamento hidrotermico nas caracteristicas de qualidade de mangas para exportacao / Analysis of the irradiation and thermal treatment combined effect in the quality of mangoes for exportation . 2009. Dissertacao (Mestrado) - Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP, Sao Paulo. 61 p. Orientador: Susy Frey Sabato. DOI: 10.11606/D.85.2009.tde-24062009-182130

    Abstract: Pretende-se com este trabalho estudar o tratamento hidrotérmico e a irradiação como método combinado de conservação e de desinfestação de frutas, otimizando o impacto destes nas características desejadas do produto final. Para isso foram utilizados banhos térmicos com diferentes tempos e temperaturas (46o C, 70 min e 52 oC, 5 min), e diferentes doses de radiação gama (doses 0,3 e 0,75 kGy) em mangas Tommy Atkins procedentes da região de Petrolina. As mangas tratadas pelo método combinado foram armazenadas em temperaturas idênticas à do processo de transporte e estocagem comercial (11º C por 14 dias e temperatura ambiente 25º C por 12 dias), simulando as condições reais a que são submetidas ao serem exportadas. As frutas foram avaliadas através de análises físico-químicas para serem determinados os parâmetros mais adequados de tratamento. Conforme previsto por Oliveira (1998) o método combinado de irradiação e tratamento hidrotérmico apresentou resultados superiores aos métodos individuais no aumento da vida de prateleira.

    Palavras-Chave: food processing; fruits; mangoes; gamma radiation; hydrothermal synthesis

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  • IPEN-DOC 05639

    WETTER, NIKLAUS U. . Uma Analise no dominio espectral do mecanismo de travamento de modos. 1993. Tese (Doutoramento) - Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP, Sao Paulo. 121 p. Orientador: Nilson Dias Vieira Junior.

    Palavras-Chave: lasers; pulse generators; mode locking; optical properties; laser cavities; crystal defects; neodymium lasers; solid state lasers; reflectivity

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  • IPEN-DOC 25022

    PERES, JOSE C.G.; HERRERA, CRISTHIANO da C. ; ROSSI, WAGNER de ; VIANNA JUNIOR, ARDSON dos S.. Analysis of a microreactor for synthesizing nanocrystals by computational fluid dynamics. In: WORLD CONGRESS OF CHEMICAL ENGINEERING, 10th, October 01-05, 2017, Barcelona, Spain. Proceedings... 2017.

    Abstract: A microreactor designed to synthesize nanocrystals was built applying laser pulses with duration of femtoseconds in a quartz board. This precise machining technology allowed dimensioning the microchip cross section as a trapezoidal shape with base lengths of 120 μm and 200 μm and depth of 150 μm. The microchip is comprised of four inlets for reactants, a mixing section with 40 curves after the inlet section to ensure proper mixing of the species and 22 serpentine channels, with 22,000 μm length each, to allow crystal growth. Flow field throughout the microchip was investigated by computational fluid dynamics considering inlet flow rates between 12.5 and 2000 μL min-1. Hexahedral meshes were used to discretize the geometry as its cross section is uniform and to reduce the total number of elements. Advection terms were solved by the high resolution scheme. Numerical solutions were converged when the maximum residual value was less than 10-4 and the domain imbalance was less than 1%. Flow throughout the channels is laminar as the maximum Reynolds number observed is 850. The tridimensional velocity profile is a paraboloid whose vertex is influence by the centrifugal force: at the curved sections, such force accelerates flow towards the outer part of the channels, moving the maximum velocity point to this zone. The centrifugal force also creates secondary flows. These structures enhance mixing in the direction perpendicular to the main flow and behave like turbulent flows in macroscopic systems, allowing proper mixing without additional power consumption. Proper coupling between microchip geometry and its operating conditions was verified by simulating the dispersion of a non-reactive tracer injected in one of the inlet ports while feeding the others with water. For low flow rates, the tracer flows parallel to the water stream up to half of the mixing section and full mixing occurs after the second serpentine channel. For flow rates higher than 250 μL min-1, it shows secondary fluxes are intensified and promote mixing after both the third curve at the mixing section and at the beginning of the serpentine channels after the fourth reactant inlet, ensuring better conditions if the desired reaction is limited by contact between the reactants.

