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Navegação IPEN por ano de publicação "2021"
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MORAIS, ALINE V. de; MELO, CAMILA G.
; GARCIA, VANESSA S.G.
; PEREIRA, MARIA da C.C.
; ROSA, JORGE M.; BORRELY, SUELI I.
.
Toxicidade do efluente e consumo hídrico e energético no tingimento de poliamida.
In: SILVEIRA, JOSE H.P. (Org.).
Meio Ambiente, Sustentabilidade e Tecnologia.
Belo Horizonte, MG: Poisson,
2021.
p. 91-97,
v. 8,
cap. 9.
DOI:
10.36229/978-65-5866-123-8.CAP.09
Abstract:
O uso racional da água é imprescindível no setor industrial e deste modo necessita de tecnologia e esforços que permitam o reuso desse recurso natural. O estudo concentrou-se na determinação do consumo hídrico e energético durante o tingimento da poliamida, bem como na avaliação do efeito tóxico do efluente para o microcrustáceo Daphnia similis. O efluente pode ser considerado como muito tóxico tendo em vista que a CE50 foi 0,61 ± 0,21 (%, v/v) após 48 horas de exposição. Conforme orientação da Resolução CONAMA 430/2011 o efluente deve ser tratado em nível tal que não induza toxicidade quando lançado no corpo receptor. Buscas por tecnologias que permitam o reúso e a melhoria dos efluentes também são necessários nessa atividade industrial.
Palavras-Chave:
liquid wastes;
textile industry;
water pollution;
daphnia;
dyes;
water resources;
polyamides;
environment;
toxic materials
MORAIS, ALINE V. de; MELO, CAMILA G.; GARCIA, VANESSA S.G.; PEREIRA, MARIA da C.C.; ROSA, JORGE M.; BORRELY, SUELI I.
Toxicidade do efluente e consumo hídrico e energético no tingimento de poliamida.
In:
SILVEIRA, JOSE H.P. (org.).
Meio Ambiente, Sustentabilidade e Tecnologia.
Belo Horizonte, MG: Poisson,
2021.
v. 8,
cap. 9.
p. 91-97.
DOI:
10.36229/978-65-5866-123-8.CAP.09.
Disponível em: http://repositorio.ipen.br/handle/123456789/32693. Acesso em: $DATA.
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TOMINAGA, F.K.
; BOIANI, N.F.
; GARCIA, V.S.G.
; SILVA, T.T.
; LEO, P.; BORRELY, S.I.
.
Toxicidade aguda e avaliação de riscos ecológicos de fármacos pertencentes a diferentes classes detectados em ambientes aquáticos.
In: CONGRESSO BRASILEIRO DE ECOTOXICOLOGIA, 16.,
16-19 de agosto, 2021,
Online.
Anais...
2021.
TOMINAGA, F.K.; BOIANI, N.F.; GARCIA, V.S.G.; SILVA, T.T.; LEO, P.; BORRELY, S.I.
Toxicidade aguda e avaliação de riscos ecológicos de fármacos pertencentes a diferentes classes detectados em ambientes aquáticos.
In:
CONGRESSO BRASILEIRO DE ECOTOXICOLOGIA, 16.,
16-19 de agosto, 2021,
Online.
Anais...
2021.
Disponível em: http://repositorio.ipen.br/handle/123456789/33695. Acesso em: $DATA.
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CABRAL, FERNANDA V.
.
Towards new therapeutic strategies for cutaneous leishmaniasis
/ Buscando novas estratégias terapêuticas para o tratamento de leishmaniose cutânea
.
2021.
Tese (Doutorado em Tecnologia Nuclear) -
Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP,
São Paulo.
123 p.
Orientador: Martha Simões Ribeiro.
DOI:
10.11606/T.85.2021.tde-18112021-095721
Abstract:
Cutaneous leishmaniasis (CL) is a zoonotic disease developed by protozoa parasites of genus Leishmania. It promotes destructive and ulcerated lesions with limited treatment options. There is an urgent need for the development of topical, cost-effective and efficacious treatments with minimized side effects to treat affected patients. The parasite-host interaction is of great importance since Leishmania parasites survive and replicate within host macrophages. As phagocytic cells, the activated macrophages produce reactive oxygen species (ROS) and nitric oxide (NO), which are toxic to pathogens, hence preventing parasites proliferation. However, Leishmania parasites can evade the host immune response and subvert antimicrobial macrophage defenses, thereby surviving within these cells even in harsh conditions. Indeed, the role played by ROS and NO in the control of CL has been under debate over the past years, emerging as potential alternatives to tackle this important neglected disease. In this regard, we aimed to evaluate the role of both NO and ROS towards antileishmanial activity using two different therapeutic strategies: (1) nitric oxide-releasing chitosan nanoparticles (NONPs) and (2) antimicrobial photodynamic therapy (PDT). For this, we focused on development and investigation of the potential of NONPs in vitro and in vivo against Leishmania amazonensis, one of the causative agents of CL. To assess the role of ROS, photodynamic therapy was investigated against different Leishmania species. Firstly, we evaluated the potential of organic light-emitting diodes (OLEDs) as a novel light source to inactivate in vitro promastigotes of L. major and L. amazonensis, using three phenothiazine dyes: Methylene blue, new methylene blue and 1,9-dimethyl methylene blue (DMMB). Then, we addressed the underlying mechanisms of DMMB-PDT upon promastigotes of L. amazonensis wild-type (WT) and miltefosineresistant (MFR) strains. DMMB-PDT effectiveness was also evaluated against intracellular amastigotes of WT and MFR together with cytotoxicity assay on mammalian cells. Our findings demonstrate that either NONPs or PDT are promising strategies to target CL and should be further explored for future preclinical and clinical trials.
