Navegação Eventos - Resumos por ano de publicação "2019"

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  • IPEN-DOC 26764

    FERREIRA, MERILYN S. ; PASK, HELEN M.; WETTER, NIKLAUS U. . Yellow laser at 573 nm generated by intracavity SHG diodeside-pumped Raman laser. In: ADVANCED SOLID STATE LASERS, September 29 - October 3, 2019, Vienna, Austria. Resumo expandido... Washington, DC, USA: OSA, 2019. (Laser Congress 2019 (ASSL, LAC, LS&C)).

    Abstract: A diode side-pumped Nd:YLiF4 crystal for fundamental wavelength generation and intracavity Stokes conversion in KGW are employed to obtained 6.1W maximum output power, 11.9% slope efficiency and 11.8% diode-to-yellow conversion efficiency at 573 nm.

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  • IPEN-DOC 27976

    MORAES, L.P.R. ; MEI, J.; MARANI, D.; FONSECA, F.C. ; SUN, Z.. Wet-chemical synthesis of CeO2 for electrochemical applications. In: INTERNATIONAL CONFERENCE ON HIGH-PERFORMANCE CERAMICS, 11th, May 25-29, 2019, Kunming, China. Abstract... 2019.

    Abstract: Nanostructured metal oxides have been extensively studied in the last decades for their physicochemical properties, which depend on the size and shape of their nanostructures. The same chemical element or compound can exhibit different properties in different shapes and dimensions. Metal oxides are a class of inorganic compounds very important in many areas of materials science due to their unique properties that enable them to have a wide range of applications, such as sensor, catalysis, ceramics, absorbents and superconductors. They are particularly attractive for electrochemical applications due to their low molecular weight, favorable electrochemical properties and low toxicity, and have been extensively studied for the development of new energy conversion and storage systems, especially because of the higher electrode surface area, leading to higher charge/discharge rates, and their rich redox reactions involving different ions. Particularly, CeO2 is a promising metal oxide as it can present defects such as oxygen vacancies which play an important role for catalytic, magnetic and electrochemical properties. In this work, different nanostructures of CeO2 were synthesized by the selfassembly approach, from molecular precursors, using Pluronic P123 as surfactant and ethylene glycol as co-surfactant in ethanol solvent in a solvothermal system. The effect of different synthesis parameters on the morphology, crystallite size and electrochemical properties were investigated via various analytical techniques. The experimental results indicated that the synthesis parameters, such as temperature, aging time and chemicals concentration, strongly influences the morphology and sizes of CeO2, thus enabling the intentionally design of different nanomaterials.

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  • IPEN-DOC 26054

    ANDRADE, M.A.B.; ALVES, C.O.; FIN, A.P.C.; SOARES, F.A.P.; SAVI, M. ; POTIENS, M.P.A. . Visual impact of infill percentages for 3D printed radiologic simulators. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 27100

    CARVALHO, ELIAS F. ; OSTERMANN, CAROLINE K. ; BUSTILLOS, JOSE O.V. . Vertical profile analysis of wind flow to obtain optimal eddy covariance parameters. In: ATTO WORKSHOP, 3rd, September 16-20, 2019, Manaus, AM. Poster... 2019.

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  • IPEN-DOC 27551

    GATTI, LUCIANA V. ; DOMINGUES, LUCAS ; ARAGAO, LUIZ; MILLER, JOHN; BASSO, LUANA; MARANI, LUCIANO; TEJADA, GRACIELA; CASSOL, HENRIQUE; CORREIA, CAIO ; IPIA, ALBER; ANDERSON, LIANA; RANDOW, CELSO V.; GLOOR, MANUEL; PETERS, WOUTER; LOPES, RAIANE; SANTOS, RICARDO ; CRISPIM, STEPHANE. Variação Interanual do Balanço de Gases de Efeito Estufa na Bacia Amazônica e seus controles em um mundo sob aquecimento e mudanças climáticas. In: REUNIÃO ANUAL DO PROGRAMA FAPESP DE PESQUISA SOBRE MUDANÇAS CLIMÁTICAS GLOBAIS, 20-21 de fevereiro, 2019, São Paulo, SP. Poster... 2019.

