Navegação Periódicos - Resumos por ano de publicação "2017"

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  • IPEN-DOC 24993

    VIANA, I.E.L.; SILVA, V.R.M.; LOPES, R.M.; ZEZELL, D.M. ; ARANHA, A.C.C.; SCARAMUCCI, T.. Efeito do laser de Er,Cr:YSGG associado ou não ao flúor no controle da erosão dental em esmalte. Brazilian Oral Research, v. 31, suppl. 2, p. 241-241, 2017.

    Abstract: Oitenta fragmentos de esmalte foram obtidos das coroas de incisivos bovinos, incluídos em resina acrílica, planificados e polidos. Uma fita adesiva foi posicionada em sua superfície polida, deixando uma janela de 4mm×1mm exposta. Os espécimes foram previamente erodidos (10min em solução de ácido cítrico a 1%, pH~2,4) e aleatoriamente alocados em 8 grupos experimentais (n=10): 1. Controle negativo (nenhum tratamento); 2. Gel de APF (flúor fosfato acidulado, 1,23% F, pH 3,6-3,9); 3. Irradiação com laser de Er,Cr:YSGG (A: 0,25W, 20Hz, 2,8J/cm2); 4. Irradiação com laser de Er,Cr:YSGG (B: 0,50W, 20Hz, 5,7 J/cm2); 5. Irradiação com laser de Er,Cr:YSGG (C: 0,75W, 20Hz, 8,5 J/cm2); 6. Gel de APF + laser A; 7. Gel de APF + laser B; 8. Gel de APF + laser C. Após, os espécimes foram submetidos a uma ciclagem erosiva (5min de imersão em solução de ácido cítrico a 0,3%, pH~2,6, seguido de imersão em saliva artificial por 60min; 4×/dia; por 5 dias). Ao final, a perda de superfície (PS) dos espécimes (em μm) foi determinada por meio de um perfilômetro ótico. Os dados foram analisados Kruskal-Wallis e Tukey (α=0,05).O grupo 7 (Gel de APF + laser B) foi o que apresentou a menor PS (mediana e intervalo interquartil: 2,97 e 2,65-3,79), sendo estatisticamente diferente do controle negativo (4,20 e 4,01-4,62) e do grupo 8 (3,24 e 2,44-4,58), no entanto, ele não diferiu significativamente dos demais grupos. Todos os grupos, com exceção do 7, não apresentaram PS significativamente diferente do controle negativo.

  • IPEN-DOC 23320

    CAVALCANTE, A.K. ; DAMASCENO, K.C. ; MAZIERO, J.S. ; MARTINI, G.A. ; ORMENIO, M.B. ; MAMEDE, F.C.S. ; MIRANDA, C.S. ; IZIDORO, J.C. ; CAMPELLO, F.A. ; FUNGARO, D.A. ; ROGERO, S.O. ; ROGERO, J.R. . Ecotoxicity evaluation of Coal Fly ash to Daphnia similis and Danio rerio. Applied Research in Toxicology, v. 2, suppl. 1, p. 48-48, 2017.

    Abstract: Coal Fly ash is a major solid waste from coal-fired power stations. In Brazil, more than 4 million tons per year of fly ash are generated with a tendency to increase every year. Only 30% of fly ash is applied as raw material for cement and concrete production. The remaining is disposed in onsite ponds, nearby abandoned or active mine sites, or landfills. The inadequate disposal of fly ash may pose a significant risk to the environment due to the possible leaching of hazardous pollutants into the surrounding soil and groundwater. A combination of leaching tests and ecotoxicological analyses were used in this work for the evaluation of the adverse effects of coal fly in non-target organisms. Ashes were collected from coal-fired power plant located in South of Brazil. Acute toxicity tests were performed with Danio rerio embryos and Daphnia similis, according to OECD 236 and ABNT NBR 12713, respectively. Coal fly ash sample was subjected to a leaching procedure using USEPA SW 864 Method 1311. The leachate was prepared in seven dilutions: 1.56%, 3.12%, 6.25%, 12.5%, 25%, 50%, and 100%. The assays were performed in triplicates and the results showed lethality of Danio rerio after 96 hours of exposure to the leachate, and the calculated LC50 was 4.39%. The ecotoxicity tests with Daphnia similis, observed immobility after 48 hours of exposure to the leachate, and EC50 calculated was 7.25%. The results of these tests indicate toxicity of the coal fly ash leachate toward exposed organisms.