Palavras-Chave:
parasites;
trypanosomes;
skin diseases;
chemical oxygen demand;
nitric oxide;
spectroscopy;
light emitting diodes
CABRAL, FERNANDA V.
Towards new therapeutic strategies for cutaneous leishmaniasis.
Orientador: Martha Simões Ribeiro.
2021.
123 f.
Tese (Doutorado em Tecnologia Nuclear) -
Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP,
São Paulo.
DOI:
10.11606/T.85.2021.tde-18112021-095721.
Disponível em: http://repositorio.ipen.br/handle/123456789/32717. Acesso em: $DATA.
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CABRAL, FERNANDA V.
; SOUZA, TIAGO H. dos S.; SELLERA, FABIO P.; FONTES, ADRIANA; RIBEIRO, MARTHA S.
.
Towards effective cutaneous leishmaniasis treatment with light-based technologies. A systematic review and meta-analysis of preclinical studies.
Journal of Photochemistry and Photobiology B: Biology,
v. 221,
p. 1-8,
2021.
DOI:
10.1016/j.jphotobiol.2021.112236
Abstract:
Cutaneous leishmaniasis (CL) is a neglected disease that represents a serious global public health concern. We performed a systematic review with meta-analysis targeting the use of light-based therapies on CL in preclinical studies since they are essential to identify the benefits, challenges, and limitations of proposing new technologies to fight CL. We searched Pubmed and Web of Science to include original preclinical researches in English that used light-based technologies to fight CL. Inclusion criteria encompassed any animal model for CL induction, an untreated infected group as the comparator, reliable and consistent methodology to develop and treat CL, focus on an antimicrobial therapeutic approach, and data for lesion size and/or parasite load in the infection site. We identified eight eligible articles, and all of them used photodynamic therapy (PDT). For the meta-analysis, three studies were included regarding the parasite load in the infection site and four comprised the lesion size. No overall statistically significant differences were observed between untreated control and PDT groups for parasite load. Differently, PDT significantly reduced the lesion size regardless of the protocol used to treat CL (in mm, SMD: -1.90; 95% CI: −3.74 to −0.07, p = 0.04). This finding is particularly encouraging since CL promotes disfiguring lesions that profoundly affect the quality of life of patients. We conclude that PDT is a new promising technology able to be topically used against CL if applied in more than one session, making it a promising ally for the management of CL.
Palavras-Chave:
protozoa;
antimicrobial agents;
therapy;
photosensitivity
CABRAL, FERNANDA V.; SOUZA, TIAGO H. dos S.; SELLERA, FABIO P.; FONTES, ADRIANA; RIBEIRO, MARTHA S.
Towards effective cutaneous leishmaniasis treatment with light-based technologies. A systematic review and meta-analysis of preclinical studies.
Journal of Photochemistry and Photobiology B: Biology,
v. 221,
p. 1-8,
2021.
DOI:
10.1016/j.jphotobiol.2021.112236.
Disponível em: http://repositorio.ipen.br/handle/123456789/32605. Acesso em: $DATA.
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SANTOS, S.C.
; RODRIGUES JUNIOR, O.
; CAMPOS, L.L.
.
Towards a new promising dosimetric material from formation of thulium-yttria nanoparticles with EPR response.
Materials Chemistry and Physics,
v. 259,
p. 1-7,
2021.
DOI:
10.1016/j.matchemphys.2020.124005
Abstract:
Advances toward new materials for dosimetry application is essential to enhance quality assurance and quality
improvement practices based on radiation protection concept. Face to this challenge the present work reports an
approach to produce thulium-yttria nanoparticles with electron paramagntic resonance response by an alternative
hydrothermal synthesis based on a relative low temperature and pressure. Distinct compositions of
thulium-yttria nanoparticles with up to 2 at.%Tm (at.%, atomic percentage) were prepared and characterized by
XRD, SEM, PCS, and EPR. The proposed synthesis method followed by thermal treatment of the precursor powder
at 1100 ◦C for 2 h provided thulium-yttria nanoparticles with rounded shape, cubic C-type structure, and mean
particle size (d50) less than 160 nm. Among all compositions formed, thulium-yttria nanoparticles prepared with
0.1%Tm presented the most remarkable EPR response. The production of fine thulium-yttria nanoparticles with
EPR response supply meaningful parameters to advance in the formation of new dosimetry materials based on
rare earths.
Palavras-Chave:
dosimetry;
thulium oxides;
yttrium;
nanoparticles;
rare earths;
electron paramagnetic resonance;
ceramics
SANTOS, S.C.; RODRIGUES JUNIOR, O.; CAMPOS, L.L.
Towards a new promising dosimetric material from formation of thulium-yttria nanoparticles with EPR response.
Materials Chemistry and Physics,
v. 259,
p. 1-7,
2021.
DOI:
10.1016/j.matchemphys.2020.124005.
Disponível em: http://repositorio.ipen.br/handle/123456789/31965. Acesso em: $DATA.
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MERIZIO, L.G.; BONTURIM, E.; ICHIKAWA, R.U.
; SILVA, I.G.N.; TEIXEIRA, V.C.; RODRIGUES, L.C.V.; BRITO, H.F..
