JavaScript is disabled for your browser. Some features of this site may not work without it.
Navegação Periódicos - Artigos por Autores IPEN "VARCA, GUSTAVO H.C."
-
FREITAS, LUCAS F. de
; VARCA, GUSTAVO H.C.
; BATISTA, JORGE G. dos S.
; LUGAO, ADEMAR B.
.
An overview of the synthesis of gold nanoparticles using radiation technologies.
Nanomaterials,
v. 8,
n. 11,
2018.
DOI:
10.3390/nano8110939
Abstract:
At a nano-level, optical properties of gold are unique and gave birth to an emerging
platform of nanogold-based systems for diverse applications, because gold nanoparticle properties
are tunable as a function of size and shape. Within the available techniques for the synthesis of gold
nanoparticles, the radiolytic synthesis allows proper control of the nucleation process without the need
for reducing agents, in a single step, combined or not with simultaneous sterilization. This review
details and summarizes the use of radiation technologies for the synthesis and preparation of gold
nanoparticles concerning fundamental aspects, mechanism, current pathways for synthesis and
radiation sources, as well as briefly outlines final applications and some toxicity aspects related to
nanogold-based systems.
Palavras-Chave:
gold;
nanoparticles;
gamma radiation;
electron beams;
x-ray sources;
radiolysis;
nanotechnology;
medicine;
diagnostic uses;
ionizing radiations
FREITAS, LUCAS F. de; VARCA, GUSTAVO H.C.; BATISTA, JORGE G. dos S.; LUGAO, ADEMAR B.
An overview of the synthesis of gold nanoparticles using radiation technologies.
Nanomaterials,
v. 8,
n. 11,
2018.
DOI:
10.3390/nano8110939.
Disponível em: http://repositorio.ipen.br/handle/123456789/29423. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
LIMA, CAROLINE S.A. de
; BALOGH, TATIANA S.
; VARCA, JUSTINE P.R.O.
; VARCA, GUSTAVO H.C.
; LUGAO, ADEMAR B.
; CAMACHO-CRUZ, LUIS A.; BUCIO, EMILIO; KADLUBOWSKI, SLAWOMIR S..
An updated review of macro, micro, and nanostructured hydrogels for biomedical and pharmaceutical applications.
Pharmaceutics,
v. 12,
n. 10,
p. 1-28,
2020.
DOI:
10.3390/pharmaceutics12100970
Abstract:
Hydrogels are materials with wide applications in several fields, including the biomedical and pharmaceutical industries. Their properties such as the capacity of absorbing great amounts of aqueous solutions without losing shape and mechanical properties, as well as loading drugs of different nature, including hydrophobic ones and biomolecules, give an idea of their versatility and promising demand. As they have been explored in a great number of studies for years, many routes of synthesis have been developed, especially for chemical/permanent hydrogels. In the same way, stimuli-responsive hydrogels, also known as intelligent materials, have been explored too, enhancing the regulation of properties such as targeting and drug release. By controlling the particle size, hydrogel on the micro- and nanoscale have been studied likewise and have increased, even more, the possibilities for applications of the so-called XXI century materials. In this paper, we aimed to produce an overview of the recent studies concerning methods of synthesis, biomedical, and pharmaceutical applications of macro-, micro, and nanogels.
Palavras-Chave:
hydrogels;
drugs;
synthesis;
cross-linking;
skin;
animal tissues;
gamma radiation
LIMA, CAROLINE S.A. de; BALOGH, TATIANA S.; VARCA, JUSTINE P.R.O.; VARCA, GUSTAVO H.C.; LUGAO, ADEMAR B.; CAMACHO-CRUZ, LUIS A.; BUCIO, EMILIO; KADLUBOWSKI, SLAWOMIR S.
An updated review of macro, micro, and nanostructured hydrogels for biomedical and pharmaceutical applications.
Pharmaceutics,
v. 12,
n. 10,
p. 1-28,
2020.
DOI:
10.3390/pharmaceutics12100970.
Disponível em: http://repositorio.ipen.br/handle/123456789/31809. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
BOARO, LETICIA C.C.
; CAMPOS, LUIZA M.
; VARCA, GUSTAVO H.C.
; SANTOS, TAMIRIS M.R. dos
; MARQUES, PAMELA A.; SUGII, MARI M.; SALDANHA, NATHALIA R.; COGO-MULLER, KARINA; BRANDT, WILLIAM C.; BRAGA, ROBERTO R.; PARRA, DUCLERC F.
.
Antibacterial resin-based composite containing chlorhexidine for dental applications.
Dental Materials,
v. 35,
n. 6,
p. 909-918,
2019.
DOI:
10.1016/j.dental.2019.03.004
Abstract:
Objeticve. The aim of this study was to develop a composite material with antibacterial activ-ity using MMT loaded with clorhexidine (CHX). For that it was used a BisGMA/TEGDMAmatrix and added low concentration of MMT/CHX. The aim was to evaluate the drug releasecapacity of MMT, and not to provide reinforcement.Methods. Six experimental composites were made with organic matrix of BisGMA/TEGDMAin equal proportions by weight. The composites received organophlizated montmorillonitewith or without CHX. The concentrations were 2,5; 5 or 10% by weight. Degree of conversion(DC) was evaluated using FTIR (peak 6165 cm-1; n = 5). Specimens for flexural properties(10×2×1 mm) were immediate tested (24h). Elastic modulus(E) and flexural strength (FS)was measured using the three point bending test (n = 10). Inibition halo was used to test theantibacterial activity against Staphylococcus aureus, Streptococcus mutans, and Porphyromonasgingivalis (n = 5 for each bacteria). The inhibition of biofilm formation (BF) was evaluated byinserting polymerized disc of composite in to a culture media colonized with Streptococcusmutans (n = 10). The release of CHX was measured using ultraviolet (255 nm) for 10 days(n = 5). The data of degree of conversion was analysed using Kruskal–Wallis/ Mann–Whitney,and the other variables using two-way ANOVA/Tukey, always considering a global level ofsignificance of 5%.Results. DC ranged from 71% to 74%. E ranged from 5.7 to 8.1 GPa. FS ranged from 61.4 to74.7 MPa. There were no statistical differences among the groups for all the variables. Forthe three bacteria tested the composites with CHX loaded presented inhibition of growthfor all concentration, except for 2,5% that did not inihibited the growth of P. gingivalis. BFwas lower for the groups with 10% MMT/CHX, all groups presented BF, even those withoutCHX loaded. All concentrations presented release off CHX during all the 28 days analyzed. Conclusions. Within the limitation of this study it can be concluded that: all concentrations
tested presented release of CHX and reduced BF. All concentration presented antibacterial
activity for the three bacteria tested, except for 2,5% that did not inhibit the growth
of P. gingivalis. The presence of MMT with CHX loaded did not interfere in the properties
evaluated.
