Reposiório IPEN: Recent submissions

  • IPEN-DOC 25223

    MESSIAS, MARCELA Di G. . Atividade antimicrobiana de crotamina e crotamina-símile proveniente do veneno de serpentes do genêro Crotalus / Antimicrobial activity of crotamine and crotamine homologue from snake venom of Crotalus genus . 2017. Dissertação (Mestrado em Tecnologia Nuclear) - Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP, São Paulo. 61 p. Orientador: Patrick Jack Spencer. DOI: 10.11606/D.85.2018.tde-19092018-142633

    Abstract: Os venenos de serpentes são alvos de pesquisas constantes, pois possuem 90 a 95% do seu peso seco em proteínas que exercem diversas atividades fisiológicas em suas presas. As espécies do gênero Crotalus estudadas no presente trabalho possuem venenos capazes de induzir alterações neurotóxicas, miotóxicas e causam distúrbios de coagulação no caso do veneno de Crotalus vegrandis. A crotamina é um peptídeo catiônico proveniente do veneno de Crotalus durissus terrificus, com atividade miotóxica e antimicrobiana já descritas. O trabalho avaliou a atividade antimicrobiana de crotamina e crotamina-símile provenientes do veneno de serpentes do gênero Crotalus. O veneno bruto foi fracionado por três diferentes métodos cromatográficos, e, para avaliar a técnica, utilizou-se SDS-PAGE. Na etapa de identificação e caracterização de crotamina, foi feito ELISA, utilizando como anticorpo primário uma IgG policlonal anti-crotamina. A fim de analisar a atividade antimicrobiana foram realizados os ensaios de difusão em gota e CIM (Concentração inibitória mínima). A citoxicidade em células murinas, foi avaliada por MTS. A purificação por duas etapas cromatográficas foi suficiente para observarmos a presença da crotamina e crotamina-símile puras (SDS-PAGE). Foram identificados dois peptídeos promissores com relação à atividade antimicrobiana no veneno de C. vegrandis. Todas as amostras testadas foram imunorreativas. Os peptídeos apresentam atividade antimicrobiana com diferentes especificidades e potências. Não houve alta toxicidade frente à linhagem celular murina, apresentando-se como um futuro protofármaco.

    Palavras-Chave: snakes; venoms; antimicrobial agents; peptides; antibodies; enzyme immunoassay; toxicity; chromatography

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  • IPEN-DOC 25212

    LUZ, H.N. da; SOUZA, F.A. ; MORALLES, M. ; CARLIN, N.; OLIVEIRA, R.A.N.; BREGANT, M.; SUAIDE, A.A.P.; CHUBACI, J.F.D.; MATSUOKA, M.; SILVA, T.F.; MORO, M.V.; RODRIGUES, C.L.; MUNHOZ, M.G.. Characterization of multilayer Thick-GEM geometries as 10B converters aiming thermal neutron detection. EPJ Web of Conferences, v. 174, p. 1-4, 2018. DOI: 10.1051/epjconf/201817401012

    Abstract: Boron-based thermal neutron detectors have recently regained some attention from the instrumentation community as a strong alternative to helium-3 detectors. From the existing concepts exploiting boron layers in position sensitive detectors, the Cascade [1] is the one that takes full advantage of the 2D capabilities of gaseous detectors, with the position resolution not limited by the architecture of the detector. In this work, a proposal for the Cascade detector, based on Thick-GEMs is presented, together with some preliminary studies of the suitable pitch that optimizes the neutron conversion efficiency, while keeping the collection efficiency intact. The characterization of Thick-GEM prototypes produced in Brazil with hole pitch from 0.75 to 3 mm shows that these devices already present a stable performance at low gains, also resulting in fair energy resolution, when cascaded with a standard KaptonTM 50 µm GEM. Results of the first attempts of boron film depositions with Ion Beam Assisted Deposition and characterization by Ion Beam Analysis are also presented.

    Palavras-Chave: thermal neutrons; boron; electron multiplier detectors; thickness gages; cascade theory; geometry; neutron detection

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  • IPEN-DOC 25668

    BARROS, LIVIA F. . Determinação de k0 e Q0 para as reações 74Se(n, γ) 75Se, 113In(n, γ) 114mIn, 186W(n, γ) 187W e 191Ir(n, γ) 192Ir / Determination of k0 and Q0 for 74Se(n, γ) 75Se, 113In(n, γ) 114mIn, 186W(n, γ) 187W and 191Ir(n, γ) 192Ir reactions . 2018. Tese (Doutorado em Tecnologia Nuclear) - Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP, São Paulo. 166 p. Orientador: Mauro da Silva Dias. DOI: 10.11606/T.85.2018.tde-21092018-143710

    Abstract: Este trabalho teve o intuito de contribuir para a melhoria na qualidade dos valores de k0 e Q0 para as reações 74Se(n, γ) 75Se, 113In(n, γ) 114mIn, 186W(n, γ) 187W e 191Ir(n, γ) 192Ir. As medições das amostras irradiadas no reator IEA-R1 e das fontes padrão da Agência Internacional de Energia Atômica (IAEA) foram realizadas por espectrometria gama de alta resolução em detector de HPGe. A fim de investigar melhor as eficiências nos intervalos de energia onde não havia pontos experimentais, foi aplicado o Método de Monte Carlo. As contribuições originais deste trabalho foram: a análise de covariância associada ao Método dos Mínimos Quadrados, que foi utilizada para o tratamento adequado das incertezas para as reações 74Se(n, γ) 75Se, 113In(n, γ) 114mIn, 186W(n, γ) 187W e 191Ir(n, γ) 192Ir estudadas neste trabalho, onde todas as incertezas parciais envolvidas no processo foram utilizadas; a determinação experimental dos fatores de auto-blindagem para nêutrons térmicos (Gth) e epitérmicos (Ge) utilizados nas determinações de k0 e Q0 para a reação 113In(n, γ) 114mIn e na determinação experimental do fator de auto-blindagem para nêutrons epitérmicos (Ge) utilizado na determinação de k0 e Q0 para a reação 186W(n, γ) 187W, que não foram observadas na literatura, além da determinação de k0 obtida para a reação 186W(n, γ) 187W na energia de 625,51 keV, que também não existe na literatura recomendada. Os valores de k0 e Q0 obtidos para todas as reações foram comparados aos valores encontrados na literatura.

    Palavras-Chave: potassium; selenium 74; indium; tungsten; iridium; isotopes; nuclear reactions; gamma spectrometers; ge semiconductor detectors; high-purity ge detectors; neutron activation analyzers; monte carlo method; least square fit; calculation methods; data covariances

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  • IPEN-DOC 25221

    OLIVEIRA, GABRIEL L. de . Síntese de TiO2 com diferentes características físicas e químicas e sua aplicação como foto-catalizador no tratamento de efluentes / Synthesis of TiO2 with different physical and chemical characteristics and its application as a photocatalyst in the treatment of effluents . 2018. Dissertação (Mestrado em Tecnologia Nuclear) - Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP, São Paulo. 80 p. Orientador: Luís Antonio Genova. DOI: 10.11606/D.85.2018.tde-05092018-155330

    Abstract: Com o crescimento industrial e urbanização, diversos tipos de poluentes estão sendo encontrados com maior frequência e concentração em corpos hídricos. Um exemplo, são os corantes utilizados pelas indústrias têxteis. Grande parte desses poluentes, não é eliminada pelos processos atuais comumente empregados em estações de tratamento de águas residuais e plantas de tratamento de água potável. Devido a este fato, novas tecnologias para o tratamento da água estão sendo desenvolvidas, como os Processos Oxidativos Avançados (POAs). O objetivo do trabalho foi avaliar os fatores (físicos, químicos e estruturais) de um fotocatalisador (dióxido de titânio - TiO2), bem como as variáveis de um reator fotocatalítico que interferem na fotocatálise heterogênea (um tipo de POA). Para isso, sintetizou-se partindo do TiCl4, compostos de TiO2 com diferentes: morfologias (microesferas e nanotubos), características físicas e químicas, de modo a avaliar suas propriedades fotocatalíticas na degradação de corantes (azul de metileno e rodamina B), comparando os resultados aos obtidos com o nanopó comercial TiO2-P25. O reator fotocatalítico foi construído permitindo variar a potência, o comprimento de onda e a distância das lâmpadas para o sistema de reação. As microesferas sintetizadas a 550° (MT550) e nanotubos de titânia (NTT) apresentaram propriedades fotocatalíticas equivalentes ou superiores às do P25. O reator otimizado operou com quatro lâmpadas UVA próximas. O pH do meio foi determinante nos ensaios de fotocatálise. Sob pH neutro, as microesferas atuaram como adsorventes e fotocatalisadoras da rodamina B e adsorventes do azul de metileno. O P25 apresentou alta capacidade catalítica, em particular para meios neutro e básico. NTT demonstrou alta capacidade de adsorção do azul de metileno, porém baixo rendimento na adsorção e fotocatálise da rodamina B.

    Palavras-Chave: titanium oxides; photocatalysis; chemical properties; physical properties; water pollution control; waste water; waste processing; oxidation

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  • IPEN-DOC 25220

    MENZEL, FRANCINE . Método para aplicação da metodologia Best Estimate Plus Uncertainty (BEPU) em um Relatório Final de Análise de Segurança (RFAS) de uma planta genérica / Application method of Best Estimate Plus Uncertainty (BEPU) methodology in a Final Safety Analysis Report (FSAR) of a generic plant . 2018. Tese (Doutorado em Tecnologia Nuclear) - Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP, São Paulo. 141 p. Orientador: Gaianê Sabundjian. DOI: 10.11606/T.85.2018.tde-10092018-153236

    Abstract: O licenciamento de uma instalação nuclear é motivado pela necessidade de proteger os seres humanos e o meio ambiente das radiações ionizantes e, ao mesmo tempo, define as bases para a concepção e a determinação da aceitabilidade da planta. Uma parte importante no processo de licenciamento é a realização de uma análise de acidentes, a qual deve estar documentada no Relatório Final de Análise de Segurança (RFAS). Existem diferentes opções de cálculo na área de acidentes, combinando a utilização de códigos computacionais e dados de entrada, para fins de licenciamento. Uma delas é a Best Estimate Plus Uncertainty (BEPU), que considera dados de entrada realistas e as incertezas associadas. As aplicações de abordagens BEPU em processos de licenciamento iniciaram-se nos anos 2000, primeiro para análise de Acidente de Perda de Refrigerante (Loss of Coolant Accident - LOCA), e depois para a análise de acidentes como um todo, documentados no Capítulo 15 do RFAS. O presente trabalho tem como objetivo principal demonstrar que é possível a aplicação da metodologia BEPU em todas as análises contidas no RFAS, identificando as disciplinas-chave do processo de licenciamento e os códigos computacionais utilizados. Este trabalho foi desenvolvido em conjunto com a Universidade de Pisa, Itália, com a colaboração do Prof. Dr. Francesco D'Áuria. A principal motivação desse trabalho é o aprimoramento da metodologia BEPU para sua implementação em reatores do tipo PWR (Pressurized Water Reactor) no Brasil e no mundo, especialmente para fins de licenciamento, uma vez que as plantas nucleares brasileiras têm pouca experiência na área de cálculo de incertezas.

    Palavras-Chave: nuclear facilities; design; reporting requirements; safety reports; safety analysis; risk assessment; deterministic estimation; data covariances; measuring methods

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  • IPEN-DOC 25208

    KATTI, K.V.; KHOOBCHANDANI, M.; THIPE, V.C.; AL-YASIRI, A.Y.; KATTI, K.K.; LOYALKA, S.K.; SAKR, T.M.; LUGAO, A.B. . Prostate tumor therapy advances in nuclear medicine: green nanotechnology toward the design of tumor specific radioactive gold nanoparticles. Journal of Radioanalytical and Nuclear Chemistry, v. 318, n. 3, p. 1737-1747, 2018. DOI: 10.1007/s10967-018-6320-4

    Abstract: We report herein an innovative approach to prostate tumor therapy using tumor specific radioactive gold nanoparticles (198Au) functionalized with Mangiferin (MGF). Production and full characterization of MGF-198AuNPs are described. In vivo therapeutic efficacy of MGF-198AuNPs, through intratumoral delivery, in SCID mice bearing prostate tumor xenografts are described. Singular doses of the nano-radiopharmaceutical (MGF-198AuNPs) resulted in over 85% reduction of tumor volume as compared to untreated control groups. The excellent anti-tumor efficacy of MGF-198AuNPs are attributed to the retention of over 90% of the injected dose within tumors for long periods of time. The retention of MGF-198AuNPs is also rationalized in terms of the higher tumor metabolism of glucose which is present in the xanthanoid functionality of MGF. Limited/no lymphatic drainage of MGF-198AuNPs to various non-target organs is an attractive feature presenting realistic scope for the clinical translation of MGF-198AuNPs in for treating prostate cancers in human patients. The comparative analysis of MGF-198AuNPs with other radioactive gold nanoparticles, functionalized either with epigallocatechin gallate or the Gum Arabic, has revealed significantly superior tumoricidal characteristics of MGF-198AuNPs, thus corroborating the importance of the tumor-avid glucose motif of MGF. Oncological implications of MGF-198AuNPs as a new therapeutic agent for treating prostate and various solid tumors are presented.

    Palavras-Chave: neoplasms; prostate; nuclear medicine; gold; nanoparticles; therapy; nanotechnology; radiation effects; brachytherapy

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  • IPEN-DOC 25207

    HARAGUCHI, MARCIO I.; KIM, HAE Y.; CALVO, WILSON A.P. . Results of process equipment imaging by tomographic gamma scan. Chemical Engineering Transactions, v. 69, p. 649-654, 2018. DOI: 10.3303/CET1869109

    Abstract: Gamma scanning is a nuclear inspection technique widely used for troubleshooting industrial process equipments in refineries and petrochemicals. A radiation source and detector move vertically along the height of the vessel and the radiation readings are used to plot the graph of density profile. In recent years, many improvements have been added to this technique, but essentially the result of gamma scanning still consists of a 1-D density plot. Developed in 2012, the tomographic gamma scan uses image reconstruction techniques to show the result of gamma scan as a 2-D density distribution image. In this work, we present the current status of the technology and the results obtained by applying the technique to real operating process equipment. The results present images that match well with the 1-D density plots obtained by the conventional gamma scan and reveal process and operational problems that has never been visualized before with the traditional technique. The tomographic gamma scan can be immediately applied in practice with low financial investment.

    Palavras-Chave: image processing; tomography; gamma radiation; equipment; gamma fuel scanning; nondestructive testing; irradiation; radiation sources; electron scanning; gamma radiography; tomography; gamma radiation; distillation; gamma sources; irradiation

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  • IPEN-DOC 25206

    FREITAS, LUCAS F. de ; VARCA, GUSTAVO H.C. ; BATISTA, JORGE G. dos S. ; LUGAO, ADEMAR B. . An overview of the synthesis of gold nanoparticles using radiation technologies. Nanomaterials, v. 8, n. 11, 2018. DOI: 10.3390/nano8110939

    Abstract: At a nano-level, optical properties of gold are unique and gave birth to an emerging platform of nanogold-based systems for diverse applications, because gold nanoparticle properties are tunable as a function of size and shape. Within the available techniques for the synthesis of gold nanoparticles, the radiolytic synthesis allows proper control of the nucleation process without the need for reducing agents, in a single step, combined or not with simultaneous sterilization. This review details and summarizes the use of radiation technologies for the synthesis and preparation of gold nanoparticles concerning fundamental aspects, mechanism, current pathways for synthesis and radiation sources, as well as briefly outlines final applications and some toxicity aspects related to nanogold-based systems.