Toward an energy-efficient synthesis method to improve persistent luminescence of Sr2MgSi2O7:Eu2+,Dy3+ materials.
Materialia,
v. 20,
p. 1-10,
2021.
DOI:
10.1016/j.mtla.2021.101226
Abstract:
The synthesis of persistent luminescent materials usually requires a multi-step long time annealing at high temperatures (>1200°C) in a resistive oven, causing a huge energy consumption. Also, to achieve reduced oxidation states of emitter ions (e.g., Eu3+ → Eu2+ ), the H2(g) atmosphere is often used, which can be dangerous and increase the costs of the process. Therefore, the development of a quick and new single-step green strategy, using in-situ low-risk atmosphere (e.g., CO(g)) and a microwave-assisted solid-state (MASS) method has been encouraged. In this work, we present a single-step method to synthesize the compound Sr2MgSi2O7:Eu2+,Dy3+ using the MASS method and the results were compared with those prepared by a conventional ceramic method. The luminescent material was prepared in 25 min of synthesis using carbon as a microwave susceptor and CO(g) atmosphere source at the same time. A higher concentration of Eu2+ emitter was identified by XANES in the MASS method product, which has a significant effect on the luminescence efficiency, as well as an improvement in the optical properties, leading to an emission 100 times more intense. Furthermore, to understand the Eu3+ reduction process under CO(g) atmosphere, we present here the innovative results of in-situ XANES analysis for the Sr2MgSi2O7:Eu2+,Dy3+ material. Finally, the MASS method makes it possible to prepare the materials with less than 5% of the ceramic method's duration in time. The energy-saving and better-quality persistent luminescent properties obtained in the MASS method provide viable applications on anti-counterfeiting markers, solar cell sensitizers, and other luminescent technologies.
Palavras-Chave:
microwave radiation;
synthesis;
rare earths;
solids;
luminescence;
annealing;
synchrotron radiation
MERIZIO, L.G.; BONTURIM, E.; ICHIKAWA, R.U.; SILVA, I.G.N.; TEIXEIRA, V.C.; RODRIGUES, L.C.V.; BRITO, H.F.
Toward an energy-efficient synthesis method to improve persistent luminescence of Sr2MgSi2O7:Eu2+,Dy3+ materials.
Materialia,
v. 20,
p. 1-10,
2021.
DOI:
10.1016/j.mtla.2021.101226.
Disponível em: http://repositorio.ipen.br/handle/123456789/32655. Acesso em: $DATA.
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CHIERENTIN, G.S.
; TEIXEIRA, B.S.
; MASTRO, N.L.
.
Total phenolic compounds of irradiated chia seeds.
Brazilian Journal of Radiation Sciences,
v. 9,
n. 1A,
p. 1-9,
2021.
DOI:
10.15392/bjrs.v9i1A.1331
Abstract:
Chia seeds (Salvia hispanica L.) is a good source of oil, protein, dietary fiber, minerals and polyphenolic compounds. In order to study the influence of the processing methods on the content of phenolic compounds, the
objective of this work was to evaluate the effect of gamma radiation, doses 0 (control), 5, 10 and 20 kGy, on the total phenolic compounds extracted from chia seeds. Seeds were first defatted and extracts produced with proper solvents. Total phenolic content was determined according to Folin-Ciocalteu’s method and the extraction solvents applied were ethanol 100%, ethanol 70%, ethanol 50%, methanol 100%, methanol 70% and methanol 50%. When using ethanol 100%, ethanol 70 %, ethanol 50%, methanol 100% and methanol 70%, the extraction yield was independent of the absorbed dose. With methanol 50%, the irradiation process affected positively the total phenolic yield from of chia seeds. In general, the absorbed dose as well as the nature of the solvent affected the extraction yield, although in a limited manner.
Palavras-Chave:
antioxidants;
cobalt 60;
dose rates;
food processing;
gamma radiation;
irradiation;
radiation dose units;
radiation effects;
seeds
CHIERENTIN, G.S.; TEIXEIRA, B.S.; MASTRO, N.L.
Total phenolic compounds of irradiated chia seeds.
Brazilian Journal of Radiation Sciences,
v. 9,
n. 1A,
p. 1-9,
2021.
DOI:
10.15392/bjrs.v9i1A.1331.
Disponível em: http://repositorio.ipen.br/handle/123456789/32094. Acesso em: $DATA.
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OLIVO-ARIAS, L.P.; ARAUJO, L.G.
.
Three-dimensional transient numerical simulation of the solid volume fraction of a fluidized bed: the role of three solution orders using a discretization scheme.
Latin-American Journal of Physics Education,
v. 15,
n. 2,
p. 2303-1 - 2303-10,
2021.
Abstract:
The FLUENT solver employed in the Computational Fluid Dynamics (CFD) has been extensively developed to extend its robustness and precision for a wide range of flow regimes. For that, the FLUENT solver has a numerical method in the pressure-based solver that has traditionally been used for incompressible and slightly compressible flows. The algorithm is based on the pressure that solves the equations in a segregated or decoupled mode. This algorithm has proven to be robust and versatile and has been used cooperatively with a wide range of physical models, including multiphase flows and conjugated heat transfer. However, there are applications in which the convergence rate of the segregated algorithm is not satisfactory, generally due to the need in these coupling scenarios between the continuity and momentum equations. The objective of this article is to validate the Eulerian model to determine the volumetric fractions of the solid phase fraction. For this, we used data from the literature and the PCSIMPLE algorithm (solver) at different orders of solution of the continuity, momentum, and turbulence equations. Also, we determined its efficiency in transient systems and how it would affect the results in the hydrodynamics of a three-phase fluidized bed reactor. The results were significant, thus representing the phenomenon of interaction between the liquid-solid and solid-gas phases.