Palavras-Chave:
composite materials;
germicides;
dentistry;
manganese compounds;
chlorine compounds;
bacteria;
staphylococcus;
streptococcus;
antimicrobial agents;
resins
BOARO, LETICIA C.C.; CAMPOS, LUIZA M.; VARCA, GUSTAVO H.C.; SANTOS, TAMIRIS M.R. dos; MARQUES, PAMELA A.; SUGII, MARI M.; SALDANHA, NATHALIA R.; COGO-MULLER, KARINA; BRANDT, WILLIAM C.; BRAGA, ROBERTO R.; PARRA, DUCLERC F.
Antibacterial resin-based composite containing chlorhexidine for dental applications.
Dental Materials,
v. 35,
n. 6,
p. 909-918,
2019.
DOI:
10.1016/j.dental.2019.03.004.
Disponível em: http://repositorio.ipen.br/handle/123456789/29927. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
GONCALVES, FLAVIA; CAMPOS, LUIZA M. de P.
; SANCHES, LUCIANA K.F.; SILVA, LARISSA T.S.; SANTOS, TAMIRIS M.R. dos
; VARCA, GUSTAVO H.C.
; LOPES, DIANA P.; COGO-MULLER, KARINA; PARRA, DUCLERC F.
; BRAGA, ROBERTO R.; SANTOS, MARCELO dos; BOARO, LETICIA C.C..
Antimicrobial activity and physicochemical performance of a modified endodontic sealer / Atividade antimicrobiana e desempenho físico-químico de um cimento endodôntico modificado.
Research, Society and Development,
v. 9,
n. 11,
p. 1-16,
2020.
DOI:
10.33448/rsd-v9i11.9401
Abstract:
Introduction: this study aimed to evaluate the antimicrobial and physicochemical properties of a commercial endodontic sealer modified by the addition of montmorillonite (MMT) nanoparticles loaded with two different drugs: chlorhexidine (CHX) or metronidazole (MET). Methods: 5 wt% MMT/CHX or MMT/MET nanoparticles were added to the sealer AH-Plus. The experimental materials were evaluated for drug release, antimicrobial activity, flow, flexural strength, and flexural modulus. Data were subjected to one-way ANOVA, Kruskal-Wallis, and Mann-Whitney tests. Results: The drug incorporation into MMT particles was 9% and 10% for CHX and MET, respectively. At 20 days after manipulation, 16.5% of the drug was released by the sealer with MMT/MET and 0.4% by MMT/CHX. The addition of both nanoparticles decreased the flow of materials, but they were still in compliance with ISO 6876-2012. The conversion, flexural strength, and flexural modulus of MMT/MET (87%, 37±7 MPa, 2.3 GPa) and MMT/CHX (78%, 29±2 MPa, 2.7 GPa) were similar in both groups but lower than in the control group (100%, 54±7 MPa, 4.0±0.7 GPa). Both experimental materials were able to form an inhibition halo for E. faecalis bacteria (CHX: 4.8±1.4 and MET: 4.0±1.6 mm), whereas the control group did not inhibit the microorganism. Conclusion: both formulations proposed as endodontic sealer presented effective antimicrobial activity and acceptable flow. The addition of MMT/CHX and MMT/MET particles decreased the conversion and mechanical properties, but further studies are required to clarify the clinical relevance of these properties.
Palavras-Chave:
antimicrobial agents;
metronidazole;
organic chlorine compounds;
dentistry;
drugs;
sealing materials;
montmorillonite;
nanoparticles;
teeth;
seals
GONCALVES, FLAVIA; CAMPOS, LUIZA M. de P.; SANCHES, LUCIANA K.F.; SILVA, LARISSA T.S.; SANTOS, TAMIRIS M.R. dos; VARCA, GUSTAVO H.C.; LOPES, DIANA P.; COGO-MULLER, KARINA; PARRA, DUCLERC F.; BRAGA, ROBERTO R.; SANTOS, MARCELO dos; BOARO, LETICIA C.C.
Antimicrobial activity and physicochemical performance of a modified endodontic sealer.
Research, Society and Development,
v. 9,
n. 11,
p. 1-16,
2020.
DOI:
10.33448/rsd-v9i11.9401.
Disponível em: http://repositorio.ipen.br/handle/123456789/31816. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
FREITAS, LUCAS F. de
; CRUZ, CASSIA P.C. da
; CAVALCANTE, ADRIANA K.
; BATISTA, JORGE G. dos S.
; VARCA, GUSTAVO H.C.
; MATHOR, MONICA B.
; LUGAO, ADEMAR B.
.
Comparison between gold nanoparticles synthesized by radiolysis and by EGCG-driven gold reduction.
Radiation Physics and Chemistry,
v. 174,
p. 1-9,
2020.