    Palavras-Chave: gold; nanoparticles; gamma radiation; electron beams; x-ray sources; radiolysis; nanotechnology; medicine; diagnostic uses; ionizing radiations

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  • IPEN-DOC 25210

    LEITE, VICTOR C.; SCHIRRU, ROBERTO; MATTAR NETO, MIGUEL . Particle swarm optimization applied to the nuclear fuel bundle spacer grid spring design. Nuclear Technology, v. 205, n. 5, p. 637-645, 2019. DOI: 10.1080/00295450.2018.1516056

    Abstract: One of the main roles of the nuclear fuel bundle spacer grid (SG) is to safely support the fuel rods (FRs) through springs and dimples. The SG design is an important matter for nuclear power plant operation when a damaged FR could release fission products. For this work, Particle Swarm Optimization (PSO) is applied to define the geometries of the springs and dimples existing in a SG. Other algorithms had been used to optimize these geometries but not PSO. This paper proposes a PSO variable model and its fitness function in order to define an optimized geometry for the spring and the dimple so that they can provide sufficient gripping forces and minimize stresses. The implemented PSO was able to generate geometries of springs and dimples with stresses minimized and with a specific required stiffness value. The results of these two characteristics are compared with other results in the literature. For further work, PSO will be used to optimize other important design characteristics of a SG: grid-to-rod fretting, coolant flow-induced vibration, and the function of mixing coolant.

    Palavras-Chave: spacers; grids; springs; optimization; fuel rods; finite element method

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  • IPEN-DOC 25205

    FREIRE, LUCIANO O. ; ANDRADE, DELVONEI A. de . Economically feasible mobile nuclear power plant for merchant ships and remote clients. Nuclear Technology, v. 205, n. 6, p. 766-780, 2019. DOI: 10.1080/00295450.2018.1546067

    Abstract: Recent studies point to a reduction of atmospheric pollution using nuclear energy for merchant ships. This work examines the development of an economically competitive nuclear power solution for merchant ship propulsion. The solution also addresses the requirements of a wider market, like islands, offshore oil platforms, and remote cities. System engineering and analysis at various product breakdown levels also propose architectural options to improve competitiveness of nuclear power in mobile nuclear power plants (MNPPs). Analyses include market research on clients and technical considerations on nuclear energy costs. The results show that an enterprise that delivers electric power to remote clients and dedicates to management of all nuclear aspects seems to be the best organizational and technical choice. Besides, ships should be of modular type and the MNPPs should be easily detachable at sea. Only container ships and remote islands demand enough power to justify the use of nuclear power. Nuclear power has high probability to be economically competitive for large container ships, however, only if public policies impose levels of risks akin to other industries.

    Palavras-Chave: nuclear power plants; nuclear energy; nuclear merchant ships; control systems; remote control; economic impact; environmental impacts; feasibility studies

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  • IPEN-DOC 25219

    SOUZA FILHO, EDVAN A. de . Caracterização de filmes de TiO2, N:TiO2 e TiO2/N:TiO2 obtidos por deposição química de organometálicos em fase vapor / Characterization of TiO2, N:TiO2 and TiO2/N:TiO2 films obtained by metallorganic chemical vapor deposition . 2017. Dissertação (Mestrado em Tecnologia Nuclear) - Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP, São Paulo. 87 p. Orientador: Marina Fuser Pillis. DOI: 10.11606/D.85.2018.tde-15062018-105555

    Abstract: Filmes finos de TiO2 e N:TiO2, e multicamadas TiO2/N:TiO2 foram crescidos sobre substratos de aço AISI 316 e Si(100), por meio da técnica de deposição química de organometálicos em fase vapor (MOCVD). Foram produzidos filmes com diferentes espessuras, nas temperaturas de 400 e 500°C. Os filmes foram caracterizados utilizando-se técnicas de difração de raios X (DRX), espectroscopia de fotoelétrons excitados por raios x (XPS) e microscopia eletrônica de varredura (MEV). A resistência à corrosão foi avaliada por meio de testes de polarização potenciodinâmica em eletrólito 3,5%p NaCl. Filmes não dopados, crescidos a 400°C, apresentaram TiO2 anatase, enquanto que os crescidos a 500°C apresentaram a fase rutilo, além de anatase. Nos filmes dopados com nitrogênio (7,29 e 8,29 at% a 400 e 500°C, respectivamente), em ambas as temperaturas, houve a formação de TiO2 anatase, bem como de fases contendo nitrogênio. Os filmes de TiO2 crescidos a 400°C ofereceram melhor proteção contra a corrosão que os crescidos a 500°C. Filmes crescidos a 500°C apresentaram estrutura colunar, que representa alto nível de porosidade, enquanto que os filmes crescidos a 400°C apresentaram estrutura mais densa. A dopagem não foi eficiente para proteger o substrato contra corrosão, provavelmente devido à formação das fases contendo nitrogênio. Os resultados para os testes com filmes compostos por multicamadas sugerem que aqueles com mais interfaces apresentam melhor resistência à corrosão. O processo de corrosão das amostras se inicia na superfície do filme, que está em contato com o meio agressivo, originando pites, que permitem ao meio corrosivo acessar o substrato metálico. O metal é atacado e dissolvido sob o filme, e resulta na delaminação do filme.

    Palavras-Chave: titanium oxides; films; thin films; doped materials; chemical vapor deposition; site characterization

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  • IPEN-DOC 25204

    DUTRA, VERUSKA C.; AQUINO, AFONSO R. . Aplicação e análise da pressão turística como indicador ambiental no Parque Estadual do Jalapão (TO) / Application and analysis of tourist pressure as an environmental indicator in Jalapão State Park (TO, Brazil). Revista Brasileira de Ecoturismo, v. 11, n. 3, p. 311-334, 2018.

    Abstract: O presente artigo visa analisar a aplicabilidade ou não do monitoramento do turismo com o foco na sustentabilidade por meio de indicadores chave do Turismo sustentável propostos pela Organização Mundial do Turismo. A aplicação foi feita em um estudo de caso na unidade de conservação Parque Estadual do Jalapão - PEJ, localizado no Estado do Tocantins, Brasil. Esta é uma pesquisa de caráter interdisciplinar, que teve como norteador o método dedutivo cujo resultado, o indicador Pressão do PEJ, será apresentado. Conclui-se que os pontos chave do turismo sustentável analisados com foco em indicadores ambientais são uma importante ferramenta de avaliação e quantificação desta atividade no destino em estudo e se mostrou adequada para o monitoramento da região. Foi igualmente possível traduzir os principais impactos ambientais que ocorrem nos atrativos e sua intensidade, o que viabilizou uma análise que objetiva traçar caminhos para a correção e prevenção dos impactos apresentados.

    Palavras-Chave: environment; environmental protection; tourism; environmental impacts; sustainable development; water pollution monitors; ecology; ecological balance; brazil

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  • IPEN-DOC 25203

    DONATUS, UYIME ; FERREIRA, RAPHAEL O.; MOGILI, NAGA V.V.; VIVEIROS, BARBARA V.G. de ; MILAGRE, MARIANA X. ; COSTA, ISOLDA . Corrosion and anodizing behaviour of friction stir weldment of AA2198- T851 Al-Cu-Li alloy. Materials Chemistry and Physics, v. 219, p. 493-511, 2018. DOI: 10.1016/j.matchemphys.2018.08.053

    Abstract: Anodizing behaviour of AA2198-T851 friction stir weldment and the corrosion behaviour of unpolished and polished weldments of the alloy have been investigated. Electrochemical and microscopic techniques were employed in the study. The results revealed that the manufacturing-process induced near-surface deformed layer significantly affected the corrosion behaviour of the weldment. Thus, the corrosion behaviour of the weldment in the polished condition (which is the common practice) was different from that of the unpolished one due to the presence of near-surface deformed layer. Anodizing as a corrosion protection method for the weldment caused the formation of pronounced non-uniform oxide layer thicknesses across the weld zones. This was because the weldment oxidized at a higher rate compared with the parent material (PM) due to an increased proportion of Li in solid solution in the stir zone of the weldment.

    Palavras-Chave: chemical reactions; corrosion; anodization; aluminium alloys; friction welding; pitting corrosion; surface properties; lithium alloys; copper alloys; microstructure

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  • IPEN-DOC 25202

    DANTONIO, PAOLA M.; KLEIN, MARIANNE O.; FREIRE, MARIA R.V.B. ; ARAUJO, CAMILA N.; CHIACETTI, ANA C.; CORREA, RICARDO G.. Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy. Bioscience Reports, v. 38, n. 5, p. BSR20180511-1 - BSR20180511-34, 2018. DOI: 10.1042/BSR20180511

    Abstract: Although most melanoma cases may be treated by surgical intervention upon early diagnosis, a significant portion of patients can still be refractory, presenting low survival rates within 5 years after the discovery of the illness. As a hallmark, melanomas are highly prone to evolve into metastatic sites. Moreover, melanoma tumors are highly resistant to most available drug therapies and their incidence have increased over the years, therefore leading to public health concerns about the development of novel therapies. Therefore, researches are getting deeper in unveiling the mechanisms by which melanoma initiation can be triggered and sustained. In this context, important progress has been achieved regarding the roles and the impact of cellular signaling pathways in melanoma. This knowledge has provided tools for the development of therapies based on the intervention of signal(s) promoted by these cascades. In this review, we summarize the importance of major signaling pathways (mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)-Akt, Wnt, nuclear factor κ-light-chain-enhancer of activated B cell (NF-κB), Janus kinase (JAK)-signal transducer and activator of transcription (STAT), transforming growth factor β (TGF-β) and Notch) in skin homeostasis and melanoma progression. Available and developing melanoma therapies interfering with these signaling cascades are further discussed.

    Palavras-Chave: melanomas; neoplasms; skin; epitheliomas; biological pathways; proteins; mitosis; cascade theory

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  • IPEN-DOC 25218

    MARQUES, CAIO P. . Determinação da taxa de desintegração dos emissores beta puros P-32 e Sr-90/Y-90 em sistema de cintilação líquida / Determination of desintegration rate of the beta pure emitters 32P and 90Sr 90Y in liquid scintillation system . 2017. Dissertação (Mestrado em Tecnologia Nuclear) - Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP, São Paulo. 68 p. Orientador: Marina Fallone Koskinas. DOI: 10.11606/D.85.2018.tde-10092018-121208

    Abstract: No presente trabalho, foram padronizados os radionuclídeos emissores beta puros 32P e 90Sr 90Y. O primeiro foi medido nos sistemas comerciais de cintilação líquida TRICARB 2100 e HIDEX 300SL, que utilizam, respectivamente, dois e três tubos fotomultiplicadores. A análise dos dados adquiridos pelo primeiro e segundo sistemas foi realizada pela aplicação dos métodos CIEMAT/NIST e TDCR, respectivamente. Para padronização da solução de 32P, foi também utilizado o sistema 4πβ empregando-se a técnica de autoabsorção. A solução de 90Sr 90Y foi padronizada no sistema de cintilação líquida, HIDEX 300SL, pelo método TDCR, e pela técnica do traçador, no sistema de coincidência 4πβ-γ o qual é composto por um contador proporcional à gás fluente, acoplado a dois cristais cintiladores de NaI(Tl). A taxa de desintegração foi determinada pela técnica de extrapolação, por meio de absorvedores externos. Para aplicação da técnica do traçador, foi utilizada uma solução de 60Co, emissor beta-gama previamente padronizado no sistema de coincidências. Foi realizada, também, uma simulação dos processos de detecção neste sistema por meio do programa ESQUEMA, que, pela simulação de Monte Carlo, prediz a curva de extrapolação da eficiência. Os resultados obtidos para o 32P nos sistemas utilizados apresentaram um bom acordo, dentro das incertezas experimentais, bem como os obtidos para o 90Sr 90Y, em sistema de cintilação e sistema de coincidência, apresentando bom acordo, dentro das incertezas experimentais. O resultado obtido pela técnica de Monte Carlo apresentou boa concordância com o valor obtido com o sistema de coincidência. Os resultados indicam a qualidade e boa precisão dos sistemas de detecção utilizados neste trabalho, quando empregados para fins metrológicos.

    Palavras-Chave: radioisotopes; beta decay radioisotopes; electron beams; phosphorus 32; strontium 90; yttrium 90; liquid scintillation detectors; monte carlo method; standardization

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  • IPEN-DOC 25209

    LEISTENSCHNEIDER, E.; LEPINE-SZILY, A.; ALVAREZ, M.A.G.; MENDES, D.R.; LICHTENTHALER, R.; AGUIAR, V.A.P.; ASSUNCAO, M.; PAMPA CONDORI, R.; SILVA, U.U. da; FARIA, P.N. de; DESHMUKH, N.; DUARTE, J.G.; GASQUES, L.R.; GUIMARAES, V.; MACCHIONE, E.L.A.; MORAIS, M.C.; MORCELLE, V.; PIRES, K.C.C.; SCARDUELLI, V.B.; SCOTTON, G.; SHORTO, J.M.B. ; ZAGATTO, V.A.B.. Spectroscopy of high-lying resonances in 9Be by the measurement of ( p, p), ( p, d), and ( p, α) reactions with a radioactive 8Li beam. Physical Review C, v. 98, n. 6, p. 064601-1 - 064601-1, 2018. DOI: 10.1103/PhysRevC.98.064601

    Abstract: We measured the 8Li(p, p)8Li, 8Li(p, d)7Li, and 8Li(p, α)5He reactions at low energies using the thick target inverse kinematics method, with a polyethylene [CH2]n target and a radioactive 8Li beam available at the Radioactive Ion Beams in Brazil facility of São Paulo. By measuring simultaneously several reaction channels (p, p), (p, d), and (p, α), the still uncertain high-lying resonances of 9Be, close to the proton threshold, can be studied and their parameters, such as energy, width, and spin parity can be more reliably determined. The experimental excitation functions of the reactions 8Li(p, p)8Li, 8Li(p, d)7Li, and 8Li(p, α)5He were analyzed using the R-matrix theory, which allows us to infer the properties of the resonances. Multichannel R-matrix analysis provides evidence for a significant clustering in the (p, d) channel. The experimental data and the multichannel R-matrix analysis will be presented.

    Palavras-Chave: spectroscopy; lithium 8 beams; beryllium 9; resonance; radioactive ion beams; elastic scattering; polyethylenes; targets; nucleosynthesis; excitation functions

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  • IPEN-DOC 25201

    CREMA, E.; ZAGATTO, V.A.B.; SHORTO, J.M.B. ; PAES, B.; LUBIAN, J.; SIMOES, R.F.; MONTEIRO, D.S.; HUIZA, J.F.P.; ADDED, N.; MORAIS, M.C.; GOMES, P.R.S.. Reaction mechanisms of the O-18+Cu-63 system at near-barrier energies. Physical Review C, v. 98, n. 4, p. 044614-1 - 044614-10, 2018. DOI: 10.1103/PhysRevC.98.044614

    Abstract: A precise quasielastic excitation function for the O-18 + Cu-63 system has been measured at energies around the Coulomb barrier at theta(LAB) = 161 degrees. The corresponding quasielastic barrier distribution has been derived. Two-neutron-, one-proton-, and alpha-transfer-excitation functions have also been measured at the same energies and angle. Coupled reaction channels calculations were performed to describe the experimental data. Largescale shell-model calculations were performed to derive most of the spectroscopic amplitudes. No surface imaginary potential was necessary for the interaction potential because almost all relevant reaction channels were explicitly included in the calculation. The theoretical results were compared to the experimental quasielastic barrier distribution and a very good agreement was achieved. The comparison of the coupled reaction channel calculations and data has put in evidence several important details of the reaction mechanism of the O-18 + Cu-63 system. The collectivity of the Cu-63 nucleus has important contribution to the reaction mechanism of this system, mainly due to its first 5/2(+) and 7/2(+) states. It was also observed a striking influence on the reaction dynamics of the O-18(2(+)) state, the two-neutron transfer and the reorientation of the target ground-state spin. The best agreement to data was achieved when the nuclear matter diffuseness for the O-18 was assumed equal to 0.60 fm, value that we have derived in a previous paper and that is 10% greater than the O-16 diffuseness. Another significant result was that the two-neutron transfer process is much more relevant than the one-neutron-transfer process, which suggests that the pairing correlation could play an important role in the transfer process of this system.