  • IPEN-DOC 24966

    SANCHES, L.K.F.; CAMPOS, L.M.P. ; PARRA, D.F. ; BRAGA, R.R.; SANTOS, M.; BOARO, L.C.C.. Conversion of endodontic sealer modified with nanoparticles carrying antibacterial drugs. Dental Materials, v. 33, suppl. 1, p. e70-e70, 2017. DOI: 10.1016/j.dental.2017.08.140

    Abstract: Purpose/aim: The aim of this study was to evaluate the polymeric conversion of a commercial endodontic sealer modified with montmorillonite nanoparticles carrying to different antibacterial drugs: clorhexidine (CHX) and metronidazole (MET). Materials and methods: The sealer used was AH Plus sealer, and 5% in weight was added of the nanoparticles carrying one of the drugs CHX or MET. Cylindrical specimens were made with 5 mm diameter and 1 mm thick (n = 5). The degree of conversion (DC) was determined using near FTIR. DC was evaluated using the absorption peak at 4529 cm−1 that decrease during polymerization, and the absorption peak at 4623 cm−1 which is unaltered as normalization. The measurements were obtained for each sample immediately, 4 h and 24 h after mixing the two pastes of the sealer. A group with no modification by the nanoparticle was added as a control. The data was analyzed using one-way ANOVA/Tukey (α = 5%). Results: Results are presented in Table 1. Table 1. Means (SD) for degree of conversion (%) at 4 and 24 h. No statistical difference was presented among groups for neither periods of evaluation. Drug DC (%) 4 h 24 h Control 35 (11) A 68 (8) A CHX 31 (11) A 81 (11) A MET 38 (6) A 77 (14) A Conclusions: Within the limitations of this study it can be concluded that addition of the nanoparticle carrying both drug did not influence the polymerization of the sealer.

  • IPEN-DOC 24397

    BARTOLINI, PAOLO ; RIBELA, MARIA T.C.P. ; DAMIANI, RENATA ; SILVA, FELIPE D. ; LIMA, ELIANA R. ; OLIVEIRA, JOAO E. ; PERONI, CIBELE N. ; TORJESEN, PETER A.; SOARES, CARLOS R. . Carbohydrate composition and site-occupancy determination in pituitary and recombinant preparations of human thyrotropin. Journal of Biotechnology, v. 256, suppl., p. S15-S15, 2017. DOI: 10.1016/j.jbiotec.2017.06.053

    Abstract: Human thyrotropin (hTSH) is a glycoprotein with three potential glycosylation sites: two in the -subunit and one in the -subunit. Carbohydrate site-occupancy is frequently neglected in glycoprotein characterization, even if related to folding, trafficking, initiation of inflammation, host defence and congenital disorders of glycosylation (CDG). For the first-time N-glycoprofiling analysis was applied to site-occupancy determination of two native pituitary hTSH, in comparison with three CHO-derived preparations of hTSH, a widely used biopharmaceutical. A single methodology provided: (i) average N-glycan mass; (ii) mass fraction of each monosaccharide and of sulfate; (iii) percent carbohydrate. The results indicate that occupancy (65–87%) and carbohydrate mass (12–19%) can be 34–57% higher in recombinant hormones. The average glycan mass is 24% lower in pituitary hTSH and contains ∼3-fold fewer moles of galactose (P < 0.005) and sialic acid (P < 0.01). The number of moles of fucose per mole of hTSH was found 2.5-fold higher in the pituitary preparations. One of these native preparations, presenting the smallest glycan mass, lowest occupancy, GalNAc, sulfate, Gal and sialic acid contents, also presented the lowest in vivo bioactivity and circulatory half-life. This methodology, extremely important for comparing a recombinant biopharmaceutical to its native equivalent, can be applied to any physiologically or clinical relevant glycoprotein.