DOI:
10.1016/j.radphyschem.2020.108959
Abstract:
Radiolytic synthesis and phytochemical-driven gold reduction for the generation of nanoparticles are successful
examples of Green Chemistry applied for nanomaterials. The present work compares these two green approaches
focusing on hydrodynamic size, stability over time, optical properties and toxicity in NIH 3T3 (ATCC® CRL-
1658™) cells and Danio rerio (Zebra Fish). The radiolytic synthesis was performed by mixing 1 mM NaAuCl4;
polyvinyl pyrrolidone 0.5%, AgNO3 6×10−5 M, propan-2-ol 0.2 M and acetone 0.06 M, followed by irradiation
at 15 kGy (5 kGy h−1, 60Co source). The EGCG-functionalized nanoparticles were synthesized by mixing 1.6 mM
of Au with 0.8 mM of EGCG in phosphate buffer (10 mM) for 2 h. Both methods yield the formation of gold
nanoparticles featuring plasmon resonance bands at 520–530 nm, polydispersity above 0.3 was relevant only for
the radiolytic protocol. Regarding stability over time, after 30 days, the nanoparticles synthesized radiolytically
presented no relevant size changes, while some aggregation was observed for the EGCG-particles. The same
nanoparticles demonstrated a lack of stability in high ionic strength medium. Slight toxicity was observed for the
EGCG-nanoparticles in Danio rerio, with an IC50 calculated as 40.49%, while no IC50 was established within the
concentration range of radiolysis-AuNPs used in this study. In conclusion, both green methods generated nanoparticles
with good control of size and optical properties, especially via reduction by EGCG. However, the
stability and toxicity results were found to be more promising for the radiolytically synthesized gold nanoparticles.
Palavras-Chave:
gold;
nanoparticles;
synthesis;
chemistry;
ecology;
polyphenols;
fishes
FREITAS, LUCAS F. de; CRUZ, CASSIA P.C. da; CAVALCANTE, ADRIANA K.; BATISTA, JORGE G. dos S.; VARCA, GUSTAVO H.C.; MATHOR, MONICA B.; LUGAO, ADEMAR B.
Comparison between gold nanoparticles synthesized by radiolysis and by EGCG-driven gold reduction.
Radiation Physics and Chemistry,
v. 174,
p. 1-9,
2020.
DOI:
10.1016/j.radphyschem.2020.108959.
Disponível em: http://repositorio.ipen.br/handle/123456789/31427. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
OLIVEIRA, JUSTINE P.R.
; MELENDEZ-ORTIZ, H.I.; BUCIO, EMILIO; ALVES, PATRICIA T.; LIMA, MAYARA I.S.; GOULART, LUIZ R.; MATHOR, MONICA B.
; VARCA, GUSTAVO H.C.
; LUGAO, ADEMAR B.
.
Current methods applied to biomaterials – characterization approaches, safety assessment and biological international standards.
Current Topics in Medicinal Chemistry,
v. 18,
n. 4,
p. 256-274,
2018.
DOI:
10.2174/1568026618666180410151518
Abstract:
Safety and biocompatibility assessment of biomaterials are themes of constant concern as
advanced materials enter the market as well as products manufactured by new techniques emerge.
Within this context, this review provides an up-to-date approach on current methods for the characterization
and safety assessment of biomaterials and biomedical devices from a physical-chemical to a
biological perspective, including a description of the alternative methods in accordance with current
and established international standards.
Palavras-Chave:
biological materials;
bioassay;
medicine;
in vitro;
in vivo;
compatibility;
composite materials;
sterilization;
standardization;
iso;
recommendations;
physical chemistry
OLIVEIRA, JUSTINE P.R.; MELENDEZ-ORTIZ, H.I.; BUCIO, EMILIO; ALVES, PATRICIA T.; LIMA, MAYARA I.S.; GOULART, LUIZ R.; MATHOR, MONICA B.; VARCA, GUSTAVO H.C.; LUGAO, ADEMAR B.
Current methods applied to biomaterials – characterization approaches, safety assessment and biological international standards.
Current Topics in Medicinal Chemistry,
v. 18,
n. 4,
p. 256-274,
2018.
DOI:
10.2174/1568026618666180410151518.
Disponível em: http://repositorio.ipen.br/handle/123456789/29332. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
VARCA, JUSTINE P.R.O.
; MARTINS, ELAINE A.J.
; VARCA, GUSTAVO H.C.
; ROMANO, RENATO L.; LEBRE, DANIEL T.; LAINETTI, PAULO E.O.
; BUSTILLOS, JOSE O.V.
.
Determination of organochlorines in soil of a suburban area of São Paulo Brazil.
International Journal of Environmental Research and Public Health,
v. 17,
n. 16,
p. 1-16,
2020.
DOI:
10.3390/ijerph17165666
Abstract:
Technological advances have promoted improvements in several science fields, especially related to environmental and analytical areas with the improvement of detection and development of environmentally friendly extraction techniques. This study applied Quick, Easy, Cheap, Effective, Rugged and Safe method (QuEChERS) for soil extraction and assessed its performance through a validation study using samples from the soil of a contaminated area in Caieiras, SP, Brazil. Nine organochlorine pesticides, including the isomers alpha, beta, gamma and delta- hexachlorocyclohexane; cis- and trans-heptachlor epoxide; cis- and trans-chlordane and heptachlor were analyzed by gas chromatography coupled to electron capture detector. The method was validated according to ISO 5725-4 (2020), EURACHEM (2014) and DOQ-CGCRE-008 (2016). The limits of detection and quantification of the method for the nine organochlorines were α-HCH (1.2 and 12.6 µg kg−1), β-HCH (1.7 and 12.0 µg kg−1), γ-HCH (1.5 and 11.6 µg kg−1), δ-HCH (0.8 and 11.6 µg kg−1), heptachlor (1.0 and 10.8 µg kg−1), cis-heptachlor epoxide (0.9 and 11.5 µg kg−1), trans-heptachlor epoxide (0.9 and 11.5 µg kg−1), cis-chlordane (0.4 and 7.9 µg kg−1) and trans-chlordane (0.5 and 10.9 µg kg−1), respectively, and all of them were within the maximum limits recommended by the EPA for the compounds α-HCH (86.0 and 360.0 µg kg−1), β-HCH (300.0 and 1.3 × 103 µg kg−1), γ-HCH (570.0 and 2.5 × 103 µg kg−1), δ-HCH (not defined), heptachlor (130.0 and 630.0 µg kg−1), cis-/trans-heptachlor epoxide (7.0 and 330.0 µg kg−1), cis-/trans-chlordane (1.77 × 103 and 7.7 × 103 µg kg−1) in residential and industrial soil, respectively. Recovery results were between 65% and 105% for almost all compounds, which is an optimum result for multi-residue analytical methods, considering the complexity of the matrix used in the study. Caieiras presented contamination levels of α-HCH in the range of 2.0 to 66.0 µg g−1, which was higher than the limits established by EPA, corresponding to 0.077 µg g−1 for residential soil and 0.27 µg g−1 for industrial soil. According to the validation study, the analytical method proposed was reliable for organochlorine quantification, and the QuEChERS was considered efficient for organochlorine extraction from soil.
