JavaScript is disabled for your browser. Some features of this site may not work without it.
Navegação Periódicos - Resumos por ID Autor IPEN "944"
-
ANGELOCCI, L.
; NOGUEIRA, B.R.
; SOUZA, C.D. de
; ZEITUNI, C.A.
; ROSTELATO, M.E.C.M.
.
Assessing Ir-192 as an alternative to I-125 in ophthalmic treatment.
Radiotherapy and Oncology,
v. 152,
Supplement 1,
p. S735-S736,
2020.
DOI:
10.1016/S0167-8140(21)01402-X
Abstract:
Purpose or Objective: Brachytherapy sources for ocular melanoma usually
contain Co-60, I-125, Pd-103 or Ru/Rh-106 as
radionuclides. Ir-192 is not a preconized radioactive
material for this purpose, although it is used for other
brachytherapy applications. Higher mean energy from
Ir-192 emission (ca. 380 keV) may be a reason for the
preference of I-125 (35 keV) or Pd-103 (21 keV) over it,
since low penetration is desired on the small structures of
the human eye. This is not, however, an excluding
criterion, considering Co-60 and Ru/Rh-106 have even
higher mean energies.
The demand in Brazil for lower-cost seeds to treat ocular
melanoma lead to the development of an Ir-192 seed to
make treatment more accessible, but since it is not used
as an ophthalmic brachytherapy source, before its
dosimetry is considered, one should care about the
possibility of using it over more stablished materials.
Considering this, the aim of this work is to assess the
possibility of using Ir-192 seeds as ophthalmic
brachytherapy sources by comparing some dosimetric
parameters of a new seed model with the most stablished
I-125 seed in literature, OncoSeed 6711. Material and Methods: As an initial study on the topic, this work relies only on
Monte-Carlo simulations using MCNP4C transport code.
Parameters analyzed are air-kerma strength, dose-rate
constant and depth-dose curve, attention given to points
within the human eye dimensions. The medium considered
was homogeneous water, as it is a good approximation to
the eye tissues in terms of composition and density and
allows for future comparisons with TG-43 based
calculations.
OncoSeed 6711 is not produced anymore, but its long term
as the reference source for dosimetry was considered. A
20 mm COMS ophthalmic applicator was also modeled and
considered to be fully loaded with each seed model to
compare the same parameters at a realistically clinical
approach. Results: As expected, due to the higher energy of the Ir-192
emission spectrum, dose fall-off on the transversal axis of
the seeds is less pronounced for the new seed model. The
steeper dose gradient for I-125 is also visible on the doserate
constant value. The effect of using a COMS applicator
only strengthens this characteristic. Depth-dose curves
were calculated up to the distance of 5 cm, both for a
single seed and for an applicator fully loaded with 24
seeds. All the eye components relevant for dosimetry are located within this range, like the cells of the crystallin
and the optical nerve. Conclusion: If one expects to use Ir-192 as an alternative to I-125 in
ophthalmic cancer treatment, at least the dosimetry
following TG-43 protocol should be carried with utmost
attention, as undesirable dose to healthy nearby tissues is
unavoidable. Crafting a different applicator most suited
for this radionuclide is a possibility that can be taken into
account. Another recommendation is to go beyond TG-43
water-based protocol and actually estimate dose to
relevant eye components.
ANGELOCCI, L.; NOGUEIRA, B.R.; SOUZA, C.D. de; ZEITUNI, C.A.; ROSTELATO, M.E.C.M.
Assessing Ir-192 as an alternative to I-125 in ophthalmic treatment.
Radiotherapy and Oncology,
v. 152,
p. S735-S736,
2020.
Supplement 1,
DOI:
10.1016/S0167-8140(21)01402-X.
Disponível em: http://repositorio.ipen.br/handle/123456789/32695. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
ROSTELATO, MARIA E.
; SOUZA, CARLA D.
; ZEITUNI, CARLOS A.
; MOURA, JOAO A.
; MARQUES, JOSE R.O.