    Palavras-Chave: copper isotopes; oxygen 18 reactions; copper 63 target; elastic scattering; chemical reactions; theoretical data; experimental data

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  • IPEN-DOC 25200

    CAVALLARI, ROGER V. ; DE LIMA, NATASHA B. ; SILVA, JULIO C.M. ; BERGAMASHI, VANDERLEI S. ; FERREIRA, JOAO C. . Preparação de suporte de catalisador a partir de biocarbono / Preparation of catalyst support from bio carbon. Periódico Tchê Química, v. 15, n. 30, p. 115-126, 2018.

    Abstract: O uso exagerado de recursos não renováveis, nas ultimas décadas, deflagrou consequências negativas para a sociedade, havendo necessidade de buscar soluções diante dos efeitos deletérios causados pelo avanço da devastação do meio ambiente. Visando contribuir com a ampliação das estratégias de controle de poluentes através do desenvolvimento de tecnologia de baixo custo, o presente trabalho tem como objetivo principal o desenvolvimento de materiais ativos com elevada resistência térmica e boa área especifica para adsorção e impregnação de metais. Neste sentido foram estudados três rotas de tratamento do biocarvão. Na caracterização do biocarbono usaram-se métodos analíticos como: Espectroscopia de Infravermelho (IV), Espectroscopia RAMAM, Medida da Área Superficial (BET), Análise Térmica (TG), Difração de Raios X (DRX) e Microscopia Eletrônica de Varredura (MEV). As diferentes condições de tratamento resultaram em mudanças na estrutura carbonácea do biocarbono com características adequadas para serem utilizados como suporte em catalisadores, apresentando sítios ativos com cargas negativamente carregadas para promover a fixação de metais em sua superfície. Verificou-se também um aumento na área superficial específica, variando entre 341,4 a 749,7 m2 g-1 e alterações nas bandas D e G do carvão e uma alta resistência à temperatura, o que promove reações catalíticas com baixa perda de catalisador.

    Palavras-Chave: renewable energy sources; resources; activated carbon; catalysts; hydrothermal systems; x-ray diffraction; scanning electron microscopy; infrared spectrometers

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  • IPEN-DOC 25199

    BRITO, TARCISIO; JULIO, ALISON; BERNI, MATEUS; PONCIO, LISIANE de C.; BERNARDES, EMERSON S. ; ARAUJO, HELENA; SAMMETH, MICHAEL; PANE, ATTILIO. Transcriptomic and functional analyses of the piRNA pathway in the Chagas disease vector Rhodnius prolixus. PLOS Neglected Tropical Diseases, v. 12, n. 10, p. e0006760-1 - e0006760-20, 2018. DOI: 10.1371/journal.pntd.0006760

    Abstract: The piRNA pathway is a surveillance system that guarantees oogenesis and adult fertility in a range of animal species. The pathway is centered on PIWI clade Argonaute proteins and the associated small non-coding RNAs termed piRNAs. In this study, we set to investigate the evolutionary conservation of the piRNA pathway in the hemimetabolous insect Rhodnius prolixus. Our transcriptome profiling reveals that core components of the pathway are expressed during previtellogenic stages of oogenesis. Rhodnius' genome harbors four putative piwi orthologs. We show that Rp-piwi2, Rp-piwi3 and Rp-ago3, but not Rp-piwi1 transcripts are produced in the germline tissues and maternally deposited in the mature eggs. Consistent with a role in Rhodnius oogenesis, parental RNAi against the Rp-piwi2, Rp-piwi3 and Rp-ago3 results in severe egg laying and female adult fertility defects. Furthermore, we show that the reduction of the Rp-piwi2 levels by parental RNAi disrupts oogenesis by causing a dramatic loss of trophocytes, egg chamber degeneration and oogenesis arrest. Intriguingly, the putative Rp-Piwi2 protein features a polyglutamine tract at its N-terminal region, which is conserved in PIWI proteins encoded in the genome of other Triatomine species. Together with R. prolixus, these hematophagous insects are primary vectors of the Chagas disease. Thus, our data shed more light on the evolution of the piRNA pathway and provide a framework for the development of new control strategies for Chagas disease insect vectors.

    Palavras-Chave: trypanosoma; protozoa; insects; proteins; rna processing; drosophila; disease vectors

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  • IPEN-DOC 25198

    BRANT, ANTONIO J.C. ; NAIME, NATALIA ; LUGAO, ADEMAR B. ; PONCE, PATRICIA . Influence of ionizing radiation on biodegradable foam trays for food packaging obtained from irradiated cassava starch. Brazilian Archives of Biology and Technology, v. 61, n. e18160520, 2018. DOI: 10.1590/1678-4324-2018160520

    Abstract: Biodegradable polymers, such as starch, cellulose, and derivatives thereof, are being studied to produce innovative packaging in the most diverse shapes (films, bags, trays, bottles, etc.) to attend this current market trend. The aim of this work was to produce foam trays from cassava starch for food packaging via extrusion followed by thermoforming process. Their formulations were based on unirradiated and γ-irradiated starches at diverse radiation absorbed doses (in kGy) in order to evaluate the influence of the irradiated starches on the physical properties of the trays. Water absorption results showed an irregular increase with the increase of the absorbed dose ( for example, 26.32% and 39.84% for the trays based on unirradiated starch 0 kGy and 1:1 (w/w) mixture of starches 0 kGy and 100.0 kGy, respectively). Other physicochemical properties were evaluated from the starches utilized and the trays obtained. Aerobic biodegradation of the foams by mass loss also was checked in soil burial test.

    Palavras-Chave: ionizing radiations; gamma radiation; cassava; starch; packaging; biodegradation; compression strength; physical properties; hot pressing; foams; absorbed radiation doses; extrusion; flexibility

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  • IPEN-DOC 25197

    BIANCOLLI, ANA L.G.; HERRANZ, DANIEL; WANG, LIANQIN; STEHLIKOVA, GABRIELA; BANCE-SOUALHI, RACHIDA; PONCE-GONZALEZ, JULIA; OCON, PILAR; TICIANELLI, EDSON A.; WHELLIGAN, DANIEL K.; VARCOE, JOHN R.; SANTIAGO, ELISABETE I. . ETFE-based anion-exchange membrane ionomer powders for alkaline membrane fuel cells: a first performance comparison of head-group chemistry. Journal of Materials Chemistry A, v. 6, n. 47, p. 24330-24341, 2018. DOI: 10.1039/c8ta08309f

    Abstract: In the last few years, the development of radiation-grafted powder-form anion-exchange ionomers (AEI), used in combination with anion-exchange membranes (AEM), has led to the assembly of AEM-based fuel cells (AEMFC) that routinely yield power densities ranging between 1-2 W cm(-2) (with a variety of catalysts). However, to date, only benzyltrimethylammonium-type powder AEIs have been evaluated in AEMFCs. This study presents an initial evaluation of the relative AEMFC power outputs when using a combination of ETFE-based radiation-grafted AEMs and AEIs containing three different head-group chemistries: benzyltrimethylammonium (TMA), benzyl-N-methylpyrrolidinium (MPY), and benzyl-N-methylpiperidinium (MPRD). The results from this study strongly suggest that future research should focus on the development and operando long-term durability testing of AEMs and AEIs containing the MPRD head-group chemistry.

    Palavras-Chave: alkaline electrolyte fuel cells; ethylene; anions; ion exchange materials; powders; radiation doses; scanning electron microscopy

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  • IPEN-DOC 25196

    ARAUJO, LEANDRO G. de ; MARUMO, JULIO T. . Reaction of ion exchange resins with Fenton's reagent. Environments, v. 5, n. 11, 2018. DOI: 10.3390/environments5110123

    Abstract: One of the most common treatment methods for spent ion exchange resins is their immobilization in cement, which reduces the release of radionuclides into the environment. Although this method is efficient, it considerably increases the final volume of the waste due to its low incorporation capacity. This work aims to evaluate the degradation of ion exchange resins by the Fenton process (H2O2/Fe (2+)). The resin evaluated was a mixture of cationic and anionic resins, both non-radioactive. The reactions were conducted by varying the catalyst concentration (25, 50, 100, and 150 mmol L-1) and the volume of hydrogen peroxide. Three different temperatures were evaluated by varying the flow of reactants, which were 50, 60, and 70 degrees C. Cement specimens were prepared from the treated solutions and two parameters were assessed-namely, final setting time and axial compressive strength. The results showed that the experimental conditions were suitable to dissolve the resins, and the Fe3+ produced as precipitate during the experiments increased the resistance of the final product. The immobilized product complied with the limits established by regulation.

    Palavras-Chave: ion exchange; reagents; resins; waste management; solid wastes; infrared spectrometers; thermal degradation; oxidation; decomposition

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  • IPEN-DOC 25195

    AQUINO, SIMONE; LIMA, JOSE E.A. de; NASCIMENTO, ANA P.B. do; REIS, FABRICIO C. . Analysis of fungal contamination in vehicle air filters and their impact as a bioaccumulator on indoor air quality. Air Quality, Atmosphere & Health, v. 11, n. 10, p. 1143-1153, 2018. DOI: 10.1007/s11869-018-0614-0

    Abstract: Studies on air quality within automotive vehicles are an emerging research area in Brazil, especially in the city of São Paulo, one of the most polluted cities in the world and with the largest fleet of vehicles in the country. Indoor air quality is an indicator of environmental health that takes into account, in addition to thermal comfort, factors that interfere in precarious air conditions, such as the presence of fungi, bacteria and carbon dioxide in indoor air-conditioned environments. The objective of the present study was to analyse the fungal contamination in air-conditioning filters collected from 21 automotive vehicles and the study found 17 fungal genera in all samples collected (100%), including toxigenic fungi such as Penicillium, Fusarim and Aspergillus, indicating that indoor air quality can compromise the health of a portion of the population, such as professional drivers. Among the Aspergillus genus, the results showed the presence of the A. flavus, A. niger, A. fumigatus, A. ochraceus and A. clavatus species, which cause severe allergic and pulmonary respiratory diseases. Air in artificially heated environments should provide comfort to its occupants but it may pose a risk to human health if the car filtration system is contaminated by pathogenic fungi.

    Palavras-Chave: fungi; air quality; air pollution; vehicles; automobiles; air filters; air conditioning; pathogens; microorganisms; wastes; indoor air pollution; urban areas

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  • IPEN-DOC 25211

    LOPES, P.S.; CORAZZA, F.G.; NAMBU, F.A.N.; ERNESTO, J.V.; VARCA, G.H.C. ; LEITE-SILVA, V.R.; ANDREO-FILHO, N.. In vitro permeability assay using an epithelial model of Caco-2/HT29-MTX/Raji-B cells: enhancer aspects of a papain-cyclodextrin complex. Toxicology Letters, v. 295, Suppl. 1, p. S75-S75, 2018. DOI: 10.1016/j.toxlet.2018.06.534

    Abstract: The oral route is one of the main routes for administration of drugs, however, the gastrointestinal tract is a hostile environment due to pH variation, presence of several digestive enzymes and the intestinal barrier that undermines the permeation of drugs. The aim of this study was to evaluate the ability of papain complexed with β-cyclodextrin to enhancer the permeation of furosemide, as a model drug, in a triple co-culture of Caco-2, HT29-MTX and Raji cells. Papain and the papain-β-cyclodextrin complex were evaluated at 0.3, 0.7 and 1.0 μM and the biophysical integrity of the cell layer was evaluated by RET (Transepitelial Electrical Resistance) at 0, 4, 24, 48 and 72 hours. The epithelium was also stained using DAPI and Alexa Fluor™ 488 Phalloidin. HPLC was employed to quantification of furosemide. The RET results at initial time for all the samples and control were in a range of 267.63 to 318.28 Ω*cm2 and after 72 h this values were raised to a range of 365.14 to 492.64 Ω*cm2. There was a decrease of RET after samples’ application, nevertheless, the results showed that the epithelium presents a recovery, proportional to the time of cell replication, and that this recovery occurs in all samples tested with no significant statistical difference. The RET recovery implies that papain, complexed or not, was not able to kill the cells, corroborating the hypothesis that the action mechanism is the disruption of the tight junction. In addition, the triple co-culture presents a higher resistance to papain action, in comparison with the Caco-2 monolayer assays, emphasizing the importance of testing new drugs, potential candidates for oral formulations, in epitheliums that faithfully mimics what actually happens in in vivo systems. The fluorescent microscopy observation of the cells stained with DAPI and the junctions stained with Alexa Fluor™ 488 Phalloidin, showed that co-culture exhibits microvilli inherent to the intestinal tissue. The results obtained in the triple co-culture model bi-directional transport experiments confirmed the significant increase in furosemide transport indicating the importance of the paracellular route. In conclusion, the triple co-culture model was successfully standardized and papain complexed with β-cyclodextrin acts probably over the tight junctions enhancing the permeation of furosemide.

    Palavras-Chave: drugs; papain; digestive system; animal cells; epithelium

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  • IPEN-DOC 25194

    METAIRON, SABRINA ; ZAMBONI, CIBELE B. ; SUZUKI, MIRIAM F. ; BUENO, CARLOS R.. Evaluation of ions and metals in the blood of GRMD dogs submitted to hASCs therapy by NAA and XRF techniques. Applied Radiation and Isotopes, v. 143, p. 107-112, 2019. DOI: 10.1016/j.apradiso.2018.10.024

    Abstract: The elements Br, Ca, Cl, Cr, Fe, K, Mg, Na, P, Rb, S, and Zn were investigated in the whole blood samples of Golden Retriever dogs submitted to cell therapy (hASCs). These analyses were performed over 2 years using Neutron Activation Analysis and X-Ray Fluorescence techniques. The results were compared with control and untreated dog's. A significant increase was observed in K blood levels. There was also variation in blood levels of Br, Cr, Fe, Rb, S, and Zn.

    Palavras-Chave: blood cells; neutron activation analysis; dogs; x-ray fluorescence analysis; therapy; adipose tissue; animal tissues; ions; metals

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  • IPEN-DOC 25193

    FURIGO, ISADORA C.; SUZUKI, MIRIAM F. ; OLIVEIRA, JOAO E. ; RAMOS-LOBO, ANGELA M.; TEIXEIRA, PRYSCILA D.S.; PEDROSO, JOAO A.; ALENCAR, AMANDA de; ZAMPIERI, THAIS T.; BUONFIGLIO, DANIELLA C.; QUARESMA, PAULA G.F.; PRADA, PATRICIA O.; BARTOLINI, PAOLO ; SOARES, CARLOS R.J. ; DONATO JUNIOR, JOSE. Suppression of prolactin secretion partially explains the antidiabetic effect of bromocriptine in ob/ob mice. Endocrinology, v. 160, n. 1, p. 193-204, 2019. DOI: 10.1210/en.2018-00629

    Abstract: Previous studies have shown that bromocriptine mesylate (Bromo) lowers blood glucose levels in adults with type 2 diabetes mellitus; however, the mechanism of action of the antidiabetic effects of Bromo is unclear. As a dopamine receptor agonist, Bromo can alter brain dopamine activity affecting glucose control, but it also suppresses prolactin (Prl) secretion, and Prl levels modulate glucose homeostasis. Thus, the objective of the current study was to investigate whether Bromo improves insulin sensitivity via inhibition of Prl secretion. Male and female ob/ob animals (a mouse model of obesity and insulin resistance) were treated with Bromo and/or Prl. Bromo-treated ob/ob mice exhibited lower serum Prl concentration, improved glucose and insulin tolerance, and increased insulin sensitivity in the liver and skeletal muscle compared with vehicle-treated mice. Prl replacement in Bromo-treated mice normalized serum Prl concentration without inducing hyperprolactinemia. Importantly, Prl replacement partially reversed the improvements in glucose homeostasis caused by Bromo treatment. The effects of the Prl receptor antagonist G129R-hPrl on glucose homeostasis were also investigated. We found that central G129R-hPrl infusion increased insulin tolerance of male ob/ob mice. In summary, our findings indicate that part of Bromo effects on glucose homeostasis are associated with decrease in serum Prl levels. Because G129R-hPrl treatment also improved the insulin sensitivity of ob/ob mice, pharmacological compounds that inhibit Prl signaling may represent a promising therapeutic approach to control blood glucose levels in individuals with insulin resistance.