    Palavras-Chave: glycoproteins; carbohydrates; trh; congenital diseases

  • IPEN-DOC 23322

    MARTINI, G.A. ; VIVEIROS, W.; QUINAGLIA, G.; FERREIRA, M.L.; ROGERO, S.O. ; ROGERO, J.R. . Blyes and fet: a preliminary understanding between effects and total estrogenic activity on surface waters. Applied Research in Toxicology, v. 2, suppl. 1, p. 43-43, 2017.

    Abstract: Endocrine disrupting chemicals (EDCs) are included in a range of substances and are present in practically all environmental matrices, generally at low concentrations. For the occurrence evaluation of these substances, several in vitro tests are employed, among of them Bioluminescent Yeast Estrogen Screening (BLYES), which measures the total estrogenic activity in EEQ. However, this assay is not able to provide information about adverse effects to aquatic organisms. In order to observe aquatic communities effects, organic extracts of surface water samples from rivers and reservoirs of São Paulo state with results above the detection limit in BLYES (> 0.1 EEQ) were performed with embryonic assays with Danio rerio. The methodology was conducted according OECD 236, to verify acute effects such as: absence of heart beats, absence of somites, no tail detachment and coagulated embryo. Embryonic malformations were evaluated, such as: reduction of organism size, cardiac and vitelline edema, spine curvature and reduction of heart beating, which are characteristics of chronic effects. Among the 21 tested samples, 24% showed acute effects for Danio rerio and 14%, chronic effects. The effects observed probably would be associated with EDCs and/or other contaminants that may bind to the receptor in BLYES assay. The information obtained by embryonic assay with Danio rerio was suitable to show the effects of these groups of contaminants of the organic extracts and would complement the BLYES response. Accomplishing tests to evaluate effects on embryo reproductive system to establish a correlation between estrogenic activity and acute and chronic effects observed on FET is necessary.

  • IPEN-DOC 24227

    ZEZELL, DENISE M. . Biofotônica e lasers levando luz para doenças / Biophotonics and lasers shining light into diseases. Brazilian Dental Science, v. 20, n. 4, 2017. DOI: 10.14295/bds.2017.v20i4.1530

  • IPEN-DOC 27112

    HERNANDES, CAMILA; SILVA, BRUNA da; KLINGBEIL, MARIA de F.G. ; MATHOR, MONICA B. ; PEREIRA, ANA M.S.; SEVERINO, PATRICIA. Avoiding chemotherapy resistance in squamous cell carcinomas: anticancer activities of terpenoids and their impact on the regulation of microRNAs. Cancer Research, v. 77, 13 Supplement, 2017. DOI: 10.1158/1538-7445.AM2017-5456

    Abstract: MicroRNAs are small noncoding RNAs that play important roles in cellular biology. They have been implicated in pharmacogenomics by down-regulating genes that are essential for drug function. In this work we verified the potential anticancer activity of the quinone methide triterpenes maytenin and 22-β-hydroxymaytenin, as well as of a quinone methide triterpene-rich extract obtained from cultivated Maytenus ilicifolia root cells, and evaluated the associated microRNA expression following half maximal inhibitory concentration (IC50) treatment. Standard selectivity index (SI) for the isolated compounds and the root cell extract was determined by the logarithmic shift in effective concentration (IC50) between cancer cell lines and oral keratinocytes. Both isolated molecules as well as the root cell extract presented pronounced antiproliferative and pro-apoptotic activities in four cell lines derived from head and neck squamous cell carcinomas, including a metastasis-derived cell line. A positive SI, with an average 2-fold increase in potency, was detected for single agents and for the extract. MicroRNA expression profiles were assessed at 24h, 48h and 72h following treatment and an average of 100 molecules presented consistent marked variation in expression levels. Considering associations of microRNAs, genes they regulate, and the drugs effects dependent on these genes, the down-regulation of miR-193a-3p and miR-21 in treated cells is of particular interest. Both microRNAs have been involved in 5-fluorouracil and cisplatin resistance, current agents of standard chemoradiotherapy for locally advanced head and neck cancer. Squamous cell carcinoma of the head and neck is one of the most common cancer types worldwide whereas treatment options based on conventional therapies or targeted therapies under development have limited efficacy. Plant-derived products are valuable sources for the development of new therapeutic options for cancer treatment or as synergistic agents in existing regular care.