; COSTA, OSVALDO L.
; FEHER, ANSELMO
; RODRIGUES, BRUNA T.
; SOUZA, DAIANE C.B. de
; PELEIAS JUNIOR, FERNANDO S.
; SORGATTI, ANDERSON
; MOSCA, RODRIGO
; MOURA, EDUARDO S. de
; ABREU, RODRIGO T.
; SOUZA, RAQUEL V. DE
; NOGUEIRA, BEATRIZ R.
.
Brazil radioactive sources production for cancer treatment.
Medical Physics International,
v. 4,
n. 2,
p. 237-237,
2016.
Abstract:
The modality, known as brachytherapy, was performed in Brazil by only a hand full of hospitals at an
extremely high cost. For producing new sources, five major areas must be considered: 1) source production:
nuclear activation and/or radiochemical reaction; 2) welding; 3) Quality control: leakage tests; 4) Dosimetry
and metrology; 5) Operational procedures; 6) validation studies. To perform all steps, a multidisciplinary team
works together to overcome difficulties. - Iridium-192 pellets: In Brazil there are 140 machines with pellets
that replacement every 5 years. Our new production line has assembly, welding and quality control hot cells. -
Iridium-192 wires: Produced since 1999. The wire is activated at IPENs IEA-R1 reactor for 30 hours with
5x1013 n/cm-2.s-1 neutron flux resulting in 192 mCi maximum activity. - Iridium-192 seed: New seed for
ophthalmic cancer treatment. The irradiation device presented 90% activity homogeneity. We are still testing
in-vivo. - Iodine-125 seeds: Largely used in low dose brachytherapy. I-125 binding yield achieved with our
new reaction was 80%; Laser welding presented 70% efficiency. Approved in all leakage tests. - Other
ongoing projects: Veterinary brachytherapy, Waste management, Radionecrosis healing with laser, calibrations
sources production, linear accelerator calculations for hospitals, sources with polymeric matrix Our Iodine-125
seeds will be available in 2018. All other projects are advancing. We will continue to develop new products
hoping to help the Brazilian population fight against cancer. For producing new sources, five major areas must
be considered: 1) source production: nuclear activation and/or radiochemical reaction; 2) welding;
3) Quality control:eakage tests; 4) Dosimetry and metrology; 5) Operational procedures;
6) validation studies. To perform all steps, a multidisciplinary team works together to overcome difficulties
Palavras-Chave:
irradiation devices;
ionizing radiations;
brachytherapy;
neoplasms;
iodine 125;
iridium 192;
radiation sources;
brazil
ROSTELATO, MARIA E.; SOUZA, CARLA D.; ZEITUNI, CARLOS A.; MOURA, JOAO A.; MARQUES, JOSE R.O.; COSTA, OSVALDO L.; FEHER, ANSELMO; RODRIGUES, BRUNA T.; SOUZA, DAIANE C.B. de; PELEIAS JUNIOR, FERNANDO S.; SORGATTI, ANDERSON; MOSCA, RODRIGO; MOURA, EDUARDO S. de; ABREU, RODRIGO T.; SOUZA, RAQUEL V. DE; NOGUEIRA, BEATRIZ R.
Brazil radioactive sources production for cancer treatment.
Medical Physics International,
v. 4,
n. 2,
p. 237-237,
2016.
Disponível em: http://repositorio.ipen.br/handle/123456789/28170. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
MOURA, E.; SOUZA, C. de; PELEIAS JUNIOR, F.S.; ZEITUNI, C.A.
; ROSTELATO, M.E.C.M.
; MATTOS, F.R.; BENEGA, M.A.G.; MOURA, J.A.
; FEHER, A.
; COSTA, A.L..
Comparison between the use loose and polymer string seeds in prostatic brachytherapy in Brazil.
Radiotherapy and Oncology,
v. 111,
Suppl. 1,
p. S98,
2014.