Palavras-Chave:
hydrodynamic model;
computerized simulation;
computer calculations;
dynamics;
fluidized beds
OLIVO-ARIAS, L.P.; ARAUJO, L.G.
Three-dimensional transient numerical simulation of the solid volume fraction of a fluidized bed: the role of three solution orders using a discretization scheme.
Latin-American Journal of Physics Education,
v. 15,
n. 2,
p. 2303-1 - 2303-10,
2021.
Disponível em: http://repositorio.ipen.br/handle/123456789/32652. Acesso em: $DATA.
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PANESI, A.R.Q.
; SILVA, R.P.
; CUNHA, E.F.
; KORKISCHKO, I.
; SANTIAGO, E.I.
.
Three-dimensional CFD modeling of H2/O2 HT-PEMFC based on H3PO4-doped PBI membranes.
Ionics,
v. 27,
n. 8,
p. 3461-3475,
2021.
DOI:
10.1007/s11581-021-04107-9
Abstract:
A complete non-isothermal model of a HT-PEMFC setup using a PBI/ H3PO4 membrane was developed, modeled, and solved using COMSOL Multiphysics. Polarization curves were simulated and compared to the corresponding experimental data. In this work, a serpentine flow field and an active area of 5 cm2 have been implemented in a computational fluid dynamics (CFD) application. The model predicts water vapor transport, mass concentration of H3PO4, temperature, and membrane current density distribution. In this model, the anode feed is pure hydrogen, and oxygen is introduced at the cathode side. The heat transfer model was coupled with the electrochemical and mass transport; a particular heating configuration is investigated for temperature distribution, emphasizing the membrane. The models showed consistency and were used to investigate the behavior of H3PO4 concentration and all transport characteristics. The concentration of phosphoric acid decreases with increasing temperature and relative humidity and the diffusive flux of water vapor increases with the decrease of the operating voltage. Two different configurations of inlet and outlet flow channels were analyzed and the results were compared.
Palavras-Chave:
fuel cells;
phosphoric acid;
fluid mechanics;
efficiency;
computer calculations;
dynamics
PANESI, A.R.Q.; SILVA, R.P.; CUNHA, E.F.; KORKISCHKO, I.; SANTIAGO, E.I.
Three-dimensional CFD modeling of H2/O2 HT-PEMFC based on H3PO4-doped PBI membranes.
Ionics,
v. 27,
n. 8,
p. 3461-3475,
2021.
DOI:
10.1007/s11581-021-04107-9.
Disponível em: http://repositorio.ipen.br/handle/123456789/32604. Acesso em: $DATA.
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VIEIRA, DANIEL P.
.
Three-dimensional cellular culture system for testing of biological effects of radiations in tumoral and non-tumoral models.
In: CONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th,
October 4-8, 2021,
São Paulo, SP.
Abstract...
São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq),
2021.
p. 89-89.
Abstract:
In vitro cell cultures are a well-known controlled test system used to analyze tumor physiologic responses
upon negative stimuli. Updated techniques, us-ing three-dimensional organization of cells in cultures, are
being increasingly used to this purpose. Research organizations and industry are striving to pro-duce in
vitro tumor surrogates that could be better test systems to antitumor agents as new compounds or to
study radiation effects on cancers. The presentation will show some techniques currently used to build
and maintain these specific cell cultures, and how experiments are evolving towards the production of
tumoroids, or tumoral organoids, which will include various cell types and additive manufacturing.
Palavras-Chave:
cell cultures;
three-dimensional calculations;
tumor cells;
radiations
VIEIRA, DANIEL P.
Three-dimensional cellular culture system for testing of biological effects of radiations in tumoral and non-tumoral models.
In:
CONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th,
October 4-8, 2021,
São Paulo, SP.
Abstract...
São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq),
2021.
p. 89-89.
Disponível em: http://repositorio.ipen.br/handle/123456789/32864. Acesso em: $DATA.
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VIEIRA, DANIEL P.
.
Three-dimensional cellular culture system for testing of biological effects of radiations in tumoral and non-tumoral models.
Biophysical Reviews,
v. 13,
n. 6,
p. 1521-1521,
2021.
DOI:
10.1007/s12551-021-00844-3
Abstract:
In vitro cell cultures are a well-known controlled test system
used to analyze tumor physiologic responses upon negative
stimuli. Updated techniques, us-ing three-dimensional
organization of cells in cultures, are being increasingly used
to this purpose. Research organizations and industry are
striving to pro-duce in vitro tumor surrogates that could be
better test systems to antitumor agents as new compounds or
to study radiation effects on cancers. The presentation will
show some techniques currently used to build and maintain
these specific cell cultures, and how experiments are
evolving towards the production of tumoroids, or tumoral
organoids, which will include various cell types and additive
manufacturing.
VIEIRA, DANIEL P.
Three-dimensional cellular culture system for testing of biological effects of radiations in tumoral and non-tumoral models.
Biophysical Reviews,
v. 13,
n. 6,
p. 1521-1521,
2021.
DOI:
10.1007/s12551-021-00844-3.