    Palavras-Chave: chemotherapy; neoplasms; epithelium; histology; rna; inhibition

  • IPEN-DOC 23128

    LEAL, CINTIA; ALVARENGA, LETICIA; SILVA, TAMIRES; BUSSADORI, SANDRA; KATO, ILKA; RIBEIRO, MARTHA ; PRATES, RENATO. Application of photodynamic therapy with led and methylene blue in streptococcus mutans in the presence of glucose- in vitro study. Lasers in Surgery and Medicine, v. 49, n. S28, p. 47-47, 2017. DOI: 10.1002/lsm.22650

    Abstract: Background: Streptococcus mutans is a microorganism associated with tooth decay; many genes that express adhesion, biofilm formation, extracellular polysaccharide, carbohydrate uptake and acid tolerance regulate its cariogenic properties. S. mutans inhabits a complex biofilm and it produces a large amount of exopolysaccharides to promote adhesion and enabling transport pumps. Photodynamic therapy involves the use of a photosensitizer (PS), which is absorbed by specific cells followed by irradiation with visible light, resulting in cell death. The aim of this study was to investigate antimicrobial photodynamic therapy on Streptococcus mutans in the presence of glucose. Study: Streptococcus mutans was grown in brain heart infusion (BHI) at 37 8C for 48 h. Inocula were prepared with pure colonies, which were suspended in phosphate buffered saline (PBS) with and without 50mM glucose. One-hundred micromolar methylene blue was used as photosensitizer and the experiments were performed with groups (control, irradiated with LED, FS without irradiation, and PDT 30, 60, and 120 s). Colony form units were counted and statistically analyzed (oneway ANOVA and Tukey 5%). Results: The irradiation as well as the photosensitizer in the dark did not cause cell death. In contrast, in experiments without glucose, PDT caused cell death proportional the amount of light used. The more light, the higher the inactivation of S. mutans and after 2 min a reduction of 7 orders of magnitude (100%) was observed. In experiments with glucose cell death was observed even increasing the radiant exposure. Conclusion: We concluded that PDT is a viable solution for inactivation of S. mutans in suspension, and that the presence of glucose activates efflux pumps in the bacterial cell wall, and it drastically reduces the effect of PDT.

    Palavras-Chave: bacteria; caries; sensitizers; photosensitivity

  • IPEN-DOC 24964

    SILVA, L.T.S.; COGO-MULLER, K.; BRANDT, W.C.; CAMPOS, L.M.P. ; PARRA, D.F. ; SANTOS, M.; BOARO, L.C.C.. Antibacterial activity of endodontic sealer modified with nanoparticles. Dental Materials, v. 33, suppl. 1, p. e13-e13, 2017. DOI: 10.1016/j.dental.2017.08.022

    Abstract: Purpose/aim: The aim of this study was to evaluate the antibacterial activity of a commercial endodontic sealer modified with montmorillonite nanoparticles carrying to different drugs: clorhexidine (CHX) and metronidazole (MET). Materials and methods: The sealer used was AH Plus sealer, and 5% in weight was added of the nanoparticles carrying one of the drugs CHX or MET. Cylindrical specimens were made with 5 mm diameter and 1 mm thick (n = 5). The antibacterial activity was evaluated by the inhibition halo test. This method was conducted according to Clinical Standard Laboratory Institute M2-A8 protocol, with some modifications (CLSI, 2003). The bacteria selected were the E. Fecallis which is the most frequently bacteria found in recidivate apical infection. Discs specimens were positioned over the agar and plates were incubated in the appropriate conditions for 48 h. After this period, inhibition zones were measured using a calliper rule. A group with no modification by the nanoparticle was added as a control. The data was analyzed using Mann–Whitney (alpha = 5%). Results: Results are presented in Table 1. For the control group no inhibition zone was formed, so the statistical analyze was performed only between the experimental groups. Table 1. Means (SD) for inhibition halo (mm). No statistical difference was presented between the drugs. Drug Inhibition halo (mm) Control 0 CHX 4.8 (1.4) A MET 4.0 (1.6) A Conclusions: Within the limitations of this study it can be concluded that the addition of the nanoparticle carrying both drugs added an antibacterial activity that was not found in the commercial sealer.