Palavras-Chave:
patients;
radiotherapy;
comparative evaluations;
polymers;
brachytherapy;
iodine 125;
damage;
prostate
MOURA, E.; SOUZA, C. de; PELEIAS JUNIOR, F.S.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M.; MATTOS, F.R.; BENEGA, M.A.G.; MOURA, J.A.; FEHER, A.; COSTA, A.L.
Comparison between the use loose and polymer string seeds in prostatic brachytherapy in Brazil.
Radiotherapy and Oncology,
v. 111,
p. S98,
2014.
Suppl. 1.
Disponível em: http://repositorio.ipen.br/handle/123456789/26357. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
MOSCA, RODRIGO C.
; SANTOS, SOFIA N.
; NOGUEIRA, GESSE E.C.; PEREIRA, DAISA L.
; COSTA, FRANCIELLI C.; ARANY, PRAVEEN; ZEITUNI, CARLOS A.
.
Efficacy of photobiomodulation therapy in mitigating skin radiation damage.
Lasers in Surgery and Medicine,
v. 50,
29,
p. S15-S16,
2018.
DOI:
10.1002/lsm.22799
Abstract:
Background: The use of sophisticated radiation dose delivery
and fractionation has significantly improved cancer care. One of
these involves localized, sustained ionizing dose delivery termed
brachytherapy. Despite it therapeutic efficacy, specific side
effects of brachytherapy include localized skin damage and
breakdown for which only palliative treatments are currently
available. The use of low dose biophotonics treatments to
promote tissue healing is termed photobiomodulation (PBM)
therapy. The aim of this study was to evaluate efficacy and
molecular pathways of PBM therapy using two common
wavelengths, red and near-infrared (NIR) to treat radiation
wounds in athymic mice subjected to brachytherapy (sustained
ionizing radiation from 125I seeds).
Study Design/Materials and Method: A pilot study was
performed with thirty-six athymic mice were accomplished for
60 days and divided into six groups: Surgical Control Group
(No radiation and no PBM treatments); Radiation Control
Group (125I seed 0.4252 mCi, no PBM); NIR-PBM Control
Group (NIR PBM alone, LED at l¼880 nm); Red-PBM Control
Group (Red PBM alone LED at l¼660 nm); Radiation- NIR
PBM Group; Radiation-Red PBM Group. Following 21 days,
radiation-induced wounds are evident. PBM treatments (both
wavelengths with output power 40mW for 20 s, fluence 20 J/cm2
on top of implantation site) were performed every week up to
60 days. Wounds were evaluated every 7 days digital imaging,
Laser Doppler Flowmetry (LDF) and tissue temperature with a
thermographic camera. We also performed mPET-CT imaging
using radioactive fluorodeoxyglucose (18F-FDG) at 51 and
81 days post-implantation. Animals were sacrifices
progressively at each time point to correlate clinical
observations with imaging and molecular tissue analyses.
Tissues were collected to analyze molecular pathways
correlating with inflammation, immune response, wound
healing and angiogenesis using mRNA (qRT-PCR) and protein
expression (immunostaining).
Results: Both PBM treated groups demonstrated significant
(p<0.05) improvements in skin radiation wound healing as
compared to radiation group. Distinct improvements in clinical
wound size and closure, improved tissue perfusion and
reduced inflammation as evidenced by decreased wound
thermal images. These wounds were also noted to have
significant differences in the cytokine profiles (TGF-b, VEGF
and PDGF) correlating with better healing responses.
Radiation damage reduces brown fat composition that can
potentially contribute to additional radiation-associated
morbidities. The mPET-CT imaging noted significant
preservation of brown fat composition in PBM-treated radiation alone groups. Further validation of these pathways
is ongoing.
Conclusion: Within the parameters of this study, PBM
treatments demonstrated improved healing in radiation wounds
due to ionizing radiation from 125I seeds. Ongoing work is
examining the precise molecular pathways contributing to these
therapeutic benefits. It is hoped this study will enable further
development of this innovative therapy for managing side-
effects from radiation treatments.