    Abstract: Ao longo dos últimos 40-­‐50 anos a Amazônia vem sofrendo muitas alterações devido ao desmatamento, queima da biomassa, mudança do uso da terra, expansão urbana, malha viária, construção de hidrelétricas, exploração de mineração, petróleo e gás, etc. Esta alteração na Floresta Amazônica vem promovendo o aumento da temperatura nesta região acima do esperado e intensificação da estação seca. Estas alterações, além das alterações climáticas vem causando impacto no Balanço de Carbono da Bacia Amazônica.

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  • IPEN-DOC 26067

    SANTOS, W.S.; NEVES, L.P.; PERINI, A.P.; CALDAS, L.V.E. . Uso de modelagem computacional para avaliação da exposição médica e ocupacional durante procedimento de cardiologia intervencionista. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

    Palavras-Chave: fluoroscopy; biomedical radiography; cardiovascular system; images; medical personnel; patients; radiation doses; radiation protection; occupational safety; computer codes; programming

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  • IPEN-DOC 26751

    ORTIZ, N. ; MAICHIN, F. ; MACEDO, M.V. . Using microstructured yeast as biotemplate for TiO2 deposition applied on amoxicillin solar photodecomposition. In: IWA INTERNATIONAL CONFERENCE ON WATER RECLAMATION AND REUSE, 12th, June 16-20, 2019, Berlin, Germany. Resumo expandido... 2019.

    Abstract: The indication of amoxicillin (AMOX) is the most frequent by the public health assistance in Brazil. After the body metabolization, the antibiotic is discharged by excretes in the sewage system; also acting as secondary pollution sources for surface water resources. The microstructured yeast culture (biotemplate) enhances the TiO2 surface area before the amoxicillin solar photodecomposition. The maximum removal percentage was 56% of AMOX with pseudo-second-order kinetics. The use of the low-frequency ultrasonic source in the TiO2 slurry dispersion after the yeast culture enhanced the TiO2 surface area and its effectiveness during the antibiotics solar photodecomposition.

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  • IPEN-DOC 27547

    YAMAGATA, CHIEKO ; LEME, DANIEL R. ; RODAS, ANDREA C.D.; HIGA, OLGA Z. ; MELLO-CASTANHO, SONIA R.H. . Use of sodium silicate waste solution as Si source to synthesize MgO-CaO-SiO2 system ceramic powder for biomedical application. In: PACIFIC RIM CONFERENCE OF CERAMIC SOCIETIES, 13th, October 27 - November 1, 2019, Okinawa, Japan. Abstract... 2019.

    Abstract: The superior biological and mechanical properties of the glass ceramic of MgO-CaO-SiO2 system [1], for fabricating bone scaffolds, have attracted considerable attention. Studies showed that glass-ceramic with the composition Wt% 7.68 MgO, 43.19 CaO and 49.13 SiO2 displays appropriate mechanical properties, good bioactivity and biocompatibility in vitro [2]. The aim of this research was to propose a novel method of synthesis of MgO-CaO-SiO2 system ceramic powder. Using a waste solution of sodium silicate derived from alkaline fusion process of zircon sand, as source of Si, MgO-CaO-SiO2 system ceramic powder was synthesized by sol-gel added to co-precipitate of Mg and Ca hydroxides. Present synthesized powder was compacted and sintered at 1300 °C for 2h to obtain CaO-MgO-SiO2 glass-ceramic that was characterized by SEM, XRD and FTIR. In vitro tests were performed by soaking the sintered samples in the simulate blood fluid (SBF, at pH 7.25 and 37 °C) to study its bioactivity. After 7 days soaking, FTIR spectra (Fig. 1) result showed the material is bioactive, confirmed by presence of infrared band at 1047 cm-1 attributed to PO43- and observation of hydroxyapatite coating on the surface of the sample (Fig. 2). Cytotocicity test according to ISO10993-5 and sample preparation according to ISO10993-12 revealed that the sample is considered non-cytotoxic and it can be eligible for further biological testes.