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  • IPEN-DOC 25710

    PERES, JOSE C.G.; HERRERA, CRISTHIANO da C. ; BALDOCHI, SONIA L. ; ROSSI, WAGNER de ; VIANNA JUNIOR, ARDSON dos S.. Analysis of a microreactor for synthesizing nanocrystals by computational fluid dynamics. Canadian Journal of Chemical Engineering, v. 97, n. 2, p. 594-603, 2019. DOI: 10.1002/cjce.23356

    Abstract: Microreactors eliminate batch-to-batch variability and allow better control over nanocrystal synthesis. A serpentine microreactor fabricated by femtosecond laser ablation is presented and characterized by computational fluid dynamics, since the micro channels show a trapezoidal cross-section mainly due to the relatively high numerical aperture of the focusing lens. Mixing, macro and micro, throughout the device was investigated for inlet flow rates between 10–500 mL min 1 and the injection of an inert tracer with the same transport properties of water. The simulation of the whole microreactor enabled the analysis of the formation and destruction of structures. For instance, secondary flows played a major role in mixing behaviour: small flow rates did not promote mixing of the tracer and a stream of pure water even after 43 curved segments, while they were perfectly mixed after 9 segments for higher flow rates. According to the mixing index, the maximum effect of convective mixing was achieved for an inlet flow rate of 250 mL min 1. Tracer dispersion and the mixing index guided a scale-up process of the microreactor, optimizing the number of curved segments while increasing total throughput. The upscaled design exhibited mixing saturation at 400 mL min 1 and promoted better control of residence time to allow nanocrystal growth.

    Palavras-Chave: lasers; ablation; nanomaterials; crystals; ; synthesis; laminar flow; mixing

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  • IPEN-DOC 28134

    RODRIGUES, RAQUEL V.; SAMPAIO, CAMILA S.; GIROTTO, ALINE C.; PINHATTI, CAROLINE P.; IWAMOTO, ALEXSANDRA S.; FREITAS, ANDERSON Z. de ; AMBROSANO, GLAUCIA M.B.; PUPPIN-RONTANI, REGINA M.; PASCON, FERNANDA M.. Analysis of enamel/restoration interface submitted cariogenic challenge and fluoride release. Microscopy Research and Technique, v. 84, n. 12, p. 2857-2866, 2021. DOI: 10.1002/jemt.23844

    Abstract: The treatment of high-risk patients still is a challenge. The understanding and development non-invasive, non-destructive, and non-ionizing techniques, can help to guide the treatment and the diagnosis of primary and recurrent caries. The present study evaluated the behavior of enamel/restoration interface after a cariogenic challenge by Fourier domain optical coherence tomography (FD-OCT), scanning electron microscopy (SEM) examination, and the fluoride release of the different restorative materials. Cavities (1.5 × 0.5 mm) were performed in enamel surface and divided into groups (n = 8): glass ionomer cement (GIC), resin-modified glass ionomer cement (RMGIC), and resin composite (RC). The samples were submitted to pH-cycling, and the solutions analyzed for cumulative fluoride by ion-analyzer. The morphology was analyzed by SEM through replicas. The optical attenuation coefficient (OAC) was calculated through exponential decay from the images generated by FD-OCT. Data were analyzed considering α = 0.05. OAC values increased for all groups after pH-cycling indicating demineralization (p < .05). Considering the remineralizing solution, RMGIC presented higher fluoride release rate, followed by GIC, while RC did not release any fluoride. Yet for the demineralizing solution, RMGIC and GIC released similar fluoride rates, overcoming RC (p < .05). Micrographs revealed no changes on the restorations margins, although enamel detachment was observed for RC and GIC after pH-cycling.

    Palavras-Chave: dentistry; caries; enamels; biological recovery; demineralization; fluorides

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  • IPEN-DOC 14984

    ALMEIDA, B.E.; OLIVEIRA, J.E. ; CARVALHO, C.M.; DALMORA, S.L.; BARTOLINI, P. ; RIBELA, M.T.C.P. . Analysis of human luteinizing hormone and human chorionic gonadotropin preparations of different origins by reversed-phase high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, v. 53, p. 90-97, 2010.

    Palavras-Chave: luteinizing hormone; hcg; glycoproteins; hypothalamus; high-performance liquid chromatography

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  • IPEN-DOC 19232

    SILVA, ANNA C.B.; GUGLIELMI, CAMILA; MENEGUZZO, DAIANE T.; ARANHA, ANA C.C.; BOMBANA, ANTONIO C.; EDUARDO, CARLOS de P.. Analysis of permeability and morphology of root canal dentin after Er, Cr:YSGG laser irradiation. Photomedicine and Laser Surgery, v. 28, n. 1, p. 103-108, 2010.