    Palavras-Chave: endocrine diseases; bromine; glucose; insulin; diabetes mellitus; homeostasis; mice

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  • IPEN-DOC 25192

    GOTARDELO, DANIEL R. ; COURROL, LILIA C.; BELLINI, MARIA H. ; SILVA, FLAVIA R. de O. ; SOARES, CARLOS R.J. . Porphyrins are increased in the faeces of patients with prostate cancer: a casecontrol study. BMC Cancer, v. 18, n. 1090, 2018. DOI: 10.1186/s12885-018-5030-1

    Abstract: Background: Experimental models of prostate cancer have demonstrated increased levels of protoporphyrin IX (PpIX) in the blood and faeces of mice. Hence, the quantification of these autofluorescent molecules could be hypothesized to be a potential marker for this type of tumour. In this case-control study, the autofluorescence of porphyrins in human faeces from patients with prostate cancer and control subjects was analysed using fluorescence spectroscopy. Methods: First, 3 mL of analytical-grade acetone was added to 0.3 g of faeces, and the mixture was macerated and centrifuged at 4000 rpm for 15 min. The supernatant was analysed spectroscopically. The emission spectra from 550 to 750 nm were obtained by exciting the samples at 405 nm. Results: A significant difference between the samples from control and cancer subjects was established in the spectral region of 670–675 nm (p = 0.000127), which corresponds to a significant increase in faecal porphyrins in patients with cancer. There was no statistically significant correlation between PSA levels and faecal porphyrins. Conclusion: In this preliminary study conducted in humans, the results show a simple and non-invasive method to assess faecal porphyrins, which have the potential to function as a tumour biomarker in patients with prostate cancer. This approach has improved sensitivity and specificity over PSA testing. Additional prospective studies with larger sample sizes are required to validate these findings.

    Palavras-Chave: protoporphyrins; neoplasms; prostate; fluorescence spectroscopy; mice; laboratory animals; biological markers; patients; porphyrins

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  • IPEN-DOC 25191

    SILVA, CLEIDE M.R. da ; CHURA-CHAMBI, ROSA M. ; PEREIRA, LENNON R.; CORDEIRO, YRAIMA; FERREIRA, LUIS C. de S.; MORGANTI, LIGIA . Association of high pressure and alkaline condition for solubilization of inclusion bodies and refolding of the NS1 protein from zika virus. BMC Biotechnology, v. 18, n. 78, 2018. DOI: 10.1186/s12896-018-0486-2

    Abstract: Background: Proteins in inclusion bodies (IBs) present native-like secondary structures. However, chaotropic agents at denaturing concentrations, which are widely used for IB solubilization and subsequent refolding, unfold these secondary structures. Removal of the chaotropes frequently causes reaggregation and poor recovery of bioactive proteins. High hydrostatic pressure (HHP) and alkaline pH are two conditions that, in the presence of low level of chaotropes, have been described as non-denaturing solubilization agents. In the present study we evaluated the strategy of combination of HHP and alkaline pH on the solubilization of IB using as a model an antigenic form of the zika virus (ZIKV) non-structural 1 (NS1) protein. Results: Pressure-treatment (2.4 kbar) of NS1-IBs at a pH of 11.0 induced a low degree of NS1 unfolding and led to solubilization of the IBs, mainly into monomers. After dialysis at pH 8.5, NS1 was refolded and formed soluble oligomers. High (up to 68 mg/liter) NS1 concentrations were obtained by solubilization of NS1-IBs at pH 11 in the presence of arginine (Arg) with a final yield of approximately 80% of total protein content. The process proved to be efficient, quick and did not require further purification steps. Refolded NS1 preserved biological features regarding reactivity with antigen-specific antibodies, including sera of ZIKV-infected patients. The method resulted in an increase of approximately 30-fold over conventional IB solubilization-refolding methods. Conclusions: The present results represent an innovative non-denaturing protein refolding process by means of the concomitant use of HHP and alkaline pH. Application of the reported method allowed the recovery of ZIKV NS1 at a condition that maintained the antigenic properties of the protein.

    Palavras-Chave: zika virus; proteins; viral diseases; hydrostatics; pressure dependence; high pressure; ph value; alkaline hydrolysis

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  • IPEN-DOC 25190

    MUCCILLO, REGINALDO ; FLORIO, DANIEL Z. de; MUCCILLO, ELIANA N.S. . Equimolar yttria-stabilized zirconia and samaria-doped ceria solid solutions. Ceramics, v. 1, n. 2, p. 343-352, 2018. DOI: 10.3390/ceramics1020027

    Abstract: Compositions of (ZrO2)0.92(Y2O3)0.08 (zirconia: 8 mol % yttria—8YSZ) and (CeO2)0.8(Sm2O3)0.2 (ceria: 20 mol % samaria—SDC20) ceramic powders were prepared by attrition milling to form an equimolar powder mixture, followed by uniaxial and isostatic pressing. The pellets were quenched to room temperature from 1200 °C, 1300 °C, 1400 °C and 1500 °C to freeze the defects configuration attained at those temperatures. X-ray diffraction analyses, performed in all quenched pellets, show the evolution of the two (8YSZ and SDC20) cubic fluorite structural phases to a single phase at 1500 °C, identified by Rietveld analysis as a tetragonal phase. Impedance spectroscopy analyses were carried out in pellets either quenched or slowly cooled from 1500 °C. Heating the quenched pellets to 1000 °C decreases the electrical resistivity while it increases in the slowly cooled pellets; the decrease is ascribed to annealing of defects created by lattice micro-tensions during quenching while the increase to partial destabilization of the tetragonal phase.

    Palavras-Chave: solid electrolytes; samarium; impedance; spectroscopy; zirconium; cerium; yttrium oxides; zirconium oxides; cerium oxides; samarium oxides; doped materials; solid solutions

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  • IPEN-DOC 25189

    BUSTILLOS, OSCAR V. . A fonte de íons por impacto de elétrons na espectrometria de massas. Revista Analytica, v. 16, n. 97, p. 38-39, 2018.

    Palavras-Chave: mass spectroscopy; molecular ions; atomic ions; ionization; electron emission; filaments; volatility

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  • IPEN-DOC 25188

    MORAIS, HENRIQUE M.; ROCHA, KAIO R.; TEIXEIRA, LETICIA dos S.; COSTA, MATHEUS F.; SAVOINE, MARCIA M. ; MENEZES, MARIO O. de . Uso de WSN em dispositivos IoT em Reserva Indígena no Tocantins. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 238-239.

    Palavras-Chave: monitoring; internet; computer networks; sensors; environment; ecology; indigenous peoples

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  • IPEN-DOC 25187

    YOSIDAKI, VANESSA de L. ; PERONI, CIBELE N. . Determinação da densidade e fragilidade óssea de camundongos com osteogênese imperfeita visando o tratamento com o gene do hormônio de crescimento murino. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 25187.

    Palavras-Chave: skeleton; hereditary diseases; skeletal diseases; mice; therapy; sth

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  • IPEN-DOC 25186

    FREIRE, RENAN P. ; SOARES, CARLOS R.J. . Purificação e caracterização da tireotrofina humana (hTSH) expressa em células de rim de embrião humano (Expi293F™) em suspensão. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 166-167.

    Palavras-Chave: tsh; hormones; purification; thyroid; glands; resins; chromatography; embryonic cells; kidneys

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  • IPEN-DOC 25185

    MEDRANO, RAFAEL M. dos S. ; WETTER, NIKLAUS U. . Guias de onda em vidros dopados com terras-raras. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 164-165.

    Palavras-Chave: rare earths; ions; doped materials; waveguides; helium-neon lasers; sampling

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  • IPEN-DOC 25184

    ORMENIO, MATHEUS B. ; ROGERO, SIZUE O. ; ROGERO, JOSE R. . Estudo da ecotoxicidade aguda do resveratrol em Daphnia similis irradiadas e não irradiadas. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 162-163.

    Palavras-Chave: drugs; antioxidants; toxicity; daphnia; radiation effects; irradiation

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  • IPEN-DOC 25183

    MATOS, MARIA C.C.V. ; MATSUDA, MARGARETH M.N. . Estudo dos sistemas cromatográficos para controle radioquímico de mertiatida (99m tc). In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 160-161.

    Palavras-Chave: chromatography; radiochemical analysis; comparative evaluations; technetium 99

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  • IPEN-DOC 25182

    FANTIN, LUIZA de B. ; FARIA, RUBENS N. de . Efeitos da substituição do eletrólito na capacitância específica e resistência em série equivalente de supercapacitores eletroquímicos. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 158-159.

    Palavras-Chave: capacitive energy storage equipment; electrochemistry; capacitance; electrolytes

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  • IPEN-DOC 25181

    JUNQUEIRA, LUCAS S. ; FAVARO, DEBORAH I.T. . Avaliação das concentrações de metais, elementos terras raras e traço em perfis de sedimentos do reservatório Graminha - Estado de São Paulo pela técnica de ativação neutrônica. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 156-157.

    Palavras-Chave: water reservoirs; sediments; trace amounts; elements; rare earths; neutron activation analysis; comparative evaluations

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  • IPEN-DOC 25180

    FRENZEL, LUCAS S. ; SABUNDJIAN, GAIANE . Experimento de circulação natural. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 154-155.

    Palavras-Chave: natural convection; computer codes; reactors; computerized simulation; pyrex; glass

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  • IPEN-DOC 25179

    PEREIRA, LUAN M. ; SAIKI, MITIKO . Determinação de constituintes inorgânicos em fitoterápicos pelo método de análise por ativação com nêutrons. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 152-153.

    Palavras-Chave: medicinal plants; quantitative chemical analysis; inorganic compounds; neutron activation analysis

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  • IPEN-DOC 25178

    RIBEIRO, LEANDRO de J. ; HAMADA, MARGARIDA M. . Desenvolvimento de projeto mecânico e eletrônico para tomógrafo industrial de primeira geração. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 150-151.

    Palavras-Chave: computerized tomography; radiation detectors; industry; stainless steels

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  • IPEN-DOC 25177

    BARROS, JULIO O.A. de ; POLITANO, RODOLFO . Relações entre propriedades mecânicas e variações de temperatura em madeiras brasileiras. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 148-149.

    Palavras-Chave: wood; mechanical properties; elasticity; temperature dependence

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  • IPEN-DOC 25176

    OLIVEIRA JUNIOR, JULIO de ; VICENTE, ROBERTO . Estimativa estatística da eficiência no esfregaço. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 146-147.

    Palavras-Chave: probabilistic estimation; sample preparation; surface area; efficiency; data analysis

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  • IPEN-DOC 25175

    ALMEIDA, JOEDSON T. de ; MATTAR NETO, MIGUEL . Simulações numéricas para avaliação estrutural de componentes mecânicos. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 144-145.

    Palavras-Chave: pressurizers; primary coolant circuits; pipelines; mechanical properties; simulation

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  • IPEN-DOC 25174

    PEREIRA, IZAQUE G. ; MATOS, BRUNO R. de . Preparação de membranas de ionômeros perfluorados através do campo magnético. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 142-143.

    Palavras-Chave: membranes; fuel cells; polymers; magnetic fields

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  • IPEN-DOC 25173

    CHAVES, IGHOR G. ; SPENCER, PATRICK J. . Isolamento e caracterização de metalopeptídases do veneno de Crotalus durissus terrificus. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 140-141.

    Palavras-Chave: peptides; venoms; snakes; separation processes; chromatography; glands; proteins

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  • IPEN-DOC 25172

    MORSELLI, GIOVANI R. ; LUGAO, ADEMAR B. . Síntese verde de nanopartículas de prata utilizando extrato de acerola (Malpighia emarginata D.C.). In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 138-139.

    Palavras-Chave: nanoparticles; silver ions; synthesis; fruits; solvents; reagents; ph value

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  • IPEN-DOC 25171

    SANTOS, GIOVANA V. dos ; MATOS, BRUNO R. de . Preparação e caracterização de compósitos de Náfion com adição de ácidos sólidos para células a combustível. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 136-137.

    Palavras-Chave: polymers; fuel cells; electrolytes; composite materials

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  • IPEN-DOC 25170

    MIRANDA, GABRIELLE da S. ; COTRIM, MARYCEL E.B. . Avaliação da qualidade da água subterrânea no campus do IPEN. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 134-135.

    Palavras-Chave: ground water; water quality; quality control; water pollution monitors; aquifers

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  • IPEN-DOC 25169

    GOMES, GABRIELA V. ; PEREIRA, DAISA de L. ; ZEZELL, DENISE M. . Estudo in vitro de um novo fotoabsorvedor para a irradiação de laser Nd:YAG na prevenção de erosão em esmalte. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 132-133.

    Palavras-Chave: neodymium lasers; absorbents; dentistry; corrosion denting; enamels

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  • IPEN-DOC 25168

    ISHIMARU, GABRIEL ; SANTOS, ELIANE C. dos ; SAIKI, MITIKO . Avaliação das frações mássicas de elementos em cascas de árvores de uma pequena área urbana. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 130-131.

    Palavras-Chave: trees; bark; pollution; air pollution monitoring; neutron activation analysis

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  • IPEN-DOC 25167

    ERETIDES, GABRIEL T. ; YAMAGATA, CHIEKO . Preparação e caracterização de pó cerâmico ZrO2-SiO2 pelo método sol-gel para aplicação em biomateriais. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 128-129.

    Palavras-Chave: zirconium oxides; silicon oxides; synthesis; ceramics; implants

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  • IPEN-DOC 25166

    CHIERENTIN, GABRIEL de S. ; DEL MASTRO, NELIDA L. . Efeito da radiação gama em propriedades reológicas da mucilagem de chia. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 126-127.

    Palavras-Chave: gamma radiation; radiation effects; seeds; rheology; polysaccharides

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  • IPEN-DOC 25165

    SILVA, FELIPE A. e ; RODRIGUES, THENNER S. . Nanopartículas metálicas suportadas em óxidos sólidos comerciais: síntese, caracterização e aplicação na reforma a vapor do etanol. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 124-125.

    Palavras-Chave: oxides; ethanol; catalysis; nanoparticles

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  • IPEN-DOC 25164

    CANDIDO, EDUARDO G. ; RODRIGUES, THENNER S. . Nanoestrelas de óxido de zinco decorados com ouro e níquel para aplicações em catálise e reforma de etanol. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 122-123.

    Palavras-Chave: zinc oxides; nanostructures; ethanol; catalysts

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  • IPEN-DOC 25163

    MATOS, DIEGO S. ; GENOVA, LUIS A. . Produção de microesferas de ferrita por gelificação interna. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 120-121.

    Palavras-Chave: microspheres; ferrite; gelation; chemical preparation

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  • IPEN-DOC 25162

    SILVA, DEBORAH Y.B. da ; MUCCILLO, ELIANA N. dos S. . Estudo da permissividade elétrica de óxidos mistos. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 118-119.