Palavras-Chave:
neoplasms;
brachytherapy;
radiation doses;
radiation injuries;
wounds;
biological recovery
MOSCA, RODRIGO C.; SANTOS, SOFIA N.; NOGUEIRA, GESSE E.C.; PEREIRA, DAISA L.; COSTA, FRANCIELLI C.; ARANY, PRAVEEN; ZEITUNI, CARLOS A.
Efficacy of photobiomodulation therapy in mitigating skin radiation damage.
Lasers in Surgery and Medicine,
v. 50,
p. S15-S16,
2018.
29,
DOI:
10.1002/lsm.22799.
Disponível em: http://repositorio.ipen.br/handle/123456789/29061. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
BAPTISTA, T.
; ROSTELATO, M.C.M.
; ZEITUNI, C.
; PERINI, E.A.
; SOUZA, C.D. de
; MARQUES, J. de O.
; NOGUEIRA, B.R.
; ANGELOCCI, L.V.
.
Efficiancy of hydrogen peroxide for cleaning production areas and equipments in the Laboratory for Brachyterapy Sources Production.
Medical Physics,
v. 44,
n. 6,
p. 2828-2828,
2017.
DOI:
10.1002/mp.12304
Abstract:
Purpose: A great challenge in the brachytherapy sources production is to
fulfill the Good Manufacturing Practices (GMPs) requirements, involving the
process validation and of all supporting activities such as cleaning and sanitization.
The increasingly strict requirements for quality assurance system, with
several norms, normative resolutions and rules that must follow both medical
products and radiochemical requirements, has led to a constant validation
concerns. The main goal of GMP is to reduce inherent risks such as product
contamination with microorganisms and cross-contamination. Methods: In the Laboratory for Brachytherapy Sources Production it was established a
cleaning program for cleanrooms and hot cells using a hydrogen peroxide
solution (6%). This work aims to assess the effectiveness of this cleaning
agent in reducing and/or eliminating microbial load into the cleanrooms and
equipments to acceptable levels in accordance with the current legislation.
Results: The analysis was conducted using the results of the environmental
monitoring program with settling contact plates in cleanrooms after the
cleaning procedures. Furthermore, it was possible to evaluate the action of
the sanitizing agent on the microbial population at the equipment and cleanrooms’
surfaces. It was also evaluated the best way to accomplish the cleaning
program considering the dosimetry factor in each production process,
hence the importance of radiological contamination. All the following environmental
monitoring procedures presented satisfactory results, showing that
the cleaning procedures was able to reduce and maintain the acceptable levels
of viable and non-viable particles for the cleanroom classification (ISO 5 and
ISO 7). The cleaning process with this sanitizer (hydrogen peroxide) can be
performed quickly right before the production; allowing the production of
brachytherapy sources without after use residues. Conclusion: This data will
help the production of a clean and reliable product.
Palavras-Chave:
radiopharmaceutical;
isotope production;
cleaning;
equipment;
clean rooms;
pollution sources;
contamination;
hydrogen peroxide
BAPTISTA, T.; ROSTELATO, M.C.M.; ZEITUNI, C.; PERINI, E.A.; SOUZA, C.D. de; MARQUES, J. de O.; NOGUEIRA, B.R.; ANGELOCCI, L.V.
Efficiancy of hydrogen peroxide for cleaning production areas and equipments in the Laboratory for Brachyterapy Sources Production.
Medical Physics,
v. 44,
n. 6,
p. 2828-2828,
2017.
DOI:
10.1002/mp.12304.
Disponível em: http://repositorio.ipen.br/handle/123456789/31132. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
SOUZA, C.D. de
; ROSTELATO, M.C.M.
; ZEITUNI, C.
; COSTA, O. da
; RODRIGUES, B.T.
; GONZALEZ, A.C.
; MARQUES, J. de O.
.
Experiment to access Iodine-125 leakage in different vials.
Medical Physics,
v. 44,
n. 6,
p. 3146-3146,
2017.