Palavras-Chave:
organic chlorine compounds;
soils;
urban areas;
pollution;
sanitary landfills;
land pollution;
pesticides;
environmental impacts;
validation;
electron-capture detectors
VARCA, JUSTINE P.R.O.; MARTINS, ELAINE A.J.; VARCA, GUSTAVO H.C.; ROMANO, RENATO L.; LEBRE, DANIEL T.; LAINETTI, PAULO E.O.; BUSTILLOS, JOSE O.V.
Determination of organochlorines in soil of a suburban area of São Paulo Brazil.
International Journal of Environmental Research and Public Health,
v. 17,
n. 16,
p. 1-16,
2020.
DOI:
10.3390/ijerph17165666.
Disponível em: http://repositorio.ipen.br/handle/123456789/31473. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
LIMA, CAROLINE S.A. de; VARCA, GUSTAVO H.C.
; COSTA, SIRLENE M. da; FERRAZ, HUMBERTO G.; SANTOS, ANA C. da S.; LOPES, PATRICIA S.; COSTA, SILGIA A. da.
Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules.
Drug Development and Industrial Pharmacy,
v. 46,
n. 9,
p. 1477-1486,
2020.
DOI:
10.1080/03639045.2020.1809445
Abstract:
The goal of this work was the development of natural polymeric microcapsules for antimicrobial drug delivery – triclosan loaded alginate and chitosan-based microcapsules for potential coating applications in substrates such as textiles or plastics. Microcapsules containing 2.5% (w/w) or 3% (w/w) triclosan in both core and matrix were synthesized and evaluated by Fourier-transform infrared spectroscopy, scanning electron microscopy, confocal microscopy, differential scanning calorimetry, thermogravimetry, and antimicrobial activity. The microcapsules produced featured spherical and mostly irregularly-shaped surfaces composed by an alginate core in a chitosan outer matrix, as revealed by confocal microscopy, and antimicrobial activity against S. aureus and E. coli with inhibition halos up to 60 mm and 25 mm respectively, granted by a triclosan loading of 61.66%. The thermal analysis suggested that the polymers protected the active substance from temperature-induced degradation. In conclusion, these microcapsules may be applied toward antimicrobial functionalization of plastics, textiles and other materials.
Palavras-Chave:
polysaccharides;
oligosaccharides;
antimicrobial agents;
drugs;
antiseptics;
sodium;
alginates;
polymers
LIMA, CAROLINE S.A. de; VARCA, GUSTAVO H.C.; COSTA, SIRLENE M. da; FERRAZ, HUMBERTO G.; SANTOS, ANA C. da S.; LOPES, PATRICIA S.; COSTA, SILGIA A. da.
Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules.
Drug Development and Industrial Pharmacy,
v. 46,
n. 9,
p. 1477-1486,
2020.
DOI:
10.1080/03639045.2020.1809445.
Disponível em: http://repositorio.ipen.br/handle/123456789/31916. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
AL-SHEIKHLY, MOHAMAD; VARCA, GUSTAVO H.C.
.
Editorial.
Radiation Physics and Chemistry,
v. 143,
n. SI,
p. 1-2,
2018.
DOI:
10.1016/j.radphyschem.2017.11.011
Palavras-Chave:
electron beams;
radiation chemistry;
physical chemistry;
linear momentum transfer;
irradiation
AL-SHEIKHLY, MOHAMAD; VARCA, GUSTAVO H.C.
Editorial.
Radiation Physics and Chemistry,
v. 143,
n. SI,
p. 1-2,
2018.
DOI:
10.1016/j.radphyschem.2017.11.011.
Disponível em: http://repositorio.ipen.br/handle/123456789/28856. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
CORAZZA, FULVIO G.; ERNESTO, JULIA V.; NAMBU, FELIPE A.N.; CALIXTO, LEANDRO A.; VARCA, GUSTAVO H.C.
; VIEIRA, DANIEL P.
; LEITE-SILVA, VANIA R.; ANDREO-FILHO, NEWTON; LOPES, PATRICIA S..
Enhancing the furosemide permeability by papain minitablets through a triple co-culture in vitro intestinal cell model.
AAPS PharmSciTech,
v. 21,
n. 7,
p. 1-10,
2020.
DOI:
10.1208/s12249-020-01796-9
Abstract:
The administration of medicines by the oral route is the most used approach for
being very convenient. Although it is the most popular, this route also has absorption, and
consequently, bioavailability limitations. In this sense, several pharmacotechnical strategies
have been used to improve drug absorption, one of which is the use of permeation
promoters. Papain is a very versatile plant enzyme that can be used as a permeation
promoter of various active compounds. This study aimed to evaluate the safety of papain and
the formulation of native papain minitablets to promote in vitro permeation of furosemide
through an innovative biomimetic triple co-culture model of Caco-2, HT29-MTX, and Raji
cells. Regarding permeation, furosemide and metaprolol concentrations are determined with
HPLC; those are used to calculate Papp. Monolayer integrity was evaluated using TEER and
Lucifer Yellow. In the presence of papain, TEER decreased two-fold and the Papp of
furosemide increased six-fold. The results suggest that native papain minitablets can be used
as therapeutic adjuvants to enhance the permeation of drugs significantly improving
bioavailability.