    Palavras-Chave: morphology; permeability; teeth; oral cavity; dentin; laser radiation; erbium; chromium; post-irradiation therapy; scanning electron microscopy; dentistry; therapy

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  • IPEN-DOC 26929

    MORENO, CAROLINA S. ; ROGERO, SIZUE O. ; GALISTEO JUNIOR, ANDRES J.; VIEIRA, DANIEL P. ; CRUZ, AUREA S.; SAKURABA, ROBERTO K.; WELTMAN, EDUARDO; ROGERO, JOSE R. . Analysis of the combined effects of resveratrol and radiation on lung cancer cells. Integrative Cancer Biology & Research, v. 1, n. 1, 2017.

    Abstract: Mucoepidermoid lung carcinoma is frequently manifested by obstructive trachea symptoms. It is necessary to develop effective curative or palliative therapeutic strategies for treating mucoepidermoid lung carcinoma through administration of compounds that improve ionizing radiation treatment, thereby increasing the effects of the treatment on tumor cells while minimizing the effects on normal tissues surrounding the tumor cells. Resveratrol is a polyphenolic phytoalexin present in wines and several plants and has a broad spectrum of biological activities, including antioxidant and anticarcinogenic effects. The biological effects of ionizing radiation plus resveratrol have been examined in different types of cell in many studies. Here, we aimed to verify the effects of resveratrol on mucoepidermoid lung carcinoma cells NCI-H292 exposed to ionizing radiation. In vitro studies in NCI-H292 cell culture using neutral red uptake assays showed that the cytotoxicity index (IC50) of resveratrol was 401.5μM, and the lethal dose 50 % (LD50) of ionizing radiation in the absence of resveratrol was 693 Gy. In vitro micronucleus assays were then performed to verify the genotoxic effects of resveratrol, and fluorescence assays were performed to evaluate the effects of resveratrol on the cell cycle, repair and injury processes, cellular necrosis, and apoptosis. The results demonstrated that 30μM resveratrol promote injury on NCI-H292 cells after 24 h of irradiation. Therefore, this study provides results able to support in vitro future investigations about radiosensitive potential of resveratrol in lung cancer cells. There is a need to investigate compounds with potential to improve the local control of lung cancer promoted by radiation therapy. This way avoiding injuries to healthy cells.

    Palavras-Chave: dna damages; in vitro; ionizing radiations; lungs; lymphokines; neoplasms; polyphenols; radiation effects; radiosensitivity

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✔ Ao efetuar a busca por um autor o RD apresentará uma relação de todos os trabalhos depositados no RD. No lado direito da tela são apresentados os coautores com o número de trabalhos produzidos em conjunto bem como os assuntos abordados e os respectivos anos de publicação agrupados.

✔ O RD disponibiliza um quadro estatístico de produtividade, onde é possível visualizar o número dos trabalhos agrupados por tipo de coleção, a medida que estão sendo depositados no RD.

✔ Na página inicial nas referências são sinalizados todos os autores IPEN, ao clicar nesse símbolo será aberta uma nova página correspondente à aquele autor – trata-se da página do pesquisador.

✔ Na página do pesquisador, é possível verificar, as variações do nome, a relação de todos os trabalhos com texto completo bem como um quadro resumo numérico; há links para o Currículo Lattes e o Google Acadêmico ( quando esse for informado).

ATENÇÃO!

ESTE TEXTO "AJUDA" ESTÁ SUJEITO A ATUALIZAÇÕES CONSTANTES, A MEDIDA QUE NOVAS FUNCIONALIDADES E RECURSOS DE BUSCA FOREM SENDO DESENVOLVIDOS PELAS EQUIPES DA BIBLIOTECA E DA INFORMÁTICA.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI, clique aqui.


2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI, clique aqui.

O Repositório Digital do IPEN é um equipamento institucional de acesso aberto, criado com o objetivo de reunir, preservar, disponibilizar e conferir maior visibilidade à Produção Científica publicada pelo Instituto, desde sua criação em 1956.

Operando, inicialmente como uma base de dados referencial o Repositório foi disponibilizado na atual plataforma, em junho de 2015. No Repositório está disponível o acesso ao conteúdo digital de artigos de periódicos, eventos, nacionais e internacionais, livros, capítulos, dissertações, teses e relatórios técnicos.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.