Disponível em: http://repositorio.ipen.br/handle/123456789/32897. Acesso em: $DATA.
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BARIA, R.
; WATANABE, S.; MUNITA, C.S.
; SILVA, P.S.C.
; TATUMI, S.H..
Thorium, uranium and potassium levels of Brazil geological sediment by gamma-ray spectrometer and instrumental neutron activation analysis.
In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE,
November 29 - December 2, 2021,
Online.
Proceedings...
Rio de Janeiro: Associação Brasileira de Energia Nuclear,
2021.
Palavras-Chave:
comparative evaluations;
geology;
neutron activation analysis;
potassium;
seawater;
seaweeds;
sediments;
thorium;
uranium;
x-ray spectroscopy
BARIA, R.; WATANABE, S.; MUNITA, C.S.; SILVA, P.S.C.; TATUMI, S.H.
Thorium, uranium and potassium levels of Brazil geological sediment by gamma-ray spectrometer and instrumental neutron activation analysis.
In:
INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE,
November 29 - December 2, 2021,
Online.
Proceedings...
Rio de Janeiro: Associação Brasileira de Energia Nuclear,
2021.
Disponível em: http://repositorio.ipen.br/handle/123456789/32563. Acesso em: $DATA.
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POLO, IVON O.
; JUNOT, DANILO O.
; NICOLUCCI, PATRICIA; CALDAS, LINDA
.
Thermoluminescent response of CaSO4:Eu,Ag detectors in 90Sr/90Y beta radiation beam / Respuesta termoluminiscente de detectores de CaSO4:Eu, Ag en un haz de radiación beta de 90Sr/90Y.
Nucleus,
v. 68,
p. 32-35,
2021.
Abstract:
The results of the thermoluminescent (TL) response of the CaSO4:Eu,Ag detectors in the 90Sr/90Y beams of the Beta Secondary Standard 2 system of the Calibration Laboratory of IPEN (LCI/IPEN) are presented. The thermoluminescent glow curves were obtained from doses between 30 mGy and 500 mGy. The detectors showed a good reproducibility of the thermoluminescent response. The calculated calibration factor was (1.166 ± 0.024) x10-3mGy/a.u. and the factor determined by linear fitting was (1.120 ± 0.014) x10-3mGy/a.u., showing a difference of only 3.9%. The lower limit of detection was (4.96 ± 0.06) mGy. The detectors presentedan appropriate sensitivity for 90Sr/90Y beta radiation. Preliminary results showed suitable dosimetric characteristics for the establishment of a transfer system for beta radiation dosimetry of 90Sr/90Y beams.
Palavras-Chave:
thermoluminescence;
sensitivity;
calcium sulfates;
strontium 90;
yttrium 90;
thermoluminescent dosemeters;
response functions
POLO, IVON O.; JUNOT, DANILO O.; NICOLUCCI, PATRICIA; CALDAS, LINDA.
Thermoluminescent response of CaSO4:Eu,Ag detectors in 90Sr/90Y beta radiation beam.
Nucleus,
v. 68,
p. 32-35,
2021.
Disponível em: http://repositorio.ipen.br/handle/123456789/32389. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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PRADO, MARILIZA C. de O.
.
Thermal damage and time of excision of micro and super pulsed diode lasers
: an ex-vivo comparative study
/ Dano térmico e tempo de excisão dos lasers de diodo micro e superpulsado: um estudo comparativo ex-vivo
.
2021.
Tese (Doutorado em Tecnologia Nuclear) -
Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP,
São Paulo.
138 p.
Orientador: Denise Maria Zezell.
DOI:
10.11606/T.85.2021.tde-08092021-150518
Abstract:
Diode lasers are portable, accessible, efficient and reliable surgical units for performing surgeries and soft tissue biopsies of the oral cavity. The newer units are equipped with micro and super pulsed technologies and systems that allow the selection of different usage parameters in terms of emission mode, duty cycle, power and pulse duration. It is, however, not known which parameters or types of diode lasers produce the most intact tissue samples in the best possible surgical time. The main objective of this ex vivo study was to compare the thermal damage and the excision time of different parameters of the micro pulsed diode laser and the super pulsed diode laser. The secondary objectives were: 1) to provide practical recommendations for performing surgical excisions with diode lasers; 2) to examine possible correlations between the area and the depth of the thermal damage, as well as between the time of excision and the thermal damage. Ten groups of ten swine tongue specimens were excised (8 mm in diameter) using a surgical blade (control group: G1); micro pulsed diode laser in different emission modes, duty cycles, average power, peak power and pulse duration (G2 - 9); and the new super pulsed diode laser (G10) with the smallest single parameter recommended by the manufacturer (average power = 3.2W, peak power = 80 W, pulse duration from 10 μs to 100 ms). The wavelength of both was 940 nm. All parameters were previously measured with the power meter and activated disposable tips were discarded right after each biopsy. The area and the histological depth of the thermal damage were quantified using the NIS-Element Basic Research software (Nikon Instruments Inc), while the excision time was measured between the clamping until the total excision of the lesion. Kruskal-Wallis and Dunn's multiple comparison tests with Bonferroni correction were applied to compare the area and depth of thermal damage, as well as the time of excision between the groups. Correlations between area and depth of thermal damage and between excision time and thermal damage were examined using Spearman's nonparametric correlation coefficient. The level of significance was set at 5%. In the experimental groups (G2 - G10), the total area of thermal damage observed was smaller in the