  • IPEN-DOC 24994

    PENHA-JUNIOR, T.; RODRIGUES, M.A.P.; BEZERRA, C.P.; FERNANDES, M.S.; VIEIRA JUNIOR, N.D.; ZEZELL, D.M. ; SAMAD, R.E.; DUTRA-CORREA, M.. Análise da rugosidade superficial de esmalte dental humano irradiado por pulsos ultracurtos de laser de Ti:Safira. Brazilian Oral Research, v. 31, suppl. 2, p. 301-301, 2017.

    Abstract: Lasers de alta potência têm sido utilizados em dentes humanos com a finalidade de remoção de cárie e adequação da superfície, criando condições ideais para procedimentos adesivos e restauradores. O objetivo deste estudo foi avaliar a rugosidade superficial de esmalte irradiado com pulsos ultracurtos de um laser de Ti:Safira. Dentes humanos incluídos em resina acrílica tiveram sua porção oclusal removida por cortadeira metalográfica, expondo a dentina, com borda em esmalte. A superfície foi planificada por politriz, padronizando a smear layer. O esmalte foi irradiado com pulsos de 25 fs (1 fs=10-15 s) em 800 nm, e densidades de energia de 0,8 a 8,0 J/cm2, com 4 kHz de taxa de repetição. Cada irradiação varreu uma área de 1 x 1 mm2, com o feixe normal à superfície, e diferentes diâmetros de feixe. A morfologia das superfícies foi avaliada por meio de microscopia eletrônica de varredura, e sua rugosidade (Ra) determinada em medidas topográficas feitas por um perfilômetro óptico. As rugosidades obtidas foram (0,29±0,03) μm para o esmalte (controle), e (1,61±0,33) μm, (1,03±0,19) μm e (2,62± 0,25) μm para as áreas irradiadas com densidades de energia de 8,0, 5,6 e 0,8 J/cm2, respectivamente. A irradiação aumentou a rugosidade da superfície, e o maior aumento ocorreu para a menor densidade de energia, o que pode ser explicado pelo maior número de pulsos sobrepostos nesta varredura (665), 10 vezes superior ao das outras (65), em consequência do maior diâmetro de feixe utilizado.

  • IPEN-DOC 27025

    FONSECA, DANIELA P.M. da ; MONTEIRO, WALDEMAR A. . Analysis by optical microscopy and x-ray diffraction of composite Cu-Cr-Ag-Al2O3 synthesized using powder metallurgy. Acta Microscópica, v. 26, Supplement B, p. 278-279, 2017.

    Abstract: The use of Nature's materials in favor of human beings has been present in its daily life for a long time, copper and its alloys have been used in function of the high thermal and electrical conductivity, good mechanical properties, resistance to corrosion, ease of fabrication and also by the high value of scrap [1]. Metal alloys can also be combined with other classes of materials in order to obtain new properties, superior to the original alloy, this union of two or more materials forms a composite [2]. The studied composite has a ternary metal alloy (copper, chromium and silver) as a matrix and a ceramic oxide (alumina) as the reinforcing phase. The addition of chromium, silver and small amounts of finely dispersed metal oxides in copper improves their mechanical properties and increases the operating temperature, causing little loss of conductivity. A possible application of this composite is in electrical contacts, electronic devices that break the passage of current in electrical circuits [1]. The objective of this study was the microstructural characterization by optical microscopy and X-ray diffraction of the composite Cu-Cr-Ag-Al2O3 processed by powder metallurgy. The samples used were fabricated in laboratory scale of 25 mm diameter, 3,5 mm  ℎ  4,0 mm of height and 6,5 g of mass, with the following chemical compositions: (a) 85% Cu – 15% Al2O3; (b) 90% Cu – 5% Cr – 2% Ag – 3% Al2O3; (c) 90% Cu – 5% Cr – 5% Al2O3; (d) 90% Cu – 7% Cr – 3% Al2O3; (e) 85% Cu – 5% Cr – 5% Ag – 5% Al2O3; (f) 90% Cu – 5% Cr – 3% Ag – 2% Al2O3; (g) 90% Cu – 3% Cr – 7% Al2O3. In order to obtain the samples, the powders were weighed on a precision balance (according to each composition), mixed manually and cold-compacted in uniaxial press with 450 MPa pressure and sintered in an EDG furnace under 10-3 torr of mechanical vacuum and 650 °C in 6 h. The samples were prepared metallographically and observed in an optical microscope, the micrographs indicated coalescing of the copper particles and other metallic elements and formation of porosity (figure 1). The X-ray diffraction data were collected for samples (a) and (e) using graphite monochromator, copper tube, 25º ≤ 2θ ≥ 90º and Δ2θ = 0,02, from the diffractograms the mean crystallite size (𝐷) and microdeformation (𝜖) were calculated using the Williamson-Hall graphical method where the approximate line has a linear coefficient equal to 1/𝐷 and the angular coefficient is equal to 4𝜖/𝜆 [3]. In both samples were identified the expected phases, in agreement with the composition, and an undesirable phase of copper oxide (figure 2). The Williamson-Hall method was not used for all phases because it requires the identification of at least three peaks. Optical micrographs indicated presence of porosity inside the structure and partial homogeneity, due to the non-dissolution of the elements involved in the metal alloy, it is necessary to do further special thermal treatments. In some samples, a third phase was recognized, whose composition demands microanalyses to be properly identified. Through the diffractograms it was possible to identify the phase of copper oxide possibly coming from the sintering stage, this phase is not desirable or this composite because it negatively influences its electrical and mechanical properties. The Williamson-Hall method obtained a straight line with good correlation and suitable values of mean crystallite size and microdeformation for the copper phase.