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  • IPEN-DOC 26843

    VICENTE, MARCOS A.A.H.; MUNHOZ JUNIOR, ANTONIO H.; MIRANDA, LEILA F. de; SARMENTO, BRUNO F.C.C.; BERNUSSI, AYRTON; OLIVEIRA, RENE ; RIBEIRO, ROBERTO R.; MORAES, DENISON A.. Use of pseudoboehmite for drug delivery system of simvastatin. In: BRAZIL MRS MEETING, 18th, September 22-26, 2019, Balneário Camburiú, SC. Abstract... São Carlos, SP: Aptor Software, 2019. p. 687-688.

    Abstract: Simvastatin is a well known anti-cholesterol drug that is commercially available in Brazil in various strengths including Simvastatin Tablets, with 10, 20 and 40 mg. Simvastatin is a drug, which is used for treating patients with hypercholesterolemia, in order to prevent atherosclerosis, cardiovascular disease, and stroke1. Today cardiovascular disease is still the leading cause of death worldwide. It should also be noted that the treatment of cardiovascular diseases was responsible for just over a third of what the Brazilian federal government disbursed between the years 2013 and 2016 in the purchase of medicines for the population. However, the side effects of simvastatin include muscle pain and liver problems. When diet and exercise are not enough to reduce cholesterol levels, drugs as simvastatin are the medication prescribed. One problem of simvastatin is the low solubility. Simvastatin is practically insoluble in water (30 μg/mL), and 0.1 M HCl (60 μg/mL) [1,2,3]. This paper presents pseudoboehmite nanoparticles synthesized via sol-gel process. The pseudoboehmite were synthesized by an ethanol/water sol–gel method using aluminum nitrate as precursos and sodium hydroxide. The pseudoboehmite with simvastatin entrapped was characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) using secondary electrons detector and EDS detector, thermal analysis (thermogravimetric analysis and differential thermal analysis) and Fourier transform infrared spectrometer (FTIR). The data shows that the simvastatin was incorporated homogenously in the pseudoboehmite. The Fourier transform infrared analysis shows that there was no degradation of the drug.

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  • IPEN-DOC 26700

    LOPES, THIAGO ; BERUSKI, OTAVIO ; KORKISCHKO, IVAN ; MANTHANWAR, AMIT M.; PISTIKOPOULOS, EFSTRATIOS N.; FONSECA, FABIO C. ; MENEGHINI, JULIO R.; KUCERNAK, ANTHONY R.. Unveiling fundamental transport phenomena in fuel cells. In: ENERGY TRANSITION RESEARCH AND INNOVATION, October 1-2, 2019, São Paulo, SP. Abstract... São Paulo: Research Centre for Gas Innovation, 2019.

    Abstract: In situ and ex situ spatially-resolved techniques are employed to investigate reactant distribution and its impacts in a polymer electrolyte fuel cell. Temperature distribution data provides further evidence for secondary flows inferred from reactant imaging data, highlighting the contribution of convection in heat as well as reactant distribution. Water build-up from neutron tomography is linked to component degradation, matching the pattern seen in the reactant distribution and thus suggesting that high, nonuniform local current densities shape degradation patterns in fuel cells. The correlations shown between different techniques confirm the use of the versatile reactant imaging technique, which is used to compare commonly used flow field designs. Among serpentine-type designs, the single serpentine is superior in both equivalent current density and reactant distribution, showing large contributions from convective flow. On the other hand, the interdigitated design is shown to produce larger equivalent current densities, while showing a somewhat poorer reactant distribution. Considering the correlations drawn between the techniques, this suggests that the interdigitated design compromises durability in favour of power output. The results highlight how established techniques provide a robust background for the use of a new and flexible imaging technique toward designing advanced flow fields for practical fuel cell applications.

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  • IPEN-DOC 27958

    BASSO, LUANA S.; GATTI, LUCIANA V. ; MARANI, LUCIANO; CASSOL, HENRIQUE L.G.; TEJADA, GRACIELA; DOMINGUES, LUCAS G. ; CORREIA, CAIO S. de C. ; IPIA, ALBER; ARAI, EGIDIO; ARAGAO, LUIZ E.O.C.; ANDERSON, LIANA O.; CRISPIM, STEPHANE P.; NEVES, RAIANE A.L.; GLOOR, MANUEL; MILLER, JOHN B.. Understanding the seasonality and interannual variability of Amazon CH4 budget and climate feedbacks based on atmospheric data from vertical profiles measurements. In: AGU CHARPMAN CONFERENCE, August 26-29, 2019, San Diego, CA, USA. Abstract... Washington, DC, USA: American Geophysical Union, 2019.