Abstract:
Purpose: There are several challenges when developing a laboratory to produce
radioactive sources. From choosing a prototype to radiation safety, the
task is enormous. During the past 15 years, our research group is developing
a laboratory to produce iodine-125 seed. These seeds are placed inside the
cancer and release radiation directly in the target. The whole production line
is full of new process and innovations. Among those, a new chemical reaction
that deposit iodine-125 onto silver (core) was developed. This paper presents
a comparison between vials in order to access their capability to retain
radioactive iodine. Also, the fixation percentage in a silver core was taken
into account. This information will be used to select a vial to be implemented
at the iodine-125 sources manufacture laboratory. Methods: Vials made
with polymers and glass was tested. Iodine-125 were placed in the vials overnight
at rt. Seven vials with different materials (glass, dark glass, and plastics)
were evaluated. Results: The selected vial (borosilicate glass 1 mL total volume)
loss 17.61% of iodine in 24 hours and presented the highest iodine
intake. It was noticeable that the vial material influenced both iodine intake
and iodine loss. The goal is to maximize the reaction yield to result in a less
costly product. Conclusion: We have selected the best vial for our reaction
in regards to leakage and yield.
Palavras-Chave:
iodine 125;
leak detectors;
silver;
borosilicate glass
SOUZA, C.D. de; ROSTELATO, M.C.M.; ZEITUNI, C.; COSTA, O. da; RODRIGUES, B.T.; GONZALEZ, A.C.; MARQUES, J. de O.
Experiment to access Iodine-125 leakage in different vials.
Medical Physics,
v. 44,
n. 6,
p. 3146-3146,
2017.
Disponível em: http://repositorio.ipen.br/handle/123456789/27822. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
SOUZA, D.B. de
; ROSTELATO, M.C.M.
; VICENTE, R.
; ZEITUNI, C.
; SOUZA, C.D. de
; RODRIGUES, B.T.
; MARQUES, J. de O.
; CARVALHO, V.
; BARBOSA, N.
.
Measurement of Iodine-125 radioactive solid waste derived from sources production laboratory for brachytherapy.
Medical Physics,
v. 44,
n. 6,
p. 2974-2975,
2017.
DOI:
10.1002/mp.12304
Abstract:
Purpose: This study aims to present a solid waste management plan for the
laboratory of radioactive sources production (LPFR), iodine-125 brachytherapy
seeds, located at the Energy and Nuclear Research Institute (IPEN). After
the implementation, it is expected to meet a demand of 8000 seeds per
month. Methods: Waste from the production of Iodine-125 sources is classified
as “Very Low Level Waste Disposal” (T1/2 ≤ 100 days) in the IAEA regulations.
Despite that, they have levels of activity above the limits established
in standard (CNEN 8.01) needing adequate management in order to guarantee
the safety of the installation, operators and environment. The solid waste
is generated in Glove box 1, were the fixation reaction (iodine-125 – core)
takes place. The wastes from this production are absorbent papers and filters
used in surface and air decontamination processes; glass vials, syringes and
needles, used in the fixation reaction. Measures of mass, volume and values
of activities generated over 5 years of production were performed for each
glove box by estimating different scenarios throughout production (supplier
switching, variation in activity by radioactive source, etc.). The concentration
of activity was also determined in order to meet the criteria established in the
standard for safe release of the waste. Results: The final volumes and activities
calculated indicated that the laboratory has enough space for temporary
storage until the release to the environment (thus not requiring treatment,
transport, and another place for management). The data collected proved that
a secure management system for radioactive waste within the facility is possible.
Conclusion: The management proposed by this work was able to safely
contemplate all stages of waste management. This data is indispensable for
the construction and licensing of the laboratory.
Palavras-Chave:
radioactive waste management;
solid wastes;
iodine 125;
brachytherapy;
regulations;
waste disposal
SOUZA, D.B. de; ROSTELATO, M.C.M.; VICENTE, R.; ZEITUNI, C.; SOUZA, C.D. de; RODRIGUES, B.T.; MARQUES, J. de O.; CARVALHO, V.; BARBOSA, N.