    Palavras-Chave: copper alloys; corrosion resistance; composite materials; electric conductivity; powder metallurgy

  • IPEN-DOC 26942

    GROSCHE, LUCAS C. ; FUNGARO, DENISE A. . Alkaline hydrothermal treatment of the waste produced in the semi-dry flue gas desulfurization system. Chemical Sciences Journal, v. 8, n. 3, p. 34-34, 2017. DOI: 10.4172/2150-3494-C1-011

    Abstract: Semi-dry flue gas desulfurization ash (SDA) is a byproduct generated from the desulfurization system of coal-fired power station. The beneficial reuse application for SDA material is relatively undeveloped and this residue is underutilized. SDA was used as raw material for the synthesis of zeolitic material by alkaline hydrothermal treatment. Different experimental conditions, such as, reaction time, temperature, alkali hydroxide concentration and solid/liquid ratio were studied. Raw ash material and synthesis products were characterized by XRD, XRF, particle size analyzer, TG-DTG-DTA and SDA was classified according to Brazilian Environmental Regulations. The results show that SDA has a higher CaO and SO3 content. The major minerals present in SDA are hannebachite, anhydrite, calcite, portlandite, gehlenite and sodium carbonate. The size of SDA particles is around 0.399-355.656 μM with median diameter of 7.63 μM. Thermal behavior of SDA was characterized by the existence of six and four stages under air and inert atmosphere, respectively. SDA can be classified as Class II A (non-dangerous/ non-inert) materials. The presence of zeolite hydroxysodalite confirms successful conversion of SDA into zeolitic material after activation in NaOH solutions. Along with the zeolitic product katoite, hydrocalumite and Al-substituted tobermorite were obtained. All the compounds formed present ionic exchange capacity. SDA utilization minimizes the environmental impact of disposal problems and further enables application for treatment of wastewater.

    Palavras-Chave: hydrothermal synthesis; acid neutralizing capacity; hydrothermal synthesis; ashes; coal; combustion; desulfurization; flue gas

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ATENÇÃO!

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2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI, clique aqui.

O Repositório Digital do IPEN é um equipamento institucional de acesso aberto, criado com o objetivo de reunir, preservar, disponibilizar e conferir maior visibilidade à Produção Científica publicada pelo Instituto, desde sua criação em 1956.

Operando, inicialmente como uma base de dados referencial o Repositório foi disponibilizado na atual plataforma, em junho de 2015. No Repositório está disponível o acesso ao conteúdo digital de artigos de periódicos, eventos, nacionais e internacionais, livros, capítulos, dissertações, teses e relatórios técnicos.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.