    Palavras-Chave: dielectric materials; electrical properties; dielectric properties; oxide minerals; perovskite; ceramics; electric conductivity

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  • IPEN-DOC 25161

    SANTOS, CAMILA M.G. ; SANTIAGO, ELISABETE I. . Otimização dos parâmetros de fabricação de MEAs para células a combustível de membrana de troca protônica (PEMFC) de alto desempenho. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 116-117.

    Palavras-Chave: fuel cells; membranes; electrodes

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  • IPEN-DOC 25160

    TAKAMOTO, ARISSA ; SAIKI, MITIKO . Determinação da composição elementar de plantas medicinais aplicando Análise por Ativação com Nêutrons. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 114-115.

    Palavras-Chave: medicinal plants; concentration ratio; elements; neutron activation analysis; thermal neutrons

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  • IPEN-DOC 25159

    GONZALEZ, ANDREZA A. del C.C. ; ROSTELATO, MARIA E.M. . Estudo de diferentes revestimentos em nanopartícula aplicada ao tratamento de câncer. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 112-113.

    Palavras-Chave: nanoparticles; neoplasms; therapy; polyethylene glycols

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  • IPEN-DOC 25158

    SANTOS, ANDRE L.P.P. dos ; STEFANI, GIOVANNI L. de . Uma análise a respeto do uso de Th/Pu em PWR’s. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 110-111.

    Palavras-Chave: thorium; plutonium; nuclear fuels; reactivity

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  • IPEN-DOC 25157

    CARVALHO, ANA C.R. de ; MOREIRA, DENISE S. . Padronização do 166mHo em sistema de coincidência por software. In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 108-109.

    Palavras-Chave: standardization; holmium 166; radioisotopes; measuring methods; computer codes

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  • IPEN-DOC 25156

    NASCIMENTO, ANA C.G. ; BONFIM, LETICIA ; VIEIRA, DANIEL P. . Avaliação da presença de radicais de nitrogênio no potencial clonogênico de células de melanoma humano (SK-MEL-37). In: PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIACAO CIENTIFICA E TECNOLOGICA; SEMINARIO ANUAL PIBIC, 24.; SEMINARIO ANUAL PROBIC, 15.; SEMINARIO ANUAL PIBITI, 8, 13-14 de dezembro, 2018, São Paulo, SP. Resumo expandido... São Paulo: IPEN-CNEN/SP, 2018. p. 106-107.

    Palavras-Chave: nitrogen; nitric oxide; melanomas; radiosensitivity

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  • IPEN-DOC 25155

    SILVA, ANDERSON G.M. da; BATALHA, DANIEL C.; RODRIGUES, THENNER S. ; CANDIDO, EDUARDO G.; LUZ, SULUSMON C.; FREITAS, ISABEL C. de; FONSECA, FABIO C. ; OLIVEIRA, DANIELA C. de; TAYLOR, JASON G.; TORRESI, SUSANA I.C. de; CAMARGO, PEDRO H.C.; FAJARDO, HUMBERTO V.. Sub-15 nm CeO2 nanowires as an efficient nonnoble metal catalyst in the room-temperature oxidation of aniline. Catalysis Science and Technology, v. 8, n. 7, p. 1828-1839, 2018. DOI: 10.1039/c7cy02402a

    Abstract: We described herein the facile synthesis of sub-15 nm CeO2 nanowires based on a hydrothermal method without the use of any capping/stabilizing agent, in which an oriented attachment mechanism took place during the CeO2 nanowire formation. The synthesis of sub-15 nm CeO2 nanowires could be achieved on relatively large scales (∼2.6 grams of nanowires per batch), in high yields (>94%), and at low cost. To date, there are only a limited number of successful attempts towards the synthesis of CeO2 nanowires with such small diameters, and the reported protocols are typically limited to low amounts. The nanowires displayed uniform shapes and sizes, high surface areas, an increased number of oxygen defects sites, and a high proportion of Ce3+/Ce4+ surface species. These features make them promising candidates for oxidation reactions. To this end, we employed the selective oxidation of aniline as a model transformation. The sub-15 nm CeO2 nanowires catalyzed the selective synthesis of nitrosobenzene (up to 98% selectivity) from aniline at room temperature using H2O2 as the oxidant. The effect of solvent and temperature during the catalytic reaction was investigated. We found that such parameters played an important role in the control of the selectivity. The improved catalytic activities observed for the sub-15 nm nanowires could be explained by: i) the uniform morphology with a typical dimension of 11 ± 2 nm in width, which provides higher specific surface areas relative to those of conventional catalysts; ii) the significant concentration of oxygen vacancies and high proportion of Ce3+/Ce4+ species at the surface that represent highly active sites towards oxidation reactions; iii) the crystal growth along the (110) highly catalytically active crystallographic directions, and iv) the mesoporous surface which is easily accessible by liquid substrates. The results reported herein demonstrated high activities under ambient conditions, provided novel insights into selectivities, and may inspire novel metal oxide-based catalysts with desired performances.

    Palavras-Chave: nanostructures; nanowires; cerium oxides; aniline; oxidation; catalytic effects; synthesis

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  • IPEN-DOC 25154

    BARABAS, ROBERTA de C. ; LIMA, ANA C. de S. ; SABUNDJIAN, GAIANE . A panoramic view of nuclear science and technology education worldwide. International Journal of Development Research, v. 8, n. 10, p. 23256-23259, 2018.

    Abstract: Nuclear energy has been used as a source of clean energy with many benefits. Nevertheless, it is still addressed with prejudice. The atomic bombing of Hiroshima and Nagasaki during World War II (1945), the Three Mile Island accident (1979), Chernobyl accident (1986), the crash of the cesium-137 in Goiânia, Brazil (1987), and the accident in Fukushima (2011) may have been responsible for the negative image of nuclear energy. Researches on education have been conducted with students concerning the conceptual and practical issues of nuclear energy. This work aims to review the literature about nuclear energy education around the world in both, elementary school and high school. Since most educational researches on nuclear energy were published after 1980, this literature review covered the researches that have been published since 1980. The data were presented in chronological order. The results from the literature review provided a clear visualization of the global nuclear energy educational scenario, showing that the theme is still addressed with prejudice due to an incorrect view of nuclear energy and a limited view of its benefits. Concerning the science textbooks, the literature reports that the theme should be better addressed, encouraging students to research more about it. The data from this literature review will serve as a reference for a future proposal for a teaching training program for Brazilian science/physics high school teachers using a new teaching approach.

    Palavras-Chave: education; nuclear energy; information dissemination; learning; public information; public opinion; technology utilization; medicine

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  • IPEN-DOC 25153

    BORGES, EDUARDO M. ; SABUNDJIAN, GAIANE ; DAURIA, FRANCESCO; PETRUZZI, ALESSANDRO. Uncertainty calculation in small break LOCA in the emergency core cooling system connected to the hot leg of Angra 2 nuclear power plant. International Journal of Nuclear Energy Science and Technology, v. 12, n. 2, p. 139-160, 2018.

    Abstract: Owing to the occurrence of nuclear accidents, worldwide nuclear regulatory organisations included the analysis of accidents considered as design basis accidents – Loss of Coolant Accident (large and small-break, LBLOCA or SBLOCA) – in the safety analysis reports of nuclear facilities. In Brazil, the tool selected by the licensing authority, Comissão Nacional de Energia Nuclear (CNEN), is RELAP5 Code. The aim of this paper is the evaluation of the performance of the Emergency Core Cooling System (ECCS) of Angra 2 nuclear reactor during SBLOCA. In this study, the RELAP5 code and the Code Internal Assessment of Uncertainty (CIAU) were used to simulate and analyse the uncertainties of the results. The postulated accident is the SBLOCA in the hot leg connected to the ECCS described in the Final Safety Analysis Report of Angra 2 (FSAR/A2). The results from this study were satisfactory when compared with the FSAR/A2.

    Palavras-Chave: reactor safety; regulations; power reactors; international regulations; loss of coolant; sbloca; lbloca; computer codes; radiation protection; eccs; safety analysis; risk assessment; angra-2 reactor

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  • IPEN-DOC 25152

    BAPTISTA FILHO, B.D. ; CABRAL, E.L.L. ; BARROSO, A.C.O. . An R-package for water and steam properties for scientific and general use. International Journal of Nuclear Energy Science and Technology, v. 12, n. 2, p. 172-195, 2018.

    Abstract: The International Association for the Properties of Water and Steam (IAPWS) develops formulations for the calculation of thermophysical properties of water as a function of different combinations of temperature, density, pressure, enthalpy, and entropy. These properties are useful for scientists and nuclear, chemical, and mechanical engineers who analyse experimental data or are involved with projects and equipment development, like heat exchangers, turbines, or nuclear power reactors. The IAPWS-95 formulation solves the fundamental equation of Helmholtz free energy as a function of temperature and density. This paper gives a description of how these equations are solved and exemplifies the use of a package developed for the free platform R. The IAPWS95 package was developed to help users to get access to the IAPWS-95 formulation in a free software environment which is growing exponentially. Transport properties were programmed using other IAPWS releases. The examples consider the uncertainty analysis of thermal parameters of a nuclear power reactor and the preparation of tables and graphs of water properties.

    Palavras-Chave: water; aqueous solutions; steam; water vapor; mechanical properties; physical properties; thermodynamic properties; water saturation; computer codes; r codes; free energy; helmholtz theorem; pwr type reactors; sensitivity analysis

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  • IPEN-DOC 25151

    ICHIKAWA, RODRIGO U. ; PARRA, JOAO P.R.L.L.; MARTINS, MURILLO L.; YOSHITO, WALTER K. ; SAEKI, MARGARIDA J.; TURRILLAS, XAVIER; MARTINEZ, LUIS G. . Size-strain analysis of iron-excess Mn–Zn ferrite nanoparticles using synchrotron diffraction and its correlation with magnetic saturation and isoelectric pH. Journal of Nanoscience and Nanotechnology, v. 18, n. 8, p. 5697-5703, 2018. DOI: 10.1166/jnn.2018.15446

    Abstract: Iron-excess Mn–Zn ferrite nanoparticles were prepared by coprecipitation with sodium hydroxide (NaOH) at different concentrations (0.1, 0.2, 0.5 and 1.0 mol/L). The results of X-ray diffraction (XRD) analysis using Whole Powder Pattern Modeling (WPPM) showed that higher concentrations of NaOH promote crystallite growth and broader dispersion in crystallite sizes. Energy dispersive X-ray spectroscopy indicates that zinc loss is noticeable when [NaOH] ≥ 0.2 mol/L. XRD revealed also a significant less-crystalline phase contribution alongside the main peaks of the nanocrystalline cubic spinel ferrite phase. The less-crystalline fraction is lower for the ferrite obtained with 0.2 mol/L of NaOH, being about 50% and more than 70% for the other samples. Despite of the less-crystalline fraction and the excess of iron, no secondary phases were detected. The Warren curves showed that the concentration of NaOH significantly influences the microstrain in the crystallites, being smaller for the sample obtained with NaOH at 0.2 mol/L. The sample prepared with this condition presented the better properties to be used as magnetic tracer in clinical diagnoses combining small mean crystallite size, low microstrain, which resulted in materials with higher magnetic saturation and high surface charge under blood pH.

    Palavras-Chave: nanoparticles; ferrite; strains; fourier analysis; synchrotron radiation; x-ray diffraction

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  • IPEN-DOC 25150

    ROVANI, SUZIMARA ; SANTOS, JONNATAN J. ; CORIO, PAOLA; FUNGARO, DENISE A. . Adsorption of bisphenol-A in aqueous solution using silica nanoparticles obtained from sugarcane ash. In: AMERICAN CHEMICAL SOCIETY. DIVISION OF CELLULOSE & RENEWABLE MATERIALS. NATIONAL MEETING & EXPOSITION, 255th, March 18-22, 2018, New Orleans, LA. Abstract... 2018.

    Abstract: Scientists around the world have searched minimize problems related to the incorrect disposal of solid wastes and water contamination. Brazil, for example, is the largest producer of sugarcane in the world, generates around 3-12 million of tons ash/year or more, and this waste can be transformed into valueadded material. In this study, we tried to solve two problems at the same time, manufacturing an adsorbent material and applies it in the remediation of contaminated water with bisphenol-A (BPA), an endocrine disrupting compounds, which alters plasma sex hormone levels in fishes [1]. The silica nanoparticles were synthetized through the addition of silicate obtained from sugarcane ash in the solution of water/butyl alcohol (1:1) with 2.5% wt. of hexadecyltrimethylammonium bromide under constant stirring. Then, 0.5 mol L-1 H2SO4 solution was added to suspension until pH 4. The nanosilica formed was washed with distilled water, filtered and dried. The silica nanoparticles and BPA adsorbed on silica were characterized by different techniques. The maximum BPA adsorption capacity obtained was 80 mg g-1. From TEM images (Fig. 1A-B) of the silica nanoparticles it is seen that all particles has less than 20 nm. Fig. 1C shows the infrared spectra of samples. The band at 1058 cm-1 is due to the Si–O–Si asymmetric stretching, the band at 965 cm-1 is due to Si-OH bending vibrational absorption, the bands at 799 and 446 cm-1 are due to the Si–O–Si symmetric stretching. The presence of other bands in the blue spectra are attributed of BPA adsorbed on silica nanoparticles, at 554 cm-1 is due to aromatic ring deformation vibration of di-substituted benzenes, at 834 cm-1 is assigned to C-H vibrations out of the plane and at 1512 cm-1 is due to aromatic C=C stretching vibration [2]. The results of characterization of the silica nanoparticles manufactured showed that the material presents potential to be employed as adsorbent for remediation of water contaminated with endocrine disrupting compounds.

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  • IPEN-DOC 25111

    CUNICO, PATRICIA ; KUMAR, ANU; ALCANTARA, RAQUEL R. ; FUNGARO, DENISE A. . Adsorption of solophenyl dyes from aqueous solution by modified nanozeolite from bottom ash and its toxicity to C. dubia. Current Nanomaterials, v. 2, n. 2, p. 95-103, 2017. DOI: 10.2174/2405461503666180201152351

    Abstract: Background: It is known that wastewater from textile industries are responsible for producing large amounts of highly contaminated effluents by various types of synthetic dyes. These compounds can be toxic, and in some cases, are carcinogenic and mutagenic and its removal is recommended. Application: In the area of water purification, nanomaterials have been applied for removal of several compounds. Of the four classes of nanomaterials, zeolites have demonstrated good results for the removal of dyes. Nanozeolite synthesized from bottom ash and modified with hexadecyltrimethylamonium (ZMB) was used as adsorbent to removal of Solophenyl Navy (SN), Solophenyl Turquoise (ST) and their hydrolyzed forms (SNH and STH, respectively) from simulated textile wastewater. Method: The physical-chemical characterization of materials was presented by using relevant analytical methods (XRD, SEM, BET surface area, etc.). Effects of parameters such as initial dye concentration, contact time and equilibrium adsorption were evaluated. The adsorption kinetics followed the pseudo-second-order model. Results: Langmuir isotherm model shows the best fit for most dyes-ZMB systems. In order to identify if ZMB presented toxicity for the environment, bioassay and toxicity identification evaluation (TIE) with C. dubia were performed. The leached of ZMB was toxic to daphinids (11.3 TU). Conclusion: TIE results appointed that the main cause of the toxicity could be due the surfactant and metal ions presents in aqueous solution.

    Palavras-Chave: toxicity; textile industry; waste water; nanoparticles; zeolites; copper; dyes; adsorption

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  • IPEN-DOC 25085

    OLIVEIRA JUNIOR, JULIO de ; VICENTE, ROBERTO . Eficiência estimada do esfregaço. São Paulo: Instituto de Pesquisas Energéticas e Nucleares - GRR, Novembro, 2018. (IPEN/GRR-REL-08/18). Aberto.