Measurement of Iodine-125 radioactive solid waste derived from sources production laboratory for brachytherapy.
Medical Physics,
v. 44,
n. 6,
p. 2974-2975,
2017.
DOI:
10.1002/mp.12304.
Disponível em: http://repositorio.ipen.br/handle/123456789/31133. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
RODRIGUES, B.T.
; SOUZA, P.D. de
; SOUZA, C.D. de
; ROSTELATO, M.C.M.
; ZEITUNI, C.
; NOGUEIRA, B.R.
; MARQUES, J. de O.
; SOUZA, A.S. de
.
Methodology for in vivo dosimetry using TLD-100 for radiotherapic treatment.
Medical Physics,
v. 44,
n. 6,
p. 2898-2899,
2017.
DOI:
10.1002/mp.12304
Abstract:
Cancer is a public health problem that affects approximately 27
million people worldwide. The most common type in Brazil among men is
prostate cancer with 61 thousand cases. There are two forms of radiotherapy
treatments that can be used: teletherapy and brachytherapy. Before starting
the teletherapy treatment, a planning is done that makes the acquisition of the
anatomical information of the patient to then classify the areas of interest. Dosimetry is performed as a quality control to ensure that the calculated dose
is equal to that received by the patient. In vivo dosimetry acts as an independent
measurement and this work aims at comparing the dosimetry performed
using thermoluminescent dosimeters (LiF: Mg, Ti - TLD - 100) with dose
values calculated in the planning system (TPS). Methods: All dosimeters
were prepared to be used in an anthropomorphic phantom. A selection of
dosimeters, 50 micro TLD’s, selected after heat treatment, were then irradiated
and a reading was made. A case planned by TPS was selected and compared
the dosimetry performed in an anthropomorphic phantom for the same
case. Results: All values obtained were within the deviation ( 5%) allowed
by the protocol. The results of this work will help to implement a new quality
program in the Radiotherapy Service at Hospital das Cl ınicas de S~ao Paulo.
Conclusion: The accurate dosimeter selection provided a feasible and reliable
evaluation that enabled the comparison.
Palavras-Chave:
neoplasms;
prostate;
radiotherapy;
brachytherapy;
thermoluminescent dosimetry
RODRIGUES, B.T.; SOUZA, P.D. de; SOUZA, C.D. de; ROSTELATO, M.C.M.; ZEITUNI, C.; NOGUEIRA, B.R.; MARQUES, J. de O.; SOUZA, A.S. de.
Methodology for in vivo dosimetry using TLD-100 for radiotherapic treatment.
Medical Physics,
v. 44,
n. 6,
p. 2898-2899,
2017.
DOI:
10.1002/mp.12304.
Disponível em: http://repositorio.ipen.br/handle/123456789/31134. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
RODRIGUES, B.T.
; ROSTELATO, M.C.M.
; SOUZA, C.D. de
; ZEITUNI, C.
; MOURA, E.S. de; SOUZA, D.B. de
; TOZETTI, C.; RODRIGUES, B.
.
New core configuration for producing Iodine 125 seeds.
Medical Physics,
v. 44,
n. 6,
p. 2828-2829,
2017.
DOI:
10.1002/mp.12304
Abstract:
Purpose: Cancer is one of the most complex public health problems. Prostate
cancer is the second most common among men. In prostate brachytherapy
use Iodine-125, which is fixated on a silver substrate, then inserted and
sealed in a titanium capsule. This work proposes a new source configuration
using epoxy resin substrate. Methods: Comparation and analysis methods
were used to define the methodology for combining iodine-125 in polymers.