    Abstract: Currently tropical land regions, like Amazon, are still poorly observed with large-scale integrating in-situ observations although they host some of the largest wetlands/seasonally flooded areas on the globe. The role of these regions in the global CH4 balance and the climate feedbacks have remained uncertain. To help this situation we have started a lower-troposphere greenhouse gas-monitoring program over tropical South America consisting of regular vertical profile greenhouse gas and carbon monoxide (CO) observations at four sites along the main airstream since 2010. Vertical profiles are sampled using light aircraft, high-precision greenhouse gas and carbon monoxide analysis of flask air, fortnightly between 2010 to 2017. Over the full period the Amazon (total area of around 7.2 million km2) was a source of CH4, of approximately 46 ± 6 Tg/year, which represent 8% of the global CH4 flux to the atmosphere. CH4 emissions from different parts of the basin vary markedly. There are comparably high emissions from the eastern part of the basin exhibiting strong variability, with particularly high CH4 fluxes in the early part of the wet season (January to March). A second period of high emissions occurs during the dry season. The cause of the high emissions is unclear. In contrast to the eastern Amazon site a clear seasonality was observed at the other three sites located further downwind along the main sir-stream, with the largest emissions occurring at the beginning of the wet season (January to March). In addition, these data show an interannual variability in emissions magnitude, so we discuss how these data can be correlate to temperature, precipitation, terrestrial water storage anomalies (from GRACE) and Fire counts (human-driven changes) that could be influencing this variability. Using a CO/CH4 emission ratio calculated in this study we find a biomass burning contribution varying between 10 and 23% of the total flux at each site. Also, we discuss what the data tell us about possible ongoing feedbacks to possible changes in temperature, precipitation and biomass burning and indicating what variables can be contributing to CH4 emissions from Amazon.

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  • IPEN-DOC 26750

    ORTIZ, N. ; NICOLAU, T.S. ; SOUZA, J.P. ; SILVA, A.. Ultrasonic TiO2 solar photodecomposition and biocarbon sorption processes to remove amoxicillin and cephalexin from binary systems. In: IWA INTERNATIONAL CONFERENCE ON WATER RECLAMATION AND REUSE, 12th, June 16-20, 2019, Berlin, Germany. Resumo expandido... 2019.

    Abstract: The cephalexin (CEPH) and amoxicillin (AMOX) antibiotics are the most indicated in the medical prescriptions in Brazil, as the antibiotics used for public health assistance and also for veterinary medicine. Nowadays Brazil is a higher protein animal producer in the world. After the metabolization, the antibiotics discharge in the sewage system and manure composition on rural areas; act as secondary pollution sources for surface water resources. The integrated processes applying the ultrasonic source before the solar photodecomposition and biosorption showed the maximum removal percentage of 91.47% for AMOX and 90.62% for CEPH. Considering the binary systems with the 17:83 proportion percentages of AMOX and CEPH the removal percentage was 89.15% and 97.90% respectively. The use of low-frequency ultrasonic waves before the solar photodecomposition increased the TiO2 surface area and effectiveness and enhanced the removal efficiency for both cephalexin and amoxicillin alone and in binary mixtures.

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  • IPEN-DOC 26842

    PIERETTI, EURICO F. ; NEVES, MAURICIO M. das ; CORREA, OLANDIR V. ; ANTUNES, R.A.. Tribological evaluation of CoCrMo alloy for biomedical applications. In: BRAZIL MRS MEETING, 18th, September 22-26, 2019, Balneário Camburiú, SC. Abstract... São Carlos, SP: Aptor Software, 2019. p. 1836-1836.