Palavras-Chave:
drugs;
diuretics;
papain;
permeability;
in vitro;
animal cells;
intestines;
mucous membranes;
cell cultures;
electrical properties
CORAZZA, FULVIO G.; ERNESTO, JULIA V.; NAMBU, FELIPE A.N.; CALIXTO, LEANDRO A.; VARCA, GUSTAVO H.C.; VIEIRA, DANIEL P.; LEITE-SILVA, VANIA R.; ANDREO-FILHO, NEWTON; LOPES, PATRICIA S.
Enhancing the furosemide permeability by papain minitablets through a triple co-culture in vitro intestinal cell model.
AAPS PharmSciTech,
v. 21,
n. 7,
p. 1-10,
2020.
DOI:
10.1208/s12249-020-01796-9.
Disponível em: http://200.136.52.105/handle/123456789/31584. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
ZAHARESCU, TRAIAN; MATEESCU, CARMEN; DIMA, ANDREEA; VARCA, GUSTAVO H.C.
.
Evaluation of thermal and radiation stability of EPDM in the presence of some algal powders.
Journal of Thermal Analysis and Calorimetry,
v. 147,
n. 1,
p. 327-336,
2022.
DOI:
10.1007/s10973-020-10319-4
Abstract:
In this paper, ecological-friendly materials based on ethylene–propylene–diene terpolymer (EPDM) with improved thermal and radiation stabilities by Chlorella vulgaris (CV) and Spirulina platensis (SP) powders were investigated by complementary procedures: FTIR spectroscopy and isothermal and nonisothermal chemiluminescence (CL). The stabilization potential of microalgae was evaluated at several degrees of γ-radiolysis by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, while the polymer resistances were studied on a large range of algal concentrations (1, 3, 5 and 10 mass%). The carbonyl and hydroxyl indices of all degraded EPDM formulations were found to be two times smaller in the presence of algal powders, if compared to the pristine material. Some dissimilarities between the oxidation development in pristine and modified EPDM appeared, especially in unirradiated samples. The activation energies required for the oxidation of EPDM and the lifetime of these samples at various temperatures between room temperature and 100 °C were calculated. The antioxidant compounds existing in the studied microalgae proved a significant influence on the stability of EPDM, mainly in the presence of SP, which was confirmed by the activation energies calculated from our CL results. The investigation of cycling thermal degradation revealed the obvious contribution of additives towards delaying EPDM ageing.
Palavras-Chave:
antioxidants;
chlorella;
ethylene propylene diene polymers;
stability;
thermal analysis;
radiations
ZAHARESCU, TRAIAN; MATEESCU, CARMEN; DIMA, ANDREEA; VARCA, GUSTAVO H.C.
Evaluation of thermal and radiation stability of EPDM in the presence of some algal powders.
Journal of Thermal Analysis and Calorimetry,
v. 147,
n. 1,
p. 327-336,
2022.
DOI:
10.1007/s10973-020-10319-4.
Disponível em: http://repositorio.ipen.br/handle/123456789/32666. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
VARCA, GUSTAVO H.C.
; QUEIROZ, RODRIGO G.
; LUGAO, ADEMAR B.
.
Irradiation as an alternative route for protein crosslinking: Cosolvent free BSA nanoparticles.
Radiation Physics and Chemistry,
v. 124,
p. 111-115,
2016.
Palavras-Chave:
gamma radiation;
cross-linking;
nanoparticles;
albumins;
synthesis;
solvents;
spectroscopy;
fluorescence spectroscopy;
proteins
VARCA, GUSTAVO H.C.; QUEIROZ, RODRIGO G.; LUGAO, ADEMAR B.
Irradiation as an alternative route for protein crosslinking: Cosolvent free BSA nanoparticles.
Radiation Physics and Chemistry,
v. 124,
p. 111-115,
2016.
Disponível em: http://repositorio.ipen.br/handle/123456789/25758. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
SOWINSKI, SEBASTIAN; VARCA, GUSTAVO H.C.
; KADLUBOWSKI, SLAWOMIR; LUGAO, ADEMAR B.
; ULANSKI, PIOTR.
A mechanistic approach towards the formation of bityrosine in proteins by ionizing radiation: GYG model peptide.
Radiation Physics and Chemistry,
v. 188,
p. 1-8,
2021.
DOI:
10.1016/j.radphyschem.2021.109644
Abstract:
One of the methods of protein crosslinking used in the synthesis of protein-based nanoparticles is the formation
of bityrosine bridges, which may be achieved by the recombination of phenoxyl-type radicals in irradiated
protein solutions. Radiation-induced formation of phenoxyl radicals in tyrosine is promoted in presence of H+. In
this work, kinetics of this process and the influence of pH were studied by pulse radiolysis measurements of a
model peptide H-Gly-Tyr-Gly-OH (GYG), which may help to solve questions raised for bigger, more complex
systems in comparable conditions. The main route of phenoxyl radicals formation consists of the addition reaction
of hydroxyl radical to the phenol ring on the tyrosine side-chain and proton catalyzed water molecule
elimination. A similar effect was observed in studies of tripeptide solutions containing phosphate buffer. The
presented data include time-resolved optical spectroscopy of transient species formed under pulse electron beam
irradiation and a comparison of the kinetics of the phenoxyl radicals formation in samples at various pH and in
presence of phosphate buffer. The postulated mechanism and obtained values of rate constants of the formation
and decay of transient species were additionally checked by simple probabilistic simulations.
Palavras-Chave:
ionizing radiations;
radiolysis;
tyrosine;
proteins
SOWINSKI, SEBASTIAN; VARCA, GUSTAVO H.C.; KADLUBOWSKI, SLAWOMIR; LUGAO, ADEMAR B.; ULANSKI, PIOTR.
A mechanistic approach towards the formation of bityrosine in proteins by ionizing radiation: GYG model peptide.
Radiation Physics and Chemistry,
v. 188,
p. 1-8,
2021.