The parameters were immersion time, reaction type, concentration of the
adsorption solution, specific activity of the radioactive solution, need for carrier and chemical form of radioactive iodine. Results: The methodology
developed with an epoxy resin was very good. The final radioactive intake on
the resin was higher than 80%. The immobilization of the radioactive solution
occurred in the matrix, without any loss or deposition of undesirable
materials on its surface, as evidenced by the smear test. The material maintains
its integrity when autoclaved at 140 °C. The curing process of the resin
was 40 minutes. With the value of the initial activity of the Iodine solution
by mass (774.2 lCi/g), it was possible to calculate the immobilization efficiency
Average of 680 lCi/g. The immersion test in distilled water at room
temperature did not exceed the limit allowed by ISO 9978, which is 5 nCi
(185 Bq), proof of no leakage. In a computational simulation by the Monte
Carlo Method, PENELOPE, the simulations were consistent with the values
adopted by the literature for the GE Healthcare model 6711, which shows the
value of the dose rate constant as 0, 965 cGy.U-1.h-1. Conclusion: The
effective method for combining iodine-125 in epoxy resin was determinated.
The major advantage was the high efficiency percentage fixation, around
82,1 3,2%, and the simplicity and safety of the process.
Palavras-Chave:
neoplasms;
prostate;
iodine 125;
polymers;
epoxides;
resins
RODRIGUES, B.T.; ROSTELATO, M.C.M.; SOUZA, C.D. de; ZEITUNI, C.; MOURA, E.S. de; SOUZA, D.B. de; TOZETTI, C.; RODRIGUES, B.
New core configuration for producing Iodine 125 seeds.
Medical Physics,
v. 44,
n. 6,
p. 2828-2829,
2017.
DOI:
10.1002/mp.12304.
Disponível em: http://repositorio.ipen.br/handle/123456789/31135. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
SOUZA, C.D. de
; ROSTELATO, M.C.M.
; ZEITUNI, C.
; GONZALEZ, A. del C.C.
; NOGUEIRA, B.R.
.
New gold-198 nanoparticle synthesis to be used in cancer treatment.
Medical Physics,
v. 45,
n. 6,
p. e243-e243,
2018.
Palavras-Chave:
aqua regia;
brachytherapy;
citrates;
decay;
gold 198;
high-purity ge detectors;
light scattering;
nanoparticles;
neoplasms;
neutron flux;
sodium compounds;
synthesis;
therapy
SOUZA, C.D. de; ROSTELATO, M.C.M.; ZEITUNI, C.; GONZALEZ, A. del C.C.; NOGUEIRA, B.R.
New gold-198 nanoparticle synthesis to be used in cancer treatment.
Medical Physics,
v. 45,
n. 6,
p. e243-e243,
2018.
Disponível em: http://repositorio.ipen.br/handle/123456789/29844. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
-
ROSTELATO, M.
; SOUZA, C. de; PELEIAS JUNIOR, F.S.; ZEITUNI, C.A.
; MATTOS, F.R.; BENEGA, M.A.G.; MOURA, J.A.
; FEHER, A.
; COSTA, O.L.
.
Study and development of a iridium-192 seed for use in ophthalmic cancer.
Radiotherapy and Oncology,
v. 111,
Suppl. 1,
p. S338,
2014.
Palavras-Chave:
radiotherapy;
iridium 192;
neoplasms;
brachytherapy;
ophthalmology;
eyes;
melanomas;
iear-1 reactor;
alloys;
scanning electron microscopy
ROSTELATO, M.; SOUZA, C. de; PELEIAS JUNIOR, F.S.; ZEITUNI, C.A.; MATTOS, F.R.; BENEGA, M.A.G.; MOURA, J.A.; FEHER, A.; COSTA, O.L.
Study and development of a iridium-192 seed for use in ophthalmic cancer.
Radiotherapy and Oncology,
v. 111,
p. S338,
2014.
Suppl. 1.
Disponível em: http://repositorio.ipen.br/handle/123456789/26358. Acesso em: $DATA.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.
Como referenciar este item
Buscar no repositório
Navegar
-
Todo o repositório
-
Esta coleção
Minha conta
Visualizar
A pesquisa no RD utiliza os recursos de busca da maioria das bases de dados. No entanto algumas dicas podem auxiliar para obter um resultado mais pertinente.