    Título do projeto: Relatório Técnico de Iniciação Científica

    Abstract: O desafio de caracterizar rejeitos constituídos de peças contaminadas com grandes dimensões decorre da dificuldade em executar métodos de medida com boa precisão e exatidão. A técnica do esfregaço é usada com frequência para determinar a concentração de radioatividade desse tipo de rejeito. Contudo, a eficiência estatística do esfregaço é pouco conhecida, dificultando o uso do método para análises quantitativas. Neste trabalho usou-se da Lei dos Grandes Números e de simulações computacionais para elaborar uma técnica capaz de determinar a eficiência média de um esfregaço e, usando esse valor, prever o valor das medidas de amostras radioativas, permitindo assim obter uma estimativa dos valores de atividades totais fazendo poucos ensaios. Os resultados se mostraram satisfatórios e descrevem uma proposta de arranjo experimental para verificar, empiricamente, a validade do método.

    Palavras-Chave: radioactive wastes; sample preparation; surface contamination; waste management; computer calculations; gaussian processes; statistical data; sampling; testing; computerized simulation

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  • IPEN-DOC 25121

    ZUFFI, ARMANDO V.F. ; ALMEIDA, ANDREIA A. ; VIEIRA JUNIOR, NILSON D. ; SAMAD, RICARDO E. . Below threshold harmonics beams characterization using the knife-edge technique. In: LATIN AMERICA OPTICS AND PHOTONICS CONFERENCE, November 12-15, 2018, Lima, Peru. Resumo expandido... 2018.

    Abstract: Using the knife-edge method we have measured gas generated BTH beams sizes in the VUV region and calculated their divergences, geometrically characterizing this light source.

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  • IPEN-DOC 25101

    MOURA, ESPERIDIANA ; LODIS, ALINE ; REIS, PEDRO ; WELLEN, RENATE. Synthesis and characterization of nanocrystalline hydroxyapatite derived from eggshell for biomedical applications. In: AMERICAN CHEMICAL SOCIETY. DIVISION OF CELLULOSE & RENEWABLE MATERIALS. NATIONAL MEETING & EXPOSITION, 255th, March 18-22, 2018, New Orleans, LA. Abstract... 2018.

    Abstract: Hydroxyapatite(HAP) a crystal-chemical analog of the bone tissue mineral component has been intensively studied in recent years as a potential bone substitute in orthopedic and dentistry because of its biocompatibility, biodegradability, bioactivity, and osteoconductive properties. Hydroxyapatite in a nanocrystalline state with uniform size and morphology has many applications in different fields of medicine ranging from targeted drug delivery to designed load-bearing implants. This work presents the synthesis and characterization of nanocrystalline hydroxyapatite derived from hen’s eggshell waste for biomedical applications. Firstly, bio-hydroxyapatite was synthesized by the wet precipitation method in which white hen’s eggshell waste was used. The white hen`s eggshells were washed, dried and reduced to powder with particle size ≤ 30 μm. Then, the eggshell powder was subjected to a heating cycle at 800 ° C for 3 hours to obtain calcium oxide. Calcium oxide was converted to bio-hydroxyapatite by the addition of a solution of distilled water and phosphoric acid under magnetic stirring at 100 ° C, until a viscous slurry was formed, which was oven dried at 110 ° C for 24 hours. The dried material was disintegrated and calcined at 900 ° C for 2 hours to obtain the hydroxyapatite phase. The bio-hydroxyapatite was irradiated with a high intensity ultrasonic (20 kHz, and 450W/cm2) in order to obtain nanocrystalline hydroxyapatite. These synthesized nanocrystalline hydroxyapatites have been characterized by XRD, FE-SEM, FTIR, and TG analyzes.

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  • IPEN-DOC 25149

    WETTER, NIKLAUS U. ; MIRANDA, ADRIANA R. de ; PECORARO, EDISON; RIBEIRO, SIDNEY J.L.; JIMENEZ-VILLAR, ERNESTO . Dynamic random lasing in silica aerogel doped with rhodamine 6G. RSC Advances, v. 8, n. 52, p. 29678-29685, 2018. DOI: 10.1039/c8ra04561e

    Observação: Correction anexado. RSC Advances, v. 8, p. 35849, 2018. DOI: 10.1039/c8ra90081g

    Abstract: Silica aerogel is a lightweight material, well known for its good mechanical and thermal characteristics, but its optical properties have received less attention, because it is weakly scattering. Here we present for the first time the lasing properties and their complex dynamics of silica aerogel doped with R6G. It is shown that the Q factors of the lasing modes determine the operation of the laser, being either resonant or ASE-lasing. For resonant lasing, the number of resonators is easily varied and the number of modes in a single resonator and their emission frequency can be dynamically adjusted, making this a truly versatile photonics material.

    Palavras-Chave: silica gel; rhodamines; lasers; randomness; fluorescence; doped materials; resonators

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  • IPEN-DOC 25148

    WANG, JAMES S.; KAWA, S.R.; COLLATZ, G.J.; SASAKAWA, MOTOKI; GATTI, LUCIANA V. ; MACHIDA, TOSHINOBU; LIU, YUPING; MANYIN, MICHAEL E.. A global synthesis inversion analysis of recent variability in CO2 fluxes using GOSAT and in situ observations. Atmospheric Chemistry and Physics, v. 18, n. 15, p. 11097-11124, 2018. DOI: 10.5194/acp-18-11097-2018

    Abstract: The precise contribution of the two major sinks for anthropogenic CO2 emissions, terrestrial vegetation and the ocean, and their location and year-to-year variability are not well understood. Top-down estimates of the spatiotemporal variations in emissions and uptake of CO2 are expected to benefit from the increasing measurement density brought by recent in situ and remote CO2 observations.We uniquely apply a batch Bayesian synthesis inversion at relatively high resolution to in situ surface observations and bias-corrected GOSAT satellite column CO2 retrievals to deduce the global distributions of natural CO2 fluxes during 2009–2010. The GOSAT inversion is generally better constrained than the in situ inversion, with smaller posterior regional flux uncertainties and correlations, because of greater spatial coverage, except over North America and northern and southern high-latitude oceans. Complementarity of the in situ and GOSAT data enhances uncertainty reductions in a joint inversion; however, remaining coverage gaps, including those associated with spatial and temporal sampling biases in the passive satellite measurements, still limit the ability to accurately resolve fluxes down to the sub-continental or subocean basin scale. The GOSAT inversion produces a shift in the global CO2 sink from the tropics to the north and south relative to the prior, and an increased source in the tropics of 2 PgC yr􀀀1 relative to the in situ inversion, similar to what is seen in studies using other inversion approaches. This result may be driven by sampling and residual retrieval biases in the GOSAT data, as suggested by significant discrepancies between posterior CO2 distributions and surface in situ and HIPPO mission aircraft data. While the shift in the global sink appears to be a robust feature of the inversions, the partitioning of the sink between land and ocean in the inversions using either in situ or GOSAT data is found to be sensitive to prior uncertainties because of negative correlations in the flux errors. The GOSAT inversion indicates significantly less CO2 uptake in the summer of 2010 than in 2009 across northern regions, consistent with the impact of observed severe heat waves and drought. However, observations from an in situ network in Siberia imply that the GOSAT inversion exaggerates the 2010–2009 difference in uptake in that region, while the prior CASA-GFED model of net ecosystem production and fire emissions reasonably estimates that quantity. The prior, in situ posterior, and GOSAT posterior all indicate greater uptake over North America in spring to early summer of 2010 than in 2009, consistent with wetter conditions. The GOSAT inversion does not show the expected impact on fluxes of a 2010 drought in the Amazon; evaluation of posterior mole fractions against local aircraft profiles suggests that time-varying GOSAT coverage can bias the estimation of interannual flux variability in this region.

    Palavras-Chave: satellites; greenhouse gases; carbon dioxide; in-situ processing; satellite atmospheres; controlled atmospheres

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  • IPEN-DOC 25147

    VINAGRE, CARMEN G.; FREITAS, FATIMA R.; MESQUITA, CARLOS H. de ; VINAGRE, JULIANA C.; MARIANI, ANA C.; KALIL-FILHO, ROBERTO; MARANHAO, RAUL C.. Removal of chylomicron remnants from the bloodstream is delayed in aged subjects. Aging and Disease, v. 9, n. 4, p. 748-754, 2018. DOI: 10.14336/AD.2017.1003

    Abstract: Dietary fats absorbed in the intestine are transported in the circulation as chylomicrons and remnants that have atherogenic potential. Although postprandial lipidemia is increased in older subjects, the specific chylomicron metabolism has not been explored in older subjects nor compared to young subjects, which is the focus of this study. After a 12 h fast, artificially-made emulsions similar to lymph chylomicrons and doubly labeled with radioactive cholesteryl esters and triglycerides were intravenously injected in 23 older (66±4 years) and 20 young (24±3 years) subjects. Sequential blood samples were collected to determine fractional clearance rates (FCR, in min-1) by compartmental analysis. Older subjects had higher LDL-cholesterol (p<0.001) and triglycerides (p<0.0001) than young subjects; HDL-cholesterol presented no difference. The emulsion cholesteryl-ester FCR was lower in older subjects compared to the young (p=0.0001). The emulsion triglyceride FCR did not differ in the two groups. Tested in vitro, however, the lipolysis of the emulsion triglycerides was less intense in the older than in the young subjects. As delayed removal of remnants, indicated by the pronouncedly smaller cholesteryl ester FCR, is related to the presence of cardiovascular diseases, this can be a risk factor which could accelerate atherogenic complications occurring in aged subjects

    Palavras-Chave: blood; age groups; chylomicrons; blood plasma; vascular diseases; age dependence; arteriosclerosis; cholesterol; triglycerides; emulsions; blood circulation; diet; fats; lipids

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  • IPEN-DOC 25146

    VILLEGAS, GETHZEMANI M.E.; MORSELLI, GIOVANNI R. ; GONZALEZ-PEREZ, GIOVANNI ; LUGAO, ADEMAR B. . Enhancement swelling properties of PVGA hydrogel by alternative radiation crosslinking route. Radiation Physics and Chemistry, v. 153, p. 44-50, 2018. DOI: 10.1016/j.radphyschem.2018.08.038

    Abstract: The development of environmentally friendly materials based on non-toxic absorbent polymers, which can ensure high water absorption for several applications in biomedical or agricultural areas, is one of the most complexes problems. In the literature, the non-toxic biodegradable polymer poly(vinyl alcohol) (PVA) was chemically modified with glyoxylic acid to obtain poly(vinylglyoxylic acid) (PVGA) as a biodegradable superabsorbent hydrogel polymer (SHAP), but in fact, the chemical crosslinking reaction decreases the water absorption capacity. In order to crosslink PVGA without losing its absorbent capacity; an alternative radiationcrosslink route has been studied. Radiation-induced crosslinking in the main C-C chain of PVGA where not all free hydrophilic groups (COOH) are involved in a crosslinking reaction as occurs in a traditional chemical reaction. The aim of this work was not only the chemical modification of 99% hydrolyzed PVA to obtain the linear and non-crosslinked PVGA at certain conditions, but also radiation crosslinking at different doses, at dose rate of 5 kGy h−1 attempting to increase the superabsorbent capacity. The samples were characterized by Scanning Electron Microscopy (SEM), Thermo-gravimetrical Analysis (TGA), Nuclear Magnetic Resonance (1H) (NMR) and Infrared Spectroscopy (FTIR). The swelling behavior was measured gravimetrically in different solvents as pure water, buffer pH 3, 7 and 10. Results showed that radiation-crosslink route improves the swelling behavior of PVGA in approximately 215% when compared with PVGA chemically crosslinked, swelled in pure water.

    Palavras-Chave: absorption spectroscopy; cross-linking; crystal lattices; dose rates; glyoxylic acid; hydrogels; infrared spectra; nuclear magnetic resonance; scanning electron microscopy; swelling; thermal gravimetric analysis

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  • IPEN-DOC 25145

    VARA-VELA, ANGEL; ANDRADE, MARIA de F.; ZHANG, YANG; KUMAR, PRASHANT; YNOUE, RITA Y.; SOUTO-OLIVEIRA, CARLOS E.; LOPES, FABIO J. da S. ; LANDULFO, EDUARDO . Modeling of atmospheric aerosol properties in the São Paulo metropolitan area: impact of biomass burning. Journal of Geophysical Research: Atmospheres, v. 123, n. 17, p. 9935-9956, 2018. DOI: 10.1029/2018JD028768

    Abstract: Smoke particles ejected into the atmosphere from biomass burning can modify the atmospheric composition around and even far from the sources. In late winter and early spring, biomass burning emissions from inland regions can be efficiently transported to urban areas in southeastern South America, thus affecting air quality in those areas. In this study, the Weather Research and Forecasting with Chemistry model was applied in order to investigate the impact of biomass burning sources on aerosol loadings and properties over the São Paulo Metropolitan Area (SPMA), in southeastern Brazil, during the period from 19 August to 3 September 2014. The model performance was evaluated using available aerosol measurements from the Narrowing the Uncertainties on Aerosol and Climate Change in São Paulo State project. The combined application of aerosol data and Weather Research and Forecasting with Chemistry simulations made it possible to represent some of the most important aerosol properties, such as particle number concentration and cloud condensation nuclei activation, in addition to evaluation of the impact of biomass burning by analyzing a 5‐day transport event, from 22 to 26 August 2014. During this transport event, differences in the average predicted PM2.5 concentration reached 15 μg/m3 (peaking at 20 μg/m3 during the nighttime hours) over the SPMA, compared with 35 μg/m3 over inland areas northwest and north of the SPMA. Biomass burning accounted for up to 20% of the baseline particle number concentration‐ and cloud condensation nuclei‐weighted relative differences over the SPMA (2,300 and 1,400 cm−3, respectively).

    Palavras-Chave: aerosols; aerosol wastes; atmospheric circulation; air pollution monitoring; smoke detectors; climatic change; biofuels; aerosol monitoring; solar radiation; brazil; meteorology; evaluation

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  • IPEN-DOC 25144

    TOMINAGA, FLAVIO K. ; BATISTA, ANA P. dos S.; TEIXEIRA, ANTONIO C.S.C.; BORRELY, SUELI I. . Degradation of diclofenac by electron beam irradiaton: Toxicitiy removal, by-products identification and effect of another pharmaceutical compound. Journal of Environmental Chemical Engineering, v. 6, n. 4, p. 4605-4611, 2018. DOI: 10.1016/j.jece.2018.06.065

    Abstract: Water contamination by the anti-inflammatory drug diclofenac (DCF) is a consequence of its incomplete removal in wastewater and sewage treatment plants, which is potentialized by interactions with other pharmaceutical contaminants. In this context, electron beam irradiation (EBI) has been considered a clean technology for degrading pharmaceutical compounds in water. Nevertheless, the identification of DCF by-products and their correlation with biological recalcitrance and acute toxicity are poorly understood. In this study, the V. fischeri test was used to characterize DCF toxicity in the absence and presence of fluoxetine (FLX), prior and after irradiation. The results showed complete DCF degradation at low dose (5 kGy). DCF concentration followed pseudo first-order decay with respect to the absorbed, with k0 = (1.33 ± 0.10) kGy−1 (DCF) and k0 = (0.90 ± 0.12) kGy−1 (DCF+FLX). In contrast, negligible TOC removal was observed even at 7.5 kGy, with the formation of recalcitrant, non-biodegradable by-products, as also suggested by the respirometry test. Despite that, the toxicity of the DCF solution diminished from (19.6 ± 1.6) TU to (6.2 ± 2.3) TU, and from (6.8 ± 0.9) TU to (3.1 ± 0.2) TU, in the absence and presence of FLX, respectively, after irradiation up to 5 kGy. Four of the eleven by-products identified by direct-injection MS were easily degraded by EBI, and one (C13H14ClNO5) was considered the least recalcitrant but the most toxic. Based on these results, a possible DCF degradation pathway is proposed, involving hydroxylation and oxidation of aromatic rings, dehalogenation and C−N bond cleavage.