DOI:
10.1016/j.radphyschem.2021.109644.
Disponível em: http://repositorio.ipen.br/handle/123456789/32383. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
LIMA, CAROLINE S.A. de
; RIAL-HERMIDA, MARIA I.; FREITAS, LUCAS F. de
; PEREIRA-DA-MOTA, ANA F.; VIVERO-LOPEZ, MARIA; FERREIRA, ARYEL H.
; KADŁUBOWSKI, SŁAWOMIR; VARCA, GUSTAVO H.C.
; LUGAO, ADEMAR B.
; ALVAREZ-LORENZO, CARMEN.
Mucoadhesive gellan gum-based and carboxymethyl cellulose -based hydrogels containing gemcitabine and papain for bladder cancer treatment.
International Journal of Biological Macromolecules,
v. 242,
n. 3,
p. 1-16,
2023.
DOI:
10.1016/j.ijbiomac.2023.124957
Abstract:
Local treatment of bladder cancer faces several limitations such as short residence time or low permeation
through urothelium tissue. The aim of this work was to develop patient-friendly mucoadhesive gel formulations
combining gemcitabine and the enzyme papain for improved intravesical chemotherapy delivery. Hydrogels
based on two different polysaccharides, gellan gum and sodium carboxymethylcellulose (CMC), were prepared
with either native papain or papain nanoparticles (nanopapain) to explore for the first time their use as
permeability enhancers through bladder tissue. Gel formulations were characterized regarding enzyme stability,
rheological behavior, retention on bladder tissue and bioadhesion, drug release properties, permeation capacity,
and biocompatibility. After 90 days of storage, the enzyme loaded in the CMC gels retained up to 83.5 ± 4.9 % of
its activity in the absence of the drug, and up to 78.1 ± 5.3 with gemcitabine. The gels were mucoadhesive and
the enzyme papain showed mucolytic action, which resulted in resistance against washing off from the urothelium
and enhanced permeability of gemcitabine in the ex vivo tissue diffusion tests. Native papain shortened
lag-time tissue penetration to 0.6 h and enhanced 2-fold drug permeability All formulations demonstrated
pseudoplastic behavior and no irritability. Overall, the developed formulations have potential as an upgraded
alternative to intravesical therapy for bladder cancer treatment.
Palavras-Chave:
hydrogels;
papain;
polysaccharides;
drug delivery;
bladder;
neoplasms
LIMA, CAROLINE S.A. de; RIAL-HERMIDA, MARIA I.; FREITAS, LUCAS F. de; PEREIRA-DA-MOTA, ANA F.; VIVERO-LOPEZ, MARIA; FERREIRA, ARYEL H.; KADŁUBOWSKI, SŁAWOMIR; VARCA, GUSTAVO H.C.; LUGAO, ADEMAR B.; ALVAREZ-LORENZO, CARMEN.
Mucoadhesive gellan gum-based and carboxymethyl cellulose -based hydrogels containing gemcitabine and papain for bladder cancer treatment.
International Journal of Biological Macromolecules,
v. 242,
n. 3,
p. 1-16,
2023.
DOI:
10.1016/j.ijbiomac.2023.124957.
Disponível em: http://repositorio.ipen.br/handle/123456789/34103. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
LIMA, CAROLINE S.A. de
; VARCA, JUSTINE P.R.O.
; ALVES, VICTORIA M.
; NOGUEIRA, KAMILA M.
; CRUZ, CASSIA P.C.
; RIAL-HERMIDA, M. ISABEL; KADLUBOWSKI, SLAWOMIR S.; VARCA, GUSTAVO H.C.
; LUGAO, ADEMAR B.
.
Mucoadhesive polymers and their applications in drug delivery systems for the treatment of bladder cancer.
Gels,
v. 8,
n. 9,
p. 1-25,
2022.
DOI:
10.3390/gels8090587
Abstract:
Bladder cancer (BC) is the tenth most common type of cancer worldwide, affecting up to four times more men than women. Depending on the stage of the tumor, different therapy protocols are applied. Non-muscle-invasive cancer englobes around 70% of the cases and is usually treated using the transurethral resection of bladder tumor (TURBIT) followed by the instillation of chemotherapy or immunotherapy. However, due to bladder anatomy and physiology, current intravesical therapies present limitations concerning permeation and time of residence. Furthermore, they require several frequent catheter insertions with a reduced interval between doses, which is highly demotivating for the patient. This scenario has encouraged several pieces of research focusing on the development of drug delivery systems (DDS) to improve drug time residence, permeation capacity, and target release. In this review, the current situation of BC is described concerning the disease and available treatments, followed by a report on the main DDS developed in the past few years, focusing on those based on mucoadhesive polymers as a strategy. A brief review of methods to evaluate mucoadhesion properties is also presented; lastly, different polymers suitable for this application are discussed.
Palavras-Chave:
adhesion;
drug delivery;
bladder;
neoplasms;
hydrogels;
polymers;
therapy
LIMA, CAROLINE S.A. de; VARCA, JUSTINE P.R.O.; ALVES, VICTORIA M.; NOGUEIRA, KAMILA M.; CRUZ, CASSIA P.C.; RIAL-HERMIDA, M. ISABEL; KADLUBOWSKI, SLAWOMIR S.; VARCA, GUSTAVO H.C.; LUGAO, ADEMAR B.
Mucoadhesive polymers and their applications in drug delivery systems for the treatment of bladder cancer.
Gels,
v. 8,
n. 9,
p. 1-25,
2022.
DOI:
10.3390/gels8090587.
Disponível em: http://repositorio.ipen.br/handle/123456789/33418. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
CORAZZA, FULVIO G.; ERNESTO, JULIA V.; NAMBU, FELIPE A.N.; CARVALHO, LUMA R. de
; LEITE-SILVA, VANIA R.; VARCA, GUSTAVO H.C.
; CALIXTO, LEANDRO A.; VIEIRA, DANIEL P.
; ANDREO-FILHO, NEWTON; LOPES, PATRICIA S..