    Abstract: The tribological behavior of the CoCrMo alloy was evaluated in the air in a nanotribometer. The chemical composition, microstructure and mechanical properties of CoCrMo alloys makes them potential materials for use as implantable medical or dental devices [1]. This work has a specific focus on covering the possible in vitro wear modes seen on metal-on metal surfaces. Ballcratering wear test was carried out for 10 min with a solid sphere of WC as counterbody, at a frequency of 75 rpm [2]. The CoCrMo samples’ citotoxicity was analyzed in order to determine if the alloy casting process and its surface finishing, current used in industry, affects the biomaterial’s biocompatibility. All tested surfaces were prepared according to the recommendations for clinical use. The results address the potential detrimental effects of hard particles in vivo such as increased wear rates (debris generation), which is greatly influenced by the normal force, and corrosion (metal-ion release). None sample was considered cytotoxic.

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  • IPEN-DOC 26053

    PRADO, E.S.P. ; MIRANDA, F.S.; PETRACONI, G.; POTIENS JUNIOR, A.J. . Tratamento de rejeitos radioativos compactáveis aplicando a tecnologia plasma para redução volumétrica. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26793

    BOIANI, N.F. ; SILVA, T.T. ; BORRELY, S.I. . Toxicity assessment of caffeine, fluoxetine and their mixture on Daphnia similis: acute and cronic effects. In: SOCIETY OF ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (SETAC) LATIN AMERICA BIENNIAL MEETING, 13th, September 15-18, 2019, Cartagena, Colombia. Abstract... Pensacola, FL, USA: Society of Environmental Toxicology and Chemistry, 2019. p. 109-109.

    Abstract: Emerging pollutants have already become a global problem, and they have been detected in dozens of countries, including Brazil. Even at very low concentrations, most of the emerging compounds are able to induce changes into biochemical system of aquatic organisms and they have also been reported as negative products to human health. Pharmaceuticals are considered as emerging contaminants detected in estuarine environment, in wastewater treatment facilities, lakes and rivers and even in sea waters. Generally the pharmaceuticals are detected among many other compounds into the ecosystem. The interaction of mixtures of contaminants is an important issue to be considered in monitoring programs as well as the negative effect to aquatic biota. The aim of the present paper was the assessment of toxic effects of pharmaceuticals exposed to Daphnia similis crustacean, individual and combined mixture of caffeine and fluoxetine. Caffeine (CAF) is a stimulant with cardiac, cerebral, diuretic and respiratory effects while Fluoxetine (FLX) is a selective serotonin re-uptake inhibitor, widely prescribed as antidepressant, (also known as Prozac®). The juveniles of D. similis were exposed separetaly to both caffeine (100mg/L) and to fluoxetine (20mg/L), and to a mixture of both (50mg/L caffeine and 20mg/L fluoxetine). Several experimental trials of acute immobilization test were performed. EC50 values ranged from 29,7 to 31 mg/L-1 for caffeine, and from 1.0 to 1.4 mg/L-1 for fluoxetine. Antagonistic effects of binary mixtures (EC50 = 15.2%) were observed. A chronic reproduction test was performed for the mixture of pharmaceuticals. We observed effects on D.similis survival, after 5 days. The mixture led to decrease of 72% in the reproduction, in maximum concentration (2.5% of the mixture – CAF 50ppm + FLX 20ppm). Concerning the importance of assessing toxicity the elected pharmaceuticals concentration were higher than those detected in the envinroment. These results may be incorporated into risk assessments analysis in order to protect sensitive aquatic ecosystems more effectively.

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  • IPEN-DOC 27947

    SILVA, ANDERSON M.B.; SOUZA, DIVANIZIA N.; JUNOT, DANILO O. ; CALDAS, LINDA V.E. . Thermoluminescent analysis of silver addition in CaSO4 : Tb. In: ENCONTRO DE OUTONO DA SOCIEDADE BRASILEIRA DE FÍSICA, 42., 26-31 de maio, 2019, Aracaju, SE. Resumo... São Paulo, SP: Sociedade Brasileira de Física, 2019.