G3 group (continuous mode, average power = 1.5W; median = 0.91 mm2 ; p = 0.009). All other groups had thermal damage areas larger than 1 mm2 with G7 (pulsed mode, duty cycle = 33%, average power = 1.5W, peak = 5.4W and pulse duration of 100 μs) and G9 (pulsed mode, duty cycle = 50%, average power = 1.5W, peak = 3.6W and pulse duration = 1 ms) producing the largest damage areas (median 1.93 and 1.97 mm2 , respectively). In the multiple comparison, controlling the level of global significance, G3 presented a median area of thermal damage significantly smaller than those of G7 (p = 0.013) and G9 (p = 0.036). There were no statistically significant differences in the depth of thermal damage between the groups (p = 0.12). The median excision times of G1 (scalpel) and G10 (super pulsed) were significantly shorter than those found in the micro pulsed diode laser groups (G1 = 50; G10 = 69; G2 to G9 ranged from 142 to 238 seconds; p < 0.001). There was a direct correlation between the depth and area of thermal damage, but no correlation was found between the excision time and thermal damage. The use of the micro pulsed diode laser in continuous mode with average power = 1.5 W produced biopsies with the smallest area of thermal damage and greater tissue integrity, while the use of the super pulsed diode laser (average power = 3.2W, peak power = 80W, pulse duration from 10 μs to 100 ms) allowed faster excisions. Area and depth of thermal damage correlated directly. In clinical practice, the micro pulsed diode laser should be considered in continuous mode, at 1.5 W output power with 1.8 W peak power as the best option when aiming to achieve maximum tissue integrity. Whereas the use of super pulsed diode laser with output power = 3.2W, peak power = 80W, pulse duration from 10 μs to 100 ms, produced the best relationship between thermal damage and excision time, and is recommended when practical necessity requires rapid excisions with reasonable tissue integrity. The use of micro pulsed diode laser in pulsed emission mode with high peak power and long pulse duration should be avoided when performing oral biopsies so that tissue integrity is not compromised and hinders the histopathological analysis of the lesions.
Palavras-Chave:
diode-pumped solid state lasers;
thermionic diodes;
semiconductor diodes;
electromagnetic pulses;
internal electromagnetic pulses;
pulse techniques;
excision repair;
animal tissues;
oral cavity;
damage;
diagnostic techniques;
biopsy;
temperature dependence;
thermal efficiency;
penetration depth;
depth dose distributions;
optical depth curve;
histological techniques;
optical microscopy
PRADO, MARILIZA C. de O.
Thermal damage and time of excision of micro and super pulsed diode lasers
: an ex-vivo comparative study.
Orientador: Denise Maria Zezell.
2021.
138 f.
Tese (Doutorado em Tecnologia Nuclear) -
Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP,
São Paulo.
DOI:
10.11606/T.85.2021.tde-08092021-150518.
Disponível em: http://repositorio.ipen.br/handle/123456789/32287. Acesso em: $DATA.
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-
REIS, S.L.
; GROSSO, R.L.
; MUCCILLO, E.N.S.
.
Thermal and spectroscopic characterization of sol-gel-synthesized doped lanthanum gallate.
Journal of Thermal Analysis and Calorimetry,
v. 146,
n. 4,
p. 1561-1567,
2021.
DOI:
10.1007/s10973-020-10113-2
Abstract:
In this study, a complex oxide solid solution consisting of lanthanum gallate with partial substitutions for strontium and magnesium (La0.9Sr0.1Ga0.8Mg0.2O2.85) was synthesized by the sol–gel route, aiming to obtain a sinter active powder and a final material that could be stoichiometrically controlled. The thermal behavior of the synthesized powder involves several steps of decomposition. The linear shrinkage of green compacts up to 1500 °C was 31%. The bulk conductivity of sintered specimens increases with sintering temperature up to 1400 °C. The stoichiometry was maintained for sintering temperatures up to 1450 °C. Elemental mapping obtained by energy-dispersive spectroscopy evidenced magnesium segregation at the grain boundaries. The overall results evidence the suitability of the synthesis method for preparing doped lanthanum gallate.
Palavras-Chave:
thermal gravimetric analysis;
differential thermal analysis;
lanthanum compounds;
powders;
synthesis
REIS, S.L.; GROSSO, R.L.; MUCCILLO, E.N.S.
Thermal and spectroscopic characterization of sol-gel-synthesized doped lanthanum gallate.
Journal of Thermal Analysis and Calorimetry,
v. 146,
n. 4,
p. 1561-1567,
2021.
DOI:
10.1007/s10973-020-10113-2.
Disponível em: http://repositorio.ipen.br/handle/123456789/32405. Acesso em: $DATA.
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-
TABACOW, FABIO B.D.
; ZUFFI, ARMANDO V.F.
; MALDONADO, EDISON P.; SAMAD, RICARDO E.
; VIEIRA JUNIOR, NILSON D.
.
Theoretical and experimental study of supersonic gas jet targets for laser wakefield acceleration.
In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE,
May 31 - June 2, 2021,
Online.
Proceedings...
Piscataway, NJ, USA: IEEE,
2021.
DOI:
10.1109/SBFOTONIOPC50774.2021.9461936
Abstract:
This work reports a theoretical and
experimental study of supersonic gas jets to be used as targets
in laser wakefield acceleration. A comparison between
theoretical and experimental results ismade in order to
estimate the results of a de Laval nozzle manufactured in our
laboratory, used to produce a N2 gas target. The comparison
between the results shows that Computational Fluid
Dynamicssimulations are able todescribe the phenomena of the
supersonic gas jet.