    Palavras-Chave: waste water; sewage; liquid wastes; waste processing; toxic materials; inflammation; electron beams; toxicity; water treatment plants; drugs; irradiation; antipyretics; carbon

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  • IPEN-DOC 25143

    SOUZA, J.P. ; GROSSO, R.L. ; MUCCILLO, R. ; MUCCILLO, E.N.S. . Phase composition and ionic conductivity of zirconia stabilized with scandia and europia. Materials Letters, v. 229, p. 53-56, 2018. DOI: 10.1016/j.matlet.2018.06.091

    Abstract: Sintered specimens of zirconia-10 mol% scandia pure and codoped (up to 1.25 mol%) with europium sexquioxide were prepared by solid-state synthesis, aiming to stabilize at room temperature the high-conductivity cubic phase. High-temperature X-ray diffraction and differential scanning calorimetry results reveal that small amounts of the codopant reduce the enthalpy of phase transition, and full stabilization is evidenced for 1 mol% europium sexquioxide. The low-temperature (<600 C) ionic conductivity increases with increasing codopant content.

    Palavras-Chave: zirconium; sintering; solid electrolytes; phase transformations; scandium; europium; thermal analysis; electrical properties; ionic conductivity

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  • IPEN-DOC 25142

    SOARES, EDSON P. ; CASINI, JULIO C.S.; VIEIRA, LIGIA S.; SILVA, FRANKS M.; FARIA, RUBENS N. de ; TAKIISHI, HIDETOSHI . Effect of hydrogen decrepitation pressure on the particle size of rare earth based alloys for Ni-MH battery production. Materials Science Forum, v. 930, p. 637-642, 2018. DOI: 10.4028/www.scientific.net/MSF.930.637

    Abstract: This paper presents the results obtained from the hydrogenation and decrepitation of three LaNi-based alloys, La0.7Mg0.3Al0.3Mn0.4Co0.5Ni3.8, La0.7Mg0.3Al0.3Mn0.4Cu0.5Ni3.8 and La0.7Mg0.3Al0.3Mn0.4Sn0.5Ni3.8, in the as-cast condition. The procedure for decrepitating the alloys to be used in the negative electrode of the batteries was carried out using a combination of various hydrogen pressures (2-9 bar) at room temperature. At 2 bar of H2 it was revealed that Co, Cu and Sn have influence on the microstructures of the hydrogenated alloys and on the efficiency of hydrogen decrepitation. None of these alloys required thermal heating to activate and start the hydrogen absorption process. The decrepitated materials were characterized by scanning electron microscopy (SEM). The electrochemical measurements were performed using the tested negative electrode between two Ni(OH)2 electrodes as a battery cell.

    Palavras-Chave: hydrogenation; rare earths; transition elements; alloys; electric batteries; hydrogen; lanthanum alloys; nickel alloys; microanalysis

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  • IPEN-DOC 25141

    SILVA, FLAVIA R.O. ; YOSHITO, WALTER K. ; COSENTINO, IVANA C. ; BRESSIANI, ANA H.A. ; LIMA, NELSON B. . Synthesis and characterization of novel crystalline mesoporous beta-tricalcium phosphate nanoparticles. Materials Science Forum, v. 930, p. 63-66, 2018. DOI: 10.4028/www.scientific.net/MSF.930.63

    Abstract: A nano-sized magnesium substituted beta-tricalcium phosphate (Mg:β-TCP) was synthesized by an aqueous precipitation method, at room temperature, in one single step. In the present study, the novel and stable Mg:β-TCP resulted in a crystalline and spherical nanoparticles (diameter of approximately 20 nm) with mesoporous structures and a high specific surface area (about 574 m2/g). These special characteristics make this novel crystalline mesoporous Mg: β-TCP nanoparticles ideal candidates for drug delivery system and a promising non-viral vector for gene therapy.

    Palavras-Chave: nanoparticles; coprecipitation; phosphates; calcium phosphates; magnesium; porous materials; synthesis; gene therapy

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  • IPEN-DOC 25140

    SILVA, RODRIGO P. da; TUDELA, DIEGO R.G.; MUNITA, CASIMIRO S. ; HAZENFRATZ, ROBERTO ; TATUMI, SONIA H.; YEE, MARCIO; MITTANI, JUAN C.R.. Firing temperature determination and thermoluminescence dating of a brick with cuneiform characters found in the ruins of Ancient Babylon / Determinação da temperatura de queima e datação por termoluminescência de um tijolo com caracteres cuneiformes encontrado nas ruínas da antiga Babilônia. Revista do Museu de Arqueologia e Etnologia, n. 28, p. 58-69, 2017. DOI: 10.11606/issn.2448-1750.revmae.2017.133911

    Abstract: This paper aims to study a brick with inscriptions in cuneiform characters in which the sentences are almost complete. Typological studies in agreement with historical records suggest that the tablet was manufactured in the 6th century BCE during the dynasty of Nebuchadnezzar II, Great King of Babylon. The sample was studied by X-ray diffraction analysis (XRD), electron paramagnetic resonance (EPR), thermoluminescence (TL), and instrumental neutron activation analysis (INAA) techniques. The results showed that the brick is 2350 years old (± 40) and its firing temperature was lower than 400 °C.

    Palavras-Chave: thermoluminescence; x-ray diffraction; electron spin resonance; historical aspects; neutron activation analysis

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  • IPEN-DOC 25139

    SILVA, DANILO L.C. e ; KASSAB, LUCIANA R.P.; SANTOS, ANTONIO D. dos ; PILLIS, MARINA F.. Evaluation of carbon thin films using raman spectroscopy. Materials Research, v. 21, n. 4, 2018. DOI: 10.1590/1980-5373-MR-2017-0787

    Abstract: Carbon thin films deposited by the magnetron sputtering technique were evaluated by Raman spectroscopy to study the influence on their crystallinity caused by different parameters like the carbon deposition time, the different buffer-layers and substrates employed and also two distinct heat treatments. The present results showed that the choice of these parameters plays an important role in the production of these films. The results also indicate the possibility of using the technique for the production of carbon thin films to be employed in future in applications with controlled content of structural defects, predominance of ordered sp2 bondings and tendency of graphitization.

    Palavras-Chave: thin films; sputtering; graphite; raman spectroscopy; carbon; magnetrons

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  • IPEN-DOC 25138

    SILVA, J.O.; NONATO, F.B.C.; SAMPAIO, F.G.A.; CALDAS, L.V.E. . Evaluation of some dosimetric properties of a dedicated plane parallel ionization chamber for radiotherapy electron beams. Brazilian Journal of Radiation Sciences, v. 6, n. 3, p. 1-13, 2018. DOI: 10.15392/bjrs.v6i3.547

    Abstract: Ionization chambers are the reference detectors for electron beam dosimetry. In this paper a dedicated radiotherapy plane parallel ionization chamber manufactured with low cost materials is presented for dosimetry in electron beams. The ionization chamber tested has a sensitive volume of 0.4 cm³. Both the collecting electrode and the guard ring were painted with a homogeneous mixture of nail polish and graphite. The dedicated ionization chamber presented a linear response with electron absorbed dose within the range 0.5 to 8.0 Gy, an increase of its response with the field size increasing, an angular dependence within ±5°, as recommended by international standards, and a polarity effect of 0.78% according to the field size. Considering the results obtained, it is possible to conclude that the plane parallel ionization chamber tested in this work presents potential use for elec - tron beam dosimetry in clinical routine.

    Palavras-Chave: absorbed radiation doses; dosimetry; electron beams; ionization chambers; performance; phantoms; planning; radiotherapy

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  • IPEN-DOC 25137

    SELLERA, FABIO P.; GARGANO, RONALDO G.; ANJOS, CAROLINA dos; BAPTISTA, MAURICIO da S.; RIBEIRO, MARTHA S. ; POGLIANI, FABIO C.. Methylene blue-mediated antimicrobial photodynamic therapy: a novel strategy for digital dermatitis-associated sole ulcer in a cow – A case report. Photodiagnosis and Photodynamic Therapy, v. 24, p. 121-122, 2018. DOI: 10.1016/j.pdpdt.2018.09.004

    Palavras-Chave: methylene blue; antimicrobial agents; cattle; inactivation; photosensitivity; therapy; ulcers

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  • IPEN-DOC 25136

    SANTOS, S.C. ; RODRIGUES JUNIOR, O. ; CAMPOS, L.L. . EPR response of yttria micro rods activated by europium. Journal of Alloys and Compounds, v. 764, p. 136-141, 2018. DOI: 10.1016/j.jallcom.2018.06.063

    Abstract: Rare earth (RE) materials present excellent properties, which importance is recognized worldwide. Innovation approaches in energy, medicine, communication, transportation, militarism, and radiation dosimetry consist in RE based materials. As yttrium oxide (Y2O3) exhibits intrinsic lattice characteristics that enable doping with others RE elements (Y2O3:RE), new materials with promising characteristics can be developed. This work aims to evaluate EPR response of europium-yttria (Y2O3:Eu) rods obtained by bio-prototyping. Ceramic rods containing up to 10 at.%Eu were irradiated with gamma doses from 0.001 to 150 kGy and evaluated by Electron Paramagnetic Resonance (EPR) at room temperature with X-band EPR. Based on results, Y2O3:Eu rods with 2 at.%Eu exhibited the most significant response, in which linear behavior arose from 0.001 up to 50 kGy. Fading and thermal annealing evaluations revealed that 2 at%.Eu improved dosimetric characteristics of yttria remarkably. These innovative findings afford that Y2O3:Eu is a promising material for radiation dosimetry.

    Palavras-Chave: yttrium; europium; dosimetry; electron spin resonance; rare earths; design; materials testing; microstructure; hydrothermal synthesis

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  • IPEN-DOC 25135

    ROSSETTO, CLEUSA M.; ICHIKAWA, RODRIGO U. ; MARTINEZ, LUIS G. ; CAREZZATO, GERALDO L. ; CARVALHO, ALEXANDRE M.G.; TURRILLAS, XAVIER. In situ hydration of sulfoaluminate cement mixtures monitored by synchrotron X-Ray diffraction. Materials Science Forum, v. 930, p. 153-157, 2018. DOI: 10.4028/www.scientific.net/MSF.930.153

    Abstract: Mixtures of calcium sulfoaluminate and Portland clinkers with gypsum were hydrated with deionized water. The pastes were introduced in 0.7 mm borosilicate capillary tubes and kept at 40 ºC while diffraction patterns were collected every 35 s for approximately 3 hours with a monochromatic radiation of 12 keV at the XRD1 beamline of the Laboratório Nacional de Luz Síncrotron (LNLS) in Campinas, SP - Brazil. The main crystalline phases (C2S, C3S, ettringite, ye’elemite and gypsum) involved in the hydration were quantified by Rietveld analysis. The most noticeable fact was the absence of portlandite as a crystalline precipitate, most likely due to the capture of calcium ions to form ettringite.

    Palavras-Chave: hydration; aluminates; cements; portland cement; x-ray diffraction; synchrotrons; calcium sulfates

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  • IPEN-DOC 25134

    RICCI, GIANNINA; SANTOS, DANIEL W.; KOVACS, JOSEPH A.; NISHIKAKU, ANGELA S.; SANDES-FREITAS, TAINA V. de; RODRIGUES, ANDERSON M.; KUTTY, GEETHA; AFFONSO, REGINA ; SILVA, HELIO T.; MEDINA-PESTANA, JOSE O.; FRANCO, MARCELLO F. de; COLOMBO, ARNALDO L.. Genetic diversity of Pneumocystis jirovecii from a cluster of cases of pneumonia in renal transplant patients: Cross-sectional study. Mycoses, v. 61, n. 11, p. 845-852, 2018. DOI: 10.1111/myc.12823

    Abstract: Pneumocystis jirovecii can cause severe potentially life-threatening pneumonia (PCP) in kidney transplant patients. Prophylaxis of patients against PCP in this setting is usually performed during 6 months after transplantation. The aim of this study is to describe the molecular epidemiology of a cluster of PCP in renal transplant recipients in Brazil. Renal transplant patients who developed PCP between May and December 2011 had their formalin-fixed paraffin-embedded (FFPE) lung biopsy samples analysed. Pneumocystis jirovecii 23S mitochondrial large subunit of ribosomal RNA (23S mtLSU-rRNA), 26S rRNA, and dihydropteroate synthase (DHPS) genes were amplified by polymerase chain reaction (PCR), sequenced, and analysed for genetic variation. During the study period, 17 patients developed PCP (only four infections were documented within the first year after transplantation) and six (35.3%) died. Thirty FFPE samples from 11 patients, including one external control HIV-infected patient, had fungal DNA successfully extracted for further amplification and sequencing for all three genes. A total of five genotypes were identified among the 10 infected patients. Of note, four patients were infected by more than one genotype and seven patients were infected by the same genotype. DNA extracted from FFPE samples can be used for genotyping; this approach allowed us to demonstrate that multiple P. jirovecii strains were responsible for this cluster, and one genotype was found infecting seven patients. The knowledge of the causative agents of PCP may help to develop new initiatives for control and prevention of PCP among patients undergoing renal transplant and improve routine PCP prophylaxis.

    Palavras-Chave: kidneys; transplants; pneumonia; diseases; genetics; epidemiology; patients; immune system diseases

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  • IPEN-DOC 25133

    AKBARI-JEYHOUNI, REZA; OCHBELAGH, DARIUSH R.; MAIORINO, JOSE R.; DAURIA, FRANCESCO; STEFANI, GIOVANNI L. de . The utilization of thorium in Small Modular Reactors – Part I: neutronic assessment. Annals of Nuclear Energy, v. 120, p. 422-430, 2018. DOI: 10.1016/j.anucene.2018.06.013

    Abstract: This work presents a neutronic assessment to convert a Small Modular Reactor (SMR) with uranium core to the thorium mixed oxide core with minimum possible changes in the geometry and main parameters of SMR core. This option is due to most of SMR are designed to be strongly poisoned in the beginning of cycle and to have a long cycle. Thorium can be used as an absorber in the beginning of the cycle and also be used as a fertile material during the cycle, it seems to be a good option to use (Th/U)O2 as SMR’s fuel. The main neutronic objectives of this study is achieving longer cycle length for SMR by using the minimum possible amount of burnable poison and soluble boron in comparison with reference core. The Korean SMART reactor as a certified design SMR has been chosen as the reference core. The calculations have been performed by MCNP code for homogeneous and heterogeneous seed and blanket concept fuel assemblies. The results obtained show that the heterogeneous fuel assembly is the one which gives longer cycle length and used lower amount of burnable poison and soluble boron, and also consumes almost the same amount of 235U.