    Abstract: According to results of the literature, some unusual rare earth elements, such as terbium, have been shown to be promising as a dopant in CaSO4 matrix. Silver has also been used in the co-dopant function. As there are no reports on the structural characterization of CaSO4 : Tb with the incorporation of silver, the aim of this work was to produce and characterize terbium doped CaSO4 crystals, co-doped with silver oxide (Ag (Ox)) and silver nanoparticles (Ag (NP)). The main purpose is to use them as alternative TL dosimeters to those commercially available. The phosphors were produced by the slow evaporation route and characterized by X-ray diffraction (XRD), which confirmed the viability of the route, and by scanning electron microscopy (SEM). The silver nanoparticles were produced by the method of Lee and Meisel and characterized by ultraviolet-visible spectrophotometry (UV-Vis), SEM and XRD. The composites in the form of pellets were obtained from the addition of Teflon to the phosphors. The TL emissions of the new materials produced were investigated. It was observed that the addition of silver as a co-dopant in the CaSO4 : Tb matrix shifts its main TL peak to higher temperatures, and the presence of Ag (NP) increases the intensity of this peak. By means of the TL emission curves of the composites, some parameters associated with the charge transfer processes in these materials were determined. The lower detection limit of the composites was also evaluated. The crystals of CaSO4 : Tb; Ag(NP) presented higher sensitivity than CaSO4 : Tb; Ag(Ox). All samples have a luminescent signal reproducible and linear, with TL responses proportional to the absorbed doses.

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  • IPEN-DOC 27328

    DE FREITAS, L.F. ; DA CRUZ, C.C. ; VARCA, G. ; LUGAO, A.B. . The presence or absence of ethanol in radiolytic synthesis medium leads to different kinds of hybrid papain-gold nanoparticles. In: WORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGÃOS ARTIFICIAIS, 6th, October 29-31, 2019, São Paulo, SP. Abstract... 2019. p. 27-27.

    Abstract: Gold nanoparticles are widely used for a plethora of applications, however, the short and long term environmental impacts of those nanoparticles when they reach the soil, rivers, and sea have just recently been taken into consideration. Novel synthetic routes have been developed without the use of toxic reducing or capping agents so that the products are biocompatible and environment-friendly, in the so-called Green Nanotechnology. One of these methods is the radiolytic synthesis using gamma radiation, which does not require the use of any reducing agent. Different conditions in the synthesis medium can lead to different products, therefore the aim of this study was to investigate the effect of the presence of ethanol on the nanoparticles generated via radiolysis using gamma radiation. The synthesis medium consisted on a mixture of NaAuCl4 (5 x 10-4 mol L-1), isopropanol (0.2 mol-1); and papain as a stabilizer and coating agent (1 mg mL-1), with or without the presence of 20% ethanol. The samples were irradiated with 10 kGy in a gamma multipurpose irradiator (60Co source) and stored at 4 ºC until use. Their hydrodynamic diameter and zeta potential was assessed with a Zetasizer Nano ZS90 device (Malvern Instruments UK), and images of transmission electron microscopy (TEM) were taken in order to observe the real size and morphology of the nanoparticles in a 40,000X magnification. The presence of ethanol indeed leads to different kinds of nanoparticles. Their hydrodynamic diameter was 8.773 ± 2.3 nm (papain-AuNPs without ethanol) and 9.976 ± 2.9 nm (papain- AuNPs with 20% ethanol), and their zeta potentials were 34.4 ± 4,2 mV and 25.3 ± 3.58 mV, respectively. The TEM images revealed that when ethanol is absent, the nanoparticles formed consist on a gold core (approximately 5 nm in diameter) with papain coating. When ethanol is present, though, the nanoparticles consist on a papain core (approximately 10 nm) decorated with smaller gold nanoparticles. In conclusion, both protocols lead to stable nanoparticles with good control of size, especially in the absence of ethanol, but according to the desired applications, ethanol can be useful for the generation of nanoparticles with higher enzymatic activity from papain, i.e. proteolytic and permeation-enhancing activities.

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  • IPEN-DOC 26558

    GARCEZ, AGUINALDO S.; NARDINI, ELISA F.; CARDOSO, RIELSON; RIBEIRO, MARTHA S. . The potential of phytotherapeutic compounds available on the market as a new photosensitizers for dental antimicrobial PDT: a photochemical and photobiological in vitro study. In: HASAN, TAYYABA (Ed.) INTERNATIONAL PHOTODYNAMIC ASSOCIATION WORLD CONGRESS, 17th, June 28 - July 4, 2019, Cambridge, Massachusetts, USA. Abstract... Bellingham, WA, USA: SPIE, 2019. (Proceedings SPIE 11070).