Papain-cyclodextrin complexes as an intestinal permeation enhancer: permeability and in vitro safety evaluation.
Journal of Drug Delivery Science and Technology,
v. 55,
p. 1-11,
2020.
DOI:
10.1016/j.jddst.2019.101413
Abstract:
Oral drug delivery is the main route for drugs administration. However, some drugs have poor permeability
across the intestinal barrier. Papain has been widely used in pharmaceutical applications due to its debridement
properties and the ability to promote skin permeation of drugs. It is known that papain complexation with
cyclodextrins improves its biological stability. In this paper, the ability of the native papain-cyclodextrin complexes
is shown be an oral permeation enhancer to furosemide, using a Caco-2 monolayer system to evaluate
drug permeability and apparent permeability coefficient. Analysis of the in vitro cytotoxicity over CHO–K1, Hep
G2 and Caco-2 cell lines and genotoxicity over CHO–K1 and Hep G2 cell lines were also performed. Papaincyclodextrins
complexes did not show any cytotoxicity above 31 μg/mL. No significant genotoxic damage was
observed. Papain and cyclodextrin complexes induced almost 2.5-fold increase in furosemide permeation
compared to controls, and maintenance of the paracellular integrity of the Caco-2 cells monolayer was confirmed.
The papain complexes may be safely applied in pharmaceutical formulations, not only as a therapeutic
agent but also as a strategic pharmaceutical adjuvant, promoting permeation of low oral permeability drugs.
Palavras-Chave:
papain;
chelating agents;
oligosaccharides;
drugs;
antimitotic drugs;
enzymes;
enzyme activity;
membrane transport
CORAZZA, FULVIO G.; ERNESTO, JULIA V.; NAMBU, FELIPE A.N.; CARVALHO, LUMA R. de; LEITE-SILVA, VANIA R.; VARCA, GUSTAVO H.C.; CALIXTO, LEANDRO A.; VIEIRA, DANIEL P.; ANDREO-FILHO, NEWTON; LOPES, PATRICIA S.
Papain-cyclodextrin complexes as an intestinal permeation enhancer: permeability and in vitro safety evaluation.
Journal of Drug Delivery Science and Technology,
v. 55,
p. 1-11,
2020.
DOI:
10.1016/j.jddst.2019.101413.
Disponível em: http://repositorio.ipen.br/handle/123456789/31106. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
PINO-RAMOS, VICTOR H.; RAMOS-BALLESTEROS, ALEJANDRO; LOPEZ-SAUCEDO, FELIPE; LOPEZ-BARRIGUETE, JESUS E.; VARCA, GUSTAVO H.C.
; BUCIO, EMILIO.
Radiation grafting for the functionalization and development of smart polymeric materials.
Topics in Current Chemistry,
v. 374,
n. 5,
p. 1-28,
2016.
DOI:
10.1007/s41061-016-0063-x
Abstract:
Gamma radiation has been shown particularly useful for the functionalization
of surfaces with stimuli-responsive polymers. This method involves the
formation of active sites (free radicals) onto the polymeric backbone as a result of
the high-energy radiation exposition over the polymeric material. Thus, a
microenvironment suitable for the reaction among monomer and/or polymer and the
active sites is formed and then leading to propagation to form side-chain grafts. The
modification of polymers using high-energy irradiation can be performed by the
following methods: direct or simultaneous, pre-irradiation oxidative, and pre-irradiation.
The most frequently used ones correspond to the pre-irradiation oxidative
method as well as the direct one. Radiation-grafting has many advantages over other
conventional methods because it does not require the use of catalyst nor additives to
initiate the reaction and usually no changes on the mechanical properties with
respect to the pristine polymeric matrix are observed. This chapter is focused on the
synthesis of smart polymers and coatings obtained by the use of gamma radiation. In
addition, the diverse applications of these materials in the biomedical area are also
reported, with focus in drug delivery, sutures, and biosensors.
Palavras-Chave:
polymers;
functions;
functionals;
drug delivery;
sensors;
graft polymers;
gamma radiation
PINO-RAMOS, VICTOR H.; RAMOS-BALLESTEROS, ALEJANDRO; LOPEZ-SAUCEDO, FELIPE; LOPEZ-BARRIGUETE, JESUS E.; VARCA, GUSTAVO H.C.; BUCIO, EMILIO.
Radiation grafting for the functionalization and development of smart polymeric materials.
Topics in Current Chemistry,
v. 374,
n. 5,
p. 1-28,
2016.
DOI:
10.1007/s41061-016-0063-x.
Disponível em: http://repositorio.ipen.br/handle/123456789/27187. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
VARCA, GUSTAVO H.C.
; PEROSSI, GABRIELA G.
; GRASSELLI, MARIANO; LUGAO, ADEMAR B.
.
Radiation synthesized protein-based nanoparticles: A technique overview.
Radiation Physics and Chemistry,
v. 105,
p. 48-52,
2014.
Palavras-Chave:
proteins;
papain;
nanostructures;
particles;
ionizing radiations;
proteins;
cross-linking
VARCA, GUSTAVO H.C.; PEROSSI, GABRIELA G.; GRASSELLI, MARIANO; LUGAO, ADEMAR B.
Radiation synthesized protein-based nanoparticles: A technique overview.
Radiation Physics and Chemistry,
v. 105,
p. 48-52,
2014.
Disponível em: http://repositorio.ipen.br/handle/123456789/23260. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
FERRAZ, CAROLINE C.
; VARCA, GUSTAVO H.C.
; RUIZ, JUAN-CARLOS; LOPES, PATRICIA S.; MATHOR, MONICA B.
; LUGAO, ADEMAR B.; BUCIO, EMILIO.
Radiation-grafting of thermo- and pH-responsive poly (N-vinylcaprolactam-co-acrylic acid) onto silicone rubber and polypropylene films for biomedical purposes.
Radiation Physics and Chemistry,
v. 97,
p. 298-303,
2014.