Palavras-Chave:
interferometry;
acceleration;
wakefield accelerators;
computer calculations;
fluid mechanics;
nozzles;
supersonic flow
TABACOW, FABIO B.D.; ZUFFI, ARMANDO V.F.; MALDONADO, EDISON P.; SAMAD, RICARDO E.; VIEIRA JUNIOR, NILSON D.
Theoretical and experimental study of supersonic gas jet targets for laser wakefield acceleration.
In:
SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE,
May 31 - June 2, 2021,
Online.
Proceedings...
Piscataway, NJ, USA: IEEE,
2021.
DOI:
10.1109/SBFOTONIOPC50774.2021.9461936.
Disponível em: http://repositorio.ipen.br/handle/123456789/32344. Acesso em: $DATA.
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-
MELO, PEDRO B. dos S.; CARDOSO, ELBIS S.; SAMAD, RICARDO E.
; MOTTA, CLAUDIO C..
Theoretical analysis of the influence of Photodarkening on the gain of a YDCFL.
In: SBMO/IEEE MTT-S INTERNATIONAL MICROWAVE AND OPTOELECTRONICS CONFERENCE,
October 24-27, 2021,
Fortaleza, CE.
Proceedings...
Danvers, MA, USA: Institute of Electrical and Electronic Engineers (IEEE),
2021.
DOI:
10.1109/IMOC53012.2021.9624806
Abstract:
An analytical formulation was developed to study the influence of the Photodarkening (PD) on the gain behavior of a ytterbium doped double-clad fiber laser (YDCFL). To formalize the modeling, the fundamental equations that describe the continuous wave laser in the steady state tandem pumping regime were employed. It was possible to observe the dependence of the YDCFL signal gain with temperature, absorption and emission cross sections, and with the higher level population density. Since the gain is related to these laser parameters, it may change significantly with increasing temperature in the fiber due to the PD effect.
Palavras-Chave:
doped materials;
ytterbium ions;
optical fibers;
gain
MELO, PEDRO B. dos S.; CARDOSO, ELBIS S.; SAMAD, RICARDO E.; MOTTA, CLAUDIO C.
Theoretical analysis of the influence of Photodarkening on the gain of a YDCFL.
In:
SBMO/IEEE MTT-S INTERNATIONAL MICROWAVE AND OPTOELECTRONICS CONFERENCE,
October 24-27, 2021,
Fortaleza, CE.
Proceedings...
Danvers, MA, USA: Institute of Electrical and Electronic Engineers (IEEE),
2021.
DOI:
10.1109/IMOC53012.2021.9624806.
Disponível em: http://repositorio.ipen.br/handle/123456789/32853. Acesso em: $DATA.
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-
MENDES, LUCAS S.; NACARATTI, DAVI P.; SAMAD, RICARDO E.
; MOTTA, CLAUDIO C..
Theoretical analysis of the efficiency of a 7 × 1 end-pumped power combiner.
In: SBMO/IEEE MTT-S INTERNATIONAL MICROWAVE AND OPTOELECTRONICS CONFERENCE,
October 24-27, 2021,
Fortaleza, CE.
Proceedings...
Danvers, MA, USA: Institute of Electrical and Electronic Engineers (IEEE),
2021.
DOI:
10.1109/IMOC53012.2021.9624827
Abstract:
An analytical formulation for the power transmission efficiency of a 7 × 1 end-pumped combiner has been developed and is reported in this paper. The formulation is supported by the Coupled-Mode Theory, and considers the modal coupling in a straight, circular cross section, optical fiber whose radius decreases monotonically. Within this scope, the power efficiency for each input fiber is determined for different tapers shapes.
Palavras-Chave:
optical fibers;
coupling;
power transmission;
pumping
MENDES, LUCAS S.; NACARATTI, DAVI P.; SAMAD, RICARDO E.; MOTTA, CLAUDIO C.
Theoretical analysis of the efficiency of a 7 × 1 end-pumped power combiner.
In:
SBMO/IEEE MTT-S INTERNATIONAL MICROWAVE AND OPTOELECTRONICS CONFERENCE,
October 24-27, 2021,
Fortaleza, CE.
Proceedings...
Danvers, MA, USA: Institute of Electrical and Electronic Engineers (IEEE),
2021.
DOI:
10.1109/IMOC53012.2021.9624827.
Disponível em: http://repositorio.ipen.br/handle/123456789/32852. Acesso em: $DATA.
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-
FREITAS, LUCAS F.
; FERREIRA, ARYEL H.
; THIPE, VELAPHI C.
; VARCA, GUSTAVO H.C.
; LIMA, CAROLINE S.A.
; BATISTA, JORGE G.S.
; RIELLO, FABIANE N.
; NOGUEIRA, KAMILA
; CRUZ, CASSIA P.C.
; MENDES, GIOVANNA O.A.
; RODRIGUES, ADRIANA S.
; SOUSA, THAYNA S.
; ALVES, VICTORIA M.
; LUGAO, ADEMAR B.
.
The state of the art of theranostic nanomaterials for lung, breast, and prostate cancers.
Nanomaterials,
v. 11,
n. 10,
p. 1-31,
2021.