✔ É possível efetuar a busca de um autor ou um termo em todo o RD, por meio do
Buscar no Repositório
, isto é, o termo solicitado será localizado em qualquer campo do RD. No entanto esse tipo de pesquisa não é recomendada a não ser que se deseje um resultado amplo e generalizado.
✔ A pesquisa apresentará melhor resultado selecionando um dos filtros disponíveis em
Navegar
✔ Os filtros disponíveis em
Navegar
tais como: Coleções, Ano de publicação, Títulos, Assuntos, Autores, Revista, Tipo de publicação são autoexplicativos. O filtro,
Autores IPEN
apresenta uma relação com os autores vinculados ao IPEN; o
ID Autor IPEN
diz respeito ao número único de identificação de cada autor constante no RD e sob o qual estão agrupados todos os seus trabalhos independente das variáveis do seu nome;
Tipo de acesso
diz respeito à acessibilidade do documento, isto é , sujeito as leis de direitos autorais, ID RT apresenta a relação dos relatórios técnicos, restritos para consulta das comunidades indicadas.
A opção
Busca avançada
utiliza os conectores da lógica boleana, é o melhor recurso para combinar chaves de busca e obter documentos relevantes à sua pesquisa, utilize os filtros apresentados na caixa de seleção para refinar o resultado de busca. Pode-se adicionar vários filtros a uma mesma busca.
Exemplo:
Buscar os artigos apresentados em um evento internacional de 2015, sobre loss of coolant, do autor Maprelian.
Autor: Maprelian
Título: loss of coolant
Tipo de publicação: Texto completo de evento
Ano de publicação: 2015
✔ Para indexação dos documentos é utilizado o Thesaurus do INIS, especializado na área nuclear e utilizado em todos os países membros da
International Atomic Energy Agency – IAEA
, por esse motivo, utilize os termos de busca de assunto em inglês; isto não exclui a busca livre por palavras, apenas o resultado pode não ser tão relevante ou pertinente.
✔ 95% do RD apresenta o texto completo do documento com livre acesso, para aqueles que apresentam o significa que e o documento está sujeito as leis de direitos autorais, solicita-se nesses casos contatar a Biblioteca do IPEN,
bibl@ipen.br
.
✔ Ao efetuar a busca por um autor o RD apresentará uma relação de todos os trabalhos depositados no RD. No lado direito da tela são apresentados os coautores com o número de trabalhos produzidos em conjunto bem como os assuntos abordados e os respectivos anos de publicação agrupados.
✔ O RD disponibiliza um quadro estatístico de produtividade, onde é possível visualizar o número dos trabalhos agrupados por tipo de coleção, a medida que estão sendo depositados no RD.
✔ Na página inicial nas referências são sinalizados todos os autores IPEN, ao clicar nesse símbolo será aberta uma nova página correspondente à aquele autor – trata-se da página do pesquisador.
✔ Na página do pesquisador, é possível verificar, as variações do nome, a relação de todos os trabalhos com texto completo bem como um quadro resumo numérico; há links para o Currículo Lattes e o Google Acadêmico ( quando esse for informado).
ATENÇÃO!
ESTE TEXTO "AJUDA" ESTÁ SUJEITO A ATUALIZAÇÕES CONSTANTES, A MEDIDA QUE NOVAS FUNCIONALIDADES E RECURSOS DE BUSCA FOREM SENDO DESENVOLVIDOS PELAS EQUIPES DA BIBLIOTECA E DA INFORMÁTICA.
O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.
A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.
1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI,
clique aqui.
2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI,
clique aqui.
O Repositório Digital do IPEN é um equipamento institucional de acesso aberto, criado com o objetivo de reunir, preservar, disponibilizar e conferir maior visibilidade à Produção Científica publicada pelo Instituto, desde sua criação em 1956.
Operando, inicialmente como uma base de dados referencial o Repositório foi disponibilizado na atual plataforma, em junho de 2015. No Repositório está disponível o acesso ao conteúdo digital de artigos de periódicos, eventos, nacionais e internacionais, livros, capítulos, dissertações, teses e relatórios técnicos.
A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.
O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.