Palavras-Chave:
biological materials;
polypropylene;
silicones;
rubbers;
graft polymers;
gamma radiation;
polyvinyls;
acrylic acid;
cytology;
toxicity;
fibroblasts
FERRAZ, CAROLINE C.; VARCA, GUSTAVO H.C.; RUIZ, JUAN-CARLOS; LOPES, PATRICIA S.; MATHOR, MONICA B.; LUGAO, ADEMAR B.; BUCIO, EMILIO.
Radiation-grafting of thermo- and pH-responsive poly (N-vinylcaprolactam-co-acrylic acid) onto silicone rubber and polypropylene films for biomedical purposes.
Radiation Physics and Chemistry,
v. 97,
p. 298-303,
2014.
Disponível em: http://repositorio.ipen.br/handle/123456789/9020. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
FERRAZ, CAROLINE C.
; VARCA, GUSTAVO H.C.
; LOPES, PATRICIA S.; MATHOR, MONICA B.
; LUGAO, ADEMAR B..
Radio-synthesized polyacrylamide hydrogels for proteins release.
Radiation Physics and Chemistry,
v. 94,
p. 186-189,
2014.
Palavras-Chave:
hydrogels;
polyacrylates;
papain;
blood serum;
albumins;
cattle;
ionizing radiations;
cytology;
toxicity
FERRAZ, CAROLINE C.; VARCA, GUSTAVO H.C.; LOPES, PATRICIA S.; MATHOR, MONICA B.; LUGAO, ADEMAR B.
Radio-synthesized polyacrylamide hydrogels for proteins release.
Radiation Physics and Chemistry,
v. 94,
p. 186-189,
2014.
Disponível em: http://repositorio.ipen.br/handle/123456789/9007. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
Buscar no repositório
Navegar
-
Todo o repositório
-
Esta coleção
Minha conta
Visualizar
A pesquisa no RD utiliza os recursos de busca da maioria das bases de dados. No entanto algumas dicas podem auxiliar para obter um resultado mais pertinente.
✔ É possível efetuar a busca de um autor ou um termo em todo o RD, por meio do
Buscar no Repositório
, isto é, o termo solicitado será localizado em qualquer campo do RD. No entanto esse tipo de pesquisa não é recomendada a não ser que se deseje um resultado amplo e generalizado.
✔ A pesquisa apresentará melhor resultado selecionando um dos filtros disponíveis em
Navegar
✔ Os filtros disponíveis em
Navegar
tais como: Coleções, Ano de publicação, Títulos, Assuntos, Autores, Revista, Tipo de publicação são autoexplicativos. O filtro,
Autores IPEN
apresenta uma relação com os autores vinculados ao IPEN; o
ID Autor IPEN
diz respeito ao número único de identificação de cada autor constante no RD e sob o qual estão agrupados todos os seus trabalhos independente das variáveis do seu nome;
Tipo de acesso
diz respeito à acessibilidade do documento, isto é , sujeito as leis de direitos autorais, ID RT apresenta a relação dos relatórios técnicos, restritos para consulta das comunidades indicadas.
A opção
Busca avançada
utiliza os conectores da lógica boleana, é o melhor recurso para combinar chaves de busca e obter documentos relevantes à sua pesquisa, utilize os filtros apresentados na caixa de seleção para refinar o resultado de busca. Pode-se adicionar vários filtros a uma mesma busca.
Exemplo:
Buscar os artigos apresentados em um evento internacional de 2015, sobre loss of coolant, do autor Maprelian.
Autor: Maprelian
Título: loss of coolant
Tipo de publicação: Texto completo de evento
Ano de publicação: 2015
✔ Para indexação dos documentos é utilizado o Thesaurus do INIS, especializado na área nuclear e utilizado em todos os países membros da
International Atomic Energy Agency – IAEA
, por esse motivo, utilize os termos de busca de assunto em inglês; isto não exclui a busca livre por palavras, apenas o resultado pode não ser tão relevante ou pertinente.
✔ 95% do RD apresenta o texto completo do documento com livre acesso, para aqueles que apresentam o
significa que e o documento está sujeito as leis de direitos autorais, solicita-se nesses casos contatar a Biblioteca do IPEN,
bibl@ipen.br
.
✔ Ao efetuar a busca por um autor o RD apresentará uma relação de todos os trabalhos depositados no RD. No lado direito da tela são apresentados os coautores com o número de trabalhos produzidos em conjunto bem como os assuntos abordados e os respectivos anos de publicação agrupados.
✔ O RD disponibiliza um quadro estatístico de produtividade, onde é possível visualizar o número dos trabalhos agrupados por tipo de coleção, a medida que estão sendo depositados no RD.
✔ Na página inicial nas referências são sinalizados todos os autores IPEN, ao clicar nesse símbolo
será aberta uma nova página correspondente à aquele autor – trata-se da página do pesquisador.
✔ Na página do pesquisador, é possível verificar, as variações do nome, a relação de todos os trabalhos com texto completo bem como um quadro resumo numérico; há links para o Currículo Lattes e o Google Acadêmico ( quando esse for informado).
ATENÇÃO!
ESTE TEXTO "AJUDA" ESTÁ SUJEITO A ATUALIZAÇÕES CONSTANTES, A MEDIDA QUE NOVAS FUNCIONALIDADES E RECURSOS DE BUSCA FOREM SENDO DESENVOLVIDOS PELAS EQUIPES DA BIBLIOTECA E DA INFORMÁTICA.
O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.
A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.
1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI,
clique aqui.
2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI,
clique aqui.
O Repositório Digital do IPEN é um equipamento institucional de acesso aberto, criado com o objetivo de reunir, preservar, disponibilizar e conferir maior visibilidade à Produção Científica publicada pelo Instituto, desde sua criação em 1956.
Operando, inicialmente como uma base de dados referencial o Repositório foi disponibilizado na atual plataforma, em junho de 2015. No Repositório está disponível o acesso ao conteúdo digital de artigos de periódicos, eventos, nacionais e internacionais, livros, capítulos, dissertações, teses e relatórios técnicos.
A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.
O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.