    Abstract: This study evaluated Curcuma longa, Citrus lemon, Hamamelis virginiana and Hypericum perforatum available on the market as photosensitizers (FS) in Antimicrobial Photodynamic Therapy (aPDT). Each FS were analyzed in a spectrophotometer between 350 and 750 nm, to determine the ideal light source. Once the absorption bands were determined, 3 light sources were selected to determine the concentration of use, the compounds were verified at different concentrations on bovine dentin samples to evaluate the risk of staining. Once the concentration was determined, FS were evaluated for cytotoxicity on fibroblast culture. Each compound was then irradiated with each light source and evaluated for indirect reactive oxygen species (ROS) production. The bacterial reduction was tested in culture of E. faecalis in planktonic form and in biofilm using energy of 10 J and Energy Density of 26 J/cm2. The tested compounds had light absorption in three bands of the visible spectrum: violet (405 nm), blue (470 nm) and red (660 nm). At 1:6 concentration, none of the compounds promoted tooth staining, as none of the compounds showed significant toxicity in cells or bacterial suspension. In addition, when the compounds were irradiated at each wavelength, significant ROS production was observed. When the aPDT was performed on the planktonic and biofilm bacteria, significant microbial reduction was observed for both cases, reaching up to 5Logs of reduction. In conclusion, extracts of Curcuma longa, Citrus lemon, Hamamelis virginiana and Hypericum perforatum, showed potential for use in aPDT as photosensitizing agents.

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  • IPEN-DOC 26559

    SABINO, CAETANO P.; BAPTISTA, MAURICIO S.; RIBEIRO, MARTHA S. ; LINCOPAN, NILTON. The mechanisms of bacterial inactivation via MB-APDT avoid drug resistance. In: HASAN, TAYYABA (Ed.) INTERNATIONAL PHOTODYNAMIC ASSOCIATION WORLD CONGRESS, 17th, June 28 - July 4, 2019, Cambridge, Massachusetts, USA. Abstract... Bellingham, WA, USA: SPIE, 2019. (Proceedings SPIE 11070).

    Abstract: Antimicrobial photodynamic therapy (APDT) is trending as a powerful therapeutic platform to minimize the negative impacts of microbial drug resistance. The mechanisms of action of APDT are imposed as a generalized oxidation of all cellular structures. Therefore, is assumed that the development of resistance to APDT is very unlikely to occur due to its multitarget oxidative effects. Even though the instant effects of APDT may be interesting to several situations, the few microbial cells left alive after irradiation procedure may be enough to allow tissue recolonization. Therefore, to ensure higher effectiveness of APDT protocols should also rely on therapeutic combinations with longer lasting effects. In this study, we report the statistical correlation of bacterial inactivation rate with the degradation rate of lipids, proteins and DNA. We observed that APDT mediated by methylene blue (MB) and red light can induce degradation of enzymes associated with drug resistance. Thus, cells exposed to sublethal doses of MB-APDT may recover sensitivity to antibiotics they were previously resistant. This fact may lead to a time interval where highly resistant pathogens become sensitive to most standard drugs, such as penicillin. Additionally, we observed that drug-resistance genes present in bacterial DNA are severely damaged. Hence, drug resistance gene expression and/or dissemination to other cells should also be impaired. In summary, we can conclude that APDT also challenges drug resistance by degradation of related enzymes and DNA.

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  • IPEN-DOC 26777

    FREIRE, L.O. ; ANDRADE, D.A. de . The four functions of elementary pipe design from constructal law. In: CONSTRUCTAL LAW AND SECOND LAW CONFERENCE, March 11-13, 2019, Porto Alegre, RS. Resumo expandido... 2019. p. 1-4.

    Abstract: Constructal law explains the sense of evolution (morphing to improve flows) of beings, but paradoxes do exist as not all vegetables have a tree form. Also, not all animals are optimized for displacement. This work aims at identification of the design functions or objectives that guide evolution under the overall statement of constructal law. This work adopted the system engineering technique of segregation between functions (abstract objectives) and solutions (physical entities). Further, this work introduced the assumptions of flow under external threats and pipes subject to leakages. Results showed that there are always elements doing four functions in pipe element: to reduce flow entropy, to protect flow channel, to retain flow content and to increase flow drive. Although the four functions are always present, natural systems typically privileges some functions over others, depending on environmental pressures. As a solution to improve flows, animal brains also fit in the model of four functions. Human mind seems to have groups of instincts associated to each of the four pipe design functions (fear, attachment, curiosity and greed). Finally, the four functions model unified physics and animal psychology.