    Palavras-Chave: small modular reactors; thorium; smr reactor; m codes; feasibility studies; neutron reactions; fuel assemblies

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  • IPEN-DOC 25132

    PORFIRIO, DARILENA M.; MONTEIRO, LUCILENA R. ; COSTA, MARCONDES L. da. Rainwater geochemistry inside the Barcarena power station at the mouth of the Tocantins River. Environmental Technology, 2018. DOI: 10.1080/09593330.2018.1516801

    Abstract: Most of South America lacks studies on rainwater composition. The present study evaluates rainwater composition and bulk deposition inside Barcarena power station, located at the mouth of the Tocantins River with Amazon River in Brazil. In 2012, 24-h rainwater samples were collected inside the ELETRONORTE power plant (n = 93), and pH, EC, cations and anions were analyzed. In order of abundance, the rainwater ions were Na+ > Cl− > SO4−2 > Ca+2 > K+ > F− > Mg+2 > NH4+-N > NO3−-N. pH values ranged from 4.5 to 6.9, with 17 events with pH <5.6 and 5 events with pH < 5.0. Sodium and Cl− were the dominant ions with sea salt as main contribution. Acidity, enrichment factors and principal component analysis (PCA) indicate that F−, SO4−2 and NO3−-N in the rainwater came from anthropogenic sources. Fluoride correlated strongly (>0.85) with Ca+2 and Mg+2, likely originated from same source in the aluminum production chain. Potassium originated from a mixture of anthropogenic and natural sources, with a good correlation (>0.70) with NO3−-N and NH4+-N, indicating biomass burning and fertilizer origins. In 2012, Barcarena total bulk deposition ranged from 14,070 to 17,890 mg m−2 y−1 with significant contributions of SO4−2 (2,385 to 2,851 mg m−2 y−1), F− (419 to 479 mg m−2 y−1) and NO3−-N (128 to 280 mg m−2 y−1). EC values (4 to 254 µS cm−1) indicated a medium site pollution severity (> 175 µS cm−1), which increased the risk of damage to electrical components.

    Palavras-Chave: pollution; rain water; enrichment; ions; power plants; geochemistry; rivers; brazil

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  • IPEN-DOC 25131

    POLO, IVON O. ; SANTOS, WILLIAM S. ; CALDAS, LINDA V.E. . Modelling the absorbed dose rate of the beta standard BSS2 147Pm source. Applied Radiation and Isotopes, v. 140, p. 83-86, 2018. DOI: 10.1016/j.apradiso.2018.06.015

    Abstract: The dosimetric measurements of 147Pm beta radiation beams have limitations due to their low energy, low dose rate, great dispersion and attenuation in air or tissue. In this work, the Monte Carlo model was developed for a 147Pm absorbed dose rate determination. This model consists of an extrapolation chamber and a 147Pm beta radiation source. Moreover, the absorbed dose rate was determined by experimental measurements and the MCNP Monte Carlo code was used. The relative number of particles that crossed the radioactive source window and the particles that crossed the extrapolation chamber entrance window were determined. The source fluence spectrum was also determined. The results of the simulation and the experimental calculations are in agreement with the absorbed dose rate from the PTB calibration certificate. The results obtained are considered acceptable, and they agree within the uncertainties. The difference between the experimental result and that from the Monte Carlo model, compared to that from the calibration certificate, was only 0.8% in both cases.

    Palavras-Chave: absorbed radiation doses; beta sources; dose rates; extrapolation chambers; monte carlo method; promethium 147; simulation

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  • IPEN-DOC 25130

    POLO, IVON O. ; SANTOS, WILLIAM de S. ; CALDAS, LINDA V.E. . Determination of correction factors in beta radiation beams using Monte Carlo method. Applied Radiation and Isotopes, v. 140, p. 50-54, 2018. DOI: 10.1016/j.apradiso.2018.06.011

    Abstract: The absorbed dose rate is the main characterization quantity for beta radiation. The extrapolation chamber is considered the primary standard instrument. To determine absorbed dose rates in beta radiation beams, it is necessary to establish several correction factors. In this work, the correction factors for the backscatter due to the collecting electrode and to the guard ring, and the correction factor for Bremsstrahlung in beta secondary standard radiation beams are presented. For this purpose, the Monte Carlo method was applied. The results obtained are considered acceptable, and they agree within the uncertainties. The differences between the backscatter factors determined by the Monte Carlo method and those of the ISO standard were 0.6%, 0.9% and 2.04% for 90Sr/90Y, 85Kr and 147Pm sources respectively. The differences between the Bremsstrahlung factors determined by the Monte Carlo method and those of the ISO were 0.25%, 0.6% and 1% for 90Sr/90Y, 85Kr and 147Pm sources respectively.

    Palavras-Chave: extrapolation chambers; radiations; monte carlo method; backscattering; bremsstrahlung; beta dosimetry

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  • IPEN-DOC 25129

    PILLIS, MARINA F. ; OLIVEIRA, MARA C.L. de; ANTUNES, RENATO A.. Surface chemistry and the corrosion behavior of magnetron sputtered niobium oxide films in sulfuric acid solution. Applied Surface Science, v. 462, p. 344-352, 2018. DOI: 10.1016/j.apsusc.2018.08.123

    Abstract: In this work, magnetron sputtered Nb2O5 films were obtained at two different deposition times. The surface chemistry of the deposited layers was investigated by X-ray photoelectron spectroscopy (XPS). The corrosion behavior was assessed by electrochemical impedance spectroscopy, potentiodynamic polarization and potentiostatic polarization tests in 0.5 M H2SO4 + 2 ppm HF solution at room temperature. The Nb5+/Nb4+ ratio decreased with the deposition time, leading to a higher surface activity for the film obtained at 30 min. This result was confirmed by its lower impedance values and higher current densities when compared to the 15′-film. Surface chemistry played a major role on the corrosion behavior of the sputtered films and can be tailored by the deposition time.

    Palavras-Chave: niobium oxides; magnetrons; sputtering; corrosion; x-ray photoelectron spectroscopy; sulfuric acid; stainless steels; corrosion resistance; surfaces; chemistry

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  • IPEN-DOC 25128

    PESQUEIRA, E.I.O. ; MUSCI, C.S. ; ROSSI, J.L. . Influence of the geometric characteristics of the mini-implants on mechanicals properties using artificial bone similar to anterior, middle and posterior regions of the jaws. Materials Science Forum, v. 930, p. 276-282, 2018. DOI: 10.4028/www.scientific.net/MSF.930.276

    Abstract: The objective of this study was to identify the best torque of insertion and removal of mini-implants with a twin screw design (compact and self-drilling) into artificial bones with density and trabecular thickness, similar to anterior, middle and posterior regions of the jaws. Observation of the mini-implants surface using electron microscopy was performed before and after the tests. The torque values obtained during the insertion and removal was measured by digital torque wrench. The analyzed results led to the conclusion that the insertion and removal torques were larger with increase in bone density and cortical thickness. The design of the threads of the miniimplants influenced the insertion torque. Threads with smaller pitch increased the value of insertion torque. The anterior bone drilling installation reduces the insertion torque independent of bone density. Torque increased mainly by increasing the bone density and not necessarily with increased cortical thickness suggesting that the bone density of the trabecular bone must be considered in designing the installation of mini-implants.

    Palavras-Chave: bone mineral density; hydrocortisone; mechanical properties; dentistry; torque; implants; threaded joints; jaw; drilling

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  • IPEN-DOC 25127

    ORTIZ, NILCE ; LIMA, GISELLE N.S. ; NICOLAU, THAMIRES S. ; REIS, ANNA C.S. . Solar/TiO2 photodecomposition and adsorption of tertiary antibiotics systems. International Journal of Latest Engineering and Management Research, v. 3, n. 6, p. 76-83, 2018.

    Abstract: The antibiotic residues are present usually in mixtures in soils and rivers sediment in the range of ng L-1 to μg L-1 around the world and cause, among many things, the proliferation of super-resistant bacteria. The study analyzes the efficiency of titanium dioxide (TiO2) and the solar photodecomposition of binary and tertiary systems of cephalexin, amoxicillin, and oxytetracicline from contaminated water discharges. The calculated kinetic constants of pseudo-first order, pseudo-second order and intraparticle diffusion confirm the better agreement with the pseudo-second-order. The isotherms parameters and constants of Langmuir, Freundlich, Redlich-Peterson (R-P) indicated the Langmuir and R-P isotherms have better correspondence, and the experimental results indicate 45% of removal percentage of antibiotics mixture in just 120 min of time stirring. The amoxicillin has the higher removal percentages followed by cephalexin and the lowest percentage was for oxytetraciclin. This behavior is explained by the chemical bond energy of the chemical structure, lower for amoxicillin increasing until the oxytetraccilin structure. The water treatment using Advanced Oxidative Processes - POA with TiO2 and solar radiation at different concentrations an mixtures of antibiotics followed by adsorption process rises as an efficient and ready to use water treatment to reach better water quality for reuse purposes.

    Palavras-Chave: titanium oxides; decomposition; adsorption; biomass; antibiotics; solar radiation; penicillin; oxidation

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  • IPEN-DOC 25126

    OLIVEIRA, J.R.B.; FINOCCHIARO, P.; AGODI, C.; BOZTOSUN, I.; CAPPUZZELLO, F.; FARIA, P.N. de; GASQUES, L.; LINARES, R.; MEDINA, N.H.; MENDES, D.R.; MORALLES, M. ; SOLACKI, S.O.; ZAGATTO, V.A.B.; ALCANTARA-NUNEZ, J.A.; GONZALEZ-ALVAREZ, M.A.; AGUIAR, V.A.P.; ESCUDEIRO, R.; KURMAN, V.. New spectrometer projects for challenging particle-gamma measurements of nuclear reactions. Journal of Physics: Conference Series, v. 1056, 2018. DOI: 10.1088/1742-6596/1056/1/012040

    Abstract: Two new gamma spectrometer projects are under development, both with some challenging technical characteristics in common, one for the investigation of weakly bound nuclear beam reactions at near barrier energies, and the other for the measurement of double charge exchange reactions in the 15-70 MeV per nucleon range. The first one is being developed and tested at the IFUSP, and the other is going to be built and installed at the LNS, INFN, under the NUMEN collaboration. The main characteristics of the two projects are presented and discussed.

    Palavras-Chave: gamma radiation; gamma spectrometers; gamma spectra; measuring methods; radiation sources; gamma detection; beams

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  • IPEN-DOC 25125

    OLIVEIRA, JUSTINE P.R. ; MELENDEZ-ORTIZ, H.I.; BUCIO, EMILIO; ALVES, PATRICIA T.; LIMA, MAYARA I.S.; GOULART, LUIZ R.; MATHOR, MONICA B. ; VARCA, GUSTAVO H.C. ; LUGAO, ADEMAR B. . Current methods applied to biomaterials – characterization approaches, safety assessment and biological international standards. Current Topics in Medicinal Chemistry, v. 18, n. 4, p. 256-274, 2018. DOI: 10.2174/1568026618666180410151518

    Abstract: Safety and biocompatibility assessment of biomaterials are themes of constant concern as advanced materials enter the market as well as products manufactured by new techniques emerge. Within this context, this review provides an up-to-date approach on current methods for the characterization and safety assessment of biomaterials and biomedical devices from a physical-chemical to a biological perspective, including a description of the alternative methods in accordance with current and established international standards.

    Palavras-Chave: biological materials; bioassay; medicine; in vitro; in vivo; compatibility; composite materials; sterilization; standardization; iso; recommendations; physical chemistry

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  • IPEN-DOC 25124

    NASCIMENTO, C.R.; ASFORA, V.K.; GONCALVES, J.A.C. ; KHOURY, H.J.; BARROS, V.S.M.; KALIL, L.F.; BUENO, C.C. . The performance of a multi guard ring (MGR) diode for clinical electron beams dosimetry. Applied Radiation and Isotopes, v. 141, p. 112-117, 2018. DOI: 10.1016/j.apradiso.2018.07.002

    Abstract: The dosimetric response of a multi guard ring structure (MGR) diode has been studied with clinical electron beam energies from 5 MeV to 15 MeV. The results showed that the MGR dose response is linear in the range of 5–320 cGy and presents reproducibility with variation coefficients less than 0.4%. The field output factors measured with the MGR agreed within 2% with those measured with an ionization chamber. This study evidences that this diode can be used for clinical electron beam dosimetry.

    Palavras-Chave: electron beams; electron dosimetry; ionization chambers; mev range 01-10; mev range 10-100; rings; security personnel; semiconductor detectors; semiconductor materials

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  • IPEN-DOC 25123

    NASCIMENTO, MAURICIO S.; FRANCO, ANTONIO T.R.; FRAJUCA, CARLOS; NAKAMOTO, FRANCISCO Y.; SANTOS, GIVANILDO A. dos; COUTO, ANTONIO A. . An experimental study of the solidification thermal parameters influence upon microstructure and mechanical properties of Al-Si-Cu alloys. Materials Research, v. 21, n. 5, 2018. DOI: 10.1590/1980-5373-MR-2017-0864

    Abstract: Metals solidification involves the transformation of the molten metal back into the solid state. Solidification structures impact heavily on the final product's characteristics. The microstructure effects on metallic alloys properties have been highlighted in various studies and particularly the dendrite arm spacing influence upon the mechanical properties such as tensile strength has been reported. In the present investigation, Al-10wt%Si-2wt%Cu and Al-10wt%Si-5wt%Cu alloys were directionally solidified upward under transient heat flow conditions. The experimental results include solidification thermal parameters such as tip growth rate and cooling rate, optical microscopy, volume fraction of the eutectic mixture, primary dendritic arm spacing and ultimate tensile strength. Experimental growth laws of primary dendrite arm spacing as a function of the solidification thermal parameters are proposed. The Hall-Petch mathematical expressions were used to correlate the ultimate tensile strength as a function of the primary dendritic arm spacing. It was found that the alloy with higher copper content had a more refined structure. More refined structures had higher ultimate tensile strength values.

    Palavras-Chave: solidification; mechanical properties; microstructure; dendrites; aluminium alloys; silicon; copper; eutectics; tensile properties

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A pesquisa no RD utiliza os recursos de busca da maioria das bases de dados. No entanto algumas dicas podem auxiliar para obter um resultado mais pertinente.

✔ É possível efetuar a busca de um autor ou um termo em todo o RD, por meio do Buscar no Repositório , isto é, o termo solicitado será localizado em qualquer campo do RD. No entanto esse tipo de pesquisa não é recomendada a não ser que se deseje um resultado amplo e generalizado.

✔ A pesquisa apresentará melhor resultado selecionando um dos filtros disponíveis em Navegar

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A opção Busca avançada utiliza os conectores da lógica boleana, é o melhor recurso para combinar chaves de busca e obter documentos relevantes à sua pesquisa, utilize os filtros apresentados na caixa de seleção para refinar o resultado de busca. Pode-se adicionar vários filtros a uma mesma busca.

Exemplo:

Buscar os artigos apresentados em um evento internacional de 2015, sobre loss of coolant, do autor Maprelian.

Autor: Maprelian

Título: loss of coolant

Tipo de publicação: Texto completo de evento

Ano de publicação: 2015

✔ Para indexação dos documentos é utilizado o Thesaurus do INIS, especializado na área nuclear e utilizado em todos os países membros da International Atomic Energy Agency – IAEA , por esse motivo, utilize os termos de busca de assunto em inglês; isto não exclui a busca livre por palavras, apenas o resultado pode não ser tão relevante ou pertinente.

✔ 95% do RD apresenta o texto completo do documento com livre acesso, para aqueles que apresentam o significa que e o documento está sujeito as leis de direitos autorais, solicita-se nesses casos contatar a Biblioteca do IPEN, bibl@ipen.br .

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ESTE TEXTO "AJUDA" ESTÁ SUJEITO A ATUALIZAÇÕES CONSTANTES, A MEDIDA QUE NOVAS FUNCIONALIDADES E RECURSOS DE BUSCA FOREM SENDO DESENVOLVIDOS PELAS EQUIPES DA BIBLIOTECA E DA INFORMÁTICA.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI, clique aqui.


2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI, clique aqui.

O Repositório Digital do IPEN é um equipamento institucional de acesso aberto, criado com o objetivo de reunir, preservar, disponibilizar e conferir maior visibilidade à Produção Científica publicada pelo Instituto, desde sua criação em 1956.

Operando, inicialmente como uma base de dados referencial o Repositório foi disponibilizado na atual plataforma, em junho de 2015. No Repositório está disponível o acesso ao conteúdo digital de artigos de periódicos, eventos, nacionais e internacionais, livros, capítulos, dissertações, teses e relatórios técnicos.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.