DOI:
10.3390/nano11102579
Abstract:
The synthesis and engineering of nanomaterials offer more robust systems for the
treatment of cancer, with technologies that combine therapy with imaging diagnostic tools in the
so‐called nanotheranostics. Among the most studied systems, there are quantum dots, liposomes,
polymeric nanoparticles, inorganic nanoparticles, magnetic nanoparticles, dendrimers, and gold
nanoparticles. Most of the advantages of nanomaterials over the classic anticancer therapies come
from their optimal size, which prevents the elimination by the kidneys and enhances their
permeation in the tumor due to the abnormal blood vessels present in cancer tissues. Furthermore,
the drug delivery and the contrast efficiency for imaging are enhanced, especially due to the
increased surface area and the selective accumulation in the desired tissues. This property leads to
the reduced drug dose necessary to exert the desired effect and for a longer action within the tumor.
Finally, they are made so that there is no degradation into toxic byproducts and have a lower
immune response triggering. In this article, we intend to review and discuss the state‐of‐the‐art
regarding the use of nanomaterials as therapeutic and diagnostic tools for lung, breast, and prostate
cancer, as they are among the most prevalent worldwide.
Palavras-Chave:
nanomaterials;
nanotechnology;
neoplasms;
theranostics
FREITAS, LUCAS F.; FERREIRA, ARYEL H.; THIPE, VELAPHI C.; VARCA, GUSTAVO H.C.; LIMA, CAROLINE S.A.; BATISTA, JORGE G.S.; RIELLO, FABIANE N.; NOGUEIRA, KAMILA; CRUZ, CASSIA P.C.; MENDES, GIOVANNA O.A.; RODRIGUES, ADRIANA S.; SOUSA, THAYNA S.; ALVES, VICTORIA M.; LUGAO, ADEMAR B.
The state of the art of theranostic nanomaterials for lung, breast, and prostate cancers.
Nanomaterials,
v. 11,
n. 10,
p. 1-31,
2021.
DOI:
10.3390/nano11102579.
Disponível em: http://repositorio.ipen.br/handle/123456789/32305. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
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-
LIMA, VERA M.F. de
; PEREIRA JUNIOR, ALFREDO; OLIVEIRA, GUILHERME L. de.
The spreading depression propagation: how electrochemical patterns distort or create perception.
Open Journal of Biophysics,
v. 11,
n. 2,
p. 133-146,
2021.
DOI:
10.4236/ojbiphy.2021.112003
Abstract:
At the transition from quiescence to propagating waves recorded in isolated
retinas, a circular electric current closes in the extracellular matrix; this circular
current creates a magnetic torus flow that, when entering quiescent tissue
in front of the wave, recruits elements and when leaving behind, helps to
build the absolute refractory state. The waving magnetic torus is the consequence
of the vortex effect and explains the energy boost that drives propagation.
Methods: We interpret experimental results from intrinsic and extrinsic
fluorescence dyes, voltage, calcium and pH sensitive, optical signals from isolated
retinas, and time series recordings using ion exchange resins: Ca, K, pH,
Na, Cl recorded extracellularly at retinas, cerebellums and cortices coupled to
spreading depression waves. Finally, we checked the ECoG activity, also a
time series, at the transition from after discharges to spreading depression in
rat hippocampus. Results: The integrated assessment of the diversified measurements
led to the realization that the magnetic flow at the wavefront is a
major contributor to the wave propagation mechanisms. This flow couples
mass and charge flows as a swirling torus from excited to quiescent tissue.
Conclusions: An alternative model of the brain is possible, apart from the
classical HH and molecular biology model. Physical chemistry of charged gels
and its flows explains the results. The conceptual framework uses far from
equilibrium thermodynamics.
Palavras-Chave:
brain;
electrochemistry;
retina;
resonance;
central nervous system;
vortices;
vortex flow
LIMA, VERA M.F. de; PEREIRA JUNIOR, ALFREDO; OLIVEIRA, GUILHERME L. de.
The spreading depression propagation: how electrochemical patterns distort or create perception.
Open Journal of Biophysics,
v. 11,
n. 2,
p. 133-146,
2021.
DOI:
10.4236/ojbiphy.2021.112003.
Disponível em: http://repositorio.ipen.br/handle/123456789/31942. Acesso em: $DATA.
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Como referenciar este item
Buscar no repositório
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A pesquisa no RD utiliza os recursos de busca da maioria das bases de dados. No entanto algumas dicas podem auxiliar para obter um resultado mais pertinente.
✔ É possível efetuar a busca de um autor ou um termo em todo o RD, por meio do
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, isto é, o termo solicitado será localizado em qualquer campo do RD. No entanto esse tipo de pesquisa não é recomendada a não ser que se deseje um resultado amplo e generalizado.
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, por esse motivo, utilize os termos de busca de assunto em inglês; isto não exclui a busca livre por palavras, apenas o resultado pode não ser tão relevante ou pertinente.
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O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.
A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.
1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI,
clique aqui.
2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI,
clique aqui.
O Repositório Digital do IPEN é um equipamento institucional de acesso aberto, criado com o objetivo de reunir, preservar, disponibilizar e conferir maior visibilidade à Produção Científica publicada pelo Instituto, desde sua criação em 1956.
Operando, inicialmente como uma base de dados referencial o Repositório foi disponibilizado na atual plataforma, em junho de 2015. No Repositório está disponível o acesso ao conteúdo digital de artigos de periódicos, eventos, nacionais e internacionais, livros, capítulos, dissertações, teses e relatórios técnicos.
A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.
O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.