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✔ A pesquisa apresentará melhor resultado selecionando um dos filtros disponíveis em Navegar

✔ Os filtros disponíveis em Navegar tais como: Coleções, Ano de publicação, Títulos, Assuntos, Autores, Revista, Tipo de publicação são autoexplicativos. O filtro, Autores IPEN apresenta uma relação com os autores vinculados ao IPEN; o ID Autor IPEN diz respeito ao número único de identificação de cada autor constante no RD e sob o qual estão agrupados todos os seus trabalhos independente das variáveis do seu nome; Tipo de acesso diz respeito à acessibilidade do documento, isto é , sujeito as leis de direitos autorais, ID RT apresenta a relação dos relatórios técnicos, restritos para consulta das comunidades indicadas.

A opção Busca avançada utiliza os conectores da lógica boleana, é o melhor recurso para combinar chaves de busca e obter documentos relevantes à sua pesquisa, utilize os filtros apresentados na caixa de seleção para refinar o resultado de busca. Pode-se adicionar vários filtros a uma mesma busca.

Exemplo:

Buscar os artigos apresentados em um evento internacional de 2015, sobre loss of coolant, do autor Maprelian.

Autor: Maprelian

Título: loss of coolant

Tipo de publicação: Texto completo de evento

Ano de publicação: 2015

✔ Para indexação dos documentos é utilizado o Thesaurus do INIS, especializado na área nuclear e utilizado em todos os países membros da International Atomic Energy Agency – IAEA , por esse motivo, utilize os termos de busca de assunto em inglês; isto não exclui a busca livre por palavras, apenas o resultado pode não ser tão relevante ou pertinente.

✔ 95% do RD apresenta o texto completo do documento com livre acesso, para aqueles que apresentam o significa que e o documento está sujeito as leis de direitos autorais, solicita-se nesses casos contatar a Biblioteca do IPEN, bibl@ipen.br .

✔ Ao efetuar a busca por um autor o RD apresentará uma relação de todos os trabalhos depositados no RD. No lado direito da tela são apresentados os coautores com o número de trabalhos produzidos em conjunto bem como os assuntos abordados e os respectivos anos de publicação agrupados.

✔ O RD disponibiliza um quadro estatístico de produtividade, onde é possível visualizar o número dos trabalhos agrupados por tipo de coleção, a medida que estão sendo depositados no RD.

✔ Na página inicial nas referências são sinalizados todos os autores IPEN, ao clicar nesse símbolo será aberta uma nova página correspondente à aquele autor – trata-se da página do pesquisador.

✔ Na página do pesquisador, é possível verificar, as variações do nome, a relação de todos os trabalhos com texto completo bem como um quadro resumo numérico; há links para o Currículo Lattes e o Google Acadêmico ( quando esse for informado).

ATENÇÃO!

ESTE TEXTO "AJUDA" ESTÁ SUJEITO A ATUALIZAÇÕES CONSTANTES, A MEDIDA QUE NOVAS FUNCIONALIDADES E RECURSOS DE BUSCA FOREM SENDO DESENVOLVIDOS PELAS EQUIPES DA BIBLIOTECA E DA INFORMÁTICA.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI, clique aqui.


2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI, clique aqui.

O Repositório Digital do IPEN é um equipamento institucional de acesso aberto, criado com o objetivo de reunir, preservar, disponibilizar e conferir maior visibilidade à Produção Científica publicada pelo Instituto, desde sua criação em 1956.

Operando, inicialmente como uma base de dados referencial o Repositório foi disponibilizado na atual plataforma, em junho de 2015. No Repositório está disponível o acesso ao conteúdo digital de artigos de periódicos, eventos, nacionais e internacionais, livros, capítulos, dissertações, teses e relatórios técnicos.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.